ʻO ka diabetes-mellitus non-kaʻai maʻamau ka mea maʻamau o ka maʻi (90-95% o nā maʻi āpau āpau. ʻO ka hoʻokele maikaʻi ʻana o kahi maʻi maʻi e koi wale nō i ka loli ʻana o ke ola, akā, ʻo ka mālama ʻana i nā lāʻau lapaʻau maʻamau. Kuhi pū ʻia nā sulfonylurea (SM) i loko o ka papa inoa o nā lāʻau lapaʻau nui loa no ka maʻi maʻi, ʻo ia kekahi o nā koho lapaʻau kaulana loa no kēlā me kēia algorithm.
Loaʻa i ka hana kiʻekiʻe me ka hoʻohaʻahaʻa maikaʻi a me ka hoʻokele waiwai i hiki i ka lōʻihi ke hoʻohana i nā derivatives o SM ma ke ʻano nui o nā lawelawe hypoglycemic waha, e mālama ana iā lākou i ka regimens therapy a i ka wā e hoʻololi i ka insulin.
Pono ka maʻalahi o ka lāʻau antidiabetic maikaʻi loa e hoʻokele, me ka liʻiliʻi o ka hopena o nā ʻaoʻao (a ʻaʻole wale nō ka hypoglycemia), ka uku, kūpono kūpono a palekana ʻole. E kau i kēia mau koi ʻO Gliclazide (ma ka Latin Gliclazide) kahi lāʻau lapaʻau mua o ka papa CM.
Pharmacology Glycaside
ʻO Gliclazide, kahi kiʻi e hiki ke ʻike ʻia ma kēia ʻāpana, kahi lāʻau lapaʻau e hōʻike ana i nā papa o nā derivatives o SM o ka hanauna 2.
ʻO ka mea nui (akā ʻaʻole wale ia) ka hopena o ka lāʻau lapaʻau ka hypoglycemic: e hoʻonui ana i ka hana o ka insulin endogenous e nā b-cell o ka pancreas. Ma ka hoʻouluʻana i ka glycogen synthase, hoʻomaikaʻi ka gliclazide i ka hoʻohana ʻana i ka glucose o ka musio. Hoʻomaʻi hou ka lāʻau i nā ʻāpana glycemic wikiwiki, me ka metabolic latent diabetes.
Mai ka loaʻa ʻana o ka meaʻai i loko o ke kaomi ʻike a hiki i ka manawa o ka hana ʻana i ka insulin me nā papa, ʻoi aku ka nui o ka manawa ma mua o ka ʻole o lākou. ʻO Hyperglycemia, i hoʻonāukiuki ʻia e ka ʻai ʻana o nā kalapona, me ka maikaʻi loa o ka gliclazide.
ʻO ka Pharmacokinetics o ka lāʻau
Mai ka hāwele ʻana, e hoʻomoʻi koke ʻia ka lāʻau a piha. Loaʻa ka pae kiʻekiʻe i ka awelika mai 2 a 6 mau hola, a no nā papa me kahi hopena lōʻihi - mai ka 6 a hiki i 12 mau hola. ʻO ka lōʻihi o ka hoʻolahaʻana he lā maʻamau. Me nā protein koko, pili ka lāʻau lapaʻau me ka 85-99%. ʻO ka lāʻau lapaʻau ka biotransformed i loko o ka ate, ka hana ʻana i nā metabolites, kahi maikaʻi e hoʻopilikia ai i ka microcirculation.
Hoʻomoe ka hapa hoʻopau hapa-ola i waena o nā hola 8-12. Ma ka Gliclazide MV - 12-16 mau hola. I ka manawa like, ua hoʻopau ʻia ka 65% o ka lāʻau ma ke ʻano o nā metabolites i loko o ka pāʻai, 12% ma waena o nā ʻōpū.
I ka wā i kauoha ʻia ai ke lāʻau lapaʻau?
Hoʻolālā ʻia ka lāʻau lapaʻau no ka mālama glycemic o ka maʻi type 2, ma ke ʻano he monotherapy a no ka hui pū ʻana me nā lāʻau lapaʻau antidiabetic waha a i ʻole ka hoʻomākaukau ʻana i ka insulin.
Hoʻomaopopo nā ʻōlelo aʻoaʻo Gliclazide no ka hoʻohana ʻana i ka hoʻohana ʻana i ʻāpana o nā mea paʻakikī no ka mālama ʻana i nā pilikia o ka microcirculation. No ke kumu o ka pale ʻana, kauoha ʻia kekahi lāʻau lapaʻau e pale i ka hoʻokumu ʻana i nā hoʻopiʻi mai ka maʻi maʻi - retinopathy, neuropathy, nephropathy, nā hōʻeha a me ka puʻuwai.
Nā Contraindications no Gliclazide
ʻO ka papa inoa o nā contraindications e pili ana i ka Glyclazide wale nō, akā no kēlā me kēia hui āpau (me kahi mea maʻamau maʻamau).
I waena o nā pāpā ʻole:
- ʻAno maʻi type 1;
- Ketoacidosis (puka diabetes);
- ʻO ka maʻi hypersmolar a i ʻole comic coma;
- Hoʻopili i nā ʻano o nā hiʻohiʻona;
- Nā ʻōwili a me nā renal;
- Hōʻeha koʻikoʻi;
- Leukopenia;
- Hyper- a me hypothyroidism;
- ʻO ke kālai;
- Paresis o ka ʻōpū;
- ʻO nā maʻi lēʻahele me ka loaʻa ʻole o nā mea kanu kūpono ʻole.
Wāwī palapala noi
ʻO ke kaupalena wale nō o ka wā o nā keiki, no ka mea, ʻaʻole i hoʻokū ʻia ka palekana a me ka hopena o kēia pūʻulu o nā maʻi.
I kekahi mau pilikia pathological (hana hoʻolālā, ka noiʻi radiopaque), koi ʻia kahi hoʻololi manawa ʻole i ka insulin (maʻamau ʻo 48 mau hola ma mua a he 48 mau hola ma hope o ke kaʻina hana).
ʻO ka maʻi lapaʻau me ka lāʻau lapaʻau e contraindicated i ka wā hapai, a inā i mālama ʻia ka hana i ka wā lactation, e hoʻoneʻe ʻia ke keiki i ka meaʻai maoli.
Nā hopena hopena
ʻO kēia manawa, ua hōʻike ʻia nā laha ma ʻEulopa a me USA e pili ana i ka pilina i waena o ka hoʻomohala ʻana i nā kumuwaiwai o SM me ka hoʻomākaukau ʻana o ka insulin a me ka nui o ka maʻi pancreitis a me ka maʻi pancreatic cancer. ʻO ka ʻike ʻole ʻia, ʻoiai ʻo ka gliclazide ka lāʻau kumu maoli, ua he ia i ke ʻano palekana.
Aia kahi papa inoa piha o nā hopena i hala ʻole ʻia i ka papaʻaina.
| ʻO ka ʻaoʻao kahi ka hopena | Nā koho no nā hopena kūpono kūpono |
| ʻŌpala Gastrointestinal | nā maʻi dyspeptic i ke ʻano o ka maʻi pā, ka luaʻi ʻana, ka ʻeha o ka ʻōpū |
| Hāpai | nā kūlana hypoglycemic |
| ʻŌnaehana ʻōnaehana | eosinophilia, cytopenia, anemia |
| ʻIli | Allergy, photosensitivity |
| Nā hui ʻōpū | ka hoʻololi ʻana, ʻae ʻole o ka hui ʻana, nā ʻeha, ka uhai |
I ka ʻike ʻana i ka pōʻino o nā kūlana hypoglycemic, mai kuhikuhi i Gliclazide no nā maʻi maʻi pākeke a me ka nele o ka pōʻaiʻai a me ka nele o ke kākoʻo pilikino, ʻoi aku me nā cardiac a me nā māka.
Nā Hoʻohui Kūʻai
Hiki i ka Gliclazide ke hoʻonui i ka inhibitor ACE, nā steroid anabolic, β-blockers, fluoxidine, cimetidine, salicylates, miconazole, MAO inhibitors, fluconazole, theophylline, pentoxifylline, tetracyclines.
Ua nāwaliwali ka hopena o ka glycoside me ka hoʻohana ʻana i ka barbiturates, glucocorticoids, sympathomimetics, saluretics, contraceptives waha, Rifampicin, estrogens.
Pehea e hoʻopili ai
Lawe ʻia ka Glycloside me ka meaʻai. Ua luku ʻia ka papa papaʻa ʻole, me kaʻole ʻole, holoi ʻia i ka wai. E koho ke kauka i nā ʻōpiopio hoʻokahi, me ka mālama i ke ʻano o ka maʻi a me ka hopena o ka maʻi maʻi i ka lāʻau lapaʻau. ʻO ka maʻamau hoʻomaka ʻaʻole eʻoi aku ma mua o 80 mg, inā ʻaʻole pono ka nui, e hoʻonui ikaika ka ʻaha.
Hoʻohui ka hana maʻamau i kēlā me kēia lā mai 30 mg a 120 mg, e noʻonoʻo ana i ke ana o ka maʻi diabetes a me nā palena o nā makahiki. I kekahi mau kūlana, hiki i ka 320 mg ke kuhikuhi.
Inā makemakeia ka manawa hoʻokipa, ʻaʻole hiki iā ʻoe ke pāpālua i ka helu. Pono ka lāʻau e lawe i ka manawa mua.
ʻO ka hoʻohana ʻana i nā hui paʻa, ʻaʻole hiki ke loaʻa wale me ka metformin, ka mea i hoʻohana nui ʻia i ka lehulehu o nā ʻelele o SM, akā pū kekahi me nā paʻakikī paʻakikī.
ʻO ka ʻaina kakahiaka, kahi mea e hopu ai i ka lāʻau lapaʻau, pono e nānā pono, me ka liʻiliʻi o ka haʻahaʻa o nā powa. ʻO ka pōloli i ka lā, ʻoi aku me ka hoʻoulu ʻia o ke kino, hiki ke hoʻowai i ka hypoglycemia. Hiki ke ʻano like paha ma hope o ka inu ʻona.
ʻO ka maʻi maʻamau i ka wā ʻelemakule e pili pono ana iā Glyclazide, no ka mea he nui aʻe lākou e hoʻomohala i ka glycemia. ʻO nā lāʻau pōkole pōkole e like me ke Glyclazide maʻamau e kūpono no kēia ʻāpana o nā maʻi.
Hoʻohana like nā papa i hoʻololi ʻia i nā lā a pau o ke ao, ʻoi aku, hoʻokahi ka hana o kēlā lāʻau lapaʻau. ʻO ka hapa o Gliclazide MV ka hapalua o ka loli maʻamau. Loaʻa ia ka lāʻau no 3-5 mau makahiki, a laila e piʻi aʻe ka hopena o ke kūpaʻa - he ʻāpana hapa a hoʻopau paha i kona kū pono. I kēlā mau kūlana, e hoʻololi ka endocrinologist i ka regimen lapaʻau.
ʻO ka lāʻau lapaʻau mua, e like me kona mau generics, he kūpono wale nō i ka hoʻololi ʻana i ke ola - haʻahaʻa haʻahaʻa ka nui o ka haʻalulu haʻahaʻa, lawa a me ka hoʻoikaika kino maʻamau, ka mālama ʻana i ke kūlana ʻona, a nānā i ka hiamoe a me ka hoʻomaha ʻana.
ʻO ka mea nui ka mālama ʻana i ka glycemia i ka lā me ka hoʻopaʻa ʻana i nā hualoaʻa i ka diary o kahi maʻi maʻi. Ma hope o ke kaumaha koʻikoʻi, ka hana ʻana o ke kino, pōʻino a loaʻa ka nui o ka titration. ʻO ka nānā ʻana i kou kūlana a me ka launa mau ʻana me kāu kauka e kōkua i ka hōʻalo ʻana i nā hopena koʻikoʻi.
Nā hana kūpono
No ka paleʻana i ka hoʻoulu ʻana o ka hypoglycemic, he mea nui ia i ka kakahiaka kakahiaka ma hope o kahi paila, pale i ka pōʻai i ka lā, a ke kāpae i ka waiʻona mai ka meaʻai. Hiki i ka hoʻohālike like o nā b-blockers ke uhi i nā hōʻailona hypoglycemic. He mea nui ia no nā maʻi maʻi maʻi e hahai i nā meaʻai liʻiliʻi.
E kōkua i ka mea ʻai i ka make overdose
Inā loaʻa i ke ala ʻae ʻia kahi i ʻoki ʻia, ʻike ʻia nā hōʻailona o ka overdose.
- Nā kūlana o kaʻeha;
- Hoʻonui i ke koko;
- Ulo;
- ʻAukaha, huhū;
- Nā hōʻike hoʻohanohano;
- Hoʻopilikia ke nānā aku i ke kino;
- Na hemahema o ka hana olelo;
- Cramping;
- Pūlā hou.
Inā ua loaʻa kahi glycemia i kahi ʻano koʻikoʻi a ʻaʻohe ka ka mea i hōʻino i kona kūlana, pono ʻo ia i ka hoʻokipa ʻoʻiʻi nui. No ka hoʻopau i ka hoʻouka ʻana i nā hola mua, pono ke kuhi i ka 50 mg o ka glucose (30% r) i loko o ka uaua a me ka hana hoʻoiho - dextrose (10% r) i loko o ka uaua. He mea nui ia i nā lā mua e kiaʻi pinepine i ka glycemia. ʻO nā Dialysis me kahi overdose o gliclazide ka maikaʻi ʻole.
Hoʻolālā kikowaena a me nā ʻano
Ma nā hua ʻōlelo o ka prevalence, ʻo ka mākaukau o SM ka lua wale nō i Metformin. ʻO kekahi o nā pono pono o kahi lāʻau lapaʻau ke loaʻa nei: no Gliclazide, ke kumukūʻai i loko o ka paʻa lāʻau lāʻau ʻaʻole iʻoi aku ma mua o 160 rubles. no 30 pcs. ^ E Ha yM. I loko o ka pūnaewele kūʻai lapaʻau, hāʻawi ʻia ka lāʻau lapaʻau ma lalo o nā inoa kālepa kūʻokoʻa: Glyclazide-Akos, Glyclazide Canon, Glidiab-MV. Hoʻomaʻamaʻa ʻia ka lāʻau lapaʻau i nā ʻano like like, aia kahi koho me kahi hoʻokuʻu i hoʻololi ʻia o ka māhele kumu.
Aia nā papa i kahi momona cream a me kahi liʻiliʻi iki. Aia i loko o nā papa o nā papa konumona he 10, 20 a 30 mau mau kamepiula. ʻO nā pōpō. Hoʻopili ʻia nā pani i nā pahu o 10, 20, 30, 60 a me nā papa he 100.
Aia i kēlā me kēia papa pākuʻikuʻi i ka gliclazide o ka hana, i hoʻohui ʻia me ka cellulose, hypromellose, colloidal silicon dioxide, magnesium stearate.
ʻO ka ʻano like me ka hopena lōʻihi o Glycaside MV i kūʻai pū ʻia i nā pahu like 15 a 30 mau papa i loko o kahi pahu a pahu paha.
ʻO kahi manaʻo nui o kēia papa o nā lāʻau lapaʻau ka mea hiki ke hoʻomohala i ka pale ʻana: e like me nā helu helu, 5% o nā maʻi maʻi e lawe nei i nā derivatives o SM no ka manawa lōʻihi e hoʻololi i ka insulin i ka wā.
ʻO Glyclazide Generic
ʻO Gliclazide - ka lāʻau lapaʻau mua, nā lāʻau āpau a pau me ka waiwai like ʻole a i ʻole ka hopena kākahi lāʻau, analogues. Loaʻa iā Glidiab ke kumukūʻai maikaʻi loa a me ka maikaʻi ma waena o nā analogue Gliclazide e kumukūʻai ana iā 111-137 rubles. Hāʻawi ʻia ka mahalo nui i nā kauka e nā lāʻau lapaʻau Diabeton a me Diabeton MV. ʻO ke kumukūʻai o nā lāʻau lapaʻau mai 250 a 320 mau rubles.
I waena o nā lāʻau lapaʻau e kū pono ana i ka pae helu 4 ATX, 4 ka mea i kaulana loa:
- Kūkulu;
- Glimepiride;
- Amix;
- Glibenclamide;
- Amaryl;
- Maninil.
Inā ma hope o ke kahakaha ʻana iā Glyclazide hou, ʻike ʻia ka nānā ʻole, hōʻike i ka ʻeha ʻole i kāu kauka. Malia paha, ma hope o kahi loiloi hou, e hoʻēmi ai ia i ka ʻohiʻī a koho paha i ke aniani kūpono. ʻO ka hoʻokūkū pū me nā Generics oe pono i kou olakino.
ʻO Gliclazide - nā loiloi o ka maʻi maʻi a me nā kauka
ʻO ka maʻi hypoglycemic hou o ka maʻi maʻamau ʻo 2 ke hoʻohālikelike ʻia, "ʻili ʻia" i nā hemahema o ke kanaka maʻi, pono ia e nānā i kona makahiki a me nā hiʻohiʻona maʻi e hōʻemi ai i ka maʻi maʻamau, e hoʻololi i ka hopena maikaʻi loa o ka maʻi a hoʻonui i ke ola o kahi maʻi maʻi.
ʻOiaʻiʻo, ʻaʻole kūpono ia ʻo Glyclazide no nā kānaka a pau, a me nā mea hou e hoʻohaʻahaʻa i ke kō, eia naʻe hiki ke hōʻoia ʻia e kūpaʻa ana ka lāʻau a me nā ʻiliʻaneʻane me nā kūlana o kēia mau makahiki i kēia manawa, e kū pono a hoʻomau i ke kōkua ʻana i ka maʻi maʻi maʻi e hoʻokele pono i ka maʻi ʻona.
E pili ana i ka mālama ʻana i ka maʻi lapaʻau o ka ʻikepili 2-goth type i ka wikiō
