Exenatide: kumukūʻai a me nā kiko'ī o Bayeta

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ʻO ka lāʻau lapaʻau Baeta, ka mea ikaika o ka exenatide, i manaʻo ʻia he lāʻau kūʻokoʻa hypoglycemic ʻokoʻa. Hoʻohana ʻia ka mea hana i ka mālamaʻana i nā maʻi maʻi type 2, ʻoi pū kekahi me ka luhi.

Hoʻohana pū ka maikaʻi o kēia lāʻau'ōnaehana me ka hana o ka hana i ka pono nui, e hōʻemi ana i ka pae o ka glucose i loko o ke koko.

Hoʻonui ia i ka mea huna o ka insulin, a me ka mea hoʻi, ma ka hoʻoulu ʻana i nā huaole, e loaʻa pū kekahi i nā hopena o ke kō.

  • hoʻonui i ka hana o nā pūlama beta pancreatic, e alakaʻi ana i ka hoʻonui ʻana o ka hana hana i ka insulin;
  • hōʻemi i ka mea huna o ka glucagon, e hoʻonui ai i ka ʻike o ka glucose i loko o ka ate;
  • lohi i ka hoʻokuʻu i loko o ka ʻōpū.

ʻO kahi pōmaikaʻi nui o kahi mea like e like me ka exenatide ʻo ia ka hoʻonui ʻana i ka hana o ka insulin mai ka parenchyma, a laila oki i kona huna ʻana i ka wā e hoʻi mai ka pae ʻai koko i ka maʻamau.

No laila, ʻo ka maʻamau o kahi kūlana hypoglycemic i ke kanaka ua kokoke loa ia me ka ʻole.

Ma hope o ka komo ʻana o ka waiwai o ke kino o ke kanaka, hoʻomaka koke ʻo ia e hana a hiki i kahi pae kiʻekiʻe i kāna hana i loko o ʻelua mau hola. ʻO ka lōʻihi o ka exenatide he 24 mau hola, no laila, ʻo ka hoʻolahaʻana iā ia i hoʻokahi manawa i ka lā e hāʻawi i ke kahe o ke kōʻai ma loko o nā hola 24 like.

Eia kekahi, hoʻēmi ka exenatide i ka momona o ke maʻi maʻi, ma muli o ia, e hoʻopau ai i ka ʻai, ke ʻano a me ke ʻano o ka ʻōpū o ka puʻuwai, a ʻaʻole ia e hoʻihoʻuku koke me ke wikiwiki.

No laila, ʻaʻole nā ​​mea o kēia mea hoʻokū i ka pae o ke kō i loko o ke koko, akā kōkua pū kekahi i ka hoʻopau ʻia o ka 4-5 kileka he nui.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

ʻO ka lāʻau lapaʻau wale nō ka mea e loaʻa ai ka exenatide ʻo Baeta. Ma kahi o ka mea nui, aia kahi liʻiliʻi o nā mea hou: sodium acetate trihydrate, mannitol, metacresol, acetic acid a me ka wai hoʻoneʻe.

Hoʻokuʻu ʻia e nā hui ʻelua ʻelua - ʻo AstraZeneca lāua ʻo Bristol-Myers Squibb Co (BMS). Hoʻokahi wale ka Baeta i hoʻokahi puka dosage - 250 mg ampoules e loaʻa ana i kahi hopena maʻalahi, no kēlā me kēia mea i kahi penikala ʻiwikoa kūikawā me ka nui o ka 1,2 ai ʻole 2.4 ml.

Ke kūʻai ʻia nei ka lāʻau ma ka papaʻaina, no laila hiki ke kauka ʻana i ke kauka hele ke kuhikuhi i ka mea maʻi. Ma hope o ka loaʻa ʻana o ka mea maʻi i nā ampoules, pono ia e heluhelu pono i nā ʻōkuhi no ka hoʻohana.

Hoʻohana ʻia kēia lāʻau lapaʻau me ka monotherapy a me ka mālama hou aku o ka maʻi diabetes mellitus type 2, i hiki ʻole ke kaohi i ke pae o ka glycemia. Aia ke aʻo i kahi papa inoa o nā lāʻau lapaʻau i hiki ai iā ʻoe ke hoʻohui i ka lapaʻau ʻana o Bayet:

  • biguanides;
  • kumuliiu aoli;
  • Thiazolidinedione;
  • ka hui pū ʻana o thiazolidinedione a me metformin;
  • ka hui pū ʻana o ka sulfonylurea a me ka metformin.

ʻO ka makeʻana o ka lāʻau lapaʻau he 5 mcg i kēlā me kēia lā 1 ma mua o ka pāʻina nui. Hoʻopiʻi ʻia ma lalo o ka ʻili i ka ʻōpū, ka forearm a me nā ʻūhā paha. Inā kūleʻa ka ʻoihana, ma hope o nā lā 30 e hoʻonui ka nui i ka 10 mcg ʻelua i ka lā hoʻokahi. I ka hihia o ka hoʻohui ʻana i ka lāʻau lapaʻau me nā derivatives sulfonylurea, pono e hoʻemi ʻia ka nui o ka hopena e pale ai i ka hōʻemi wikiwiki i ka pae gula. I ka wā o ka hoʻolahaʻana o ka hoʻonā, pono e hahai ʻia nā lula e like me kēia:

  1. ʻaʻole ke alakaʻi ʻia ka lāʻau lapaʻau ma hope o ka ʻaina.
  2. Mai hōʻino i ka luhi a intramuscularly paha;
  3. inā ua hoʻololi ka hopena i ka kala a i ʻole nā ​​mea liʻiliʻi, ʻaʻole pono e hoʻohana ʻia;
  4. i ka wā o ka mālama ʻana, hiki i ka hoʻouluʻana o ka antibody.

ʻO ka lāʻau lapaʻau e mālama i kahi wahi pōʻeleʻele i nā keiki liʻiliʻi ma kahi wela o 2-8C.

ʻO 2 mau makahiki ka ola o ka pale, a ʻo ka hoʻonā ʻana i ka peni ʻo ka syringe he 30 mau lā ma kahi mahana ʻaʻole he 25 mau kiʻekiʻe.

Nā hiʻohiʻona a me nā hopena maikaʻiʻole

E like me nā lāʻau ʻē aʻe, ʻo ka lāʻau lapaʻau Bayeta kekahi mau contraindications:

  • maʻi mellitus type 1;
  • ketoacidosis (nā maʻi i ka hoʻoliʻiliʻi ka hana);
  • nā hana renal (huahelu o CC ma mua o 30 ml / min);
  • ka hikiʻole i nā mea āpau o nā lāʻau;
  • ke ʻano o ka hana o ka holo ʻana ʻole me ka indigestion;
  • lawe ana i kahi keiki a me ka umauma;
  • na keiki a me na opio malalo o na makahiki 18 aku.

No kekahi kumu, e laʻa me ka hoʻohana ʻole ʻana i ka lāʻau, hiki i nā hopena ʻaoʻao.

  1. maʻi kūlohelohe - urticaria, rashes ma ka ʻili, kaʻili;
  2. hanaʻole o ka pūnaehana ʻana - ka maʻi a me ka hoʻopuka, ka hakakā nui loa, constipation a i ʻole ʻūhā, hoʻemi i ka mea momona a me ka paona;
  3. nā hana ʻino o ke kikowaena kūwaho - hoʻonāukiuki, luhi, nā ʻeha me nā maʻi o ka maʻi a me nā ʻeha;
  4. hepatic a i ʻole renal;
  5. hoʻonui Serum creatinine;
  6. mokuahi hypoglycemic, hyperhidrosis, pancreatitis.

I kēlā mau kūlana, pono ke kamaʻilio e nīnau me ke kauka e hoʻoponopono i ka regimen lapaʻau.

Pono ʻoe e hōʻemi i ka dosage a i ʻole hoʻokū i ka lawe ʻana i kēia lāʻau lapaʻau.

ʻO ke kumukūʻai, nā loiloi a me nā analogues o ka lāʻau lapaʻau

Hiki ke kūʻai ʻia ka lāʻau Baeta ma kahi lāʻau kūʻai a waiho paha i kahi kauoha ma ka Pūnaewele. ʻO ka mea no ke kau ʻia ka lāʻau lapaʻau, ʻo ke kumukūʻai no ia, e like me ia, kiʻekiʻe loa. No laila, ʻaʻole hiki i nā mea āpau ke kūʻai aku.

Kūlike ke kumukūʻai e pili ana i ka nui o ka hoʻonā, ke kumukūʻai o ka halihali a me ka palena o ka mea kūʻai:

  • 1,2 ml syringe pen - mai 4246 a 6398 Russian mau rubles;
  • 2.4 ml syringe pen - mai 5301 a 8430 mau rubles Lūkini.

Nui nā poʻe maʻi i loaʻa i ka hoʻonā ʻana o Bayet i kēia me kēia lāʻau lapaʻau. ʻO ka mea mua, hoʻohana ʻia i hoʻokahi wale nō i ka lā, a me ka lua, e hoʻēmi maoli ai i ka maʻi glucose a me ke kino o ke kino i loko o kahi kanaka lohi.

Eia naʻe, ma hope o ka hoʻokuʻu o ka lāʻau lapaʻau, hana nā mea hana i kahi noiʻi kūʻai mahele i lawe i nā mea maʻi manuahi. Ua hōʻike ʻia nā hopena o ka hōʻike ʻana i ka hapa nui o nā poʻe e lawe nei i ka lāʻau lapaʻau i kēia mau hopena maikaʻi ʻole:

  1. Flatulence, constipation, i nā hihia ʻokoʻa - ka maʻi pancreatitis.
  2. Urticaria, pruritus, alopecia (lauoho lauoho), angioedema, maculopapular rash.
  3. ʻO ka lepo ma muli o ka luaʻi, makemake ʻole e lilo ka kaumaha.
  4. ʻO ka palupalu, nā nele a ʻole ka lula ʻana o ka hoʻāʻo.
  5. Impaired 'ōpole hana, hoʻokiʻekiʻe ke kiʻekiʻe, pale ʻole a i ʻole kona hoʻohui.
  6. ʻO ka hōʻike manaʻo anaphylactic.

E like me nā analogue e hoʻopili ana i ka waiwai like, ʻaʻohe mau. Ma ka mākeke lāʻau moʻo lāʻau Lūkia, hiki iā ʻoe ke loaʻa wale i nā lāʻau lapaʻau e loaʻa ana i ka hopena therapeutic like. Hoʻopili kēia me ka mimetin mimetin - Viktoza a me Januvius. Hiki i nā ʻike kikoʻī hou aku e pili ana iā lākou ma ka Pūnaewele a nīnau aku i kāu kauka.

A no laila, ʻo exenatide, aia i loko o ka mākaukau o Bayeta, hoʻomaikaʻi maikaʻi i ka pae o ka glucose i loko o ke koko a ʻaʻole alakaʻi i ka hypoglycemia. Kūkulu ke kauka i kēia lāʻau lapaʻau, e kinai i nā contraindications hiki, ke kūlohelohe a me ka noʻonoʻo ʻana i nā ʻano kūʻokoʻa o ka mea maʻi. Ke hoʻohana nei i ka lāʻau lapaʻau, hiki iā ʻoe ke pale i nā hōʻailona o ka maʻi maʻi ma kahi lōʻihi. E ola kino!

No ka loaʻa ʻana o ka uku mau ʻia, pono e loaʻa i ka mālama ʻana no ka maʻi type 2. Pehea e mālama ai i kahi maʻi e haʻi i ka mea loea i ka wikiō ma kēia ʻatikala.

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