ʻO ka maʻi mellitus o ka maʻi type 2 ke manaʻo ʻia he ʻano ʻoluʻolu ke ʻano o ka maʻi, i ʻole ka pono o ka hoʻokele ʻana o ka insulin. No ka mālama i ke kōpaʻa koko, pono kēia mau ana:
- Ke kaupaila ʻana;
- Nā hana kino kino;
- Lawe i nā lāʻau lapaʻau e kōkua i ka hoʻemi ʻana i ke kō.
ʻO ka lāʻau lapaʻau Antidiabetic he mau lāʻau lapaʻau e loaʻa ai ka nui o ka hāmeʻe o ka hormone a i ʻole ka lāʻau sulfa sulfa. Hoʻohana hou nā Endocrinologists i nā lāʻau antidiabetic no ka hui biguanide.
ʻO ke ʻano o nā lāʻau lapaʻau e wehewehe ʻia ai e ke ʻano a me ka paʻakikī o ka maʻi.
Inā hoʻokomo ʻia ka insulin a me nā lāʻau e pili ana i ka insulin i loko o ke kino, lawe ʻia ka lāʻau antidiabetic ma ke alo. ʻO ka maʻamau, ʻo kēlā me kēia mau papa a me nā ʻopi e kōkua i ka hoʻokahe koko haʻahaʻa.
Pehea e hana ai ka insulin
ʻO kēia hiona a me nā lāʻau lapaʻau me kona hōʻiliʻili ʻo ke ala wikiwiki loa a hilinaʻi hoʻi e hoʻi i ka pae koko koko i ka maʻamau. Eia kekahi, ʻo ia:
- Hoʻemi ia i nā haʻuki glucose ʻaʻole wale i loko o ke koko, akā pū kekahi i nā urine.
- Hoʻonui i nā neʻe glycogen ma ke kikoʻī o nā ʻiʻo.
- Hoʻokomo i ka lipid a me ka protein metabolism.
Akā aia kēia lāʻau lapaʻau i kahi kikoʻī koʻikoʻi: hana wale nō me ka hoʻoponopono makua. ʻO ia, ma ka ʻōlelo ʻana, a me ka lāʻau lapaʻau e komo i loko o ke ake momona o ka subcutaneous, ʻaʻole i loko o ka ʻili, ka ʻili a me nā vein.
Inā ʻaʻole hiki i ka mea maʻi ke lawelawe i ka lāʻau lapaʻau e like me nā kānāwai āpau, pono ʻo ia e ʻimi i ke kōkua mai kahi kahu hānai i kēlā me kēia manawa.
ʻO nā lāʻau Sulfa
Hoʻokomo kēia mau lāʻau antidiabetic i ka hana o nā lāʻau beta i hana ʻia e ka pancreas. Ma waho o lākou, ʻaʻole hiki ke synt synthesis. ʻO nā pōmaikaʻi o sulfonamides ka mea like like lākou me ka ʻole o ke ʻano o ka hoʻokuʻu. Hiki ke lawe ʻia lākou i nā papa.
ʻO ka maʻamau, ua hoʻokomo pū ʻia nā lāʻau sulfa like i ka papa inoa o nā mea maʻi i kā lākou 40 makahiki i ka wā e lawe ʻole ai ka meaʻai i nā hopena i manaʻo ʻia. Akā e hoʻomau wale nō ka lāʻau lapaʻau inā:
- Ma mua o kēia, ʻaʻole i lawelawe ʻia ka insulin i loko o nā koina nui;
- ʻO ka hōʻeha o ka maʻi maʻi maʻi maʻalahi.
Sulfanilamides ua contraindicated i kēlā mau hihia:
- I ka piko maʻi maʻi.
- M mōʻaukala o ka precomatosis.
- ʻO Renal a i ʻole ka hemahema i ka hana ʻoi loa.
- ʻOi ka haʻahaʻa o ka glucose i ke koko.
- Pākuʻi poloka o nāu;
- Ma kahi maʻi maʻi.
ʻO nā hopena hopena paha ka haki i lalo: ʻo ka emi ʻana o ka leukocytes a me nā platelets i loko o ke koko o ka mea maʻi me ka maʻi maʻi, ka hōʻeha ʻana i ka ʻili, ka huinaʻi ʻana o ka ʻōnaehana ʻano ma ke ʻano o ka nausea, ka ʻōpū, a me ka luaʻi.
Ma kahi o 5% o nā maʻi e hōʻemi i ka lāʻau sulirilamide antidiabetic, a i hoʻokahi kekona a i ʻole he ʻeha nā hopena.
ʻO nā derivatives sulfonylurea eʻoi aʻe ka nui e pili ana i ka chlorpropamide a me ka bukarban. ʻOi aku ka maʻalahi o Maninil, predian, gluconorm. I nā poʻe maʻi maʻi, hiki i ka hoʻohana ʻana i kēia mau lāʻau e hoʻomohala i ka maʻi hypoglycemic. Aia ma kahi kohu maʻi maʻi maʻi, i kauoha ʻia i ka lipocaine.
Pono nā lāʻau lapaʻau e pili ana i ka insulin a i ʻole ka hāʻawi ʻana i kāna hana e hoʻohana pono ʻia e like me nā ʻōlelo aʻoaʻo. Mai hana i ka dosage, manawa o ka hoʻokele a me nā kūlana. Pono ʻoe e hoʻomanaʻo mau ma hope o ka lawelawe ʻana o ka insulin, pono kahi kīʻai.
Inā ʻaʻole, hiki ke hoʻoulu ʻia kahi hoʻouka o ka hypoglycemia. ʻO ka ʻōuli kūpono loa o ka hāʻule nui o ka honu koko:
- Ka haʻalulu ma nā pū a me nā wāwae;
- ʻO ka nāwaliwali a me ka lethargy, aiʻole nā wīwī;
- Ka hoʻoikaika koke ʻana o ka pōloli;
- ʻʻAla
- ʻO nā palpitations puʻuwai;
- ʻOno ʻaʻohū.
Inā ʻaʻole paʻa koke ka nui o ke kō, hoʻomoʻeha ka mea maʻi, a nalowale ia i ka ʻike a hāʻule i kahi coma.
ʻO nā lāʻau lapaʻau ʻē aʻe
Hoʻohana pinepine ʻia ʻo Biguanides i ka mālama ʻia ʻana o ka mellitus type type 2. Aia kekahi ʻano ʻelua o kēia ʻano lāʻau lapaʻau:
- ʻO ka hana puʻupuʻu - eia kahi glibudit;
- ʻO ka hana i ka lōʻihi loa, ʻo ia ka mea hoʻokele ma ke ʻano, he retard dioformin.
Loaʻa ka lōʻihi o ka hana o ka biguanides no ka hoʻopiʻi ʻana o nā pā multilayer. Hoʻokahi i loko o ka digestive tract, lōlulu lākou i kēlā me kēia. No laila, hoʻomaka ka māhele ikaika o ka lāʻau lapaʻau i hoʻolaha ʻia wale nō i loko o ka pūpū liʻiliʻi.
Akā e hoʻopunipuni nā kālā me kahi ʻano like ʻole inā e hana ke kino o ka mea maʻi i ka exogenous a i ka endogenous insulin.
Hana ʻia ʻo Biguanides i ka mālama ʻana i ka mellitus type type 2 e hoʻomaikaʻi ana i ka wāwahi a lawe a i ka hoʻoneʻe o ka glucose ma o ka ʻiwi o ka huakaʻi. A he hopena maikaʻi kēia ma ke kūlana o ka mea maʻi. Me ka hoʻohana maʻamau ʻana i kēia mau lāʻau, ua kākau ʻia nā mea penei:
- Hoʻololi ka hōʻaila o ka glucose.
- ʻO ka haʻahaʻa haʻahaʻa o ka glucose i ka pā liʻiliʻi.
- ʻO ka hoʻokūkū o ka lipid metabolism.
- Hoʻemi i ka hana ʻana o nā pūna momona.
Eia kekahi, hiki i nā biguanides ke hōʻoki i ka momona a hoʻemi i ka pōloli. ʻO ia ke kumu i kuhikuhi pinepine ʻia i nā poʻe maʻi nā maʻi. Ua hoʻohālikelike ʻia kēia mau mea i loko o ia mau hihia:
- ʻAno maʻi type 1
- Ke kaumaha koʻikoʻi;
- ʻLelo a me ka lactation;
- Nā maʻi maʻi pāpaʻi;
- Ke ala o kaʻeha a me nā ate;
- ʻO kekahi hana hoʻokō.
I ka endocrinology, ʻo ka hui pū ʻana o nā lāʻau lapaʻau o kēia hui lāʻau me ka sulfanilamides ke ʻano nui i hoʻomaʻamaʻa ʻia no ka mālama ʻana i ka maʻi type 2. Hoʻohana pinepine ʻia nā manawa ma nā hihia kahi e kau pono ai ka hoʻolilo ʻana a me kona mana.
ʻO nā kumumana o nā sulfonylureas a me ka hoʻomākaukau ʻana o ka pūʻulu biguanide nā mea maʻamau maʻamau e hoʻohana ʻia no ka hoʻomau a hoʻomaikaʻi i ke ʻano o ka mea maʻi me ka maʻi diabetes type 2.
Aia kekahi mau lāʻau lapaʻau e kōkua pū ana i ka mālama ʻana i ke kōpaʻa koko a hoʻoponopono iā ia inā pono.
E pili ana kēia:
- Thiazolidinediones - lāʻau lapaʻau o kēia lāʻau lapaʻau ka hopena i ka hoʻopili ʻana o nā lāʻau e loaʻa ana i ka insulin i loko o nā kiko adipose subcutaneous.
- ʻO nā inhibitor Alpha-glucosidase - ke kāohi nei i ka hana o nā enzymes e hoʻoikaika i ka hana o ke kōpau, ma laila e hoʻopiʻi ai i ka pae o glucose i ke koko. ʻO kahi lāʻau ākea kaulana a kaulana kaulana i kēia hui ʻo Glucobay. Akā i ka manawa e lawe ʻia ana, ʻike ʻia nā hopena like e like me ka lemulence, colic, a me ka peʻemani (maʻi).
- ʻO Meglitinides - ʻo kēia mau lāʻau me ka hoʻohaʻahaʻa i nā pae o ke kō, akā hana iki aʻe. Hoʻonohonoho lākou i ka hana o ka pancreas, hoʻomaka ka hormone insulin e hana hou aku me ka ikaika loa, kēlā me kēia ʻike, i ka hoʻemi ʻana o ka glucose i ke koko. Ma loko o ke kīleʻa, ua hōʻike ʻia lākou me Novonorm a me Starlex.
- ʻO nā lāʻau lapaʻau hui like ʻole nā lāʻau o ka hui e hui pū ai i kekahi mau ʻāpana i hana like i nā ʻōlelo like ʻole: e hoʻoulu i ka synthesis o ka insulin, e hoʻonui i ka hiki o nā mea pili i ia mea, a hoʻemi i ka hana o ke aliʻi. Hoʻopili kēia ma o Glucovans, nā mea nui o ka glyburide a me ka metformin.
Ua hana pū ʻia nā lāʻau antidiabetic o ka hana prophylactic i hiki ke pale i ka hoʻokumu ʻana o ka type 2 diabetes mellitus. ʻAʻole ʻike ka poʻe i ka maʻi i ka maʻi, akā, he kuhihewa ʻia lākou, ʻaʻole hiki ke hana me ka ʻole o lākou. ʻO kēia ʻo Metformin, Prekoz. Pono ka hoʻokomo ʻana i nā lāʻau lapaʻau me kahi ʻano kūpono a me nā meaʻai.
Hoʻolālā ʻia nā papa Chlorpropamide i ʻelua kikowaena like ʻole - 0.25 a me 0.1 mg. ʻOi aku ka maikaʻi o kēia lāʻau ma mua o ka butamide, hiki i kāna lōʻihi ke lōʻihi ma mua o 36 mau hola ma hope o ka lawe ʻana i hoʻokahi pākahi. Akā i ka manawa like, he lāʻau nui ka lāʻau a mālama i nā hopena ʻokoʻa, e ʻike ʻia ana e ʻoi aku me ka lāʻau butamide.
Ua kuhikuhi ʻia ia ma ka mālama ʻana i nā ʻano haʻahaʻa a me nā ʻano maʻalahi o ka maʻi mellitus type 2. Aia nā lāʻau lapaʻau o nā hanauna like ʻole - e hoʻoholo kēia i ko lākou kūpono, hiki i nā hopena hopena a me ke kaha hou.
No laila, ʻo nā lāʻau lapaʻau o nā sulfonamides hanauna mua i kipi mau i ka hapaʻumi o kahi grama. ʻO nā lāʻau lapaʻau i nā lua o nā hui like ʻole e lilo i nā mea iʻa, akā ʻoi aku ka ikaika, no ka mea, ʻo kā ko lākou dosie ka mea i loko o nā ʻāpana o ka milligram.
ʻO ka lāʻau nui ka lua o ka gibenclamide. Ke aʻo wale nei i ka hana a ke kino ma ke kino o ka mea maʻi. ʻO nā mea ikaika o ka lāʻau lapaʻau ka hopena hōʻeuʻeu i nā beta beta o nā pancreas, ke lawe koke ʻia nei lākou, a, me he mea laʻa, ʻae ʻia ka maikaʻi, ʻaʻohe hopena ʻaoʻao.
Nā hopena ma hope o ka lawe ʻana iā Gibenclamide:
- Hoʻemi ka wai koko
- Hoʻemi i ka pae o ka cholesterol maikaʻiʻole;
- ʻO ka hoʻokiolo koko ʻana a me ke pale ʻana i nā kahakaha koko.
Maikaʻi kēia lāʻau lapaʻau me ka non-insulin-depend type type 2 diabetes mellitus. ʻO ka lāʻau ke kuhikuhi i hoʻokahi manawa a ʻelua paha ma ka lā ma hope o ka ʻaina.
ʻO Glyclazide (a i ʻole ka maʻi diabetes, ke kuhi) kekahi mea waiwai hou loa e loaʻa ana i ka hopena hypoglycemic a me ka angioprotective. Ke lawe ʻia nei, hoʻomanawanui ka pae o ka glucose i loko o ke koko a hoʻomau nā mea maʻamau no ka manawa lōʻihi, ʻoiai ka palena o ka hoʻokumu ʻana o ka microthrombi. ʻO ka Angiopathy kahi hanana maʻamau i ka maʻi diabetes.
Hoʻopau ʻo Glyclazide i ka hōʻuluʻulu ʻana o nā platelets a me nā ʻāpana koko wīwī, hoʻokau i ka kaʻina kūlohelohe o ka parietal fibrinolysis. Mahalo i kēia mau waiwai o ka lāʻau lapaʻau, hiki iā ʻoe ke pale aku i ka hopena maikaʻi loa loa i ka maʻi diabetes mellitus - ka hoʻomohala ʻana o ka retinopathy. Noi ʻia ʻo Gliclazide i kēlā poʻe maʻi maʻi ʻānō i ka microangiopathies.
ʻO Glycvidone (glurenorm) kahi lāʻau lapaʻau me kahi waiwai kūikawā. ʻAʻole wale ia e hoʻemi wale i ke kōʻai koko, akā ua hoʻopau loa ia i ke kino mai ke kino ma o ka huehue. Ma muli o kēia, hoʻohana ʻia i ka mālama ʻana o nā mea maʻi me ka maʻi type 2 me ka maikaʻi ʻole.
Hiki i nā ʻōkuhi inā hoʻohui ʻoe i kēia mea hana me nā lāʻau lapaʻau mua. No laila, koho pono ʻia kekahi hui ʻana me ka makaʻala.
ʻO Glucobai (acarbose) - ke pale aku nei i ka hoʻopio ʻana o ka glucose i loko o ka ʻōpū a me ke kōkua ʻana e hōʻemi i ke kō koko. Loaʻa i nā papa me kahi dosage o 0,05 a me 0.1 mg. ʻO ka lālia ka hopena o ka pale i ka alpha-glucosidases peʻipiʻi, e hoʻopili aku ai me ka hoʻopili ʻana o nā kalapona a no laila ke pale i nā kōpona mai ka hoʻomoʻi ʻana i nā glucose i nā polysaccharides.
ʻO kahi hoʻohana lōʻihi o ka lāʻau lapaʻau ʻaʻole e hoʻololi i ke kaumaha o ka mea maʻi, he mea waiwai nui ia no nā maʻi maʻi obese. Hoʻonui pinepine ʻia ka nui o ka lāʻau o ka lāʻau: i ka pule mua ʻaʻole ʻoi aku ma mua o 50 mg, hoʻokaʻawale ʻia i ʻekolu mau pona,
A laila e hoʻonui i ka 100 mg i kēlā me kēia lā, a ma hope, inā pono, i 200 mg. Akā i ka manawa like, ʻaʻole pono ka nui o ka nui o kēlā me kēia lā ma kahi o 300 mg.
ʻO ka Andamide ka lāʻau mua loa mai ka sulfonamide pūʻulu, ʻo kona hopena nui ka hoʻowalewale ʻana i nā ʻōhua beta, a, ma muli, ʻo ke kāpili ʻana o ka insulin i ka pancreas. Hoʻomaka ia e hana i ka hapalua hola ma hope o ka hoʻokele ʻana, hoʻokahi i hoʻokahi manawa no 12 mau hola, no laila ua lawa ia e lawe i 1-2 mau lā i kēlā lā. Hoʻopau maʻamau ia me nā hopena ʻole.
