ʻO Liprimar 10 kahi mea synthetic a loaʻa i ka hopena lipid-hoʻohaʻahaʻa. Pono pono ka lāʻau pono e hōʻemi i ka kolamu a me nā lipoproteins haʻahaʻa haʻahaʻa. A ma muli kahi o ka hoʻolālā ʻana o nā pāpaʻi atherosclerotic ma nā paia o nā kīʻaha koko, ua emi iho ka pae o ka triglycerides a hoʻomaikaʻi ka metabolism momona i ke kino. ʻO ke kumu o ka hana o ka hana a atorvastatin, kahi e pono ai e kāpae i ka hypercholesterolemia.
Inoa Kūʻai ʻole honua
Atorvastatin.
Pono Liprimar 10 e hoʻohaʻahaʻa i ka cholesterol a me nā lipoproteins haʻahaʻa haʻahaʻa.
ATX
C10AA05.
E hoʻokuʻu i nā palapala a me ka ʻano
Loaʻa ka lāʻau lapaʻau i nā papa hana enteric-coated. ʻO ka pāʻina dosage ka 10 mg o ka atorvastatin calcium ma kahi ʻano ikaika. No ka wikiwiki o ka komo ʻana a me ka hoʻonui ʻana i ka bioavailability, ua pā ka papa i nā mea hou aku:
- mikulamulamina selulose;
- magnesium stearate;
- waiū waiū;
- huki ʻana;
- sosa ʻo ke pākeke laupili;
- kalehuʻi kālele.
ʻO ka hui pū ʻana o nā papa me ka cellulose microcrystalline, magnesium stearate, waiʻaila waiū, hyprolose, sodium croscarmellose, calcium carbonate.
ʻO ka membrane kiʻi'ōmaʻomaʻo i nā kākela candelilla, hypromellose, polyethylene glycol, talc, emulsion simethicone, titanium dioxide. Ma nā papa keʻokeʻo o ka ʻano elliptical, ua kālai ʻia ka "kahakaha" PD 155 "a me ke kiko o ka waiwai ikaika.
Ka hana lāʻau lapaʻau
ʻO Liprimar ka māhele o ka lāʻau lipid-hoʻemi haʻahaʻa. ʻO ka mea hoʻoneʻe atorvastatin ka mea koho blocker o HMG-CoA reductase, ka polokalamu nui pono e pono ai no ka hoʻololi ʻana o ka 3-hydroxy-3-methylglutaryl coenzyme i mevalonate.
Ma ka hiki ʻana o kahi ʻano hoʻoilina o ka hypercholesterolemia (hoʻonui i ka cholesterol), i hoʻohui ʻia o ka dyslipidemia, ke ʻano ikaika o Liprimara e kōkua i ka hoʻemi ʻana i ka plasma o ka kolamu o ka kolamu (Ch), apolipoprotein B, VLDL a me LDL (lipoproteins haʻahaʻa haʻahaʻa) a me ka nui o nā triglycerides. Hoʻokomo ʻia ʻo Atorvastatin i ka hoʻonuiʻana i ka lipoprotein density kiʻekiʻe (HDL).
ʻO ka hana o ka hana ma muli o ke kaohi ʻana o ka hana o HMG-CoA reductase a me ka pale ʻana i ka hoʻokumu ʻana o ka cholesterol i nā hepatocytes.
Hiki i ke Atorvastatin ke hoʻonui i ka nui o nā mea hōʻemi lipoprotein haʻahaʻa haʻahaʻa ma ka ʻaoʻao o waho o ka membrane cell cell, e alakaʻi ai i ka uptake a me ka luku ʻana i ka LDL.
Hiki i ka lāʻau lapaʻau ke hoʻonui i ka nui o nā mea hōʻemi lipoprotein haʻahaʻa haʻahaʻa ma ka ʻaoʻao o waho o ka membrane cell cell.
Hoʻopili ka mea hana ikaika i ka hōʻailona o ka kolamu LDL a me ka nui o nā lipoproteins e hoʻopilikia ai, ma muli o ka mea i hoʻonui ʻia ai ka hana o nā mea LDL. I ka poʻe maʻi me ka homozygous herpaio hypercholesterolemia kū i ka hana o ka lipid-hoʻemi haʻahaʻa, hoʻēmi ʻia LDL. Hoʻomaopopo ka hopena therapeutic i loko o 2 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau. Ua hoʻopaʻa ʻia ka hopena kiʻekiʻe loa ma hope o hoʻokahi mahina o ka mālama ʻana me Liprimar.
Lapaʻau lāʻau
Ma hope o ka lawelawe ʻana ma ka waha, ʻaʻole palau nā papa ma lalo o ka hana o ka waikawa hydrochloric i loko o ka ʻōpū, e hāʻule ana i ka jejunum proximal. Ma kēia ʻāpana o ka digestive tract, hoʻomaʻemaʻe ka membrane kiʻi i ka hydrolysis.
Ua wāwahi ka papa, nā mea kanu a me nā lāʻau lapaʻau e hoʻomaka i ke kūleʻa ma o ka microvilli kūikawā.
Hoʻokomo ʻia ʻo Atorvastatin i ke kahe koko mai ka paia ʻōpū, kahi i loaʻa ai i nā pae plasma nui loa i loko o 1-2 mau hola. I nā wahine, ʻo ka piʻi ʻana o ka waiwai ikaika he 20% kiʻekiʻe ma mua o nā kāne.
Loaʻa ka bioavailability 14-30%. ʻO ka haʻahaʻa haʻahaʻa ma muli o ka metabolet ka parietal o atorvastatin i nā membous mucous o ka ʻōpū o ka ʻōpū a me ka hoʻololi ʻana o ka isoenzyme CtoP3A4 i nā poupuna o nā ate. Hoʻopili ka mea ola i ka albumin e 98%, ʻo ia ke kumu he maikaʻi ʻole ai ka hemodialysis. ʻO ka hoʻopau hapa-hapalua ke ola i nā hola 14. Ke hoʻomau nei ka hopena therapeutic no 20-30 mau hola. Ke waiho mālie nei ʻo Atorvastatin i ke kino ma o ka urinary system - ʻo 2% wale nō o ka nui i loaʻa i loko o ka urine ma hope o hoʻokahi pae.
Nā hōʻailona no ka hoʻohana ʻana
Hoʻohana ʻia ka lāʻau lapaʻau ma ka hana lapaʻau e mālama ai:
- ʻO ka hypercholesterolemia mua o kahi ʻano hoʻoilina a me nā mea ʻole hoʻoilina;
- ke kiʻekiʻe o ka endogenous kiʻekiʻe o ka triglycerides kūʻai i ka mālamaʻana i nā meaʻai;
- hoʻoilina homozygous hypercholesterolemia me ka hana haʻahaʻa o nā hānai a me nā ʻano lāʻau ʻē aʻe o ka lāʻau lapaʻau;
- ua hui pū ʻia o ka hyperlipidemia.
Ua hōʻike ʻia ka lāʻau lapaʻau e like me ke keʻena o ka pale ʻana o ka maʻi puʻuwai no nā poʻe maʻi i ka haʻalele ʻana i nā hōʻailona o ka maʻi naʻau coronary, akā me nā mea pōpilikia: ka wā ʻelemakule, nā hana maikaʻi, ke kiʻekiʻe o ke koko, ka maʻi mellitus Hōʻuluʻulu ka mea pilikia i nā poʻe me kahi predisposition i ka hypercholesterolemia a me kahi haʻahaʻa o HDL.
Hāʻawi ʻia ka lāʻau lapaʻau e like me ke ʻano pale no ka maʻi naʻau.
Hoʻohana ʻia ka lāʻau lapaʻau e pili ana i ka hanaʻai no ka hoʻomohala ʻana i ka dysbetalipoproteinemia. Hoʻohana ʻia ʻo Liprimar i mea e pale ai i ka hoʻomohala ʻana o nā hoʻopiʻi i ka poʻe maʻi me ka ischemia myocardial e hōʻemi i ka hopena o ka make, ka puʻuwai ʻeha, nā hōʻeha a me nā hoʻokipa maʻi na ka angina pectoris.
Nā Hoʻohui
ʻAʻole i kuhikuhi ʻia ka lāʻau lapaʻau no ka nui o ka hiki ʻana o nā ʻili i nā mea kikoʻī o Liprimar, a i nā mea i hala iho nei:
- maʻi ʻeha nui;
- keiki malalo o 18 makahiki;
- hoʻonui i ka hana plasma o ka transpase hepatic ma mua o 3 mau manawa.
Pono e mālama pono i ka hōʻino ʻana i ka waiʻona.
Pehea e lawe ai i ka Liprimar 10
Ua kuhikuhi ʻia nā papa no ka hoʻokele waha, me ka manawa o ka lā a me ka pāʻina paha. Ke lawe ʻia nei ka lāʻau lapaʻau me ka hana ʻole ʻana o ka meaʻai hypocholesterolemic, ke kaupaona ʻana i ke kaupaona ʻana me ke kua o ka morbid obesity, hana. Inā ulu ka hoʻonui i ka cholesterol e kahi maʻi mākaʻi, ma mua o ka hoʻohana ʻana iā Liprimar, pono ʻoe e hoʻāʻo e kāpae i ke kaʻina pili nui. I ka wā o ka papa lapaʻau holoʻokoʻa holoʻokoʻa, pono ʻoe e pili i kahi kīʻai kūikawā.
Ke lawe ʻia nei ka lāʻau lapaʻau me Liprimar 10 me ka hoʻopiʻi ʻole ʻana o ka meaʻai hypocholesterolemic.
ʻO ka mahele i kēlā me kēia lā he 10-80 mg no ka hoʻohana hoʻokahi a ua hoʻoponopono ʻia ma muli o ka hana o LDL-C a ma ka loaʻa ʻana o ka hopena therapeutic.
ʻO ka dosage kiʻekiʻe e ʻae ʻia he 80 mg.
I ka wā o ka mālama ʻana me Liprimar, pono ia e nānā i ka mālama ʻana o ka plasma o nā lipids i kēlā me kēia mau hebedoma 2-4, a ma hope o kāu e pono ai e nīnau i kāu kauka e pili ana i nā loli.
E hoʻopau i ka ʻano o ka hyperlipidemia i hui ʻia, pono ia e lawe i ka 10 mg hoʻokahi i ka lā hoʻokahi, ʻoiai he hypercholesterolemia mana homozygous e koi i ka nui o ka hopena therapeutic o 80 mg. I ka hopena hope, hoʻemi ʻia ka nui o ka cholesterol ma o 20-45%.
Lawe i ka lāʻau lapaʻau no ka maʻi maʻi maʻi
ʻO nā mea maʻi me ka maʻi maʻi maʻi e akahele i ka wā e hele ai ka hypercholesterolemia. Holoi kēlā mau kānaka no ka hoʻomohala ʻana i ka maʻi naʻau coronary. Hoʻohana ʻia ka liprimar i ke ʻano o ka pale ʻana i ka infarction myocardial. Ua hoʻoholo ʻia ka nui o ka hewa e ke kauka hele ʻana ma muli o ka pae o ka cholesterol.
ʻO nā mea maʻi me ka maʻi maʻi maʻi e akahele i ka wā e hele ai ka hypercholesterolemia.
Hiki paha ke hoʻokaʻawale i ka hapalua
ʻAʻohe pilikia iki ma nā papa, ʻo ia ka mea e hiki ʻole ke hoʻokaʻawale i ke ʻano dosage.
Nā hopena hopena o Liprimara 10
Me ka hoʻohana pono ʻana o ka lāʻau lapaʻau, hiki i nā hopena ʻaoʻao ke ʻano i hoʻololi ʻia i ka hoʻokokoke ʻana.
ʻŌpala Gastrointestinal
ʻO paha ke ʻano o ka luaʻi, ke ʻōpū, ka ʻeha i ka ʻāina epigastric, constipation a me ka lemulewa. Ma nā hanana lohi, hiki i ka hoʻōla me ka Liprimar ke hoʻonāukiuki i ka anorexia, kahi kaʻina hana i nā maʻi pancreas, hepatitis a me nā jaundice.
Hematopoietic mau hui
I nā hihia pinepine, ulu ʻia ka poloka o ka iwi, me ka thrombocytopenia.
ʻO Liprimar 10 hiki ke kumu i ka ʻeha.
Pūnaehana pīhoihoi waena
Hōʻike maikaʻi ka hopena me ka hōʻino ʻana i ka ʻōnaehana puni e like me:
- ʻōpala
- malekema holomua;
- ʻthenlelo hemolele;
- hōʻeha a me ka ʻeha;
- hōʻemi a hoʻopau i ka nānā ʻole;
- peka neuropathy hana pili;
- amnesia.
Mai ka pūnaehana urinary
I nā kāne, hiki paha i kahi neʻe erectile a me ka mālama ʻana i ka urinary.
Mai ka papa huhū
Hiki paha i ke Dyspnea.
Allergies
Me ka hopena e hōʻike i nā hopena anaphylactic, rashes ma ka ʻili, ʻulaʻula, ʻaina, erythema exudative, necrosis o ka momona momona subcutaneous. Ma nā hihia koʻikoʻi, hoʻomohala ka edema a Quincke a me ka pīhoihoi anaphylactic.
Ma mua o ka lāʻau i ka nīnau e hiki ai ke hoʻonāukiuki i ka nānā ʻana o nā rashes i ka ʻili.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻole hoʻolawa ka lāʻau lapaʻau i nā hana e pono ai ka pane wikiwiki a me ka ulu. I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, ʻae ʻia ka hoʻokele kaʻa a me ka kāohi o nā ʻenehana paʻakikī.
Nā ʻōlelo kikoʻī
Ke mālama nei me ka Liprimar i kēlā me kēia 6 hebedoma, pono e alakaʻi i ka nānā ʻana i nā maʻi neʻeha e pili ana i nā ate a me nā hōʻailona o ALT, AST. Inā he ʻoi aku ka hana o nā aminotransferases ma luna o ka palena palena o ke maʻamau ma mua o 3 mau manawa, pono e kūkā i ke kauka e pili ana i ka hoʻemi hōʻemi.
Ma muli o ke ʻano hypocholesterolemic therapy, i kekahi mau manawa, ua ʻike ʻia ka hiʻohiʻona o ka ʻehaʻā o ka ʻāʻā i kahi oʻo o ke myopathy. I ka manawa like, ua hōʻike nā noiʻi noiʻi i kahi hoʻonui o 10 mau i ka hana o ka phosphokinase creatine i hoʻohālikelike ʻia me ka pāʻuna.
Inā nāwaliwali o ka mea maʻi a me ka hōʻeha i loko o nā ʻuhane o ke kuʻekuʻe, he mea pono ia e hoʻa i ka lawe ʻana i ka lāʻau.
I nā hihia lohi, ua hoʻomohala ka rhabdomyolysis - hōʻino ʻia ka necrotic i ka ʻōpū ma ke ʻano, ua hele pū ʻia me ka hāʻule ʻole o ka renal.
Pono e hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau me ka hōʻemi o ke koko.
ʻO kahi maʻi Renal he hopena o ka myoglobinuria. No ka hōʻemi ʻana i ka leʻaleʻa o ka rhabdomyolysis, pono ʻoe e ʻae i ka lawe ʻana i ka lāʻau lapaʻau i nā hihia aʻe:
- i ka wā o ka hana hoʻokipa me kahi ākea ākea;
- hoʻopōʻino koʻikoʻi i kaʻeha;
- ke emi ʻana o ka hoʻemi koko;
- trauma mechanical;
- wahī ʻaʻe.
Pono e ʻike ʻia ka mea maʻi e pili ana i ka loaʻa o ka rhabdomyolysis. Me ka ʻae i ka hoʻomaʻamaʻa ʻana, ua koi ʻia ka mea maʻi e ʻimi i ke kōkua olakino me ka loaʻa ʻana o ka nāwaliwali o ka ʻōpū a me ke ʻano o nā ʻeha ʻole ʻike ʻole, i hele pū ʻia e ka maʻi a me ka luhi.
Kuhi ʻana iā Liprimar i nā keiki 10
ʻAʻole ʻae ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana ma nā keiki pediatrics.
Hoʻolaha ka waipuna
ʻAʻole pono e kāwili ʻia ka lāʻau lapaʻau me nā huahana ʻaka. Hoʻopili ka Ethyl alkohol i ke kaila waena, hepatobiliary a me ka ʻōnaehana uila, a no laila ua hoʻemi ʻia ka hopena hypocholesterolemic o Liprimar. Hiki i ke ulu ʻana o nā pāpaʻi atherosclerotic ma nā paia o ke kīʻaha koko.
ʻAʻole pono e kāwili ʻia ka lāʻau lapaʻau me nā huahana ʻaka.
ʻOi aku ka liprimar 10
Ke hele ʻia kahi overdose, nui nā hopena o ka ʻaoʻao. ʻAʻole i hoʻomohala ʻia kahi mea hoʻopiʻi kū'ē i laila, no laila, i ka wā o ka hoʻokipa ʻana, e mālama ʻia ana ka mālama maʻi.
Hoʻopili pū me nā lāʻau ʻē aʻe
ʻO Cimetidine, Phenazone, Azithromycin, antacids, Terfenadine, Warfarin, Amlodipine ʻaʻole e pili i ka pāla lāʻau pharmacokinetic o Liprimar a ʻaʻole i pai aku me ka atorvastatin.
ʻAʻole hiki ke hoʻohui ʻia ʻana
Ma muli o ka hopena o ka pilikia o nā ala neuromuscular, ʻaʻole i ʻōlelo ʻia ʻo ka lawelawe ʻokoʻa o Liprimar i:
- nā pāpuni sikina cyclosporin;
- nā kinikini momona nikotinic;
- Erythromycin;
- nā lāʻau lapaʻau antifungal;
- nā huaʻai.
Hoʻokomo ʻia ka hoʻokele ʻana o Liprimar a me Erythromycin.
ʻO kēlā mau hui lāʻau hiki ke alakaʻi i myopathy.
Me ka mālama pono
A ʻoi ʻia e akahele aka me ka hoʻohana ʻana iā Liprimar me nā lāʻau lapaʻau ʻē aʻe.
- Hiki i ke Atorvastatin ke hoʻonui i ka AUC o nā ulu i waha ma o 20-30%, e like me nā hormones i loaʻa i ka hoʻomākaukau.
- Atorvastatin me kahi papa o 40 mg o ka hui pū me ka 240 mg o Diltiazem alakaʻi i kahi hoʻonui o ke kaila plasma o ka atorvastatin i ke koko. I ka lawe ʻana o 200 mg o Itraconazole me 20-40 mg o Liprimar, ʻike ʻia kahi hoʻonui o AUC o atorvastatin.
- Hoʻopili ke Rifampicin i nā pae plasma o atorvastatin.
- ʻO Colestipol ka mea e hōʻemi ai i ka lālani plasma-hoʻemi haʻahaʻa.
- Me ka hui pū me ka digoxin, ʻoi ka ʻike ʻana o ka hopena ma hope o 20%.
Hoʻopake i ka wai kīloi i ka hana a ka cytochrome isoenzyme CYP3A4, kahi mea ke inu nei i ka 1,2 lita o ka wai citrus i kēlā me kēia lā, hoʻonui ʻia ke kō o ka atorvastatin. Hoʻomaopopo kekahi hopena like i ka wā e lawe ai i nā inhibitor CYP3A4 (Ritonavir, Ketoconazole).
ʻAʻole pāpā ʻia ʻo Liprimar e hoʻohana i nā wahine hāpai 10.
Hoʻohana i ka wā hāpai a me ka lactation
Lā ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau no nā wahine hāpai, ʻoiai aia kekahi hopena o ka halaʻole o ka waiho pololei ʻana o nā ʻili a me nā ʻoka i ka wā o ka hoʻolālā ʻana o ka embryonic. ʻAʻohe ʻikepili ma ka hiki i Liprimar e komo i ka halihā hematoplacental.
I ka wā o ka lāʻau lapaʻau, pono e ʻaole ka umauma.
Nā kuʻina
ʻO nā haʻahaʻa o ka lāʻau lapaʻau he hopena like ia me ka:
- Atoris;
- Tulip;
- Vazator;
- Atorakord;
- Atorvastatin-SZ.
Hoʻololi ʻia ka pau ma hope o ke kūkā kamaʻilio maʻi.
Waihue huaʻōlelo waiho nā huaʻōlelo
Kūʻai aku ʻia ka lāʻau lapaʻau e ka lāʻau lapaʻau.
Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?
ʻAʻohe.
Kumukūʻai no Liprimar 10
ʻO ka kumukūʻai maʻamau o nā papa he 10 mg ʻo 750-1000 rubles.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Pono e mālama i ka lāʻau lapaʻau i kahi wahi me ka hoʻohaʻahaʻa haʻahaʻa o ka awelika i ke mahana o + 15 ... + 25 ° C.
ʻO ka lā kau
3 mau makahiki
Mea hana
Gedecke GmbH, Kelemānia.
ʻO ke kūloko ʻana o Liprimar - kūʻai ʻia ka lāʻau ʻo Atoris i nā lāʻau lapaʻau ma muli o ka hoʻolālā.
Nā Hōʻikeʻike Liprimar 10
Elvira Ignatieva, 76 makahiki, Lipetsk
6 mau mahina i hala aku nei, i ka wā i lawe ʻia ai ka hoʻāʻo koko ākea, ua hōʻike ʻia kahi kiʻekiʻe o kolesterol o 7.5 mmol. Loaʻa iaʻu kahi patula cardiovascular, no laila, i pale aku ai i nā hoʻopiʻi vascular, pono i hoʻokaʻawale ʻia ka cholesterol i kahi manawa pōkole. Kauka ke kauka ʻo Liprimar 40 mg i kēlā me kēia lā. Ua kiʻekiʻe ke kumukūʻai, akā ua hoʻāpono ʻia ma ka maikaʻi. Ua hōʻike ʻia kahi hōʻike hope loa i ka emi ʻana o ka cholesterol i 6 mmol.
Kristina Molchanova, 24 makahiki, Yaroslavl
Loaʻa ka makuahine iā i ka atherosclerosis o nā moku o nā haʻahaʻa haʻahaʻa a ke hoʻonui ʻia ana kāna kolamu a me LDL. Ua koho mua ʻia ʻo Rosuvastatin, ʻaʻole i kūpono. ʻAʻole i loli ka maikaʻi. Ma hope o Rosuvastatin, ua kau ʻia ʻo Liprimar.Mahalo i ka lāʻau lapaʻau, ua hōʻike ka profile lipid hope i nā holomua: ua hoʻemi ka cholesterol a me ke kino, ua hoʻonui nui ʻia ka piʻi ʻana o ka lipoproteins kiʻekiʻe.
