Glibenclamide - nā ʻōlelo aʻoaʻo e pili ana i ka mea pōʻino a me nā mea e pili ana iā ia

ʻO Glibenclamide ka mea kaulana loa a me ka hoʻohana ʻia o ka derogative sulfonylurea me nā waiwai e hoʻohaʻahaʻa i ka waihona. I ka makahiki 2010, ua hāʻawi ʻia ʻo ia ʻo Kreutzfeld Prize hanohano, ka mea i hāʻawi ʻia no ka hoʻokō pharmacological. Hoʻopau piha ka lāʻau lapaʻau i nā koina paʻa i kau ʻia e ke komite koho, ua hōʻoia ʻia kona hopena e nā makahiki he nui o ka noiʻi a me ka hana lapaʻau.

He liʻiliʻi nā lāʻau lapaʻau e hiki ke hoʻohanohano no nā makahiki 20 o ka nānā a me kahi noiʻi piha i nā hopena lohi o kona hoʻohana. ʻO ka uku haʻahaʻa o nā paila he nui ka hoʻemi ʻana i ka uku holoʻokoʻa o ka mālamaʻana i ka maʻi maʻi. E like me nā mea o ka hōʻemi a me ka hana kūpono, ua komo pū ka glibenclamide i ka papa inoa o nā lāʻau kūpono i hoʻohana ʻia no ka maʻi maʻi. Ma waho aʻe o ia, ʻo Metformin wale nō a me ka insulin i hāʻawi ʻia i ka hanohano.

Nā hōʻailona no ka koho

ʻO ke ʻano o ke ʻano maʻi maʻi maʻi maʻi holomua ka mea e pono ai ka mālama ʻana. ʻOiai i nā kūlana o ka mālama glycemic maikaʻi, e hoʻomāhuahua ka nui o nā hana o nā cell beta i ka poʻe maʻi a me ka nui o ka hana ʻana i ka insulin i loko o lākou e emi ai. Me ka hoʻokiʻekiʻe mau ʻana i ka kō, hoʻāla ʻia nā ʻōnaehana luku. Hiki ke ʻike ʻia nā loli mua i ka hana huna i ka manawa maʻi. I kekahi mau mea maʻi, ʻaʻole pili iki lākou i ke kiʻekiʻe o ka kō, a e hoʻopiʻi ai i ka maʻi diabetes, pono wale nō ka mea e pono ai, ka metformin a me ka hoʻonaʻauao kino.

ʻO ka maʻi diabetes, he hiki ʻole i nā cell beta maikaʻi ke hana no lākou iho a no nā kaikunāne make, pono lākou e kau i nā secretagogues. Ke hoʻoikaika nei lākou i ka synthesis o ke kō, e hana ana i nā ʻōna e hana ikaika.

I ka wa e kuhikuhi ʻia ai ka glibenclamide:

ʻO ka maʻi maʻi a me nā hoʻohaʻahaʻa manaʻo e hana ia i ka wā ma mua

• Ka hana maʻamau o ke kō -95%
• Hoʻokuʻuina o ka pua thrombosis - 70%
• Hoʻopau i kahi puʻuwai ikaika -90%
• Hoʻopau i ke kiʻekiʻe o ke koko - 92%
• ʻO ka hoʻonuiʻana i ka ikehu i ka wā, hoʻomaikaʻi i ka hiamoe i ka pō -97%

1. Manaʻo ʻia ka lāʻau lāʻau ʻo ia kekahi o nā keʻena huna ikaika loa, no laila ke hōʻike ʻia nei i nā mea maʻi me ka maʻi maʻi me ka hoʻohaʻahaʻa nui ʻana i kā lākou iho ponoʻī, me ka mea i hōʻike ʻia e ka glycemia kiʻekiʻe loa i ka manawa o ka hōʻike. Me ka mellitus diabetes decompensated, ʻaʻole e piʻi koke ka hoʻomaikaʻi, hoʻoliʻiliʻi ka glucose ma kahi o 2 mau pule. Hoʻomaopopo i ka maʻi maʻi me ka hyperglycemia liʻiliʻi ma hope o ka loaʻa ʻana o ka maʻi maʻi.
2. Hōʻike ʻia ka Glibenclamide no ka hoʻonui ʻana i ka lāʻau e hoʻohui i nā mea hana ʻē aʻe. Ua hōʻike ʻia ʻo ia nō kekahi mau lāʻau haʻahaʻa kolohe o ke kō e kū nei i nā kumu o ka hyperglycemia mai nā ʻaoʻao ʻē aʻe i ʻoi aku ka maikaʻi o hoʻokahi. E hoʻomaʻamaʻa i ka kahe metabolic, hiki ke hoʻohui ʻia i ka glibenclamide me ka insulin a me nā papaʻaila e hoʻohiolo ai i ke kō, koe wale nō ʻo PSM a me ka pālolo.

Ke koho ʻana i ka lāʻau lapaʻau, pono e noʻonoʻo ʻia e hoʻoluhi ana i nā pū me nā beta e hana me ka ikaika nui. Wahi a noiʻi, ʻo ke hoʻoulu ʻana e alakaʻi i kahi hōʻemi iki i ko lākou manawa ola. No ka mea ʻo ka glibenclamide ka ikaika loa o kāna hui, ua ʻōlelo ʻia kēia hopena maikaʻi loa no ia ma mua o ka PSM hou. Inā ʻimi kahi maʻi maʻi e hoʻomau i ka synthesis o ka insulin i ka lōʻihi loa, hiki i ka mālama ʻana me ka glibenclamide e hoopanee a hiki i nā lāʻau nāwaliwali nāwaliwali e pale aku i ka maʻi diabetes.

Pehea ka hana ʻana o ka glibenclamide

Ka hoʻomaopopo maikaʻi ʻana i ke ʻano o ke hana o ka glibenclamide a wehewehe ʻia i ka ʻōlelo kikoʻī i ka ʻōlelo kuhikuhi no ka lāʻau. Hāʻawi ka pahū i nā kahawai KATF aia ma ka membrane o nā hua beta, e alakaʻi ana i ka pau ʻana o ka pāhana i loko o nā kōpona, nāwaliwali i ka polarization o ke membrane a me ka komo ʻana o nā papa calcium. Ke hoʻonui nei i ka hoʻolōʻihi o ka calcium ma ka ʻōpū e hoʻoikaika i ke kaʻina o ka hoʻokuʻu i ka insulin mai ia i loko o ka wai o intercellular, a laila i loko o ke koko. Hoʻemi ʻia ka kulu maʻi ma muli o ka hiki i ka insulin ke halihali iā ia mai nā pili koko i nā kiko. ʻO Glibenclamide ka ʻoi aku ka ikaika ma mua o nā mea ʻē aʻe PSM e hoʻopili ai i nā ʻĀpana beta-cell, no laila ʻoi aku ka hopena o ka haʻalulu maikaʻi.

Ua hoʻonui ʻia ka ikaika o ka lāʻau lapaʻau me ka hoʻonui ʻana i ka nui. ʻAʻole i hilinaʻi ʻia ka hopena o ka glibenclamide me ka glycemia, hana ka lāʻau lapaʻau me ka nui o ka glucose a me ka hemahema, no laila e lawe ʻia, pono ʻoe e makaʻala a nānā ʻia ke kōpaʻa inā loaʻa kekahi mau hōʻailona e like me ka hypoglycemic e kū mai.

Ma waho aʻe o ka hypoglycemic nui, kahi hopena peripheral hou kekahi hiʻohiʻona o ka PSM āpau. Wahi a nā ʻōlelo kuhikuhi, hoʻoliʻiliʻi ka glibenclamide i ka pale ʻana o ka insulin i nā ʻamela kinipona a me ka momona, ua hāʻawi ʻia i ka emi ʻana o ka glucose.

Ua hoʻokaʻawale ʻē ʻia nā hopena cardivascular o ka lāʻau. Ka mea i hiki i ka glibenclamide ke pani i nā kano KATF ʻaʻole wale i nā cell beta, akā pū kekahi pū kekahi o nā naʻau - cardiomyocytes. ʻO ke ʻano kuʻuna, hiki ke hoʻopilikia i nā hopena o ka hōʻeha ʻana o ka puʻuwai ma nā maʻi maʻi. Ma nā hoʻokolohua hoʻokolohua, ʻaʻole hōʻoia ʻia kēia hopena. Eia kekahi, loaʻa kahi hopena antiarrhythmic i loaʻa i ka glibenclamide, e hōʻemi ana i ka make ma ka hopena o ke ischemia. Wahi a nā kauka, he nui ka poʻe i hopohopo e hoʻonohonoho i ka lāʻau Glibenclamide no kekahi maʻi maʻi i hōʻeha ʻia, ʻoiai ka ʻike noiʻi.

Hoʻomoe ʻo Glibenclamide

Kahi ka poʻe maʻi maʻamau me ka glibenclamide e ka lāʻau Maninil, ka mea i hana ʻia ma Kelemona e Berlin-Chemie. He kūlohelohe kēia lāʻau lapaʻau, me kona komo ʻana he nui o nā haʻawina i hana ʻia i hoʻopaʻa pono ʻia a me ka palekana o glibenclamide. ʻO Maninil he 3 papa koho. I loko o nā papa 1.75 a me 3.5 mg, ʻo ka hana ikaika ka mea i kahi micronized kūikawā, hiki iā ia ke hōʻemi i ka glycemia me kahi haʻahaʻa o ka lā lapaʻau. 5 mg maninyl ka loko glibenclamide maʻamau.

Nā ʻaloglelo i Rusia ma:

• ʻO Statiglin mai Farmasintez-Tyumen a me Glibenclamide mai ka hui ʻo Ozon (reg. ʻO ka palapala inoa ʻo Atoll LLC). ʻO kēia mau lāʻau lapaʻau ke ʻano like o nā mea like ʻole, akā ʻaʻole i haʻi ʻia nā mea hana i ka noho ʻana o ka glibenclamide micronized i kekahi o nā koho.
• ʻO nā papa Glibenclamide i hana ʻia e Moskhimpharmpreparaty, Pharmstandard-Leksredstva, Biosynthesis, Valenta Pharmaceutical i hoʻokahi dosage o 5 mg. Hiki iā lākou ke hoʻokaʻawale e loaʻa i ka hapa hapalua o 2.5 mg.

He mea pono ia e nānā wale nei lākou o nā analogues maʻi maoli, ʻoiai no ke kūʻai ʻana nā ʻoihana i ka glibenclamide ma waho o ka hapa, ma India. ʻO ka wehe wale nō ʻo Statiglin, ua kākau ʻia ma 2017. ʻO Glibenclamide no ia mea ma Rusia i ka hui BratskKhimSintez.

Hoʻopili ʻia nā ʻōkuhi Maninil āpau no ka bioequivalence a loaʻa kahi like. Hoʻomaopopo nā loiloi maʻi maʻi i kēia mau lāʻau like ʻana, akā ke makemake mau nei ka poʻe maʻi maʻi e kūʻai i ka lāʻau mua, ma muli o kona kaulana nui a ma ke kumukūʻai haʻahaʻa.

Ma ka loiloi ʻana i nā loiloi, ʻike pinepine ʻia ka hui pū ʻana o ka glibenclamide a me ke metformin. ʻO nā mea ʻelua e lilo i nā ʻāpana ʻelua o nā lāʻau Glucovans, Glimecomb, Gluconorm. ʻO Metglib, Glibomet a me nā mea ʻē aʻe.

Nā ʻōkuhi no ka hoʻohana

Aʻo ke aʻo ʻana no ka hoʻohana ʻana e hoʻoholo i ka pono o ka glibenclamide pakahi no kēlā me kēia maʻi.

1. ʻAʻole heʻoi aku ka hopena hoʻomaka ma mua o 2.5 mg, me ka hyperglycemia koʻikoʻi - 5 mg. Hāʻawi ʻia e hoʻomaka i ka mālama ʻana me ka glibenclamide wale nō inā hiki i ka mālama glycemic pinepine a hiki wale nō ke kuhikuhi ʻia a ma lalo o ka mākaʻi o kekahi kauka. ʻAʻole pono mākou e poina e hiki i ka lāʻau lapaʻau ke hōʻeha i ka hypoglycemia, me ka paʻakikī. ʻO ka lāʻau lapaʻau i loko o kahi liʻiliʻi liʻiliʻi i inu i hoʻokahi lā, 20 mau minuke ma mua o ka ʻaina kakahiaka. Lawe ʻia ka glibenclamide Micronized ma mua o ka ʻai.
2. Inā ʻaʻole i hoʻi mai ka hoʻokaʻa o ke kō i ka maʻamau i loko o ka hebedoma, e hoʻonui mālie ka dosage, e hoʻonui ana i ka 1.75-2.5 mg hoʻokahi i ka pule. I kahi kōpake a hiki i ka 10 mg, ua inu ka glibenclamide i ke kakahiaka. Inā makemake ʻia kahi nui nui e uku i ka maʻi diabetes, ua ʻawaʻawa ka lāʻau ma mua o ka ʻaina kakahiaka a ma mua o ka ʻaina. ʻO ka lawe ʻana i ka glibenclamide ma mua o ka wā hiamoe e pāpā ʻia e nā ʻōkuhi, no ka mea hiki iā ia ke alakaʻi i ka hypoglycemia nocturnal.
3. ʻO ka nui maʻa loa he 3 papa o 5 mg. ʻElua ʻelua o lākou e inu i ke kakahiaka, hoʻokahi ma mua o ka ʻaina.

Nā hopena hopena

He haʻahaʻa loa ka lōʻihi o nā hopena ʻokoʻa ma ka hopena me Glibenclamide. Me nā kūpono kūpono a me ka hoʻokō pono ʻana i nā kauoha no ka hoʻohana ʻana, a ua loaʻa nā hopena hopena i ka mea e pili ana i ka 1% o nā maʻi maʻi, e hōʻike ana i kahi palekana kiʻekiʻe o ka lāʻau.

ʻO ka hypoglycemia a me ke kaupaona hopena he hopena ia o ka pōʻino a me kahi overdose o glibenclamide. Wahi a nā maʻi maʻi maʻi, inā e hoʻopiʻi ʻoe i kāu papaʻai, helu i ka nui o nā mea kākena i kēlā me kēia papaʻai, mai hakipoka i nā meaʻai, hoʻonohonoho i nā mea ʻai i ka wā e hoʻolōʻihi ʻia ana, hiki ke hoʻemi ʻia ka hopena o kēia mau ʻaoʻao.

ʻO ka hoʻokipa ʻia e hoʻohālikelike ʻia

Ke hōʻike nei ke aʻo i ka pāpā i ka lawe ʻana i nā papa Glibenclamide i nā hana aʻe:

• ina he launaa a o kana mau mea i noi ai mamua;
• inā nele kahi maʻi maʻi i nā pū poli beta (type type diabetes type 1, pancreatic resection);
• ma kahi kūlana o ka decompensation maʻa o ka maʻi mellitus me ka ketoacidosis a i nā kūlana kiʻekiʻe loa o ka decompensation ma muli o nā hōʻeha koʻikoʻi a me nā maʻi;
• me nā pilikia nui a me ka maʻi hepatic;
• ma ka hihia o ka intolerance lactose, aia i loko o ka lāʻau lapaʻau me kahi mea kōkua;
• i ka wā hāpai, lactation;
• i nā keiki maʻi maʻi.

Me ka mālama akahele loa, pono e hoʻokō i ka mālama ʻana i nā maʻi hormonal, mea inu wai, hoʻoweliweli ʻana i nā maʻi o ka wā kahiko, ma ke ʻano kiʻekiʻe.

Ke keu

Kū pinepine ka overdose i ka hypoglycemia. I ka hana mua, hiki ke hoʻopau ʻia e ka hoʻokele waha hou i ka maʻi glucose. Inā hōʻeha ka hypoglycemia, ʻōlelo ke aʻo ʻana i ka hoʻokele subcutaneous o glucagon. I ka manawa like, pono ka maʻi diabetes i ka mālama koke ʻana i nā maʻi maʻi. Me ka overdose koʻikoʻi o ka lālani Glibenclamide, hoʻohaʻawili pinepine ka meli i ka lā, no laila ke kuhi ʻia ka mea maʻi me ka hopena o ka glucose intravenously a nānā i kona kūlana.

Nā mea hoʻohālikelike o Glibenclamide a me nā hili

ʻO nā mea e pili kokoke ana i ka glibenclamide aia nā mea ʻē aʻe o ka sulfonylureas. I kēia manawa, hoʻohana nui ka glyclazide, glimepiride, ʻaʻohe liʻiliʻi o ka glycidone.

ʻO nā papa inoa glibenclamide kūpono loa:

ʻO nā Gliptins, ka mea e hoʻoulu ai i ka synthesis o ka insulin, ʻoi aku nā mea kūʻai loea glibenclamide momona. ʻO Glyptins kahi mahele o Januvii, Ongliza, Xelevia, Galvus, Trazhenty, ma kā lākou mālama lāʻau ma ka palena o 1,500 rubles. kēlā me kēia mahina. ʻAʻole hiki i kēia mau lāʻau ke kumu i ka hypoglycemia, ʻaʻole i hāʻawi i ka luku ʻana i nā pū beta, akā ʻaʻole e hōʻemi i ka hilo me ka wikiwiki e like me ka glibenclamide. Wahi a nā loiloi, hāʻawi nā glyptins i nā hopena maikaʻi loa me ka hoʻomaka ʻole o ka glycemia kiʻekiʻe.

He kumukūʻai ma nā lāʻau lapaʻau

ʻO Maninil e loaʻa ana i ka glibenclamide micronized ke kumukūʻai 130-160 rubles. puia me ke papa papa he 120. ʻO Maninil 5 mg ka mea maʻalahi loa, ʻo ke kumukūʻai o kahi pahu e pili ana i ka 120 rubles. ʻO ke kumu o nā anianiʻenehana kūloko he haʻahaʻa loa: mai 26 mau rubles. no na papa he 50 a elima paha rubles. no 120 papa. No laila, ʻo ke kiʻekiʻe nui o ke ʻano, ʻaʻole ke kiʻekiʻe o ke ʻano o ka mālama ʻana i ka 100 mau rubles. kēlā me kēia mahina.

Hiki ke loaʻa ka lāʻau Glibenclamide i ka manuahi ma kekahi wahi o Rūsia, inā he maʻi mellitus ka mea maʻi, a hoʻopaʻa inoa ʻia me kahi endocrinologist.

Nā Hōʻike Kokua