ʻO ka Atomax pili i nā lāʻau lapaʻau-statins o ka hanauna III, he hopena lipid-hoʻemi. He mea mālama paʻa hoʻokūkū hoʻokūkū o HMG-CoA reductase, he enzyme e catalyates i kahi palena palena mua o ka synthesis synthesis.
Ua kūpono ka hoʻohana ʻana i ka lāʻau lapaʻau i ka mālama ʻana i ka hypercholisterinemia a hoʻokiʻekiʻe i kāu thyoglobulin (TG). Mahalo i Atomax, hiki i nā lipid metabolism ke hōʻoluʻolu a paʻa i nā hopena koʻikoʻi o ka cholesterol kiʻekiʻe.
I kēia ʻike hiki iā ʻoe ke loaʻa nā ʻike kikoʻī e pili ana i ka lāʻau Atomax, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, kumukūʻai, nā loiloi hoʻomanawanui a me nā lāʻau like ʻole.
E hoʻokuʻu i ke ʻano a me ka ʻano
ʻO ka Atomax kahi lāʻau lapaʻau e kuhikuhi ana i ke kāohi ʻana i ka hoʻōla ʻia o HMG-CoA, ka mea e hoʻopiʻi ai i ka hōʻemi o ka testosterone synthesis i nā pūpuna ate. ʻAʻole e like me nā statins o ka hanauna mua, ʻo Atomax ka lāʻau lapaʻau o ke kumu synthetic.
Ma ka mākeke farmacological hiki iā ʻoe ke loaʻa i ka lāʻau lapaʻau i hana ʻia e ka hui India HeteroDrags Limited a me nā mea kanu hale o Nizhpharm OJSC, Skopinsky Pharmaceutical Plant LLC.
Loaʻa ka atomax i ke ʻano o nā papa keʻokeʻo e puni ana i nā ʻaoʻao me ka ʻaoʻao convex. Mai luna mai ua uhi ʻia lākou me ka membrane kiʻi. ʻO ka pūpū hoʻokahi he 30 papa.
Aia ka papa papa i 10 a 20 mg paha o ka waiwai ikaika - atorvastatin calcium trihydrate.
Eia kekahi ma kahi o ka māhele nui, aia kēlā me kēia papa a me kāna ʻili i kekahi nui.
- sosa ʻo ke pākeke laupili;
- pauku talcum hoʻomaʻemaʻe;
- lactose manuahi;
- magnesium stearate;
- ʻōpala palaoa;
- kaleka ka calcium;
- povidone;
- eloe ailaʻoni ʻoni koa hoʻoneʻe;
- crospovidone;
- triacetin;
Eia kekahi, ʻo kahi hapa o ka carbon Titanium e komo i ka hoʻomākaukau.
Ka hana o ka hana o ka hana ikaika
E like me ka mea i hōʻike mua ʻia, ʻike ʻia ka hopena lipid-hoʻemi ʻia o Atomax ma ka pale ʻana i ka hoʻoneʻe ʻia o HMG-CoA. ʻO ka pahuhopu nui o kēia enzyme e hoʻohuli ai i ka methylglutarylcoenzyme A i ka waona mevalonic, kahi mea o mua o ka cholesterol.
Hoʻopili ka Atorvastatin i nā selika mahele, e hoʻohaʻahaʻa ana i ka nui o ka LDL a me ka hana kolamu. Hoʻohana pono ia e nā poʻe maʻi e loaʻa ana i ka hypercholesterolemia homozygous, ʻaʻole hiki ke mālama ʻia me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i ka cholesterol. ʻO ka dinamika o ka emi ʻana o ke kaohi o ka kolamu e hilinaʻi pono ana i ka hopena o ka mea nui.
ʻAʻole ʻōlelo ʻia ʻo Atomax e lawe ʻia i ka wā o ka pāʻina, me ʻai ʻai liʻiliʻi i ka helu o ka heʻe ʻana. Hoʻopili maikaʻi ka mea ola i ka ʻāpana kūwili. ʻO ka ʻike nui loa o ka atorvastatin e mālama ʻia i nā hola 2 ma hope o ka noi.
Ma lalo o ka mana o nā enzyme kūikawā CY a me CYP3A4, hiki i ka metabolism ke hana i loko o ka ate, ma muli o kahi i hana ai ka metabolite parahydroxylated. A laila weheʻia nā metabolites mai ke kino me nā hua bile.
Nā hōʻailona a me nā contraindications no ka hoʻohana ʻana o ka lāʻau lapaʻau
Hoʻohana ʻia ʻo Atomax e hoʻohaʻahaʻa i ka cholesterol. Kūkulu ke kauka i kahi lāʻau lapaʻau i hui pū me ka mea ʻai meaʻai no kēlā me nā maʻi e like me ka mahele nui, heterozygous familial a non-familial hypercholesterolemia.
He kūpono nō ka hoʻohana ʻana i nā papa no ka nui o ka nui o ka serum o kāuroglobulin (TG), ke lawe ʻole mai ka hakahaka i nā hopena i makemake ʻia.
Hoʻopili maikaʻi ʻo Atorvastatin i ka cholesterol i loko o nā mea maʻi me ka hypercholesterolemia homozygous homozygous, i ka wā ʻole ka mālama lapaʻau ʻana a me ka meaʻai ʻole e hoʻokūkū i ka metabolid lipid.
Ke papa ʻia ʻo Atomax no kekahi mau maʻi o nā maʻi. Aia ke aʻo i kahi papa inoa o nā contraindications i ka hoʻohana ʻana o ka lāʻau lapaʻau.
- ʻO nā keiki a me nā wā'ōpiopio ma lalo o nā makahiki 18.
- ʻO ka wā hānau o kahi keiki a me ka umauma.
- Hewa ʻole o ka Hepatic ma kahi o kahi kumu i ʻike ʻole ʻia.
- Hypersensitivity i nā ʻāpana o ka huahana.
ʻO ka lāʻau lapaʻau e kuhikuhi ʻia me ka mālama nui ʻana i ka hihia o ka hypotension arterial, kahi helu hōʻemi o nā electrolytes, nā hewa maikaʻi o ka ʻōnaehana endocrine, nā ala ʻatikala, nā waiʻona maʻi a me ka epilepsy, ʻaʻole hiki ke hoʻokele.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
ʻO kahi mea nui i ka mālamaʻana i ka Atomax ʻo ka mālama ʻana i kahi meaʻai kūikawā. Hoʻolālā ka mea kanu i ka hōʻemi ʻana i ka hoʻokomo o nā meaʻai i loaʻa ka cholesterol kiʻekiʻe. No laila, hoʻokaʻawale ka meaʻai i ka ʻai ʻana i ka viscera (kaʻili, palolo), hua yolks huaʻai, pata, ka momona puaʻa, etc.
ʻO ka hewa o ka atorvastatin e like me 10 a 80 mg. Ma ke kānāwai, ke kauka nei ke kauka kau i kahi pualikua mua o 10 mg i kēlā me kēia lā. Hoʻokomo ʻia kekahi mau mea i ka nui o ka lāʻau o ka lāʻau, e like me ka pae o LDL a me ka kolamu piha, nā pahuhopu o ka mālama a me kona pono.
ʻO ka hoʻonuiʻana i ka dosage hiki ke lawe ʻia ma hope o 14-21 mau lā. I kēia hihia, kauoha ʻia ka ʻike ʻana o nā lipids i ka plasma koko.
Ma hope o 14 mau lā o ka mālama ʻana, ʻike ʻia ka emi ʻana o ka pae o ka cholesterol, a ma hope o 28 mau lā o ka hopena therapeutic kiʻekiʻe. Me ka hoʻomehana lōʻihi, hoʻi ka lipid metabolism i ka maʻamau.
Pono e mālama i ka pōpoki o ka lāʻau i loko o kahi e pale ʻia mai ka mālamalama kūpono i ka liʻiliʻi o nā keiki liʻiliʻi. Hoʻohālikelike ke ʻano o ka mālama ʻana o ka mahana mai 5 a 20 degrees Celsius.
ʻO ka ola o kaʻola he 2 mau makahiki, ma hope o kēia manawa ke pāpā ʻia ka lāʻau lapaʻau.
Hoʻolilo kūlohelohe a me ka overdose
Ke kāohi pilikino ʻana i ka lāʻau no ka lāʻau lapaʻau paʻa paʻa loa.
ʻO kekahi manawa, hiki i kahi lāʻau lapaʻau ke hōʻeha i nā hopena ʻino i ka mea maʻi.
Ma mua o ka hoʻohana ʻana i ka Atomax, pono ʻoe e kamaʻilio i kāu kauka.
Ke hōʻike nei ka pauku aʻo i ka hiki ke loaʻa i kēlā ʻano hopena.
- Nā hemahema o ka pūnaehana nū nui: aseweic syndrome, hiamoe maikaʻi ʻole a hiamoe paha, pō ʻoe ʻōpio, amnesia, hōʻeha, hōʻeha, ka puʻuwai, tinnitus, pilikia pilikia, paresthesia, neuropathy peripheral, ʻāhaʻohaʻe, ʻeha maloʻo.
- ʻO nā hopena pili i nā hui sensory: ka hoʻomohala ʻana o ke kuli, ka kohu conjunctiva.
- ʻO nā pilikia o ka ʻōnaehana cardiovascular me ka hematopoietic: phlebitis, anemia, angina pectoris, vasodilation, orthostatic hypotension, thrombocytopenia, hoʻonui i ka holo o ka naʻau, arrhythmia.
- ʻO ka hapa o ka wahī a me ka ʻōnaehana o ka biliary: constipation, diarrhea, nausea a me ka luaʻi, ka ʻōpū o ka ʻōpū, he colatic hepatic, belching, heartburn, hoʻonui i ka hoʻokumu ʻana i ka maʻi, ka pancreatitis kiʻekiʻe.
- Hōʻike mau i ka ʻili: ka ʻeha, ka ʻū, ka eczema, ka keʻa ʻana o ka maka, ka photosensitivity.
- ʻO nā pilikia o ka ʻōnaehana musculoskeletal: nā mākaʻi o ka ʻōpū o nā haʻahaʻa haʻahaʻa, ʻeha i ka hōʻeha ʻana o nā ʻōpū a me hope, myositis, rhabdomyolysis, arthritis, exacerbation of gout.
- Maʻa urination: hoʻopili ka urination, cystitis.
- Ka hoʻoholoʻana i nā ʻāpana kaulike: hematuria (koko i loko o ka urine), albuminuria (protein i loko o ka urine).
- Nā kumuwaiwai ʻē aʻe: hyperthermia, hoʻemi i ka makemake moekolohe, erectile dysfunction, alopecia, ka momona nui, seborrhea, stomatitis, kaomi kuihuna, rectal, vaginal a me nā wahaebleeds.
ʻO ka lawe ʻana i nā dosis kiʻekiʻe o ka atorvastatin hoʻonui i ka hopena o ka hina ʻana, a me ke myopathy (maʻi neuromuscular) a me ka rhabdomyolysis (ka palena nui o ka myopathy).
I kēia lā, ʻaʻohe ʻano antidote kūikawā no kēia lāʻau lapaʻau.
Inā loaʻa nā hōʻailona o ka overdose, pono lākou e hoʻopau. I kēia hihia, ʻaʻole maikaʻi ka hemodialysis.
Hoʻopili pū me nā lāʻau ʻē aʻe
Hiki i nā mea ikaika ke hana i nā mea lapaʻau i waena o lākou iho, i kahi hopena i hiki ke hoʻoikaika ʻia ai ka nāwaliwali ka hopena therapeutic o Atomax.
ʻO ka hiki ʻana ke launa ma waena o nā mea like ʻole o nā lāʻau like ʻole e pono i ka mea maʻi e hoʻomaopopo i ke kauka e pili ana i ka lawe ʻana i nā lāʻau e pili ana i ka hana Atomax.
I nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau hypolipidemic, ua piha ka ʻike e pili ana i ka pai ʻana me nā lāʻau lapaʻau ʻē aʻe.
Hoʻomaopopo ke aʻo
- Hoʻohui ʻia ka mālama ʻana me ka cyclosporine, erythromycin, fibrates a me nā ʻenehana antifungal (kahi hui o azoles) e hoʻonui i ka hōʻeha o ka pathology neuromuscular - myopathy.
- I ka wā o ka noiʻi, ʻaʻole ʻo ka lawelawe like ʻana o Antipyrine i ka loli nui i ka pharmacokinetics. No laila, ua ʻae ʻia ka hui ʻana o nā lāʻau ʻelua.
- ʻO ka hoʻokaʻawale ʻina o nā suspensions e loaʻa ana i ka ʻenekena sela magnesium a i ʻole alumina hydroxide, e alakaʻi i ka hoʻemi ʻana i ka ʻike o ka atorvastatin i ka plasma.
- ʻO ka hui pū ʻana o ka Atomax me nā lāʻau mālama hoʻomohala i loaʻa nā mea liʻiliʻi loa a me ka norethindrone e hoʻonui ai i ka AUC o kēia mau mea.
- ʻO ka hoʻohana pinepine ʻana o colestipol i ka pae o ka atorvastatin. Ma kēia e hoʻomaikaʻi ai i ka hopena lipid-hoʻohaʻahaʻa.
- Hiki ke hoʻonui paha i ka atomax i nā mea i pili i ka digoxin i loko o ke kahawai. Inā pono, ʻo ka mālama ʻana me kēia lāʻau e pono ai ma lalo o ka mālama mālama olakino.
- ʻAʻole pili i ka hoʻomalu Parallel o Azithromycin i ka manaʻo o ka hana ikaika o ka Atomax i nā kaila koko.
- ʻO ka hoʻohanaʻana o ka erythromycin a me clarithromycin e hoʻonui i ka pae o ka atorvastatin i ke koko.
- I ka wā hoʻokolohua hoʻokolohua, ʻaʻohe i ʻike ʻia nā hopena kūlohelohe ma waena o Atomax a me Cimetidine, Warfarin.
- Ke hoʻonui nei i ka pae o ka waiwai hana i ʻike ʻia i ka wā e hui pū ai ka lāʻau lapaʻau me nā blocker protease.
- Inā pono, e ʻae ke kauka iā ʻoe e hoʻohui i ka Atomax me nā lāʻau lapaʻau, ʻo ia hoʻi ʻo Amplodipine.
- Nā haʻawina e pili ana i ka pili ʻana o ka lāʻau lapaʻau me nā lāʻau antihypertensive.
Me ka hui pū ʻana o Atomax me nā estrogens, ʻaʻohe hewa i nānā ʻia.
Kumukūʻai, nā loiloi a me nā hoʻohālike
He liʻiliʻi nā ʻike ma ka hopena o ka hoʻohana ʻana iā Atomax ma ka Pūnaewele. ʻO ka mea ʻoi i kēia manawa, ua hoʻohana ʻia nā statins heʻohana ma nā hana lapaʻau. ʻO kēia mau lāʻau lapaʻau he dosage haʻahaʻa a ʻaʻole i kumu i nā hopena ʻaoʻao he nui.
He paʻakikī maoli ka Atomax e kūʻai aku i loko o nā lāʻau lapaʻau o ka ʻāina ma muli o ke ʻano o kēia manawa he aneane ʻole ia. I ka awelika, ʻo ke kumukūʻai o kahi pōpeku (30 mau papa o 10 mg) mau pilina mai 385 a 420 mau rubles. Inā kūpono, hiki ke kauoha ʻia i ka lāʻau ma ka pūnaewele ma ka pūnaewele mana o nā mea hana.
Aia nā loiloi he mau loiloi ma ka lipid-lowering agent ma nā papa kūkā. ʻO ka hapa nui, e kamaʻilio lākou i ka ulu ʻana o nā hopena ʻino aʻo ka lawe ʻana i ka lāʻau. Eia nō naʻe, ʻokoʻa nā manaʻo like ʻole.
Ma muli o nā ʻano like ʻole contraindications a me nā hopena maikaʻiʻole, i kekahi manawa ke kahakaha nei ke kauka i kahi synonym (kahi lāʻau me ka mea like ʻole like ʻole) a i ʻole kekahi analogue (e ʻano ana i nā ʻokoʻa like ʻole, akā hoʻokō pū kekahi hopena therapeutic like pū kekahi).
Hiki ke kūʻai aku i nā hōʻailona like o Atomax ma ka mākeke lāʻau Lūkini:
- Atovastatin (Helu 30 ma 10 mg - 125 rubles);
- Atorvastatin-Teva (No. 30 no 10 mg - 105 mau rubles);
- Atoris (ʻAe. 30 no ka 10 mg - 330 rubles);
- Liprimar (Helu 10 ma 10 mg - 198 rubles);
- Novostat (ʻAʻohe 30 no 10 mg - 310 rubles);
- Tulip (ʻAʻole. 30 no ka 10 mg - 235 rubles);
- Torvacard (ʻAʻole. 30 ma 10 mg - 270 mau rubles).
I waena o nā mea kikoʻī kūpono o Atomax, pono ia e hoʻokaʻawale i nā lāʻau lapaʻau:
- Akorta (ʻAʻole. 30 no ka 10 mg - 510 rubles);
- Krestor (ʻAʻole. 7 no 10 mg - 670 rubles);
- Mertenil (No. 30 no 10 mg - 540 rubles);
- Rosuvastatin (Helu 28 ma 10 mg - 405 rubles);
- Simvastatin (ʻAʻole. 30 ma 10 mg - 155 mau rubles).
Ka nānā pono ʻana i ka lāʻau lapaʻau Atomax, nā ʻōlelo e pili ana i ka hoʻohana ʻana, ke kumukūʻai, ka hoʻohālikelike a me ka manaʻo o nā mea kūʻai aku, ʻo ka mea maʻi, me ka ʻaha hui e hele nei i nā mākaʻikaʻi loiloi i ka pono o ka lawe ʻana i ka lāʻau.
Hāʻawi ʻia ka ʻikepili e pili ana i nā statins i ke wikiō ma kēia ʻatikala.
