ʻO kaʻenehana Glucose oxidase a me nā hexokinase no ka hoʻoholo ʻana o ka glucose serum i loko o ke koko

ʻO ka maʻi kūpono, koi ʻia ke hoʻoponopono ʻana i nā ʻano o ka hōʻike o ka lāʻau.

ʻO ke ala no ka hoʻoholo ʻana i ka glucose serum ka mea maikaʻi loa no ka nānā ʻana i ka maʻi hyper- a me hypoglycemia i loko o nā maʻi me ka maʻi mellitus.

Hiki i ke ala ke hiki iā ʻoe ke hoʻoponopono i ka lāʻau lapaʻau o kēia mau hōʻemi metabolic. Hiki nō hoʻi nā ʻaihue o ka glucose i loko o ke koko āpau a me kāna plasma.

Nā kaʻina no ka hoʻoholo o ka glucose i ke koko

Ua nui ka nui o nā ʻano hana no ka hoʻoholo ʻana i ka nui o ka glucose i ke koko.

ʻO kekahi o lākou (reductometric, colorimetric) i hoʻohana ʻole ʻia ma muli o nā hōʻemiʻiliʻili a me ke kūleʻa haʻahaʻa.

ʻO ka manawa pinepine, ua hoʻohana ʻia nā haʻawina enzymatic. ʻO ke ʻano o ka oxidase glucose ke ʻano o ka hopena ʻōnaehana e hele mai ana ke hoʻomehana ʻia o ka mea momona. E hoʻoholo ai ka Hexokinase i ka hana koko ma ka hexokinase.

ʻO ke ala oxucase Glucose

Hoʻokumu ʻia ka pākuʻina o glucose oxidase no ka hoʻoholo ʻana i ka glucose o ke koko ma muli o kāna hopena oxidation ma lalo o ka mana o kahi enzyme. Ma kēia hihia, hoʻokumu ʻia ka hydrogen peroxide, paʻa ia i ka chromogen waiwai, ʻo ke kaona o ka mea e hoʻoholo ai i ka nui o nā glucose.

Hoʻohana ʻia ka ʻōnaehana glucose oxidase no:

• intolerance ʻōpiopio;
• pentosuria;
• lolionia lactulose.

ʻO ka hemahema o ka noiʻi, hiki i ka hydrogen peroxide ka mea e hiki ke hoʻokaʻawale i ka chromogen a me ka ascorbic acid, uric acid, a me bilirubin i loko o ke koko. Kuhi ʻia ka nui o ka glucose i ke ʻano o ka photometric, ʻike ʻia ka ʻikepili i ka ikaika hoʻomehana me ka pakuhi calibration.

I nā kūlana keʻena, hiki iā ʻoe ke hoʻoholo i ke kiʻekiʻe o ka mea:

1. i ke koko venous. ^ E Ha yM. Hoʻohana ʻia nā mea kākau manu;
2. i ke koko capillary. Lawe ʻia ka pā mai ka manamana lima.

Aia ke ʻano o ka electrochemical i ka hoʻohana ʻana o nā electrodes i loaʻa ka glucose oxidase. Hoʻoholo ʻia ka nui o ka hydrogen peroxide, a i ʻole ke koena o ka oxygen i hoʻopau ʻia i loko o ke kaʻina hana o ka maʻi oxidation.

Ka hana Hexokinase

ʻO ka waiwai ka mea nui e hoʻoliʻoli i ka metabolism glucose e hoʻoponopono ai i ka wikiwiki o ke kaʻina i loko o nā pūpū.

Ma lalo o nā kūlana hana, ʻo ka glucose phosphory template ma lalo o ka hana hexokinase ma muli o ka adenosine triphosphoric acid.

Ma muli o kēia hopena, ua kūkulu ʻia nā molekala aila, ka nui o ka mea e hoʻoholo ai e ka pae o ka hoʻoiho ʻana i ka māmā ma ka zona ultraviolet. ʻO ka hanana nexokinase wikiwiki ka wikiwiki, ʻo ia hoʻi kahi hōʻailona o ka maʻi hōʻino.

Hoʻomākaukau ʻai

Hoike ʻia nā haʻawina o ka serum koko no ka glucose

• nā lua maʻi no ka maʻi maʻi, ka nānā ʻana i nā maʻi;
• nā pilikia ma ka kelepaʻi thyroid, gland pituitary;
• momona;
• kahea ʻana i ka hoʻoliʻiliʻi glucose.

Ma mua o ka nānā ʻana, pono e nānā ʻia nā ʻano o nā kūlana i ʻike ʻia nā hopena e like me ka hiki.

1. lawe ʻia ka hoʻokolokolo ʻana ma kahi ʻōpū ʻole. Lawe ʻia ka waiwai i ke kakahiaka;
2. kahi lā i nā lā ma mua o ka hōʻike ʻana, pono ʻoe e pale i ka hoʻoikaika kino kino, ke kaumaha;
3. ma ka mea maʻi ʻo kēlā me kēia lā e liʻiliʻi loa ma kahi o 150 mau mau o nā kīmeka. Me kahi hemahema, e piʻi nui ka pae o ka glucose, a e emi malie ana, e kaawale ana i ka ʻikepili helu;
4. i ka lā hoʻokahi ma mua o ka maʻi, ʻaʻole hiki iā ʻoe ke inu a inu i ka waiʻona;
5. ʻAʻole hiki iā ʻoe ke hana i kahi haʻawina ma hope o nā hana kaumaha, ka hānau keiki, i ka hele ʻana o ka mumū. Ua hoʻohālikelike ʻia kahi huli ʻana ma ka cirrhosis o ka ate, ka hoʻonui ʻana i nā maʻi o ka ʻōpū, kaʻina hana;
6. ʻelua lā ma mua o ka hoʻopaʻa ʻana, ʻaʻole ʻoe e haʻalele i nā kaʻina hana physiotherapeutic, e lawe i ka contraceptives waha, diuretics, psychotropic drug, caffeine.

Hiki i ka loiloi ke hāʻawi i kahi hopena maikaʻi ʻole i ka maʻi hypokalemia a me nā maʻi endocrine (Cush's syndrome, thyrotoxicosis).

Serum glucose helu i ka makahiki

Pili ʻia nā mea kūpono maʻamau i ka makahiki:

• ma ke kahe koko hiki mai i 2,5 a 5.3 mmol / l;
• i nā pēpē mua - mai 1.1 a 3 mmol / l;
• i na keiki o ka la mua o ke ola - mai 2.22 a 3.33;
• i ka malama o makahiki mai 2.7 i ka 4.4;
• i nā keiki ma luna o 6 makahiki mau makahiki - mai 3.3 a 5.5 mmol / l;
• i nā pākeke ma lalo o 60 makahiki - mai 4.4 a 6.3;
• i nā poʻe kahiko - mai ka 4.6 a i ka 6.1 mmol / l.

Hōʻike ʻia ka hypoglycemia i nā pākeke me nā waiwai glucose i emi iho ma mua o 3.3 mmol / l, a me ka hyperglycemia - ʻoi aku ma mua o 6.1 mmol / l

He aha ke kuhikuhi / hoʻonui?

ʻO ka Hyperglycemia (kahi hoʻonui i ke kahe o ke koko) i nānā ʻia me:

• nā kuhi hewa ʻana o ka hana o ka hormonal pono o ka huehue o ka pituitary, nā kaomi thyroid: thyrotoxicosis, acromegaly, ʻeha o Cush;
• ʻO nā maʻi o ka pancreatic: maʻi maʻi, pancreatitis, cystic fibrosis, tumor phenomena, hemochromatosis;
• nā maʻi o nā ate, nā pēpē;
• nā maʻi hana o ka ʻōnaehana: hemorrhages, tumor, ʻeha hōʻeha;
• huʻonoʻi me ka eter, hydrocyanic acid;
• me ka meningitis, epilepsy;
• nā maʻi ʻeha: myocardial infarction, angina pectoris;
• waiora B 1;
• kuni kuni.

ʻImi ʻia ka hypoglycemia i nā maʻi me nā:

• ka pūpū o ka mokupuni pancreatic, hapa o glucagon;
• nā pōʻino o ka ate i lawe ʻia e ka lāʻau arsenic, mea inu ʻawaʻawa, antihistamines, ka phosphorus, pūhui mercury, benzene, paracetamol;
• nā aho maʻalili i ka wā e hoʻokumu ai i ka glycogen, he hopena i ka gluconeogenesis;
• nā hopena endocrine: maʻi addison, hypothyroidism;
• nā maʻi o nā pūpū, nā puʻuwai ma muli o ka malabsorption.

Nā wikiō pili

E pili ana i ka hoʻoholoʻana o ka glucose serum i ke koko ma ke wikiō:

Ka pono o ka pae o ka glucose e pono ai no ka maʻi kūpono a me ka hoʻoponopono ʻana no ka maʻi maʻi. ʻO ke ʻano hexokinase hoʻokolohua e pili i ka hoʻoholo ʻana o ka hana he serok hexokinase. ʻO ke ʻano maʻi oxidase e hoʻoholo i ka nui o nā kumuwaiwai i ka plasma, cerebrospinal fluid.

Hana ʻia kahi ʻano loiloi ma kahi ʻōpū ʻole. Ma ka pō o ke aʻo ʻana, ʻaʻole hiki iā ʻoe ke komo i ka hana kino kino, inu i ka waiʻona a me ka uahi. ʻO ka mea nui o ka hana ka hoʻopaʻa ʻana i ka hoʻāla o ka glucose oxidation me ke komo ʻana o ka oxidase glucose e hoʻohālikelike ʻia, kahi i hana ʻia ai ka hydrogen peroxide.

ʻO ka manawa pinepine, ua hoʻohana ʻia ke ʻano ma ke keʻena ʻo endocrinology o nā haukapila. Hoʻopuka ʻia ka hoʻokolokolo me ka hoʻohana ʻana i nā mea analenika, photomone. I ka ulia pōpilikia, hoʻohana ʻia nā glucometer portable.