Hoʻopili i nā meaʻai meaʻai, ua hoʻohana ʻia nā nui o nā lāʻau lapaʻau e mālama i kahi maʻi maʻamau e like me ka atherosclerosis.
ʻO kekahi o lākou he fluvastatin, ʻo ia kahi mau hypocholesterolemic e hakakā i ka kolikoli i ke koko o ke kanaka.
ʻO Fluvastatin kahi 'pala'āpana i loaʻa ia i kahi keʻokeʻo a i' ai melemele paha ke kala. Hoʻohuʻi maikaʻi ka wai i loko o ka wai, kekahi mau alkohol, he mau kūlana hygroscopic.
ʻO kekahi o nā meaʻenehana huahana (generics), kahi o nā mea maʻi fluvastatin ikaika, ʻo Leskol Forte. ʻO kahi papa lōʻihi nā papa hana i ʻāʻihi ʻia. He poepoe lākou, he ʻano biconvex me nā kihi beveled. Loaʻa ai 80 mg o ka fluvastatin i 1 papa.
He lāʻau lapaʻau synthesized synthesized. Mālama i ka hana a HMG-CoA reductase, hoʻokahi o nā hana o ka hoʻololi ʻana o HMG-CoA i ka mea mua o ka sterols, ʻo ia ka kolamu, mevalonate. Hana ka hana i ka ate, kahi i emi ai ka kolamu, ka hoʻonui ʻia ʻana o ka hana a nā LDL receptors, kahi hoʻonui i ka kaʻe ʻana o ka neʻe o ka lāʻau LDL. I ka hopena, ma muli o ka hana o kēia mau hana a pau, aia ke emi ʻana i ka cholesterol koleka.
Ua hōʻike ʻia nā ʻepekema me ka nui o ka nui o ka kolamu LDL a me ka triglycerides i loko o ke kaila koko, ua ulu ka atherosclerosis a me ka pilikia o ka hoʻomohala ʻana i nā maʻi naʻau a me ka maʻi vascular, e hele pinepine ana i ka make. Akā, ʻo ka hoʻonui ʻana i nā pae kiʻekiʻe lipoprotein he hopena kū'ē.
Hiki iā ʻoe ke nānā i ka hopena lapaʻau i ka wā e lawe ai i ka lāʻau lapaʻau ma hope o 2 mau hebedoma, hiki i ka nui o kona hōʻeha ʻana i loko o hoʻokahi mahina mai ka hoʻomaka ʻana o ka mālama ʻana a mālama ʻia i ka holoʻokoʻa o ka hoʻohana ʻana o fluvastatin.
ʻO ke kauā kiʻekiʻe loa, ʻo ka lōʻihi o ka hana a me ka hapalua ola wale nō i hilinaʻi ʻia e:
- ʻO ka palapala kuhikuhi i hoʻohana ai ka lāʻau;
- ʻO ka maikaʻi a me ka manawa o ka ʻai, ke kiko o ka momona i loko;
- ʻO ka lōʻihi o ka manawa o ka hoʻohana;
- ʻO nā hiʻohiʻona pilikino o ke kaʻina hana kūlohelohe kanaka.
I ka manawa o ka sodium fluvastatin i hoʻohana ʻia i nā mea maʻi me ka hypercholesterolemia a i ʻole i hoʻoliʻawale ʻia ka dyslipidemia, ʻike nui kekahi i ka nui o ka LDL a me ka triglyceride kiʻekiʻe a me ka hoʻonui o HDL cholesterol.
I ka manawa koho pono ia e hoʻokō i nā loiloi kūikawā.
Inā loaʻa i kahi maʻi o ka naʻau ke kanaka, he predisposition no rhabdomyolysis, hoʻohana i nā lāʻau 'ē aʻe o ka hui statin a i hōʻino hōʻino i nā mea inu ʻawaʻawa, ua kauoha ʻia ka flvastatin me ka akahele. Ma muli o ke hoʻopiʻi ʻana paha o ka ate, no laila, ma mua o ka lawe ʻana, ma hope o 4 mau mahina a i ka manawa o ka hoʻonui ʻana i ka hōʻaʻe, pono nā mea āpau e kuhikuhi ākuhi i nā ʻano o ka ate. Loaʻa nā hōʻike i nā hihia i loaʻa pinepine ʻole i ka hoʻohana ʻana i ka mea i kōkua i ka hoʻomaka ʻana o ka hepatitis, i ʻike wale ʻia i ka wā mālama, a i ka hopena i hala;
ʻO ka hoʻohana ʻana o ka flvastatin i kekahi mau hihia ke kumu i ka helehelena o myopathy, myositis a me rhabdomyolysis. Pono ka poʻe maʻi e hoʻomaopopo i ke kauka e pili ana i ka helehelena o ke ʻehaʻeha o ka ʻehaʻeha, ke kaumaha a me ka nāwaliwali o ka ikaika, ʻoi aku ka nui o ka mahana;
I mea e pale ai i ka hoʻomohala ʻana o ka rhabdomyolysis ma mua o ka hoʻohana ʻana, pono ia e noiʻi i ka ʻike ʻana o ka creatok phosphokinase i ka hiki ʻana o nā maʻi o ka pēpē i nā mea maʻi; maʻi maʻi thyroid; nā ʻano maʻi āpau o ka ʻōiwi; mea inu wai inu.
I nā mea maʻi i ʻoi aku ma mua o 70 mau makahiki, pono e nānā ʻia ka nui o ka CPK ma mua o nā mea ʻē aʻe e wānana ana i ka hoʻomohala ʻana o ka rhabdomyolysis.
I loko o kēia mau pilikia a pau, e loiloi ke kauka hele i nā pono o ka mālama ʻana a me nā pilikia e pili ana. Ma lalo o ka kiaʻi a mālama pono ʻia nā maʻi. I ka hihia o ka hoʻonui nui ʻana i ka neʻe o CPK, ua hoʻoholo hou ʻia ia ma hope o hoʻokahi pule. Inā hōʻoia ia ka hopena, ʻaʻole kuhi ʻia ka mālama ʻana.
Me ka nalowale ʻana o nā hōʻailona a me ka normalization o ka ʻike ʻana o ka phosphokinase creatine, ua hoʻomaka ʻia ka hoʻomau ʻana o ka lapaʻau me ka maʻi flvastatin a i ʻole nā statins e hoʻomaka e hoʻomaka me ka haʻahaʻa haʻahaʻa haʻahaʻa a ma lalo o ka mālama maʻamau.
ʻO kahi mea nui ʻo ka mālama ʻana i kahi meaʻai hypocholesterol ma mua o ka hoʻomaka ʻana o ka lāʻau lapaʻau a ma ka wā o ka mālama ʻana.
Lawe ʻia ia mea ma ke ʻano, me ka manaʻo o ka ʻahaʻaina. Pono e hoʻolilo i ka papa piha, holoi ʻia me ka nui o ka wai maoli, 1 ka manawa i kēlā lā.
No ka mea ʻoi aku ka hopena hypolipidemic nui e ka wiki 4, ʻo kahi loiloi o ka lāʻau e pono ai e hele ma mua o kēia manawa. ʻO ka hopena hopena o ka Lescol Forte wale nō e hoʻomau wale me ka hoʻohana lōʻihi.
I ka hoʻomaka ʻana i nā maʻi, ʻo ka lāʻau i ʻōlelo ʻia e 80 mg hoʻokahi i ka lā, kahi kaulike ia me ka 1 papa o Leskol Forte 80 mg. I mua o kahi hōʻemi o ka maʻi, hiki i 20 mg o ka fluvastatin, a i ʻole 1 capsule Leskol 20 mg, hiki ke kuhikuhi. E koho i ka dosis mua, ʻike ke kauka i ka mua o ka cholesterol i ke koko o ka mea maʻi, hoʻolālā i nā pahuhopu o ka lāʻau a mālama i nā hiʻohiʻona pilikino o ka mea maʻi.
Ma ka hanana e loaʻa ai ka mea maʻi i ka maʻi puʻuwai coronary a ua loaʻa iā ke operasyon angioneoplastic, ke ʻano neʻe mua ʻana o ka maʻi me ka 80 mg i kēlā me kēia lā.
ʻAʻole hana ʻia ka hoʻoponopono ʻia ʻana i nā maʻi maʻi me nā hana renal impaired. ʻO kēia ma muli o ka hapanui o ka Fluvastatin i hoʻopili ʻia e ka ate, a he wahi liʻiliʻi wale nō o nā mea i loaʻa i ke kino i hōʻiliʻili i ka urine.
I ka wā e hoʻokele ai i ka noiʻi, ua hōʻike ʻia ka maikaʻi a me ka hoʻomanawanui maikaʻi ʻaʻole no nā maʻi ʻōpio, akā no nā poʻe hoʻi o 65 mau makahiki o ko lākou mau makahiki.
I nā makahiki he 65 ma mua o 65 mau makahiki, ua hōʻike hou ʻia ka pane i ka mālama ʻana, ʻoiai ʻaʻole i loaʻa he data e hōʻike ana i ke ahonui hou.
He nui nā hopena o ka lāʻau lapaʻau:
- ʻO ka pinepine, hiki ke nānā ʻia ka hopena o ka thrombocytopenia;
- Loaʻa paha i ka hopena o ka hiamoe hiamoe, nā kuʻuna, paresthesia, dysesthesia, hypesthesia;
- Luhi pinepine ʻia ke ʻano o vasculitis;
- ʻO ke ʻano o nā pilikia o ka ʻeha gastrointestinal - dyspepsia, ʻeha o ka ʻōpū, nausea;
- ʻO ka helehelena o nā maʻi kūlohelohe, eczema, dermatitis;
- ʻO ka ʻehaʻeha o ka ʻōpū, myopathy, myositis, rhabdomyolysis, a me nā hopena e like me ka lupus like me ka hanana.
Hoʻomaopopo ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana e nā mea maʻi maʻi:
- Ke hōʻike nei i ka nui o ka nui o ka kolamu, triglycerides, haʻahaʻa haʻahaʻa lipoprotein cholesterol, apolipoprotein B, me ka hypercholesterolemia mua a me hyperlipidemia;
- I ke alo o ka maʻi naʻau coronary e lohi i ka hoʻomohala ʻana o ka atherosclerosis;
- E like me ka pale mea pale ma hope o angioplasty.
Hoʻopili ke kakoo ʻia no ke hoʻohana ʻana ma ke alo o kahi alitine i nā ʻāpana; nā mea maʻi me nā maʻi pūpū, me ka piʻi o ke kiʻekiʻe o nā enzyme o ka ate; i ka wā hāpai a me ka lactation i nā wahine; kamalii malalo o 10 mau makahiki aku.
Me ka mālama aka, pono ia i kuhikuhi i kahi lāʻau lapaʻau no ka poʻe maʻi me ka epilepsy, me ka waiʻona wai, hiki ʻole ke hoʻololi a me ka hoʻōla i myalgia.
ʻAʻole mālama ʻia nā hopena pōʻino me ke ʻano hoʻokahi o ka 80 mg.
Ma ka hana ke kau nei i nā lāʻau lapaʻau i ka maʻi maʻi ma ke ʻano o nā papa me ka hoʻokuʻu ʻia i hoʻokuʻu ʻia ma kahi pāʻina 640 mg no nā lā 14, ke ʻano o nā hopena o ka hopena mai ka gastrointestinal tract, hoʻonui i nā kiʻekiʻe o ka plasma o transaminases, ALT, AST.
Hoʻokomo ka cytochrome isoenzymes i ke kaona o ka lāʻau. Ke ʻano o ka hōʻea o kekahi o nā ala metabolic e kū nei, e uku ʻia ia i ka uku o nā poʻe ʻē aʻe.
Hoʻohui ʻole ʻia ka hoʻohana ʻia ʻana o ka lāʻau Fluvastatin a me nā HMG-CoA reductase inhibitors.
ʻO nā substrates a me nā mea paʻa o ka pūnaehana CYP3A4, erythromycin, cyclosporin, a me intraconazole e liʻiliʻi i ka hopena o ka pharmacology o ka lāʻau.
I mea e hoʻonui ai i ka hopena hoʻohui, ua noi ʻia ka colestyramine e hoʻohana ʻole ʻia ma mua o 4 mau hola ma hope o ka fluvastatin.
ʻAʻohe contraindications i ka hui pū ʻana o ka lāʻau me ka digoxin, erythromycin, itraconazole, gemfibrozil.
ʻO ka hoʻopiʻi hui ʻana i ka lāʻau me ka phenytoin hiki i ka hoʻonui ʻana i ke kao o ka plasma o ka hopena, no laila, pono e mālama ʻia me ka mālama ʻana i kēia mau lāʻau. I kekahi mau hihia, pono ke koi ʻia o ka hoʻoponopono ʻia.
Aia ka piʻi ʻana o ka neʻe i loko o ke koko koko o ka diclofenac inā lawe pū ʻia me fluvastatin.
Hiki ke hoʻohana pū ʻia ʻo Tolbutamide a me losartan.
Ma ka hanana e pilikia ai ka mea i ka diabetes mellitus type 2 a lawe i ka fluvastatin, pono e hoʻomaʻemaʻe ʻia ka nui o ka mālama ʻana a ma lalo o ka mālama kiaʻi mau, ʻoi aku ke ʻano o ka piʻi ʻana o ka lā i kēlā me kēia lā o ka fluvastatin i 80 mg i kēlā me kēia lā.
Ke hui pū ʻia ka lāʻau lapaʻau me ka ranitidine, cimetidine a me omeprazole, he nui nui ka nui o ka pae ʻana o ka plasma kiʻekiʻe a ua ʻike ʻia ʻo AUC o ka mea, e hoʻemi ʻia ka plasma o Fluvastatin.
Me ka makaʻala, hoʻohui i kēia ʻano me nā anticoagulants o ke ʻano warfarin. Hoʻomaopopo ʻia e nānā i nā manawa prothrombin i kēlā me kēia manawa, inā pono, hoʻoponopono i ka dosage.
I kēia manawa, ʻike ʻia ka lāʻau lapaʻau e kekahi mau loiloi maikaʻi loa mai nā mea maʻi i lawe ia e like me ke mālama lapaʻau. Pono e hoʻomaopopo ʻia, i mea e hoʻokō ai i ka hopena kiʻekiʻe, pono ia e hoʻokō pono i kahi ola olakino, ka ʻai kūpono a me ka hoʻoluʻu kino ʻana. Eia kekahi, ʻanuʻu ʻia ka lōʻihi o ka hoʻohana ʻana, no ka mea he hopena lōʻihi nā lāʻau lapaʻau, i loko o ia hopena he hopena maikaʻi o ka nui o ka cholesterol i loko o ke koko.
Pono nā lāʻau lapaʻau e pili ana i ka flvastatin i nā lāʻau lapaʻau me kahi lāʻau lapaʻau.
E haʻi nā loea i nā statins i loko o kahi wikiō ma kēia ʻatikala.
