ʻO Vasilip kahi lāʻau lapaʻau na loko o ka lipid-lowing group. ʻO ke kumu nui o kāna hana ka mea e kuhikuhi ana i ka hoʻohaʻahaʻa ʻana i ka pae o nā lipids (nāʻu) i ka koko. Loaʻa ʻia nā Vasilip i ke ʻano o nā papa keʻokeʻo i loko o kahi kiʻiʻoniʻoni kiʻiʻoniʻo, puni, ʻuʻuku convex ma nā ʻaoʻao ʻelua.
ʻO ke kumu hana nui o kēia hoʻoponopono ka simvastatin. Aia pū kekahi i nā mea waiwai ʻē aʻe e like me ka lactose monohydrate, pregelatinized starch, anhydrous citric acid, vitamin C, mais starch, magnesium stearate a microcrystalline cellulose. I ka papa ʻaina iho ma ka talc, propylene glycol, hypromellose a me ka titanium dioxide.
ʻO ke ʻano o ka lāʻau lapaʻau he ʻelua mau ʻano - 20 a 40 mg kēlā me kēia.
Ke hana o ka hana a vasilip
No ka mea ʻo Vasilip no nā lāʻau lapaʻau lipid-ʻohi, kūpono ke ʻano o ka hana. ʻO ka mea mua, ʻo vasilip i hōʻemi i ka kaila o ka kolamu o ka kolamu ma ke koko. Aia kekahiʻano he lua o ka cholesterol - "hewa" a "maikaʻi." ʻO ka "maikaʻi" kahi lipoproteins haʻahaʻa haʻahaʻa, a ʻo ka "maikaʻi" hoʻokahi lipoproteins density kiʻekiʻe.
He hopena ʻo Vasilip i ka hoʻomaka mua ʻana o ka pae cholesterol. Hoʻokomo ia i ka hoʻololi o HMG-CoA (hydroxymethylglutaryl-coenzyme A) i ka waila mevalonic. Ke hele nei kēia loli ma lalo o ka mana o ka enzym HMG-CoAreductase. ʻO ka hopena o Vasilip i ka hopena kaumaha i kēia enzyme, ma muli o ke ʻano o ka cholesterol i kū ʻole ai. Hoʻopilikia ka lāʻau lapaʻau i ka kolamu, aia i ke kino. E hōʻemi ana i ka nui o ka kolamu e pili pū ana me ka lipoproteins low haʻahaʻa, a ke hōʻemi nei hoʻi i ka neʻe o ka triglycerides.
ʻO kēia mau mea o kahi ʻano lipid ke kuleana no ka hoʻokumu ʻana i nā plas atherosclerotic i ka lumen o nā ona. Akā hoʻonui ka lāʻau i ka nui o ka cholesterol "maikaʻi" - pili i nā lipoproteins density kiʻekiʻe. ʻO ka pae o apolipoprotein B hoʻi i hōʻemi ʻia - kahi kahu ʻai ʻokoʻa kūikawā e kuleana ai no ka lawe ʻana i ke kolamu ma o ke kino.
Hoʻopili iki i ka hoʻemi ʻana i ka pae o kekahi mau ʻano o lipids, ʻo ka mea hoʻomohala nui o Vasilip ka hopena i ka paia o nā kīʻaha koko a ma luna o ke koko ponoʻī. ʻO nā mea koko e like me macrophages, ka mea e alakaʻi nei i ka hana o ka hoʻopiʻi ʻana i ka mālama kolala, ke hoʻomake ʻia nei e ka hana o ka lāʻau lapaʻau, a hoʻopau ʻia nā pōpoki ponoʻī. Eia nō hoʻi, ʻo ke kāpili ʻana o nā mea i kapa ʻia ʻo isoprenoids, nona ke kuleana no ka ulu ʻana o nā hua o ka membrane muscular o nā moku, me ka hoʻohaʻahaʻa iki ʻia, no ka mea ʻaʻole e palalalanu ka pā o nā ipu, a ʻaʻole ʻoliki i kā lākou lumen. A ma laila, kahili maikaʻi ʻo Vasilip i nā kīʻaha koko a hoʻomaikaʻi i ke kahe koko.
Loaʻa ka hopena nui loa ma hope o hoʻokahi mahina a me hoʻokahi mahina.
ʻO nā hiʻohiʻona o nā pharmacokinetics o vasilip
Ua nānā ʻia ʻo Vasilip. He mea maikaʻi loa ia ma ka pā o ka ʻili liʻiliʻi. ʻO ka paona loa o ka lāʻau lapaʻau ka nānā ʻia hoʻokahi a i ʻelua mau hola ma hope o ka lawe ʻana, akā ma hope o nā hola 12 he haʻahaʻa ia i 10%. Hiki ke kiʻi i ka lāʻau lapaʻau me ka meaʻai, ʻaʻole kēia e hopena i kona hopena. Pēlā nō, ʻaʻole ia e hōʻiliʻili i loko o ke kino me ka hoʻohana mau ʻana. Hoʻopaʻa loa ka lāʻau i nā protein koko, aneane 100%.
ʻO ka Vasilip i hoʻololi ʻia i kahi pūnaehana ikaika i loko o ka puuwai. ʻO kēia pūhui ua kapa ʻia ʻo ia he beta hydroxy acid. Lawe ʻia kāna ʻōpio (kina.) Ma o ka ʻōpū nui. Hoʻokomo ʻia ka lāʻau lapaʻau i ke ʻano o nā metabolites (nā huahana hoʻololi).
Hoʻopili ʻia kahi hapa o ia mea e nā keiki, akā he hana ʻole o ka pūnao e waiho ma o nā keiki.
Hoʻomoe i ka hapalua-ola - ʻo ka manawa o ka hōʻemi o ka lāʻau ma ke koko e hoʻēmi i kēlā me kēia manawa 2 mau manawa - i like i hoʻokahi hola a me kanalima kumāiwa mau minuke.
Nā hōʻailona a me nā contraindications no ke hoʻohana
Hoʻomaʻamaʻa pinepine nā kauka i nā vasilip no kahi maʻi e like me ka atherosclerosis. ʻO kāna kumu i ka hypercholesterolemia mua a i ʻole i hoʻoliʻihui ʻia ka dyspidemia (kahi kuʻe o ka ratio o nā lipids koko) he mea maʻamau nō hoʻi, a me ka hana kino maʻamau, ke kaumaha ʻana o ka kaumaha, ma hope o kahi meaʻai paʻa, a i ʻole ka hopena o nā lāʻau lapaʻau.
ʻO kekahi hōʻailona'ē aʻe he nui ka maʻi homozygous herna. He kūlohelohe, i ka ʻaukā, nā meaʻai a me ka hoʻokomo o nā lāʻau lapaʻau antiatherosclerotic hou e hahai ʻia. Ua ʻōmapa ʻia ʻo Vasilip no ka pale ʻana i nā maʻi o ka pūnao cardiovascular me ka atherosclerosis i ʻole a he maʻi diabetes paha, ʻoiai ke kiʻekiʻe ka hōʻeha ʻana o ka puʻuwai, ʻeha a me nā ʻano like ʻole vascular. A ʻo ka mea hope loa, ua hoʻokiʻekiʻe ʻia ka kolamu ma ka hōʻa ʻole o kekahi hōʻike.
Vasilip contraindicated i nā kūlana e like me:
- maʻi pūpū o ka ʻāʻī a i ʻole ke kaha hana;
- ka lōʻihi hoʻonui i nā enzyme o ka naʻau me ke kumu ʻole.
- hapai a lactation;
- makahiki liʻiliʻi;
- maʻi kūlohelohe i simvastatin a i ʻole kekahi mau mea o ka lāʻau.
Pono e mālama pono i nā mea maʻi i loaʻa i kēia mau maʻi a i ʻole kekahi mau kūlana kikoʻī:
- Me ka inu nui ʻana i ka waiʻona.
- I mua o nā maʻi e hoʻopiʻi i ka ate.
- ʻO ka heleʻana o nā hoʻonāʻana o nā electrolyte ma ke kino.
- ʻO nā hōʻino koʻikoʻi o ka ʻoihana endocrine a me ka metabolism.
- ʻO ke kahe mau ana me ka neʻe (hypotension).
- Lesikui Septic o ke kino.
- ʻO nā maʻi o ka ʻōnaehana kūʻai.
- Epilepsy ʻokoʻa.
- ʻO ka hōʻeha nui a me ka hōʻeha paha traumatic.
- ʻO ka hapa o ka lactase, kahi enzyme e wāwahi i ka lactose (ʻo ka waiū waiū).
- ʻO ka paleʻana i nā kaʻina o ka hoʻopiliʻana o ka lactose.
ʻO ka hoʻohana pū ʻana i nā lāʻau lapaʻau e like me ka cyclosporine, fenofibrate, amiodarone, verapamil, diltiazem, nicotinic acid, gemfibrozin, a me ka wai huakai, pono nō hoʻi e akahele me ka hoʻohana ʻana i ka vasilip.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
Ma mua o ka hoʻohana pono ʻana i ka lāʻau lapaʻau, pono ʻoe e kamaʻilio me kāu kauka e pili ana i ka inu pono ʻana iā ʻoe a e ʻike pū me ka palapala. ʻO ka hoʻoponopono kaulike maʻamau e lawe i hoʻokahi papa a ʻoi paha mau manawa i hoʻokahi lā i ka wā hiamoe.
A paipai ʻia e lawe i ka lāʻau lapaʻau iā ia iho i ka pō, no ka pō ke lawe ʻia nei ke ʻano o ka nui o ka nui o ka cholesterol, a i ʻōlelo ʻia ka hopena o ka lāʻau. Hoʻomaka ma kahi hoʻomaka me kahi hapa o 10 mg. ʻO ka dosis ʻokoʻa loa ka 80 mg i kēlā me kēia lā. Ua kuhikuhi ʻia no nā poʻe maʻi me nā ʻōmaʻomaʻo holomua o nā maʻi, me ka hopena kiʻekiʻe hoʻi i nā hoʻopiʻi mai ka naʻau a me nā kīʻaha koko. ʻO ke ʻano i koi ʻia ma ka hapa he nui ke koho ʻia i loko o hoʻokahi mahina. Koho ʻia ka lōʻihi o ke ʻano o ka mālama ʻana i kēlā me kēia maʻi i kēlā me kēia kauka.
Pono e hoʻomanaʻo ʻia ʻo ia ke lawe iā Wazilip, ka mea maʻi i make i ke ʻano, he ʻano pono ia e mālama ai. I kekahi mau hihia, ua kuhikuhi pū ʻia i nā lāʻau lapaʻau lipid-haʻahaʻa. No nā mea maʻi me ka maʻi e like me ka hypercholesterolemia, hoʻomaka ka mālamaʻana i kahi kinikona o 10 mg, akā hiki ke hoʻonui ʻia i 40 mg e hoʻokō ai i kahi hopena hou aʻe. No ka ʻano hoʻoilina o kēia maʻi, ua hoʻokaʻawale ʻia ke alakaʻi ʻana iā Vazilip i ʻekolu mau manawa i ke kuhikuhi ʻana i ka nui e ʻae ʻia (80 mg), a i ʻole 40 mg o ka lāʻau lapaʻau i kuhikuhi hoʻokahi i ka lā ma mua o ka hiamoe.
ʻO Vasilip ka hopena i makemake ʻia i ka hoʻohana hoʻokahi a i hui pū ʻia me nā mea hana anti antololesterolemus, inā paha, me nā kuʻuna a me ke ohe bile. ʻO kēia mau lāʻau e like me colestyramine, colestipol.
Me ka hoʻohana pū ʻana o ka cyclosporine, gemfibrozil, waikika nicotinic a me nā lāʻau lapaʻau mai ka pūʻulu o nā fibrates, hoʻomaka lākou me kahi wai lāʻau o 5 mg, a me ka nui o ka mea i hāʻawi ʻia he 10 mg. I kēia hihia, ʻaʻole ʻoe e hoʻonele i kēia pākuʻi. Inā lawe ka mea maʻi i nā lāʻau lapaʻau e kūʻē i ka arrhythmia a me ke koko o ke koko nui, e like me Amiodarone a me Verapamil, a laila ʻaʻole nui ka nui o ka maʻi o Vasilip i ka 20 pākahi i kēlā me kēia lā, no ka mea, ʻaʻole paʻa ka hoʻomau.
Inā ʻeha kahi kanaka i kahi ʻeha ikaika o ka hina ʻana, ma ke ʻano o ka filtration glomerular ʻaʻole iʻoi aku ma mua o 30 ml / min., A laila, kuhikuhi ʻia ʻo Vasilip i loko o kahi kuʻi e ʻoi aku ma mua o 10 mg i hoʻokahi lā. Pono e hoʻonui maikaʻi ʻia ka ʻona, a ma ia ʻano ka mea e ʻike mau ai ka mea maʻi.
Inā paʻa ke kaulike māmā a loli, ʻaʻole i loli ka dosage. Hoʻoikaika ia no ka poʻe kahiko.
Nā hopena hopena o ka vasilip a me ka overdose
E like me ka hapanui o nā lāʻau lapaʻau, hiki iā Vasilip ke hoʻonāukiuki i ka ʻike ʻana o kekahi mau hopena o ka hopena i ke kino o ka mea maʻi.
ʻO nā hopena ʻino mai ka hoʻohana ʻana o vasilip ka mea lahilahi.
Aia nā hopena ʻaoʻao mai nā ʻōnaehana like ʻole.
Pūnaehana digestive: paʻakikī ka ʻōpū, ka ʻeha i ka ʻōpū, ka hoʻomohala ʻana i ka nunui o ka hau, indigestion, nausea, ka wā hele a kaʻi ʻana i nā maʻi, nā maʻi ʻeha, nā hoʻololi ʻana i nā ʻāpana o ka ate a me ka pancreas, hoʻonui i nā ʻāpana ʻoka o ka huina o nā huina o ka huina, ka alkaline phosphatase a me nā manamana phosphokinase.
Pūnaehana ʻōlaʻi a me nā ʻōpū sensory: ʻeha o ka ʻōpū, ke kaumaha, ka leʻaleʻa o ka maʻi hopohopo, neuropathy, pilikia hāʻule i ka hiamoe, nā hōʻike hoʻomālamalama, ʻike maka a me ka hoʻāʻo.
ʻŌnaehana musculoskeletal: myopathies (pathologies o ka ʻōnaehana o ka muscular), ka hoʻohui ʻana o nā mākala, ka ʻehaʻeha o ka naʻau a me ka twitching convulive.
Hōʻike piha: ka hiʻohiʻona piha o ka nānā nui ʻana i ka lāʻau, kahi i ka nui ai ka maʻi, nā hōʻike ʻana o ka lupus, ka hōʻeha ʻana i ka naʻau nui, dermatomyositis, kahi hōʻemi o ka helu platelet, ka hoʻonui ʻia ʻana o ka nui o eosinophils, vasculitis, kahi wikiwiki o ka erythrocyte sedimentation rate, ʻeha a me nā hoʻonaninani i nā ʻōpū, urticaria, hoʻonui ka mālamalama ʻana i ka mālamalama, ka maʻi, ka ʻulaʻula o ka maka, ka palupalu nui, paʻakikī ka hanu
Nā hōʻike ʻolike: rashes, itching, focal baldness o ke poʻo (alopecia).
Eia kekahi, hiki i ke emi ʻana o ka nui o nā sela koko ʻulaʻula a me ka hemoglobin (anemia), hoʻonāwī huehue hoʻonā, hoʻemi i ka libido, a me nā palpitations.
Ke nānā ʻia aku ka puhoi o Vasilip ke hoʻonui ʻia ka nui o kahi 3.6 g Ma kēia hihia, pono ia e holoi i ka ʻōpū, lawe i ka ulana a i ʻole laxative ke koena o ka lāʻau i ka manawa e komo ai, a hoʻihoʻi koke ka puka mai ke kino. ʻO ka mea maʻi e nānā mau ʻia.
Aia nā analogues o Vasilip e like me Atorvastatin, Krestor, Lovastatin, Rosuvastatin, Akorta. Aia lākou a pau i nā pūʻulu o nā statins. Hiki ke kūʻai ʻia ka lāʻau lapaʻau ma kēlā me kēia lāʻau lapaʻau ma ka lāʻau lapaʻau. He kumukūʻai a Vasilip - i loko o 250 rubles. Ma mua o ka hoʻohana ʻana, e akahele e heluhelu i ka manual noi noi.
ʻO ka mea loea i ke wikiō ma kēia ʻatikala e kamaʻilio e pili ana i ka simvastatin a me nā lāʻau lapaʻau e pili ana iā ia.
