ʻO Onglisa kahi lāʻau lapaʻau no nā maʻi maʻi, ʻo ke ʻano ikaika o nā saxagliptin. ʻO Saxagliptin kahi lāʻau lapaʻau i kauoha ʻia no ka mālama ʻana i ka maʻi maʻi 2.
I loko o 24 mau hola ma hope o ka hoʻokele ʻana, ua pale ʻia nā hana a ka DPP-4. Inhibition o ka enzyme i ka wā e launa pū me ka glucose e hoʻonui i ka manawa 2-3 i ka pae o ka glucoseagon like me ka peptide-1 (ma aneʻi ʻo GLP-1) a me ka glucose-e hilinaʻi i ka insulinotropic polypeptide (HIP), e hōʻemi ana i ka hoʻoliʻi o ka glucoseagon a hoʻoulu i ka pane o nā cell beta.
I ka hopena, hoʻonui ka ʻikepili o ka insulin a me C-peptide i ke kino. Ma hope o ke hoʻokuʻu ʻia ʻana o nā insulin a nā cell beta o ka pancreas a me ka glucagon mai nā pūpū alpha, ua hoʻemi nui ʻia ka wikiwiki o ka glycemia a me ka glycemia postprandial.
Pehea ka palekana a me ka hoʻohana pono ʻana o ka saxagliptin i loko o nā ʻano like ʻole i loiloi ʻia i loko o nā noi ʻelua i hoʻopaʻa ʻia i loko o ka wahi no ka pelekane, ua hōʻike ʻia ka maʻi 4148 me ka maʻi mellitus type 2.
I ka wā o nā noiʻi, ua ʻike nui ʻia ka hoʻomaikaʻi ʻana i ka hemoglobin glycated, ka wikiwiki o ka plasma plasma a me ka glucose postprandial. ʻO nā mea maʻi i hoʻoiho ʻole i ka monopoli saxagliptin i hoʻohua ʻia i nā hopena i manaʻo ʻia nā mea hoʻohālike e like me ka metformin, glibenclamide a me thiazolidinediones.
ʻO nā hōʻike hōʻike mai nā mea maʻi a me nā kauka: 4 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻōla, loaʻa wale ka saxagliptin, hoʻemi ka pae o ka hemoglobin glycated, a ua emi ka hoʻoliʻi ʻana o ka glucose glucose ma hope o 2 mau pule.
Nā moʻolelo like i hoʻopaʻa ʻia i kahi hui o nā poʻe maʻi i kuhikuhi ʻia i ka lāʻau hoʻohui me ka hoʻohui ʻana o ka metformin, glibenclamide a me thiazolidinedione, hana nā analogues i ka hanana like.
I nā kūlana a pau, ʻaʻole i ʻike ʻia ka hoʻonui ʻia ʻana o ka paona kino o nā maʻi.
Ke noi ongliza
Ua hōʻike ʻia ka lāʻau lapaʻau i nā mea maʻi me ka maʻi o ke ʻano maʻi type 2 i kēlā mau kūlana:
- Me ka monotherapy me kēia lāʻau lapaʻau i hui pū me ka hana kino a me ka lāʻau hoʻolaʻa;
- Me ka hui pū ʻana me ka metformin;
- I ka haʻalele ʻana o ka hana o ka monotherapy me metformin, derivatives o ka sulfonylurea, thiazolidinediones ma ke ʻano he lāʻau lapaʻau hou.
ʻOiai ʻo ka lāʻau onglise he nui i hoʻomaʻamaʻa i kekahi o nā haʻawina a me nā hoʻokolohua, ʻo ka loiloi e pili ana i ka hōʻoluʻolu loa, hiki ke hoʻomaka ʻia ke ʻano ma lalo o ka mālama ʻana o kekahi kauka.
Nā maʻi hoʻohālikelike i ka hoʻohana ʻana o onglise
No ka mea e hoʻopilikia pono ai ka lāʻau lapaʻau i ka hana o nā beta a me nā cell alpha, e hoʻoikaika nui i kā lākou hana, ʻaʻole hiki ke hoʻohana mau. Ua pale ʻia ka lāʻau.
- I ka wā hāpai, hānau a hānau keiki.
- ʻO nā poʻe'ōpio ma lalo o 18 makahiki.
- ʻO nā mea maʻi me ka maʻi diabetes mellitus type 1 (ʻaʻole i aʻo ʻia ka hana).
- Me ka inikini insulin.
- Me ka ketoacidosis maʻi maʻi.
- ʻO nā mea maʻi me ka galactose congenital intolerance.
- Me ka naʻauao pilikino i kekahi o nā ʻano o ka lāʻau.
ʻAʻohe hihia e hoʻowahāwahā ʻia nā kauoha no ka lāʻau lapaʻau. Inā he kānalua e pili ana i ka palekana o kona hoʻohana, pono e koho ʻia nā mea pale a i ʻole kekahi ʻano loea e hoʻohana ai.
Hana ʻia ʻo Dosage a me ka hoʻokele
Hoʻohana ʻia ʻo Onglisa ma ke ʻano me ka ʻole o ka meaʻai. ʻO ka awelika hāmeʻa hāpana i kēlā me kēia lā o ka lāʻau lapaʻau ma ka 5 mg.
Inā lawe ʻia ke ʻano hui lāʻau, ʻae ʻole ka loli o ka lā maʻamau o ka saxagliptin, ua kūʻokoʻa ka nui o ke ʻano o ka metformin a me nā deralona sulfonylurea.
I ka hoʻomaka ʻana o ka hui hui ʻana me ka hoʻohana ʻana i ka metformin, e hōʻike ʻia ka nui o nā lāʻau lapaʻau.
- Onglisa - 5 mg i kēlā me kēia lā;
- Metformin - 500 mg i kēlā me kēia lā.
Inā ʻike ʻia kahi ʻano kūpono ʻole, pono ke hoʻoponopono ʻia ka nui o ka metformin, hoʻonui ʻia.
Inā paha, no kekahi kumu, ua hala ka manawa o ka lawe ʻana i ka lāʻau lapaʻau, pono ka mea hoʻomau i lawe i ka paila. ʻAʻole pono kēlā me ke kānalua i ka pāpālua i kēlā me kēia lā.
No ka poʻe maʻi e loaʻaʻole ka hopena o ka renal e like me ka mea e hoʻopiʻi ana i kūpono, ʻaʻole pono ke hoʻoponopono ʻia i ka ʻaohue o onglise. Me ka hanaʻole o ka renal i ke ʻano liʻiliʻi a me nā hōʻino o ka onglis e lawe ʻia i nā liʻiliʻi liʻiliʻi - 2,5 mg hoʻokahi i ka lā.
Inā hana ʻia ka hemodialysis, lawe ʻia ka onglisa ma hope o ka hopena o ke kau. ʻAʻole i ʻike ʻia ka hopena o ka saxagliptin i nā maʻi e holo ana i ka dialysis peritoneal. No laila, ma mua o ka hoʻomaka ʻana i ka mālama ʻana me kēia lāʻau lapaʻau, pono e nānā ʻia kahi loiloi kūpono o ka hana o ka peʻahi.
Me ka hikiʻole o ka ate, hiki ke hoʻopaʻa palekana iā onglise i ka maʻa i hōʻike ʻia - 5 mg i kēlā me kēia lā. No ka mālamaʻana i nā maʻi maʻi maʻi, ua hoʻohana ʻia ka onglise i loko o ia ʻano like. Akā e hoʻomanaʻo ʻia ʻo ka lilo ʻana o ka pilikia o ka hiki ʻana o ka hoʻomaʻamaʻa ʻana i ka papa i kēia ʻano maʻi o ka maʻi maʻi.
ʻAʻohe kumu ʻike a ʻike haʻawina koʻikoʻi o nā hopena o ka lāʻau lapaʻau ma luna o nā mea maʻi ma lalo o 18 makahiki o kona mau makahiki. No laila, no nā poʻe ʻōpio me ke ʻano maʻi type 2, ua koho ʻia nā analogues me kekahi mea ikaika.
Ke koi nei i ka hoʻokaʻawale o ka onglise e koi ʻia inā ka lāʻau lapaʻau ʻia i ka manawa like me ka potent inhibitors. I kēia:
- ketoconazole,
- paulele
- atazanavir
- ailuaina
- igraconazole
- nelfinavir
- ritonavir
- saquinavir a me telithromycin.
No laila, ʻo ka palena nui o kēlā me kēia lā he 2.5 mg.
Nā hiʻohiʻona o ka mālamaʻana i nā wahine hāpai a me nā hopena
ʻAʻole ia i aʻo ʻia pehea e pili ai ka lāʻau lapaʻau i ka papa o ka hapai ʻana, a inā paha hiki ke komo i loko o ka umauma waiū, no laila, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau i ka wā o ka hānai ʻana a me ka hānai i ka pēpē. Hoʻomaopopo ʻia e hoʻohana i nā mea ʻē aʻe a i ʻole e pau ai ka ʻokiʻoki.
ʻO ka maʻamau, ma hope o nā iniha a me nā manaʻo o ka hui hoʻohui, hoʻōla maikaʻi ʻia ka lāʻau lapaʻau, i nā hihia loaʻa ʻole, e like me ka loiloi ʻana o nā loiloi, hiki ke mālama ʻia:
- Lohea
- ʻO Gastroenteritis;
- Nāuliʻi;
- ʻO ka hoʻokumuʻana o nā maʻi hopohopo o ke keaka hanu kiʻekiʻe;
- ʻO nā maʻi lēpaʻi o ka ʻōnaehana genitourinary.
Inā he hoʻokahi a oi aku paha nā hōʻailona, pono ʻoe e hoʻokuʻu i ka lāʻau a hoʻoponopono i ka dosage.
Wahi a nā loiloi, ʻoiai inā ua hoʻohana nui ʻia ka onglise i nā papa iʻoi aku ma mua o 80 mau manawa i hōʻike ʻia, ʻaʻohe hōʻailona o nā mea make. E hoʻoneʻe i ka lāʻau lapaʻau mai ke kino ma ka hihia inā hiki i kahi hoʻohālikelike, hoʻohana ʻia ke ʻano geomdialysis.
He aha hou aʻe e ʻike
ʻAʻole i kuhikuhi ʻia ʻo Onglisa me ka insulin a i loko o ka triple therapy me nā metformin a me thiazolididones, no ka mea, ʻaʻole i lawe ʻia nā noi ʻana o kā lākou pilina. Inā hōʻeha ka mea maʻi i ka maʻi a me ka hikiʻole i ka renal ka hopena, pono e hōʻemi ʻia ka nui o ka lā i kēlā me kēia lā. Diabetics me ka maluhia renal functioning e nānā mau ana i ke kūlana o nā keiki i ka wā o ka mālama ʻana.
Ua hoʻonohonoho ʻia e hiki i nā derivatives sulfonylureas ke hoʻonāukiuki i ka hypoglycemia. I mea e pale ai i ka hopena o ka hypoglycemia, pono ke hoʻoponopono ʻia i ka nui o ka sulfonylurea e hui pū ai me ka maʻi onglise. ʻO ia, hoʻemi.
Inā loaʻa i ka mea maʻi ka mōʻaukala o ka hypersensitivity i kekahi mau mea hoʻopaʻa DPP-4 ʻē aʻe, ʻaʻole i kuhikuhi ʻia ka saxagliptin. No ka palekana a me ka hana pono o ka mālama ʻana me kēia lāʻau lapaʻau no nā poʻe maʻi ma waena o nā makahiki 6 (ʻoi aku paha o 6 mau makahiki he nui), ʻaʻohe hōʻailona i kēia hihia. Ua ʻae ʻia ʻo ʻOnglisa a hana i ke ʻano like me nā maʻi maʻi ʻōpio.
No ka mea i loko o ka huahana nā lactose, ʻaʻole kūpono ia no ka poʻe i komo i ka intolerance congenital i kēia ʻano mea, nele a lactose, malabsorption glucose-galactose.
ʻO ka hopena o ka lāʻau lapaʻau ma ka hiki ke kahe i nā kaʻa a me nā lako ʻē aʻe e koi ai i kahi kiʻekiʻe o ka nānā ʻana, ʻaʻole i aʻo piha ʻia.
ʻAʻohe hopena contraindications e alakaʻi nei i kahi kaʻa, akā e hoʻomanaʻo ʻia i waena o nā hopena ʻaoʻao e hoʻohālikelike ai nā ʻeha a me nā hōʻeha.
Hoʻopili pū me nā lāʻau ʻē aʻe
Wahi a nā hoʻokolohua lapaʻau, ʻo ka loaʻa ʻana o ka hōʻiliʻili o ka onglise me nā lāʻau ʻē aʻe, inā e lawe pū ʻia i ka manawa like, he liʻiliʻi nō ia.
ʻAʻole hoʻonā o nā kānaka ʻepekema pehea e inu ai ka inu ʻana i ka inu wai, ka hoʻohana ʻana i nā lāʻau lapaʻau homeopathic, a i ʻole nā meaʻai meaʻai i ka hopena o ka lāʻau lapaʻau, ma muli o ka nele o ka noiʻi ma kēia wahi.
