Hoʻohana pinepine ʻia nā lāʻau diuretic no ka maʻi maʻamau o ka maʻi maʻamau no ka mālama ʻana i hana ʻia me ka hoʻomohala ʻana o ka maʻi hypertension, insufficiency a i ʻole ka manawa e pono e hoʻopau i ka edema wāwae.
I kēia lā, ua hoʻomohala ʻia nā nui o nā lāʻau lapaʻau i hiki ke hoʻonui i ka nui o nā urine i hoʻopā ʻia.
ʻO ke koho o ka diuretic, inā pono, pono nō e alakaʻi e ke kauka hele e pili ana i nā hopena o nā loiloi, e noʻonoʻo ana i ke ʻano o ke kino o ka mea maʻi.
ʻO ka lāʻau maʻamau hoʻokahi indapamide.
ʻO Indapamide ka hui o ka diuretics like thiazide-like. Ke loaʻa nei kēia lāʻau lapaʻa i kahi hopena vasodilating.
Hoʻohana ʻia ka diuretics ma ke ʻano o ka mālama ʻana i ka maʻi maʻi maʻa. Hoʻonui kēia mau lāʻau i ka hopena o nā inhibitor ACE.
ʻO diuretics like-Taizide, kahi a Indapamide, he hopena ʻeha i ka maʻi maʻi. Ua liʻiliʻi ka hopena o kēia mau lāʻau i ke kaʻina hana o ka paʻakai a me ka pae o ka glucose a me ka momona i loko o ke koko.
ʻAʻole ke alakaʻi o Indapamide no ka maʻi maʻamau o ka maʻi maʻamau 2 i ka hana maʻamau i ka hana maʻamau o nā lolo o ka mea maʻi.
Ke hopena nei ka lāʻau i ka nephroprotective ma ke kino o ka mea maʻi i kēlā me kēia wahi o ka pōʻino o ka pūpū, i hui pū ʻia me ka hoʻomohala ʻana i ka maʻi diabetes mellitus o kahi ʻano like ʻole o ka insulin.
Ka hoʻonohonoho ʻana o nā lāʻau lapaʻau, ka wehewehe kiko a me ka lāʻau lapaʻau
ʻO ka lāʻau lapaʻau e hana ʻia e ka ʻoihana kūʻai lāʻau ma ke ʻano o nā papa no ka hoʻokele waha.
ʻO ka lāʻau lapaʻau ma ka ʻaoʻao he ʻeleʻoni kiʻi ʻoniʻoni.
ʻO ka mea hana nui o ka lāʻau lapaʻau ka indapamide, hoʻokahi papa he 2.5 mg o ka hoʻohui.
Hoʻohui i nā mea hana ikaika, ua hoʻohui ʻia nā mea kanu pono hou e loaʻa ana i kahi kōkua kōkua i ka hoʻonohonoho o nā lāʻau.
ʻO ia mau mea kōkua hoʻohui?
- lactose monohala;
- povidone-K30;
- crospovidone;
- magnesium stearate;
- sodium lauryl sulfate;
- ka leʻaleʻa talcum.
ʻO ka hoʻonohonoho ʻana o ka ʻili o ka papa papa i ka ʻili like me nā mea kemake:
- Kahuna Hono
- Macrogol 6000.
- Talii.
- Kaapili Titanium
Aia nā papa papa i kahi pōpō, convex ke ʻano a keʻokeʻo nei.
Aia kekahi lāʻau lapaʻau i ka hui o nā lāʻau diuretic. Kokoke loa kona mau waiwai i ka diuret th thiazide.
Ma hope o ka lawe ʻana i ka lāʻau, hoʻonui ka urinary i ka sodium a me ka chlorine mai ke kino o ke kanaka. I kahi liʻiliʻi e pili ana i ke kaʻina o ka excretion o ka paʻakai a me nā magnesium ions mai ke kino.
Hiki i ka lāʻau lapaʻau ke pale i nā kaila o ka calcium o nā membrane a hoʻonui i ka elasticity o ka vascular wall o nā arteri, e hōʻemi ana i ka pale kūʻokoʻa o ka vascular o peripheral vascular system o ke kino.
ʻO ka lawe ʻana i ka lāʻau lapaʻau e kōkua i ka hōʻemi o ka hypertrophy o ka ventricle hema.
ʻAʻole pili ka hoʻohana ʻana i ka lāʻau i ka pae o ke kūpaʻa lipid i ke koko a ʻaʻole i hoʻopilikia i ka metabolism o nā gula.
ʻO ka lawe ʻana i kahi lāʻau lapaʻau e hiki ai iā ʻoe ke hōʻemi i ka hoʻonaninani ʻana i ka paia vascular i ka hopena o norepinephrine a me ka angiotensin II, a hiki iā ʻoe ke hoʻomaikaʻi i ke ʻano o ka prostaglandin E2 i loko o ke kino.
ʻO ka hoʻohana ʻana i kahi lāʻau lapaʻau ka hōʻemi ʻana i ka ikaika o ka hana ʻana o nā radical manuahi a kūpaʻa i ke kino.
Ke hoʻomau nei ka hopena hypotensive o ka lāʻau i ka hebedoma ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau a hoʻomau i hoʻokahi lā ma hope o hoʻokahi kahe i hoʻokahi lā.
ʻO ka Pharmacokinetics o ka lāʻau
Ma hope o ka lawe ʻana i ka lāʻau lapaʻau, hoʻopili piha ʻia mai ka gastrointestinal tract i loko o ka ʻōnaehana ka ka puni. Loaʻa i ka lāʻau lapaʻau ka bioavailability kiʻekiʻe, kahi ma kahi o 93%.
ʻO kaʻai ʻana he hopena lohi ma ka lawe ʻana o ka lāʻau lapaʻau i loko o ke koko, akā ʻaʻole i pili i ka nui o nā lāʻau lapaʻau i lawe ʻia. Loaʻa ka ʻike kiʻekiʻe loa i ke koko 1-2 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau ma loko.
Me ka hoʻohana mau ʻana i ka lāʻau, hoʻopau ʻia ka fluctuations i loko o kona neʻe ʻana i ke kino ma waena o nā pona. Loaʻa ka lāʻau lapaʻau i kahi kaila o ka kūlā i loko o ke kino ma hope o 7 mau lā o ka lawe ʻana i ka lāʻau.
ʻO ka hapalua o ke ola o ka lāʻau mai ka 14 a me 24 mau hola. Hele ka lāʻau lapaʻau i ka pilina me nā mea paʻakikī o ka plasma koko. ʻO ka nui o ka pilina protein e pili ana i ka 79%.
Hiki i ka hana koʻikoʻi o ka lāʻau ke hiki ke hoʻopili me elastin o nā kaanika maʻa o nā ʻaoʻao o ka pale i ka paia.
Hiki i ka lāʻau lapaʻau ke hiki ke hele i ka pale ʻana o ka ʻōpū, hiki iā ia ke hele i ka paʻa placental. Ke lawe nei i kahi lāʻau lapaʻau, hoʻohemo ʻia i loko o ka waiū umauma.
Hoʻomoe i ka metabolization o ka hana ikaika i loko o nā kiko o ke akea. Lawe ʻia ka hana o ka hana neʻe i ke ʻano o nā metabolites e nā keiki i ka nui o 60 a 80%. Me nā feces, ma kahi o 20% e hoʻoneʻe ʻia ma o nā ʻōpū.
Inā kūleʻa ka mea maʻi, ʻaʻole i loli nā pharmacokinetics o ka lāʻau lapaʻau. ʻO ka hōʻiliʻili ʻana o nā kālā i loko o ke kino ʻaʻole i he nui.
Nā ʻōmai a me nā contraindications no ka lawe ʻana i ka lāʻau lapaʻau
ʻO ka hōʻailona nui no ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi maʻi ʻo ia ka hoʻomohala ʻana i ka mea maʻi me ka hypertension arterial.
E like me nā mea olakino ʻē aʻe, ʻo Indapamide ka nui o nā contraindications no ke hoʻohana ʻana.
ʻAe ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau i ka haʻalele ʻole ʻana o kekahi mau contraindications i ka mea maʻi.
ʻO nā mea nui (contraindications) ke hoʻohana ʻana i kahi lāʻau lapaʻau ka mea e like me kēia:
- he maʻi kiʻekiʻe ka mea maʻi i nā lāʻau i hoʻokumu ʻia ma ke kumu o sulfonamide;
- maʻi ʻole i ka poʻe maʻi me ka lactose;
- ka maʻi maʻi galactosemia;
- inā hōʻike kahi kanaka i nā hōʻailona o kahi maʻi o ka malabsorption o ka glucose a galactose paha;
- ka ʻike ʻana i kahi ʻano paʻakikī o ka hana ʻole i kahi maʻi i kahi maʻi;
- ke heleʻana o nā hōʻailona o ka hypokalemia;
- ka hele ʻana mai o ka hana ʻino ʻole;
- maʻi ʻaʻai;
- ka manawa o ka ulu a me ka umauma;
- ahonui a hiki i 18 makahiki;
- ka hana ʻana i ka maʻi ma kahi o nā lawelawe like ʻole e hiki ke hoʻonui i ka kikowaena QT.
Me ka makaʻala, pono ʻoe e lawe i ka lāʻau i ka wā e ʻike ai i nā kuhi hewa i ke hana ʻana o nā pūpū a me nā ate, i kahi hihia o nā mea maʻi o ka mea maʻi i ka pae wai-electrolyte, inā aia ka hyperparathyroidism i loko o ke kino.
Eia kekahi, pono e hoʻohana pono ʻo Indapamide i ka wā e hoʻohana ai i ka lāʻau lapaʻau e hoʻohana ai i nā lāʻau antiarrhythmic.
Hoʻomaʻamaʻa ka mālama ʻana i ka wā e hoʻohana ana i ka lāʻau lapaʻau no ka hoʻomohala ʻana i ka maʻi mellitus i ke kahua o ka decompensation.
Nā ʻōkuhi no ka hoʻohana ʻana i nā papa
ʻO ka ʻae ʻana i ka lāʻau lapaʻau e lawe ʻia ana me ke ʻano o ka papaʻaina no ka ʻai ʻana. Pono ka hoʻokomo ʻana o nā papa i ka inu ʻana i ka nui o ka wai. ʻO ka manawa ʻoi loa ka lawe ʻana i ka lāʻau lapaʻau ʻo nā hola kakahiaka.
ʻO ka lāʻau lapaʻau maʻamau maʻamau no ka lapaʻau ʻana ʻo 2.5 mg a i kahi papa pākahi i kēlā me kēia lā. Inā ma hope o 4-8 mau pule o ka lapaʻau i loaʻa ʻole ka hopena i makemake ʻia, ʻaʻole pono ke hoʻonui ʻia ka hopena. Ke hoʻonui i ka dosis hana hoʻoweliweli i ka hoʻomohala ʻana i ke kino o nā hopena kūpono mai ka hoʻohana ʻana i ka lāʻau lapaʻau.
I ka loaʻa ʻole o nā hopena i ka hoʻomaʻamaʻa ʻia, ua ʻōlelo ʻia e hoʻololi i ka lāʻau lapaʻau i kahi ʻoi aku ka maikaʻi. I ka hanana e hoʻokau ʻia ana ka lāʻau me ka hoʻohana ʻana i ʻelua mau mea kanu, ua loli iki ka ʻano o Indapamide ma 2.5 mg i kēlā me kēia lā.
Ke lawe nei ʻo Indapamide i kahi kanaka, hiki i kekahi mau hopena ʻaoʻao ke hōʻike ʻia i nā pilikia ma ka hana ʻana o nā ʻōnaehana o ke ʻano.
ʻO ka hopena maʻamau ʻo Indapamide no ka maʻi maʻi i ka:
- ʻŌnaehana nenoaiu. Loaʻa paha ka hoʻomohala ʻana o ka ʻōpū, ka constipation, ke ʻano o ka ʻeha i ka ʻōpū. Loaʻa pinepine kekahi manaʻo o ka nausea a ka maloʻo ma ka waha waha. Malia paha ke ʻano o ka hoʻohālikelike i nā hihia maʻamau, hiki i ka hoʻomohala ʻana o ka pancreatitis.
- Pūnaehana pīhoihoi waena. ʻOi paha ka hoʻomohala ʻana o kahi kūlana asthenic, ke ʻano o ka hoʻonui ʻia ʻana o ka nalu ʻana, ka ʻeha me ka maʻi maʻi, ka mahuahua o ka hiamoe. I nā hihia pinepine, ʻike ʻia ka momona a me ka nāwaliwali maʻamau. I kekahi manawa aia kahi manaʻo o ka malaise maʻamau, nā mākaha o ka lā, ka huhū a me nā manaʻo o ka hopohopo.
- Ma ka ʻaoʻao o ka ʻōnaehana o ka hapanui, ka hoʻomohala ʻana o ka ʻōpū, ka pharyngitis, sinusitis a me nā, nā hihia lohi hiki ke loaʻa ka rhinitis.
- ʻŌnaehana Cardiovascular. Loaʻa ka hoʻomohala o ka hypotension orthostatic, hoʻololi i ka electrocardiogram, hiki i ka mea maʻi ke hoʻomohala i ka arrhythmias ma loko o ka puʻuwai a hoʻonui i ka puʻuwai puʻuwai.
- ʻŌnaehana papa maʻi. ʻO ka hopena kiʻekiʻe ka hoʻomohala ʻana i nā maʻi maʻamau a me ka polyuria.
- ʻO ka ʻili. ʻOi paha ka hoʻomohala ʻana o nā hopena aler i hōʻike ʻia i ke ʻano o ka hōʻeha ʻili, ka ʻeha a me nā hemorrhagic vasculitis.
Eia nā hopena āpau, hiki i ka thrombocytopenia, leukopenia, agranulocytosis, a me kahi hōʻemi o ka systemus lupus erythematosus e ulu i ka kino o ka mea maʻi.
ʻO ka hui o kahi lāʻau lapaʻau, ʻano hana i hoʻokuʻu ai, ke kumukūʻai a me nā kūlana mālama
Loaʻa ka lāʻau lapaʻau ma ke ʻano o nā papa pani, e loaʻa ana i kēlā me kēia papa pālua ka 2.5 mg o ka lāʻau.
Hoʻopili ʻia nā papa o 10 mau ʻāpana i loko o kahi ʻōhua kūmole wai i hana ʻia i ka film polyvinyl chloride a paʻa i ka alumini foil. Kūpono ʻia nā pā pākia kūikawā, a me nā ʻōlelo no ka hoʻohana ʻana i ka lāʻau lapaʻau, hoʻokomo ʻia i nā pā kāleka.
Hāʻawi ʻia ka lāʻau lapaʻau e mālama i kahi wahi pōʻeleʻele i kahi mahana ma kahi ākea mai 15 a 25 tikelika Celsius. ʻAʻole pono e loaʻa i kahi wahi i waiho ai i nā lākiō nā keiki.
ʻO 3 mau makahiki kahi e noho ai ke ola o ka noho lāʻau. Ma hope o ka pau ʻana o ka manawa mālama, ua pāpā ʻia loa ka lāʻau. Ua hoʻopau ʻia kahi lāʻau hoʻolale.
Ma kahi o Indapamide, ua hoʻokumu ʻia nā lāʻau lapaʻau nā mea e hoʻohālike ai.
ʻO ka mea maʻamau a kaulana loa i ka ʻano o nā meaʻala o ka lāʻau lapaʻau.
- ʻO Arifon Repard - ka mea i ʻike ʻia e like me ka Indapamide, ʻaʻole e pili i ka metabolism.
- ʻO Acripamide kahi mea hoʻohālikelike o Indapamide, kahi mea Lūkini mai.
- ʻO Indap kahi lāʻau i hana ʻia i ka Czech Republic.
- ʻO Noliprel kahi hui pūʻokoʻa e hoʻohana nui ana.
- He lāʻau lapaʻau kaulana ʻo Perinid no ka nui o nā maʻi.
ʻO ke kumukūʻai o Indapamide ma ke kaona o ka Russian Federation he awelika mai 12 i 120 mau rubles, e pili ana i ka mea hana a me ka wahi i kūʻai ʻia ai ka lāʻau lapaʻau.
ʻO kekahi loea mai ka wikiō e pili ana i kēia ʻatikala e kamaʻilio e pili ana i nā hiʻohiʻona lāʻau o Indapamide.
