Ma ka diabetology he wahi hoʻomohala koʻikoʻi ma ka lāʻau lapaʻau. I kēia mau makahiki i hala iho nei, ua hoʻokumu nui ʻia nā lāʻau lapaʻau hou hou i hoʻoikaika i ka hoʻokele ʻana i ka maʻi type 2. ʻO ka paona ʻana o ka ʻepekema o ka makahiki hope i kapa ʻia ʻo incretin mimetics, e hōʻemi ana i ka hemoglobin glycated e 1%. ^ E Ha yM. I kēia hihia, hoʻemi ka maikaʻi o ka mea maʻi o ka mea maʻi; ʻaʻole i hoʻonā ʻia nā mea i hoʻohui ʻia i nā hopena koʻikoʻi e like me ka hypoglycemia.
ʻO kēia mau hiʻohiʻona a pau (neutrality ma loko o ka paona o ke kino, ka nele o nā hopena maikaʻi ʻole, ka hopena kiʻekiʻe a me ke kumukūʻai kūpono) pili nō hoʻi i ka lāʻau lapaʻau lāʻau antidiabetic Metformin, kahi i lawe ai i ke kūlana alakaʻi i ka hoʻomohala ʻana i ke ʻano type 2 no ka hapalua kenekulia.
Hoʻohui ʻia ka lāʻau lapaʻau ʻAmelika Huipūloko ʻO Progliz Prolong i nā pono o ka metformin a me ka incretinomimetics, a ʻo ka manawa lōʻihi e hāʻawi i ka maʻalahi o ka hoʻohana a me ka palekana hou.
ʻO nā hiʻohiʻona lāʻau o ka lāʻau lapaʻau
ʻO ka Combogliz Prolong kahi hui paʻa o ka saxagliptin a me ka metformin, e hāʻawi ana i nā kauka a me nā maʻi maʻi i nā manawa hou e pale i kā lākou kiʻi glycemic.
Saxagliptin
He lālā inoa ʻo Saxagliptin i nā lāʻau hōʻeuʻeu. Hoʻopili ʻia nā hua manu i loko o nā ʻāpana a komo ke hākeke. Aia he 2 mau ʻano o nā hormones kūlohelohe: GLP-1 (peptide like me glucagon) a me HIP (glucose-hilinaʻi i ka insulinotropic-polypeptide).
Ke hoʻomau nei i loko o ke kahawai, hoʻomaikaʻi lākou iā 70% i ka hana ʻana o nā insulin endogenous e nā kuleana β nona i kēia hana.
Ma ka ʻokoʻa, hoʻokaʻawale ʻo incretins i ka syntagon glucagon a hoʻoweliweli i ka hoʻokuʻu o nā mea o ka ʻōpū, hana i kahi hopena saturation hou.
Ua hoʻokumu ʻia i loko o ka maʻi pāʻai me ka maʻi type 2, he haʻahaʻa loa ka hoʻohaʻahaʻa o ka endogenous incretins ma muli o ka nīne a maʻalahi nā luku e nā enzyme DPP-4 (dipeptidyl peptidase). Hoʻopili ka agonist incremental i ka hana o DPP-4, ʻoiai e mālama ana i ka hana o nā endetoma endogenous. ʻO nā mea hoʻohālike kiʻi o ka GLP-1 ka hemahema o ka pale o kēia kaomi ikaika.
ʻAʻole lōʻihi ka laha o Saxagliptin i ke ola o ka incretins, akā hāʻawi pū hoʻi i ka ulu ʻana o kā lākou mau helu i loko o ka maʻamau physiological (ʻoi loa o 2 mau manawa). ʻO ka lawe ʻana i ka incretinomimetics e hōʻemi i nā hōʻailona o ka wikiwiki a me ka glycemia postprandial. ʻO kēia mau hiʻohiʻona o ka lāʻau hiki ke hoʻopau i nā kūlana hypoglycemic.
Metformin
ʻAʻole ka hopena o ka b-cell, no laila, ʻaʻole ia e hoʻoulu i ka huna ʻana i ka insulin a ʻaʻole e hoʻouka i ka pancreas.
Ke kāohi nei ʻo ia i ka hilalelo ʻana o ka glycemia ma ka pale ʻana i ka hoʻokuʻu ʻana o ka glycogen ma ke akea ma o 30%. Hoʻopili ka Metformin i ka hoʻopili ʻana o nā molekika o ka glucose i loko o ka ʻōpū, hoʻonui i ka naʻau o nā mea hoʻopiʻi o nā pona i kā lākou iho. Ma o ka wikiwiki ʻana i ka halihali o ka glucose i ka musele, ua hoʻonui ʻia ka nui o ka ikehu o ka pono o ke kino a me ka hōʻemi ʻana o ka loli o ka kō i hoʻoilo ʻole i loko o ka momona.
ʻO ka Metformin me ka hoʻokuʻu ʻana i loaʻa ka hopena hou loa - ka liʻiliʻi o nā hopena ʻaoʻao mai ka gastrointestinal tract, stabilization o ke kaupaona ʻana. Hoʻopau i ka wai momona gasts, hoʻopau koke ka membrane, huehue ka pahu a lilo a uhi ʻia me ka gel. Mahalo i kēia matrix gel, ua hoʻokuʻu ʻia ka lāʻau lapaʻau me ka wā holoʻokoʻa o ka lā, e hāʻawi ana i nā kūlana no ka hoʻopili nui ʻana.
ʻO ka hui pū ʻana o ka incretinomimetic me metformin i ʻike ʻia e nā kauka e like me ka maikaʻi o kekahi manawa e kāohi ai i ka maʻi type 2. Ma waho o ka hōʻoluʻolu o ka loaʻa a me ke kūpaʻa o ke ahonui i kēlā mau hoʻoponopono lapaʻau, ke ʻoihana nui ka hana ʻoi loa a me ka palekana i hōʻoia ʻia. No nā maʻi maʻi o ka maʻi lohi, ʻo ia ka koho maikaʻi loa, no ka mea, ʻaʻole e hāʻawi ka lāʻau lapaʻau i ka loaʻa o ke kaupaona ʻana, ka hoʻomohala ʻana o ka hana cardiovascular gagal, pancreatitis, a me oncology.
E hoʻokuʻu i ke ʻano a me ka hoʻonohonoho Kombiglyze lōʻihi
ʻO ka hui lāʻau lapaʻau ʻAmelika ʻo Bristol-Myers Squibb e hana i ka lāʻau lapaʻau antidiabetic i ke ʻano o nā papa i ʻoniʻoni ʻia me nā mana hoʻololi.
Aia i kēlā me kēia mau kōpona 500 a 1,000 mg paha o nā mea ikaika a Metformin a me 2.5 a i ʻole 5 mg o Saxagliptin. I ka hoʻohui i nā mea waiwai, ua hoʻohui ʻia ka mea hoʻohui me ka hoʻopiha: magnesium stearate, sodium carmellose, hypromellose. ʻO ka melemele o ke kala paha he melemele, ʻulaʻula a i ʻole beige paha, i kau ʻia ma ke ʻano. Hoʻopili ʻia nā kapili i nā ʻāpana poli o ka alumini foil. Aia paha i nā pahu pepa kahi 4-8 mau papa.
E hoʻokuʻu i ka lāʻau lapaʻau lapaʻau. Ke Combogliz Hoʻonui i ke kumukūʻai ma luna o ke ala: 1000 mg + 5 mg (28 papa) - a hiki i 3250 rubles .; 1000 mg + 2.5 mg (56 papa i kēlā me kēia pūpū) - a hiki i 3130 mau rubles.
ʻOi aku ka lōʻihi o ke ola o ka lāʻau lapaʻau ma mua o 3 mau makahiki. Pono e hoʻokaʻawale ʻia nā lāʻau lapaʻau. ʻAʻole pono ka lāʻau lapaʻau i nā kūlana kūikawā no ka mālama.
Combogliz Prolong: nā ʻōlelo hoʻohana no ka hoʻohana ʻana
Koho ke kauka i ka papa hana o ka hoʻokele a me ka helu i kēlā me kēia kanaka, i ka nānā ʻana i nā kuhikuhi o ka glucometer, ʻoi aku ka nui, ka makahiki o ka maʻi maʻi, ka hopena kū hoʻokahi i nā papa. Ma keʻano holoʻokoʻa, hāʻawi ke aʻo i nā ʻōlelo hōʻike.
ʻO ka lāʻau lapaʻau lōʻihi e lawe pinepine ʻia i ka 1 r. / Lā. aoolia.
E inu i kahi papa i ke kakahiaka a i ke ahiahi paha, me ka wī ʻole. No ka hoʻopulapula i nā hoʻoponopono hoʻopukapuka, e hana ka mea kūpono o ka pale.
He mea kū hoʻokahi ka nui o kēia hewa, ʻoiai he hoʻomaka monotherapy hiki iā ia ke 1 papa (500 mg o ka metformin + 2,5 mg o saxagliptin), inā ʻaʻole hiki ke loaʻa ka hopena glycemic pololei, hoʻonui ʻia ka nui i 2 mau papa (1000 mg o metformin + 5 mg o saxagliptin).
Me ka hoʻohana like ʻana o nā lāʻau lapaʻau no ka mālama ʻana i nā maʻi concomitant, pono e noʻonoʻo i ka hopena o kā lākou pilina. No ka hōʻike, me ka hoʻokele waʻa o ka poʻe pale o CYP3A4 / 5 isoenzymes (Indinavir, Ketoconazole, Apanzodon, Itraconazole, Atazanavir), ka palena liʻiliʻi o ka saxagliptin i kuhikuhi ʻia - 2,5 mg.
ʻO nā lāʻau lapaʻau e pili ana i ka metformin me ka hopena lōʻihi o nā hopena kūpono ʻole i ke ʻano o nā maʻi dyspeptic i liʻiliʻi loa ma mua o nā analogues me ka wikiwiki. Pēlā ka pili o ke kino i nā kūlana hou, ʻaʻohe ʻeha loa no ka kaʻe ʻana o ka pēpē, Pono e lawe ʻia ka hoʻōla o ka maʻa mau, i kēlā me kēia 2 hebedoma.
Pono e hoʻololi ʻia kēlā me kēia hoʻololi i ke ʻano o ka lāʻau lapaʻau, no laila he mea nui e hoʻomaopopo i ke kauka e pili ana iā lākou i ka manawa kūpono.
Kahiana Kombiglyce Prolong
No Combogliz Prolong, kahi kuʻuna me ka pūʻulu like o nā mea hana ikaika paha ʻo Comboglis XR, kahi i hoʻoili ʻia ma Italia a me UK. ʻO ke kumu kūʻai o kahi hoʻohālikelike mai 1650 mau rubles. (28 mau papa o 1000 mg o ka metformin a me 2.5 mg o nā saxagliptin).
Ua hui pū ʻia nā hopena therapeutic o Avandamet, Yanumet, Glimecomb, GalvusMet a me Bagometui i kahi hopena therapeutic like.
E kau i nā lāʻau lapaʻau e pili ana i kahi mea hana like e like me Glyformin Prolong, Glucofage, Metadiene, Sofamet, Diaformin Od, Ongliza, Matospanin, Metfogamma, Siofora.
ʻO wai ka mea i hōʻike ʻia i ka lāʻau lapaʻau
Ua hoʻohālikelike ʻia ka lōʻihi o Combogliz no ka diabetes type 2 e hoʻomaʻamaʻa i ka mana glycemic ma ka hoʻohui ʻana i ka meaʻai haʻahaʻa-haʻahaʻa a me ka hana kino kūpono, inā ʻaʻole kahi hoʻohālike e hiki ai i ka hopena ola ke makemake i ka hopena a me ka hui ʻana o ka saxagliptin me ka metformin kūpono no ka mea maʻi.
ʻO nā contraindications kūpono a me ka pili
ʻO kahi lāʻau lapaʻau me kahi kiʻekiʻe kūloko, ʻo ia ʻo Combogliz Prolong, ʻaʻole i kuhikuhi ʻia no ka intolerance pilikino a me ka hypersensitivity i nā mea kumu o ka ʻano.
- ʻAʻole hōʻike ʻia ka lāʻau lapaʻau i nā makuahine hāpai a me ka lactating (hoʻoliuli iki ʻia lākou i ka insulin), ma muli o ka loaʻa ʻole o ka pae hōʻike kūpono no ka hana pono, ʻaʻole lākou i kuhikuhi i nā keiki.
- ʻAʻole kūpono ia ka lāʻau lapaʻau no ka maʻi maʻi me ka maʻi type 1.
- I nā maʻi renal, a me nā kūlana i hoʻonāukiuki iā lākou, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau.
- Mai hoʻohana i nā lāʻau lapaʻau e mālama i nā poʻe maʻi me nā pathology e hoʻokau i ka pololi o ka oxygen.
- Me ka ketoacidosis (puka diabetes) me a ʻole ʻole coma, loaʻa ka lāʻau lapaʻau i ka manawa pōkole.
- Hoʻopau ʻia nā peni i ka wā o nā hana, me nā hōʻeha koʻikoʻi, nā wela kuni. ʻO kahi hoʻokolohua X-ray me nā huaʻai iodine i loaʻa i ka maʻi maʻa ka mea e hoʻonāukiuki i nā ʻeha, no laila e hoʻohuli ʻia ka insulin. Ma ka huina, ua hōʻike ʻia ka lāʻau lapaʻau no 48 mau hola ma mua a he 48 mau hola ma hope o nā kaʻina hana, inā pū nō ua hilinaʻi wale ʻia nā kūlana o nā keiki a me ke ola o ka mea maʻi.
- ʻO nā pathologies Liver, lactic acidosis a me ka hilinaʻi waiʻona kekahi ma ka papa inoa o nā contraindications. ʻAʻole hiki iā ʻoe ke kuhikuhi i ka lāʻau lapaʻau i nā mea maʻi me ka genact galactose intolerance.
ʻO ka nānā pono e uku ʻia i ka maʻi maʻi o ka wā o ka pākeke, ʻoiai ʻo ka malnutritional, pancreatitis a me ka hana kino kūlohelohe i hiki ai ke hoʻonāukiuki i ka hypoglycemia.
Loaʻa i nā hopena e makemake ai a me ka make nui
Hiki i nā Saksagliptin me nā ʻano like ʻole o ka hopena.
- Sinusitis
- Migraines
- ʻEha ka naʻau;
- Lohe;
- ʻAi ʻia kahi maʻi mimi;
- ʻO nā ʻōpū o ke mele o nā neʻe i loko o ke alo;
- ʻO Thrombocytopenia;
- Nasopharyngitis;
- Hypoglycemia;
- ʻO Gastroenteritis;
- Ke pehu nei ma ka maka;
- ʻO ka pancreatitis
- ʻĀlioiaʻi.
Ua hōʻike ʻia nā noiʻi Laboratory i ka emi ʻana o ke kō o ka mauʻu B12 me ka hoʻohana mau ʻana i ka lāʻau lapaʻau, a me kekahi o ka emi ʻana o ka nui o nā lymphocytes. ʻO nā hihia o ka overdose he hoʻokahi, kū pinepine i ke hoʻohana lōʻihi o ka saxagliptin. ʻAʻole hoʻonā ka lāʻau lapaʻau i ka hoʻohālikelike, me ka nui o ka lāʻau, hemodialysis he maikaʻi ia. Ma ka hoʻohālike, mālama ʻia ke ʻano hōʻailona maʻi.
ʻOi aku ka maʻamau o ka metformin maʻamau, ʻo ka hoʻopiʻi weliweli loa he lactic acidosis.. ^ E Ha yM. Hiki iā ʻoe ke hoʻomaopopo i ke ʻano ma o nā hōʻailona aʻe:
- ʻAeʻoki;
- Hoʻololi pōkole;
- ʻEha ka naʻau;
- He koko haʻahaʻa;
- Hypothermia;
- ʻAmpslelo naʻau;
- ʻO ka haunaele o ka puʻuwai.
I kahi kūlana paʻakikī, ʻike mua ʻole ʻia, palupalu, precoma a me coma ulu. Pono ka mea i hili ai i ka haukapila, me ka loaʻa ʻole o ka mālama lapaʻau, hiki iā ia ke make. Hopu pū ʻia ka metformin momona e ka hemodialysis, he mea nui e noʻonoʻo e hiki ai i ka clearance creatinine i hōʻea iā 170 ml / min.
ʻO ka pololei o ka maʻi maʻi maʻi e hoʻokō i nā ʻōlelo a ke kauka a pau, ʻo ka haʻahaʻa o ka pilikia o nā hōʻeha koʻikoʻi. I ka hihia o Combogliz mau loa, ʻaʻole paʻakikī ia e hahai i ka papaʻa o ka lawe ʻana i ka lāʻau lapaʻau.
Nā koho no ka launa pū ʻana me nā lāʻau lapaʻau ʻē aʻe
Ke hoʻomohala nei i kahi hoʻoponopono lapaʻau no Combogliz Prolong, koʻikoʻi ke aʻoʻana i ka endocrinologist e pili ana i nā lāʻau āpau a ka maʻi maʻi e lawe ai i ka maʻi concomitant. Hiki i kekahi o lākou ke hoʻonui i ke hiki i ka hoʻohaʻahaʻa ʻana i ke kōpona o Comboglize, e kāohi kekahi i kāna hana.
No kahi manaʻo maʻamau, hiki iā ʻoe ke hoʻokele i ka papaʻaina.
Saxagliptin | Metformin |
Hoʻonui ka hopena Hyperglycemic | |
| Rifampicin, Pioglitazone, Magnesium a me Aluminum Hydroxides / Simethicone | GCS, diuretics, waikika nicotinic hormone thyroid, isoniazid, sympathomimetics, phenothiazines, estrogens, phenytoin, calcium channel blockers |
Hāʻawi i nā kūlana hypoglycemic | |
| Amprenavir, Diltiazem, Erythromycin, Fluconazole, Aprepitant, Verapamil, huʻu ʻālaʻi, Ketoconazole, aila sulfonylurea, Glibenclamide, Ketoconazole, CYP3A 4/5 isoenzymes, Famotidine | ʻO nā māka Cationic, Furosemide, nā hopena lapaʻau e pili ana i ka etanol, Nifedipine |
Amprenavir, Diltiazem, Erythromycin, Fluconazole, Aprepitant, Verapamil, huʻu ʻālaʻi, Ketoconazole, aila sulfonylurea, Glibenclamide, Ketoconazole, CYP3A 4/5 isoenzymes, Famotidine
ʻO nā māka Cationic, Furosemide, nā hopena lapaʻau e pili ana i ka etanol, Nifedipine
Hōʻike ia i nā hoʻokolohua me ka hoʻopaʻaʻana o ka hana a me ka mālama ponoʻī iā ʻoe iho me Combogliz Prolong hiki i nā hopena ola koʻikoʻi.
ʻO Combogliz Prolong: nā loiloi o ka maʻi maʻi
ʻO ke kauka lapaʻau e mālama ana i ka pono o ka hopena me ka lāʻau lapaʻau ʻo Combogliz Prolong e hoʻomaopopo i kona ʻano, a me ka maʻi maʻi maʻi no hoʻi ke kānalua nei i kona hiki.
Pono ka hoʻokele ʻana i ka maʻi diabetes i kahi ala paʻa: nā haʻahaʻa haʻahaʻa kalakika a ka haʻahaʻa, ka nānā ʻana o kēlā me kēia lā e heluhelu ai i ka heluheluʻana o ka glucometer, nā hana kino a me ke kākoʻo lāʻau lapaʻau. Ma kēia hui wale nō e hiki iā ʻoe ke helu ma ka hopena o 100% o Combogliz Prolong.
I ke wikiō, kamaʻilio profesor-endocrinologist ʻo A.S. Ametov e pili ana i nā loina o kēia mana o ka hoʻokele ʻana i ka maʻi type 2.
