ʻO Zilt kahi lāʻau lapaʻau antiplatelet maikaʻi e lohi nei i ka hoʻohui platelet. Ua kuhikuhi aku nā poʻe loea i nā maʻi i mea e pale ai i ka thrombosis, stroke a me ka hōʻeha ʻana ma ka naʻau.
Tagu inoa
ʻO ka inoa Latin ʻo Zyllt. INN lāʻau: clopidogrel.
ʻO Zilt kahi lāʻau lapaʻau antiplatelet maikaʻi e lohi nei i ka hoʻohui platelet.
ATX
B01AC04.
E hoʻokuʻu i nā palapala a me ka ʻano
Hoʻohana ʻia ka lāʻau lapaʻau i nā papa o 75 mg o ka waiwai ikaika (clopidogrel hydrosulfate). ʻO nā huahana ʻē aʻe e loaʻa:
- MCC;
- propylene glycol;
- talc;
- hao keʻa;
- nā ʻano pregelatinized ʻano mākele;
- titanium dioxide;
- macrogol-6000;
- ʻano ʻano lactose;
- hydrorated oil castor;
- hoʻohuʻihuʻi.
Hoʻohana ʻia ka lāʻau lapaʻau i nā papa o 75 mg o ka waiwai ikaika (clopidogrel hydrosulfate).
Kuhi ʻia nā pille i nā pā o 14, 28, 30, 56, 84 a me 90 mau mau polō.
Ka hana lāʻau lapaʻau
Aia ka lāʻau i ka pūʻulu o nā mea hana clopidogrel. Hoʻopili paʻa ia i ka palena o ka ADP i nā ʻāpana platelet a me ka hoʻōla hou aʻe o ka hoʻopulapula o GPIIb / IIIa (glycoprotein), ka mea e hoʻonāukiuki i ka hoʻoweliweli ʻana o ka platelet aggregation.
Ke hoʻomau nei kēia kaʻina no 1-1,5 pule. Hōʻike ka hana metabolite i ka hopena o ka hoʻōla i nā isoenzymes CYP450. Eia nō naʻe, ʻaʻole ka loaʻa i nā mea maʻi a pau nā hopena, no ka mea aia kekahi mauenenomema he polymorphism, hoʻololi ʻia ma lalo o ke ʻano o nā lāʻau lapaʻau ʻē aʻe, a i ʻole ke ʻano o ka pale ʻana o ADP.
Hōʻike ka lāʻau lapaʻau i ka hopena i ka pale ʻana o nā hopena atherothrombotic i nā mea maʻi me ka hōʻino i nā kahe koko o nā ʻano kumu like ʻole, ʻoi loa hoʻi i nā ala o peripheral, coronary a me nā cerebral arteries.
Hōʻike ka lāʻau lapaʻau i ka hopena i ka pale ʻana o nā hopena atherothrombotic i nā mea maʻi me ka hōʻino ʻana i nā kīʻaha koko o nā ʻano kumu.
Lapaʻau lāʻau
Hoʻomaʻo koke ʻia ka lāʻau lapaʻau ma hope o ka lawelawe waha. ʻO ka kaila plasma kiʻekiʻe loa o ka mea hana ikaika e hiki ai i ka 40-45 mau minuke ma hope o ka lawe ʻana i ka pāʻana o 75 mg.
Hoʻonohonoho ʻia nā mea o ka lāʻau i loko o ka puʻu. ʻO ka hapalua ola he 6 mau hola. ʻO 46% o ka lāʻau lapaʻau ke hōʻoki ʻia e nā ʻōpū, kahi i koe ma nā keiki.
Nā hōʻailona no ka hoʻohana ʻana
Hoʻohana ʻia ka lāʻau lapaʻau e pale i nā hoʻopiʻi atherothrombotic i nā maʻi maʻi pākē i hōʻike ʻia i kēlā mau ala:
- myocardial infarction;
- ischemic stroke;
- maʻi maʻi coronary;
- maʻi maʻi pāʻai (peripheral);
- ka huaʻala o ka coronary syndrome (me ka piʻi o ka mahele o ST a a ʻole ia).
Eia kekahi, ua hoʻohana ʻia ka lāʻau lapaʻau e pale i ka thromboembolic a me ka atherothrombotic komplications o ka atrial fibrillation, ka hahau.
Nā Hoʻohui
- hypersensitivity i nā mea kanu o ka lāʻau;
- hapai a lactation;
- kahe (ʻaole);
- palaualelo a me nā maʻi ākea hepatic pathology;
- mau makahiki malalo mai o 18 makahiki;
- ʻO GGM syndrome, ka lactose intolerance, ka hapa o ka lactase.
Me ka mālama pono
- nā pilikia hemahema maʻalahi a me nā momona;
- hana ʻole;
- nā kūlana e loaʻa ai ke koko o ke kahe;
- hui pū me Heparin, Warfarin a me nā glycoprotein inhibiting agents;
- ka hoʻomaloka ʻole i nā thienopyridines ʻē aʻe (Prazogrel, Ticlopidine, etc.).
Pehea e lawe ai iā Zilt?
Pono inu ka lāʻau lapaʻau i ka manawa 1 i ka lā. ʻAʻole pili ka meaʻai i ka hana a me ke kau ʻana o ka lāʻau.
Me ka ischemia, myocardial infarction a me ka manawa maʻi maʻi vard arterial, ʻo ka nui iki ka nui o 75 mg (1 pill) hoʻokahi i ka lā.
No ka poʻe maʻi me ka fibrillation atrial, kauoha ʻia ka lāʻau lapaʻau ma loko o kahi waihona ʻo 75 mg. ʻO ka palena kiʻekiʻe loa o kēlā me kēia lā he 300 mg. I kēia hihia, ua hoʻohana pinepine ʻia ka acetylsalicylic acid i kekahi manawa.
Inā kuhi ʻoe i ka hoʻohana ʻana o ka hopena hou o ka lāʻau lapaʻau, hiki iā ʻoe ke lawe i loko o nā hola 12. Ma hope o kēia, ʻaʻole pono ke kīpaha ʻia ka hoʻoponopono ʻana. Mai pāpālua i ka nui.
Pono inu ka lāʻau lapaʻau i ka manawa 1 i ka lā.
Lawe i ka lāʻau lapaʻau no ka maʻi maʻi maʻi
Inā loaʻa iā ʻoe ka maʻi maʻi, pono e kamaʻilio mau ʻoe me kahi loea ma mua o ka lawe ʻana i ka lāʻau.
Pehea ka lōʻihi e lawe ai?
ʻAʻole pono nā lōʻihi o ka lāʻau lapaʻau ma mua o 1 makahiki.
Nā hopena hopena
Hiki i ka lāʻau lapaʻau ke hōʻeha i nā hopena makemake ʻole. Inā kū ʻia kēia mau, pono koke e hoʻopili i kāu kauka.
ʻŌpala Gastrointestinal
- ʻeha i ka ʻōpū;
- maʻiʻaʻi a me ka constipation;
- lāʻau lāʻau;
- lōkohu
- ka huhū ʻana ma nā ʻāpana gastrointestinal (retroperitoneal hemorrhage);
- ninini
- utuka
- ʻumiina.
Hematopoietic mau hui
- leukopenia;
- anemia
- agranulocytosis;
- granulocytopenia;
- thrombocytopenia;
- neutropenia (ma nā hihia maʻamau).
Pūnaehana pīhoihoi waena
- poʻomanaʻo
- fiva
- pupule i maopopo;
- ʻike auditions a me ʻike ʻike;
- ʻʻAla
- hāpau.
Mai ka pūnaehana urinary
- glomerulonephritis (ma nā hihia nui loa);
- hematuria;
- hana ʻole;
- māhuahua plasma hoʻoulu.
Mai ka papa huhū
- koko mai ka ihu;
- huni o ka māhu a me ke koko mai ka ʻōpū o ka ʻōpū;
- paila interstitial o ka maʻi pneumonia;
- Nā mānoanoa bronchial.
Ma ka ʻāpana o ka io o ka hihiʻo
- ka hoemi o ka mālamalama ʻike;
- hoʻonui i ke koʻikoʻi intraocular;
- ʻike wua.
Ma ka ʻāpana o ka ate a me ka pāpaʻi biliary
- ka hopena o ka hana ʻole a me nā hana ʻē aʻe i hoʻopuni maoli;
- maʻi maʻi maʻi maʻi.
Mai ka musculoskeletal a me ka hoʻopili pili
- neʻe ʻana i ka ʻōpū māhā;
- hemarthrosis;
- myalgia;
- aopala;
- wahīwiki.
Eia kekahi, hiki ke kūleʻa anaphylactoid i ka wā e lawe ai i nā papa.
Nā ʻōlelo kikoʻī
ʻO nā mea maʻi i loaʻa i ke kaʻina hana a hōʻoki ʻia e pono me ka mālama pono ʻana i ka wā e lawe ai i ka lāʻau lapaʻau e pale ai i nā hoʻopiʻi ma muli o ke kahe koke ʻana.
Hoʻonui ka lāʻau i ka lōʻihi o ke kahe. No laila, ua hoʻonohonoho ʻia me ka mālama ʻana i nā maʻi i ka maʻi kiʻekiʻe o ia ʻano.
Ma mua o nā hana i hoʻolālā ʻia, i ka wā ʻaʻole i koi ʻia ka hana antiplatelet, pono e hoʻokuʻu ʻia ka lāʻau i ka liʻiliʻi ma lalo o 5-6 mau lā ma mua o ka hoʻokau ʻana. Pākuʻi kēia i nā kaʻina hana o nā niho hū.
Hoʻolaha ka waipuna
Hiki i ka hui pūʻana o ka lāʻau me ka waiʻona e hoʻonāukiuki i ka puʻuwai hōʻeha o ka naʻau, ka hoʻomohala ʻana o ka tachycardia a me ka bradycardia. No laila, me nā lāʻau lapaʻau, pono e pale ʻia nā hui like ʻole.
Hiki i ka hui pūʻana o ka lāʻau me ka waiʻona e hoʻonāukiuki i ka puʻuwai hōʻeha o ka naʻau, ka hoʻomohala ʻana o ka tachycardia a me ka bradycardia.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻole loaʻa ka hopena o ka lāʻau lapaʻau i ka hiki ke lawe i kahi kaʻa a me nā hana e koi ai i kahi ʻano wikiwiki a me ka nānā.
Hoʻohana i ka wā hāpai a me ka lactation
I loko o ka wā o ka make, ua kuhikuhi ʻia ka lāʻau lapaʻau i loko o nā hihia wale nō ka mea e manaʻo ʻia ai ka pōmaikaʻi.
Ke lactating a lawe i ka lāʻau lapaʻau, pono nā ʻōpū o ka pale ʻana.
ʻO Zilt ka hana i nā keiki
ʻAʻole mālama ʻia ka lāʻau lapaʻau no ka mālama ʻana i nā mea maʻi liʻiliʻi.
Hoʻohana i ka wā kahiko
No nā poʻe maʻi maʻi, ʻaʻole i hoʻoponopono ʻia ka dosage. Eia nō naʻe, pono lākou e haʻalele i ka ʻai ʻai.
No nā poʻe maʻi maʻi, ʻaʻole i hoʻoponopono ʻia ka dosage.
Ke keu
I nā hopena kiʻekiʻe loa, hiki i ka lāʻau lapaʻau ke alakaʻi i ka lōʻihi o ka manawa o ke kahe a me nā hoʻopiʻi hemorrhagic. No ka hoʻokaʻawale i ke kūlana o ka mea i hana ʻia, ua hāʻawi ʻia ka lawe ʻana i ka platelet. ʻAʻohe lāʻau antidote i ka lāʻau.
Hoʻopili pū me nā lāʻau ʻē aʻe
ʻAʻole pono e hoʻohui i ka lāʻau lapaʻau me nā anticoagulants waha ma muli o ka loaʻa o ka piʻi ʻana o ka nui o ke kahe.
ʻO nā kumu e hoʻoneʻe i nā hana o ka pā proton i ka hopena liʻiliʻi loa i ka isoenzyme CYP2C19 - Lansoprazole a me Pantoprazole. Hiki ke hoʻohui pū me lākou me ka lāʻau lapaʻau i nīnau ʻia.
ʻAʻole pili ka mea ikaika i ka lāʻau lapaʻau i nā waiwai pharmacokinetic o warfarin. Akā ʻo kēlā hui hui e hoʻonui i ka hopena o ke kahe o ka hoʻokaʻeha ma muli o ka nalo ʻana o ka ʻaʻā koko.
Ke hui pū ʻia ka lāʻau lapaʻau me Theophylline a me Digoxin, ʻaʻole loli i ko lākou pharmacokinetics.
Aine ʻia e pale aku i ka hoʻohana pū ʻana me ka omeprazole.
ʻAʻole pono e hoʻohui i ka lāʻau lapaʻau me nā anticoagulants waha ma muli o ka loaʻa o ka piʻi ʻana o ka nui o ke kahe.
Nā kuʻina
- Aterocardium;
- Hoʻolaha;
- ʻAwele;
- Brilinta;
- Deplatt;
- Avix;
- Diloxolum;
- Jendogrel;
- Clopact;
- Klopigrel.
Waihue huaʻōlelo waiho nā huaʻōlelo
Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?
ʻAʻole hiki ke loaʻa kahi lāʻau lapaʻau me ka loaʻa ʻole o kahi lāʻau lapaʻau.
Kūʻai Zilt
Hoʻomaka ka uku o ka lāʻau lapaʻau mai 120 rubles no 14 mau papa o ka 75 mg o ka mea ikaika i loko o kahi pahu pahu.
ʻAʻole hiki ke loaʻa kahi lāʻau lapaʻau me ka loaʻa ʻole o kahi lāʻau lapaʻau.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Manaʻo ʻia e mālama i ka lāʻau lapaʻau i ka lā wela ma mua o + 20 ° C, ma kahi maloʻo a maloʻo kahi i loaʻa ʻole ai ka lā.
ʻO ka lā kau
24 mahina.
Hoike no ko Sylt
Kauka
ʻOgor Kvashnin (lapaʻau), 40 makahiki, ʻo Barnaul.
ʻO kahi mea lawelawe ikaika a ikaika mai ka pūʻulu o nā hana antiplatelet. ʻO ka hana ikaika ma kona ʻano mea hiki ke hoʻolohi i ka AT. E hoʻohana i kēia mau peni no nā kumu olakino wale nō a e like me nā ʻōlelo a ke kauka. Inā hoʻowahāwahā ʻia kēia, a laila hālāwai kekahi i nā mea i makemake ʻole ʻia a me nā hoʻopiʻi.
ʻO nā maʻi maʻi
ʻO Anton Wigman, 45 makahiki, Moscow.
No nā makahiki he nui i ʻeha i ka pectoris angina. Ma kahi o 3 mau makahiki i hala iho nei ua hoʻomanawanui wau i ka mālama ʻana. Ma hope o ke kaʻina hana, lawe wau i 1 papa o kēia lāʻau lapaʻau i kēlā me kēia lā. ʻO kēia manawa i hala aku nei ʻo ia i nā hoʻokolohua, ʻaʻole i hōʻike i ke kauka i kekahi mau hōʻino, ʻo ia hoʻi, ʻike i ka hoʻomaikaʻi ʻana i ke kūlana maʻamau. Ua holomua nō hoʻi kona olakino, ʻaʻole i kū hou ke kaʻe kaua ʻana.
Vladimir Dubov, 47 makahiki, Lipetsk.
Ua pīhoihoi loa au i ka ʻoihana aloha o nā loea i ko mākou wahi e hoʻokaʻaka koke nei i koʻu kūlana pre-stroke a mālama i koʻu ola. Hele wau i nā kauka no kahi 12 mau mahina. Ua hōʻike mai ka cardiologist e pili ana i nā hopena hiki ke hoʻohana i kahi paio o nā lāʻau lapaʻau a ʻōlelo ʻia i ka hoʻohana ʻana i kēia lāʻau lapaʻau no ka mea ʻike ʻia ke kino a ʻā kekahi hoʻi i hoʻonāukiuki ʻia. ʻĀnō hoʻi nā ipu a me kaʻu mau ʻauamo.
