Manaʻo kekahi mau maʻi hānai ʻaʻole lākou i lawe i ka metformin. Akā ʻaʻole ʻino kēia, ʻo ka hapa hapalua o kēia mau mea maʻi i ʻōlelo ʻia i nā lāʻau lapaʻau e pili ana i ka metformin hydrochloride mai nā lā mua ma hope o ke ʻano o ka maʻi type kīkē 2, inā ʻaʻole ka hopena o ka noho ʻana e lawe mai i nā hopena i makemake ʻia. Ua kuhikuhi ʻia nā papa i koho ʻia me ka metformin inoa generic i mau mau ʻano ʻē aʻe (metabolic syndrome, prophylaxis o nā kūlana cardiovascular a me ka oncology), akā, ma kekahi ʻano, hiki ke kūʻai wale ʻia lākou e ka lāʻau lapaʻau.
Inā he metformin ʻoe i ka palapala, e koho iā Metformin Teva. ʻO kēia analogue kūpono o ka Lūkini mua Glucophage e hoʻokō i nā koi a pau o nā lāʻau antidiabetic kiʻekiʻe kiʻekiʻe.
ʻO Metformin Teva a me kāna hoa mua
ʻOihana kūʻiʻo Israeli huahana TEVA Pharmaceutical Industries, Ltd. ma ke kaona ʻo Petah Tikva (a me nā keʻena lunamanaʻo ma Polani, Italia a me nā ʻāina ʻē aʻe) e hana ana i nā mea kikoʻī e hoʻokumu ana i ka waiwai like (me ka metformin hydrochloride), me ka nui o ka dosage (500, 850 a me 1000 mg), me ka like o ka kao a me ka nui o ka excretion. ka hana ikaika, e like me ka lāʻau Farani. Hoʻohālikelike nā kūlana hana a me nā pono hana i ka neʻe ʻana i nā hana i nā ʻenehana i hana i ka metformin kumu.
ʻO ke ʻano o ka hoʻohana ʻana i ka mākau waha o ka hana a me ka analogue ka mea like.
ʻOi loa aku ka maʻalahi o Generative Metformin Teva: ka pahu o ka Glucofage kumu kūʻai no 330 mau rubles, kahi pahu like like o kahi ʻano - 169 rubles. Ma loko e hiki ai iā ʻoe ke loaʻa i nā blisters me ke keʻokeʻo a i ʻole ka oval (ma muli o ke ʻano lāʻau) nā papa me kahi laina hoʻokaʻawale a me nā kaha kahakaha. E maile ke kahua o, ʻaʻole me nā pōʻino a me nā haumia. Loaʻa ka Metformin-MV-Teva i loko o kahi waihona o 500 mg me nā hiki lōʻihi. ʻO ka ola mahele o nā papa he 2.5-3 mau makahiki, ʻaʻole pono ka lāʻau lapaʻau i nā kūlana kūikawā no ka mālama.
Nā hiʻohiʻona lāʻau lapaʻau o Metformin Teva
Lapaʻau lāʻau
ʻO ka mea hana nui o ka lāʻau ka metformin hydrochloride, he hui o nā derivatives biguanide e normalize i nā kikoʻī o ka glycemic o ka hookeai a me ke kōpaʻa postprandial. ʻO ke ʻano o nā hana o ka lāʻau lapaʻau he mau huakaʻi.
- Ke pale nei ka lāʻau lapaʻau i ka hana ʻana o ka glycogen i loko o ka ate ma ka pale ʻana i nā kaʻina hana o ka gluconeogenesis me glycogenolysis;
- Hoʻomaʻamaʻa ka lāʻau lapaʻau i ka pale ʻana o nā uaua i ka insulin, hoʻomaikaʻi i ka hoʻonui ʻana a me ka hana ʻana o ka glucose i nā uaua;
- Hōʻemi ka mea i ka nui o ke kaʻe o ka glucose i nā pā o ka ʻōpū.
Hoʻokomo ʻo Biguanide i ka hana ʻana o ka glycogen endogenous.
Hoʻokuʻu ʻia ka mea hiki i nā ʻōnaehana holomua glucose i ka membrane kelepona.
Ua hoʻokūpaʻa ʻia ua loaʻa i nā inika therapeutic o ka lāʻau e hoʻomaikaʻi i ka hui lipid koko: hoʻemi ʻia lākou i ka hapa o ka kolamu nui, triglycerol a me nā lipid kūloko haʻahaʻa.
Lapaʻau lāʻau
- Hoʻopau ʻO ka pae kiʻekiʻe loa o ka T o ka lāʻau me ka bioavailability piha loa a hiki i 60% ka hoʻopaʻa ʻia he 2 mau hola ma hope o ke komo ʻana i ka ʻao gastrointestinal. Me nā regimens mālama lapaʻau maʻamau, ʻo ka hōʻuluʻulu mau o ka hōʻea ʻana o ka lāʻau i loko o ke koko e nānā ʻia ma hope o hoʻokahi lā a i ʻole ʻelua, a e helu ana i 1 μg / ml. ʻO ka lawe ʻana i ka lāʻau lapaʻau me ka meaʻai e hoʻohaʻahaʻa i ke kahe o ka metabolite.
- Kahele. ʻAʻole hiki i ka mea hoʻokomo loa i ka hoʻopili ʻia me nā protein; ʻike ʻia kona mau ala i loko o nā kōnela koko wale nō. ʻO V D (ka lahilahi hoʻopuka kikowaena) ʻaʻole iʻoi aku i ka 276 lita. ʻAʻole ʻike ʻia nā Metformin metabolites i loko o ke kino; ʻaʻole i hoʻololi ʻia, e hoʻopau ʻia ana e nā keiki.
- ʻAno hānau. Hōʻike nā hōʻike o ka hepatic clearance o metformin (mai i 400 ml / min.) Hōʻike e hoʻihoʻi ʻia kona hōʻemi ʻia e ka filtration glomerular. ʻO ka hapalua o ka ola i ka manawa hope o ka excretion he 6.5 mau hola.Hila me nā hana kuhi o ka renal, hemo ka clearance, hoʻonāukiuki kēia i ka hōʻiliʻili o ka metformin i ke koko. Aia a 30% o ka lāʻau i hoʻokaʻawale ai i loko o nā pua i kona ʻano kumu.
Nā Hōʻike
ʻO ka Metformin Teva kahi lāʻau lapaʻau mua loa; ua kuhikuhi ʻia no nā pākeke a me nā keiki ma mua o 10 mau makahiki o ka hoʻokele ʻana i ka maʻi type 2 i nā manawa āpau o ka hoʻomohala ʻana i ka maʻi.
Hoʻomaopopo ʻia ka lāʻau lapaʻau inā he loli ola (haʻahaʻa-kaʻai ʻai, ka hana kūlohelohe, ka mālama ʻana i ka manaʻo o ka naʻau) ʻaʻole kāohi i ka glycemia.
Ua kūpono kēia lāʻau lapaʻau no ka monotherapy a no ka mālama paʻakikī, ʻoiai ua hui pū ʻia ka metformin me ka insulin a me nā lāʻau lapaʻau ʻanoma antidiabetic e like me kahi ʻano o ka hana ma mua o biguanides.
Nā Hoʻohui
Hoʻopili i nā mea kikoʻī o kēlā me kēia mea o nā ʻano o ka pula, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau.
- Me ka ketoacidosis maʻi maʻi, koma, precoma;
- ʻO nā maʻi me nā maʻi heʻe (CC ma lalo o 60 ml / min.);
- ʻO nā maʻi i ka pīhoihoi, me ka dehydration, nā maʻi koʻikoʻi o kahi ʻano maʻi;
- Inā nā maʻi (ka pila a hoʻonā hewa paha) e hoʻonāukiuki i ka pololi o ka oxygen hemolele;
- I ka manawa noiʻi e hoʻohana ana i nā hōʻailona hoʻohālikelike e pili ana i ka iodine;
- Me nā hana hemo o ka ate, me ka hoʻohuihui ʻawaʻawa (ikaika a koʻikoʻi paha).
Ma muli o ka nele o nā hōʻike pono o ka palekana, ua mālama ʻia ʻo Metformin Teva i nā wahine hāpai, nā kahu hānai, a me nā keiki ma lalo o 10 makahiki.
Ke kaʻa ʻole nei i nā kaʻa a me nā hana paʻakikī no ka maʻi maʻi maʻi i ka wā me ka Metformin Teva ʻaʻole contraindicated inā lawe lākou i ka lāʻau lapaʻau e like me monotherapy. Me ka hoʻomaʻamaʻa paʻakikī, pono e noʻonoʻo i nā pono o nā lāʻau ʻē aʻe.
Nā manaʻo e hoʻohana
Manaʻo ka lāʻau Metformin Teva e lawe iā ia me he piha me ka wai piha. Hiki ke loaʻa ka hopena kūpono loa me ka hoʻohana ʻana i nā papa i mua o ka papa ʻaina a i ka wā o ka pāʻina. Koho ke kauka i ka regimen dosage a me ka dosage i mālama i ke ʻano o ka maʻi, nā pathologies concomitant, ʻo ia ka makahiki o ka maʻi maʻi, ka hopena kū hoʻokahi i ka lāʻau lapaʻau.
Nā pākeke
Me ka monotherapy ʻana a i ʻole ka hōʻola paʻakikī, ʻaʻole iʻoi aku ka nui o ka hoʻomaka ʻana ma mua o nā pā 1. / 2-3r. / Lā. Hiki ke hoʻoponopono ʻia i ke ʻano ma hope o nā hebedoma 2, i ka wā e hiki ai iā ʻoe ke loiloi i ka maikaʻi o ka pau ʻana. ʻO ke hoʻonui hoʻonui i ka lohi e kōkua i ke kino e ola i ka manawa o ka hoʻololi ʻana me nā hopena kūpono ʻole. ʻO ka helu marginal o ka lāʻau lapaʻau no kēia 'o nā maʻi maʻi he 3 g / lā. me ka hoʻohana 'ana
Ke hoʻololi nei i nā kikowaena hypoglycemic me kahi lāʻau lapaʻau, alakaʻi ʻia lākou e ka hoʻoponopono lāʻau mua. No ka lohi ʻana i nā huahana, pono paha e hoʻomaha iki i ka hoʻololi ʻana i kahi papa hana hou.
Me ka hui pū ʻana me nā papa me ka inikini insulin, hoʻomaka ka metformin e lawe ʻia me ka liʻiliʻi liʻiliʻi (500 mg / 2-3 r / lā.).
Koho ʻia ka nui o ka insulin e like me ka meaʻai a me ke glucometer.
ʻO ka maʻi Diabetics
Ma nā maʻi maʻi "mākaukau", nawaliwali nā mākaukau o nā keiki, no laila, i ke koho ʻana i kahi hoʻoponopono lapaʻau, pono ke mālama ʻia ko lākou kūlana a nānā pono ʻia nā mea hōʻike.
E na keiki
ʻO nā keiki me ka maʻi hānai ma mua o 10 mau makahiki i kau ʻia e 500 mg / lā. Lawe ka papa papa i hoʻokahi manawa, i ke ahiahi, i ka wā pāʻina piha. ʻO ka hiki ke hana he titration ma hope o 2 mau pule. ʻO ka palena kiʻekiʻe loa no kēia māhele ʻo 2000 mg / lā, i hoʻohele ʻia ma luna o 3 pākēneka.
Nā hopena ʻaoʻao a me ka overdose
ʻO ka Metformin Teva kekahi o nā lāʻau lapaʻau antiidiabetic palekana loa. Ua hōʻoia ʻia kēia mau ʻike ʻia e nā haʻawina he nui a he mau makahiki o ka hoʻomaʻamaʻa ʻana i nā makahiki he nui. I ka wā o ka hoʻololi, ua hoʻomau ke 30% o nā maʻi maʻi i ka maʻi dyspeptic: nuala, luaʻi, a me ka ʻono metala mai kēlā manawa kēia manawa, hoʻemi ʻia ka makemake, pau ka pāʻina i kēlā me kēia papa.
Hōʻalo i ka titration o ka ʻai me ka hōʻeha ʻana i ka wā lōʻihi a nalowale nā hōʻailona. ʻO kahi hiʻohiʻona o ka Metformin Teva kahi liʻiliʻi o nā mea hoʻohui i nā mana. ʻO ka pinepine ka mea nāna e hoʻonāukiuki i nā hopena maikaʻi ʻole.
ʻOiai ka hoʻonui ʻana o 10 mau pā i ka pomo therapeutic no nā hana hoʻokolohua ʻaʻole i hoʻonāukiuki i ka hypoglycemia. Ma kahi o ka hōʻailona o ka lactic acidosis i nānā. Hoʻihoʻi i nā hana o ke kino e pili ana i ka maʻi infusion a me ka hemodialysis.
Ka helu ʻana i ka hoʻohanaʻana
ʻAʻohe manaʻo maikaʻi ʻole e pili ana i ka Metformin Teva. Hoʻomaopopo ka Diabetics i kona loaʻa, ka pono a me ka palekana, ʻaʻole i haʻahaʻa i nā kumukūʻai kūʻai nui.
He alakaʻi nui ʻia ka ʻoihana multinational ʻo Teva Pharmaceutical Industries Ltd i ka ʻoihana kūʻai kaiapuni honua: i ka makahiki i hala wale nō, ʻoi aku ka loaʻa ʻana o kāna waiwai nui ma mua o $ 22 biliona. Na ke kōkō kuleana ke kuleana o nā mākeke 80 nona ka mea i loaʻa i kāna huahana. No 20 mau makahiki ua hana ʻo ia me ka mea hana Lūkini, e hāʻawi ana iā lākou ma kahi o 300 mau ʻano o kāna huahana.
Mai ka makahiki 2014, ua hana ka mea kanu i Yaroslavl e loaʻa ai nā papa he 2 bilona i kēlā me kēia makahiki no Russia a me nā ʻāina ʻē. Ua wehe ʻia ka ʻoihana ʻo Teva LLC ma ke ʻano o ka hoʻokō o kāna hoʻolālā waiwai ʻenehana.
