ʻO Zokor kahi lāʻau lapaʻau e hōʻemi i ka pae o ka cholesterol koko kino, pale i ke kino mai ka hoʻomohala ʻana i nā maʻi ʻino o ka puʻuwai a me nā kīʻaha koko. He hopena maikaʻi ka lāʻau lapaʻau ma hope o nā hebedoma ʻo 2-4 mai ka hoʻomaka ʻana o ka papa o ka ʻoihana.
Noi ʻia nā papa no nā maʻi me ka maʻi mellitus; ma kēia ʻano maʻi, hiki i ka hopena o nā pilikia coronary ke hāʻule koke ma ka 55%, ka make ma ka 30%, ka nui o nā hana a me nā hōʻeha o ka naʻau ma ka 37%.
ʻAʻole hiki i kēlā me nā mea maʻi ke loaʻa ka uku o statin; ke kumukūʻai kumukūʻai ma ke kumukūʻai ma loko o hoʻokahi helu o 10 mg mau ma kahi o 500-700 Rūkū mau rubles. No Zokor i loko o kahi waihona o 20 mg e uku lākou e pili ana i 700-900 rubles.
Inā paha, no kekahi kumu, ʻaʻole kūpono nā papa Zokor no ka mea maʻi me ka maʻi diabetes, ua ʻōlelo ke kauka e hoʻomaʻemaʻe ʻo ia i nā mea hoʻomohala me nā analogues o ka lāʻau. ʻO nā mea kaulana a kaulana loa e kapa ʻia he kālā: Aterostat, Vasilip, Levomir, Zovatin. Nā huaʻōlelo kūpono:
- Atromidine;
- Lovastatin;
- Liprimar;
- Rosuvastatin.
Aia kēia mau lāʻau āpau e like me ka nui o ka waihona o ka mea nui, like ka nui o kā lākou dosimen. Ma kēia hihia, ʻo ka ʻokoʻa ma waena o nā papa e waiho i ka mea hana, ke kumukūʻai o nā mea kōkua i hoʻohana ʻia, ka palena o ke kālepa, a me ka pono o ka pākahi.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
Pono ke hoʻohana ʻana i ka lāʻau lapaʻau Zokor me ke koena ʻai haʻahaʻa haʻahaʻa haʻahaʻa. Hoʻonohonoho ʻia nā papa papaʻa i loko o kahi waihona o 5 a 80 mg, i lawe ʻia ma ka wā hiamoe. Ka pāpā ʻia i kēlā me kēia mea i ʻōlelo ʻia i hōʻike ʻia, ʻoi aku ka nui o nā lāʻau lapaʻau ka koho pākahi.
Hoʻoholo ʻia ka hoʻoponopono ʻana ma mua o hoʻokahi i kēlā me kēia 30 lā. E lōʻihi ka papa o ka mālama ʻana, inā ke kāpae ʻia ka lāʻau lapaʻau, e hoʻi ka ʻano o ka mea maʻi i kona kūlana mua.
ʻO ka ʻōnaehana maʻamau no ka maʻi maʻi, ka maʻi ʻōpū coronary, pākī ka 40 mg i kēlā me kēia lā, me ka hoʻouka ʻana i ke cardio a me ka ʻai. Me kahi ʻano maʻi o ka hypercholesterolemia, hoʻomaka ka intake i ka 10-20 mg o ka waiwai i kēlā me kēia ahiahi, inā pono, hoʻohaʻahaʻa i ka haʻahaʻa haʻahaʻa haʻahaʻa ma mua o 45%, hoʻonui ʻia ka nui o ka lāʻau i 40 mg. Pono ka mālama ʻana e ka lāʻau lapaʻau.
ʻAʻole eʻoi aku ka nui o ka nui ma kēlā me kēia lā ma mua o 10 mg inā ua kauoha ʻia ʻo Zokor me nā lāʻau lapaʻau.
- Cyclosporin;
- Danazole;
- Gemfibrozil.
ʻO ka hypercholesterolemia Familial (kahi maʻi koʻikoʻi koʻikoʻi) pili i ka lawe ʻana he 40 mg i kēlā me kēia pō ma mua o ka moe. I kekahi manawa ua kuhikuhi ʻia e hoʻohana i 80 mg o ka lāʻau lapaʻau, hoʻokaʻawale i ka nui ʻeha i ʻekolu mau manawa, e mālama ana i nā like like ʻole.
I ka manawa e hoʻohana pū ʻia ai me Verapamil a me Amiodarone, ʻo kēia kumu he 20 mg. ʻO nā palapala koʻikoʻi o ka hana ʻoleʻole e koi i ka pākiki i kēlā me kēia lā i 10 mg.
Hana ʻia ka lāʻau lapaʻau i ke ʻano o nā papa oval, ʻo kēlā me kēia pākī he 14-28 mau ʻāpana. I loko o ke kalapona hiki ʻoe ke kūʻai iā Zokor 10 a i ʻole Zokor 20 mg. Ma kahi o nā mea hana nui o ka simvastatin, aia nā papa i ka acid ascorbic (vitamin C), lactose monohidate, maʻa, citric acid a me talc.
Ma mua o ka mālama ʻana, he mea nui e lawe i nā hoʻokolohua no ka hana ate, a laila pono ʻoe e ʻōlelo hou i ka noiʻi mai kēlā manawa kēia manawa.
Inā ʻoi aku ka nui o ka palena palena o ke kumu a i ʻekolu mau manawa paha, hōʻike ʻia ka lāʻau lapaʻau e ʻoki ʻia, e hoʻololi ʻia iā ia me kahi like.
He waiwai waiwai
Hoʻomaopopo ʻia ka lāʻau lapaʻau no ka maʻi maʻi me ka predisposition i ka maʻi naʻau coronary, me ka piʻi nui o ka cholesterol koko kino. Hoʻopili ia me nā hōʻailona o ka maʻi puʻukui coronary, e hōʻemi ana i ka make o ka maʻi cardiovascular maʻi, a lilo i ke ʻano o ka pale ʻana o nā hoʻopiʻi coronary, e like me ka hahau, ka puʻuwai naʻau.
Hiki i ke Diabetics ke hilinaʻi i ka hoʻomohala ʻana i ka hana ʻino i nā moku peripheral. Me ka maʻi ischemic i hele pū me ka hypercholesterolemia, pau ke kūkulu ʻana i ka atherosclerosis coronary.
Loaʻa ka piʻi ʻana loa o ka waiwai ikaika ma hope o 1.3-2.4 mau hola ma hope o ka lawe ʻana i nā papa Zokor. Ma kahi o 85% o kahi kinaki waha ke komo koke ʻia. Hoʻohālikelike ʻia me nā lāʻau ʻē aʻe, ua ʻike ʻia nā kiʻekiʻe o nā simvastatin i nā pona o ka ate.
E noi iā Zokor:
- inā pono, hana hou i ka hana hōʻino o ke kahe koko o coronary;
- e hoʻonāukiuki i nā hana o ka angina pectoris;
- e hoʻohaʻahaʻa i ka kolamu haʻahaʻa a me ka hoʻohaʻahaʻa haʻahaʻa;
- e hoʻonui i nā kolamu momona pono;
- inā pono, e mālama i ka nui o nā triglycerides.
Ma hope o ke komo mua i ka palupalu, ua hoʻohuli ʻia, a laila ua hoʻoneʻe ʻia ka metabolites a me ka lāʻau me ka bile. ʻAʻole hilinaʻi ka hoʻohana ʻana i ka lāʻau lapaʻau ma ka mea ʻai kai, ʻaʻole pili ka meaʻai i ka pharmacokinetics o ka lāʻau.
Me ka hoʻohana mau ʻana, hōʻiliʻili ʻia i loko o nā ʻāpana o ke kino ʻaʻole i kū.
ʻO nā manaʻoʻinoʻino a me nā contraindications
E like me ke kānāwai, ua hoʻomanawanui maikaʻi ʻia ʻo Zokor e ke kino, i kahi ʻia ma ke ʻano kūlohelohe. ʻOiai ʻo kēia, e like me nā lāʻau lapaʻau ʻē aʻe, aia nā hopena ʻino. Ma kahi o 0.1-10% o nā maʻi maʻi e hōʻike ana i ka anemia, ka nānā ʻana o ka asedeic, ka pohō o ka lauoho, ka maʻiʻeleʻele, nā hōʻailona āpau, a me ka polyneuropathy maʻi maʻi.
Eia kekahi, ʻaʻole i hoʻokaʻawale ʻia ka dermatomyositis, myalgia, ka mumū ʻana i ka pancreas, nā ʻōpūʻī o nā hoepili, ʻo dyspepsia. Hiki i nā rashes keokeʻo, kaʻeha, ke nephropathy peripheral, paresthesia, rhabdomyolysis.
Hiki i ka hoʻohana ʻana i nā papa ke hōʻeha i nā poli o ke kaomi, ke kūkaʻi maʻi: ka huehue, ka maʻi lupus syndrome, urticaria, i ka ʻike ʻana i ka māmā, arthralgia. Hoʻanawanui ka poʻe maʻi me nā maʻi metabolic i ka piʻi ma ESR, hyperemia o ke kino a me ka pōkole o ka hanu.
Aia kekahi mau kūlana ikepili:
- hoʻonui hoʻonui hana o ka phosphokinase;
- he hoʻonui i ka nui o transaminase;
- ka hoʻonui ʻana i ka paʻa nitratine concentrat.
Inā hele mai nā mea i manaʻo ʻia, e koi ʻia e hoʻemi i ka dosage a i ʻole ke lawe ʻia, e hoʻohuli i ka lāʻau lapaʻau me nā analogue.
Loaʻa iā Zokor a me nā contraindications, ua komo lākou i ka wā hapai, ka manawa o ka hōʻoki ʻana, ka intolerance pilikino i nā mea o ka lāʻau lapaʻau. ʻAʻole hiki iā ʻoe ke inu i nā papa no nā maʻi o ka puʻuwai ikaika, e komo pū ana me ka transaminase kiʻekiʻe o kekahi etiology. No nā maʻi maʻi me ka hilahila i hōʻike ʻia ka nui o ka transaminase, kuhikuhi ʻia ka lāʻau lapaʻau me ka mālama.
ʻO kahi ʻōlelo like no ka palaka palaka, rhabdomyolysis. ʻAʻole kuhikuhi i nā papa kuhikuhi i koʻu wā kamaliʻi.
Hoʻopili pū me nā lāʻau ʻē aʻe
He mea nui e hoʻonohonoho i ka lawe ʻana iā Zokor me nā lāʻau lapaʻau ʻē aʻe, e pale aku nei i ka hōʻemi ʻana i ka hopena o ka hopena.
ʻO nā Fibrates, he hoʻohui i ka fenofibrate, ka waikika nicotinic, a me Zokor, kānalua i ka hopena hypocholesterolemia, hoʻonui i ka hiki ke hoʻomohala i ka myopathy.
Hiki i ka pāpaʻi ke hoʻopilikia i ka hopena o ka anticoagulants o ka Coumarin; i ka wā i hoʻohana pū ʻia, ʻike ʻia ke kauoha e ke kauka. Me kēia ala, pale ʻia ke koko.
Hoʻohana pinepine pū kekahi me kekahi mau lāʻau lapaʻau i ka hiki ʻana o ka myopathy, ma kahi maʻamau ke kamaʻilio nei mākou e pili ana i nā lāʻau lapaʻau Erythromycin, Terithromycin, Ketoconazole. ʻAʻole ia e lawe ʻia i nā kiʻekiʻe o nā papa lāʻau lapaʻau.
- Verapamil;
- Amiodarone;
- Danazole;
- Cyclosporin.
ʻO kekahi laʻa ke pale aku i ka ʻai nui ʻana i ka wai citrus, ʻoi loa ke kīhai ʻana. Hoʻonui ka huahana i ka hana o ka lāʻau lapaʻau i ka plasma koko.
Kuhi ʻia nā papa Zokor e ka lāʻau lapaʻau mai kāu kauka.
ʻO ke ola o ka noho o ka lāʻau, i lalo o ke ʻano o ka mahana, ʻaʻole iʻoi aku ma mua o ʻelua mau makahiki mai ka lā i hana ʻia ai.
Nā ʻōlelo kikoʻī
Hiki i ka hoʻohana lōʻihi o Zokor ke hōʻeha i ka myopathy me nā hōʻailona ʻano: ʻehaʻeha o ka naʻau, nā palupalu ākea, me ka piʻi ʻana o ka ʻumi o nā manawa o ka phosphokinase creatine.
Ua hoʻokau ʻo Myopathy iā ia iho i ka hopena o ka hana a ka lua. Hoʻonui ka hopena o ka myopathy me ka hoʻonui nui ʻana o kahi mea i loko o ke koko koko i ka wā e lawe ai i nā lāʻau lapaʻau.
ʻO kēlā me kēia maʻi maʻi i kau ʻia e Zokor e pono ai ke ʻike pono i ka manawa e nīnau aku i ke kauka i ka hiki koke ʻana no kekahi ʻeha a me ka ʻeha i ʻike ʻole ʻia.
I ka hoʻomakaʻana o ke kumu o ka mālamaʻana, me kēlā me kēia piʻi i dosage, pono ia e nānā i ka ʻike ʻana o ka proteinokokinase. Inā loaʻa kahi mau hōʻailona no ka hoʻokaʻawale ʻana o ka holo ʻana, e hoʻokaʻawale i ka lawe ʻana i nā pōpoki i kekahi mau lā ma mua o ke kaʻina hana. Pēlā lākou e hana ai i nā lā mua ma hope o ka wawao.
Ma mua o ka mālama ʻana me ka lāʻau lapaʻau a i ka wā o ka mālama ʻana, pono e nānā i ka hana o ka naʻau, hōʻike ʻia nā haʻawina hou no kēlā poʻe maʻi maʻi e loaʻa nā wai kiʻekiʻe.
Kahiana o Zokora Rosuvastatin
No nā mea maʻi me nā pilikia kolesterol kiʻekiʻe, ua hoʻololi ʻia ʻo Zokor i nā papa rosuvastatin. Hana maikaʻi ka lāʻau lapaʻau i kahi hana maikaʻi loa o ka hana maʻamau o ka hana ʻana o ka cholesterol kiʻekiʻe-kiʻekiʻe a hoʻohaʻahaʻa i kahi mea haʻahaʻa-haʻahaʻa.
Hāʻawi ʻia ka lāʻau lāʻau i nā statins ʻehā he nui, e hoʻohana pono ʻia e hōʻea i ka hypercholesterolemia, a ke hoʻohana ʻia ʻana i ka lāʻau lapaʻau prophylactic e kū'ē i ka atherosclerosis vascular a me nā hopena.
Mahalo i ka hoʻomaʻemaʻe ʻana i nā kahe koko, ke kāohi ʻia ʻana o nā palaka atherosclerotic, ka pale ʻana i ka hoʻomohala ʻana o ka ʻōmaika ischemic, a me ka puʻuwai puʻuwai me kahi predisposition i nā maʻi cardiovascular mai pale ʻia.
ʻO nā papa Rosuvastatin ka mea i aʻo ʻia ma waena o nā statins, ua hōʻike ʻia ka maikaʻi o nā ʻoihana. ʻO kahi hiʻohiʻonaʻokoʻa mai ka analogues nā hana:
- hakakā me ka kolokolo hewa;
- hoʻōla i nā hana hoʻowalewale luhi;
- hoʻonui i ka cholesterol maikaʻi.
ʻO ka mea nui ka mea nui o ka kaohi ʻana o ke aʻeha o ka maʻi ma ke kino o ka maʻi maʻi maʻi maʻi, no ka mea ʻoi loa ka mea e hoʻokau i ka atherosclerosis.
Hoʻonui ka lāʻau lapaʻau i ka hoʻoukaʻana o ka nitrogen, e hāʻawi i ka hoʻomaha ʻana o nā kīʻaha koko, e hana ana i kahi hopena hou. Ma hope o ka hoʻohana ʻana i nā papa, hoʻokomo koke nā mea ikaika i ka ʻōnaehana ka puni, i ka ʻuʻaka ʻia ʻia i nā kiko a me nā ʻāpana. Eia kekahi, ʻoi aku ka luhi o ka assimilation ma mua o nā mea o nā analogue, ʻoi aku ka lōʻihi o ka lōʻihi o ka excretion.
Hiki ke hōʻea i nā kūmole plasma kiʻekiʻe i nā hola 5 ma hope o ka nānā ʻana. ʻOiai ke kau ʻia nei o ka lāʻau i loko o kahi hōʻemi i hōʻemi ʻia, ʻaʻole ia e pili i ka pilina maʻamau me nā lāʻau lapaʻau ʻē aʻe.
Kūʻai a me nā contraindications
E like me nā papa ʻē aʻe, ua loaʻa nā rosuvastatin i nā cont contications. ʻO ka mea mua, ke kamaʻilio nei mākou e pili ana i ka hoʻomālamalama ʻana i kekahi mea o ka lāʻau (me ka mea hoʻohiwahiwa). Pono e hoʻomanaʻo ʻia ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā maʻi maʻi i ka wā hāpai, no nā keiki ma lalo o 18 makahiki, koe wale nō i nā hihia o ka hypercholesterolemia hoʻoilina.
Lā ʻia nā pōpoki me ka hana ʻole o ka ate ma muli o ka hana kino ʻole ma ke ʻano o ka hōʻino o ke kō, hoʻokiʻekiʻe ʻia i nā pae o nā ate.
ʻAʻole ʻae ʻia ka hoʻohana like ʻana me ka cyclosporine. Pēlā nō hoʻi kahi contraindication he myopathy - ke ʻano kuʻuna o nā uaua skeletal striated, kahi predisposition i kona hoʻomohala ʻana.
Hāʻawi ʻia ka ʻikepili e pili ana i nā statins i ke wikiō ma kēia ʻatikala.
