ʻO nā papa ʻona Yanumet no ka maʻi maʻi 2

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ʻO nā papa Yanumet no ka hoʻohana e pili ana i nā lāʻau hypoglycemic i hoʻohana ʻia no ka hoʻopiʻi ʻana i ka maʻi diabetes 2. Hoʻonui ʻia kāna kūlana e ke ʻano kū hoʻokahi o ka huahana. ʻO wai ka mea kūpono no a pehea pehea e hoʻohana pololei ai?

ʻO ka maʻamau ka hoʻohālikelike ʻia inā he loli modification a me ka hoʻopiʻi mua ʻana o ka metformin monotherapy a i ʻole ka hoʻōla paʻakikī ʻana i lawe mai i nā hopena i manaʻo ʻia. Ma kekahi manawa e kuhikuhi ʻia i nā poʻe e pili ana i ka haʻuki no ka mālama ʻana i kā lākou kiʻi glycemic. Ma kahi o kahi familiarization kikoʻī me nā ʻōkuhi, ma mua o ka hoʻohana ʻana i kēlā me kēia kūlana, he kauoha ke kauka.

Yanumet: hoʻonohonoho a me nā hiʻohiʻona

ʻO ke kumu hana ikaika i loko o ka pulu ʻo metformin hydrochloride. Hoʻopili ʻia ka lāʻau lapaʻau i ka 500 mg, 850 mg a i ʻole 1000 mg i 1 papa. Hoʻokomoʻo Sitagliptin i ka mea kanu kūpono, i loko o hoʻokahi pahu e hoʻonui ai iā 50 mg i kekahi mauʻu o ka metformin. Loaʻa nā mea hoʻonani ma ka hopena no ka mea ʻaʻole hoihoi i ka hua o nā lāʻau lapaʻau.

ʻO ka pale mau convex elongated e mālama ʻia mai i nā fakes me ka palapala "575", "515" a i ʻole "577", i ke ʻano o ka dosage. Aia i kēlā me kēia pahu pahu pepa ʻelua a ʻehā paha o nā ʻāpana 14. Hoʻolaha ka lāʻau lapaʻau.

Hōʻike ka pahu i kahi ola o ke ola o ka lāʻau lapaʻau - 2 mau makahiki. Pono e hoʻokaʻawale ʻia nā lāʻau lapaʻau. He pono nā koi no nā kūlana mālama: he wahi maloʻo ʻole ʻia i ka lā a me nā keiki me kahi keʻena wela a hiki i 25 degere.

ʻO Metformin kahi papa o nā biagudins, sitagliptin - dipeptidyl peptidase-4 (DPP-4) inhibitors. ʻO ka hui pū ʻana o ʻelua mau mea ikaika me nā hiʻohiʻona ʻē aʻe e hiki iā ʻoe ke hoʻomohala maikaʻi i ka hypoglycemia ma ka maʻi maʻi me nā maʻi type 2.

Hiki i nā pono Pharmacological

ʻO Yanumet kahi manaʻo noʻonoʻo o nā wai ʻelua hoʻohiolo i ke kō me ka hoʻohui i kekahi (i hoʻohui ʻia kekahi i kekahi) nā ʻano: metformin hydrochloride, kahi hui o biguanides, a me sitagliptin, he mea hoʻohui o DPP-4.

Synagliptin

Mālama ʻia ka ʻenehana no ka hoʻohana waha. Hoʻokumu ʻia ka hana o ka hana o sitagliptin i ka hoʻoulu ʻana o incretins. Ke hoʻokaʻawale ʻia ka DPP-4, ke piʻi aʻe o ka pae o GLP-1 a me Hept peptides, nāna e hoʻoponopono i ka homeostasis glucose. Inā he hana maʻamau kāna hana, hoʻoulu ʻia e ka incretins i ka hana ʻana o ka insulin e hoʻohana ana β-cell. Hoʻopaʻa ka GLP-1 i ka hana ʻana o glucagon e nā pona-α i loko o ka ate. ʻAʻole like kēia algorithm i ke kumu o ka hoʻolaha ʻia ʻana i nā lāʻau lapaʻau kō o ka sulfonylurea (SM) e hoʻonui ai i ka hana o ka insulin i kekahi pae glucose.

Hiki i kēlā ʻano hana ke kumu i ka hypoglycemia ʻaʻole wale i nā maʻi maʻi maʻi, akā i nā mea hoʻohiki olakino.

ʻO ka inhibitor enzim DPP-4 i loko o nā papa i ʻōlelo ʻia ʻaʻole ia e pale i nā hana o ka PPP-8 a i ʻole PPP-9 i nā enzyme. I loko o ka lāʻau lapaʻau, ʻaʻole like ka sitagliptin i kāna kūlike: GLP-1, insulin, SM derivatives, meglitinide, biguanides, α-glycosidase inhibitors, γ-receptor agonists, amylin.

Metformin

Mahalo i metformin, hoʻemi i ke kōkō ma ke ʻano maʻi maʻi type 2: ke hoʻemi nei ko lākou koʻikoʻi (a i ʻole ka postprandial a me basal), a laila e emi ana ka pale ʻana i ka insulin. He ʻokoʻa nā ka algorithm o ka hopena o ka lāʻau lapaʻau ma nā loiloi o ka hana o nā lāʻau lapaʻau haʻahaʻa e hoʻohiolo ana. Ke hōʻike nei i ka hana o ka glucogen e ka ate, hoʻohaʻahaʻa ka metformin i ka hoʻopili ʻana e nā paia o ka ʻōpū, hoʻemi i ka kū i ka insulin, hoʻomaikaʻi i ka upipake peripheral.

ʻAʻole like me nā lāleka SM, ʻaʻole hoʻonā ka metformin i ka hōʻeha ʻana i ka hyperinsulinemia a me hypoglycemia ʻaʻole hoʻi i ka maʻi maʻi me ka maʻi ʻehā, ʻaʻole hoʻi ma ka hui pū. I ka wā o ka mālama ʻana me ka metformin, e noho pū ana ka hana o ka insulin i ka pae like, akā ʻo ka wikiwiki a me ka pae ʻana o kēlā me kēia lā e emi ana.

Nā hiʻohiʻona Pharmacokinetic

ʻO ka waiwai hoʻohui ʻo Yanumen ka mea bioequivalent i kahi hoʻokaʻawale i kahi o nā dosis kūpono o Januvia a me Metformin.

Kapehu

ʻO ka bioavailability o sitagliptin he 87%. ʻAʻole ka hopena o ka hoʻohana ʻana i nā meaʻai momona a me nā kiʻekiʻe o ka calorie ma ka nui o ke kao ʻana. ʻO ka pae kiʻekiʻe o ka mea i loko o ke kahe koko e paʻa i nā hola 1-4 ma hope o ka hoʻomoʻa ʻana mai ka gastrointestinal tract.

ʻO ka bioavailability o ka metformin ma luna o kahi ʻōpū ʻūlū a hiki i 60% ma kahi o 500 mg. Me ka hapa hoʻokahi o nā inikua nui (a hiki i ka 2550 mg), ua laʻa ke kumu kūlike o ka proportionality, ma muli o ka inu haʻahaʻa. Metformin hele mai i ka hana ma hope o ka manawa ʻelua a me ka hapa. Ua hōʻea kona pae i 60%. ʻO ka kiʻekiʻe o ka metformin i hoʻopaʻa ʻia ma hope o hoʻokahi lā a i ʻole ʻelua. I ka wā ʻai, hōʻemi ka maikaʻi o ka lāʻau lapaʻau.

Kahele

ʻO ka nui o ka hoʻonuiʻana i ka synagliptin me kahi hoʻohana hoʻokahi o 1 mg o ka hui mana o nā mea komo i ka hoʻokolohua ʻo 198 l. ʻO ka pae nui o ka naki i nā protein koko he liʻiliʻi iki paha - 38%.

Ma nā hoʻokolohua like ʻole me ka metformin, hāʻawi ʻia ka pūʻulu mana i ka lāʻau lapaʻau ma ka huina o 850 mg, ka nui o ka hoʻoili ʻana i ka manawa like me ka piʻi ʻana o 506 lita.

Inā mākou e hoʻohālikelike i nā lāʻau lapaʻau o ka papa SM, hoʻomaʻamaʻa ʻo metformin i ʻole e kāohi i nā protein, he manawa liʻiliʻi kekahi mahele o ia mau wahi i loko o nā sela ʻulaʻula.

Inā lawe ʻoe i ka lāʻau lapaʻau i loko o kahi inī ʻai, hōʻele nā ​​lāʻau lapaʻau i ka pae kiʻekiʻe (<1 μg / ml) i loko o ke koko i ka lā a i ʻole ʻelua. Wahi a nā hopena o nā hoʻokolohua, ʻoiai ma ka palena palena, ʻo ka nui o ke kiko o ka mea lapaʻau i ke koko ʻaʻole iʻoi aku i ka 5 μg / ml.

Hoʻohālikelike

I kahi 80% o ka lāʻau lapaʻau e hoʻopili ʻia e nā ʻōpū, metformin ʻaʻole metabolized i ke kino, i ka pūʻulu mana hoʻomana a kokoke i nā hapa āpau i waiho i kāna ʻano kumu i kēlā me kēia lā. ʻO ka metabolism a me ka hoʻonāukiuki i loko o nā papa bile i nele loa. Ua hoʻohālikelike ʻia ka Sinagliptin like (a hiki i 79%) me ka hana liʻiliʻi me ka metabolism. I nā pilikia o nā pilikia me nā ʻōpū, pono e hoʻomaʻamaʻa ʻia ke ʻano o ka ʻōlelo o Yanumet. Me nā ala hepatic, ʻaʻole pono nā kūlana kūikawā no ka mālama ʻana.

ʻO ka Pharmacokinetics o nā lālā kūikawā o nā maʻi

  1. ʻO ka maʻi maʻi maʻi me ka maʻi type 2. ʻO ka hana o ke kaʻili a me ka hoʻoili ʻana o ka sitagliptin e like me nā hana i loko o ke kino olakino. Inā maʻamau nā pēpē, ʻaʻole i nānā ʻia nā mea ʻokoʻa i loko o nā laikini pharmacokinetic i ka wā e hoʻohana ai nā ʻelua ʻelua o ka metformin i nā maʻi maʻi a me nā limahana olakino i mālama ʻole ʻia. Cumulation o ka lāʻau hoʻokō me ka paʻa ʻana i ka maʻamau.
  2. Ma kahi pilikiaʻole, ʻaʻole i kuhikuhi ʻia ʻo Yanumet, ʻoiai ua pau ka make ʻana o nā lāʻau lapaʻau.
  3. I loko o nā ala o ke kino o ka hōʻoluʻolu a me ka hoʻohaʻahaʻa iki, ʻaʻole i hōʻike kahi hoʻokahi o kahi sitagliptin i kahiʻokoʻa nui i loko o ka hoʻopili ʻana a me ka hoʻoili ʻana. ʻAʻohe ʻikepili i ka hopena o ka lawe ʻana i ka lāʻau lapaʻau no nā maʻi ʻeha kaumaha, akā maikaʻi ʻole nā ​​wānana ma kēia hihia. Wahi a metformin, ʻaʻole i paʻi ʻia nā hopena o nā hoʻokolohua like ʻole.
  4. ʻO ka maʻi maʻamau o ka pākeke. E pili ana nā ʻokoʻa pili i nā makahiki i ka hana o ka renal, ma hope o 80 mau makahiki, ʻaʻole i hōʻike ʻia ʻo Janumet (koe wale nō me nā maʻi maʻi maʻi me ka hoʻomaʻamaʻa maʻamau o cretatinin).

ʻO ia i hōʻike ʻia a iā wai i hōʻike ʻole ʻia iā Yanumet

Hoʻolālā ʻia ka lāʻau lapaʻau e mālama i ka maʻi diabetes type 2. Ua kuhikuhi ʻia i nā hihia kikoʻī.

  1. Eia ka hoʻohui i ka hoʻololi ʻana i ka nohona olakino e hoʻomaikaʻi i ka ʻike glycemic o kahi maʻi maʻi, inā ʻaʻole ka hāʻawi ʻana o ka metformin monotherapy i kahi hopena 100%.
  2. Hoʻohana ʻia ʻo Yanumet i loko o ka hoʻokūkū paʻakikī a me nā derivatives o SM inā ʻaʻole i lawa ka hopena "metformin + lāʻau o ka pūʻulu SM + haʻahaʻa-haʻahaʻa a me ka hoʻoulu ʻana o ka ʻiʻo".
  3. Hoʻohui ʻia ka lāʻau lapaʻau, inā pono, me nā agonist receptor gamma.
  4. Inā hāʻawi ʻole ʻia i nā inikini insulin i ka uku kōpaʻa piha, ua kauoha ʻia ʻo Yanumet i ka ʻokoʻa.

Nā ʻōlelo penei i nā ʻōkuhi:

  • Hoʻopili i nā ʻano o nā hiʻohiʻona;
  • Coma (maʻi);
  • ʻO ke ʻano o nā keiki;
  • Nā maʻi maʻi pāpaʻi;
  • Kūpono ʻana i nā lāʻau lapaʻau me ka iodine (iv);
  • Haʻalulu manawa;
  • ʻO nā maʻi e hoʻonāukiuki i ka nele o ka oxygen i loko o nā kiko;
  • Hōʻeha ka naʻau, hōʻawaʻawa, inu hewa.
  • Pue; male;
  • ʻAno maʻi type 1.

ʻO ka hopena o Yanumet ma ke olakino o nā keiki, me kona palekana no kēia ʻāpana o ka maʻi maʻi, ʻaʻole i aʻo ʻia ʻo ia, no laila, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā mea maʻi ma lalo o ka 18 mau makahiki o ka makahiki.

Nā hopena hopena

Ma mua o ka hoʻohana ʻana, pono ʻoe e noʻonoʻo i ka papa inoa o nā hopena o nā hopena a me ko lākou mau hōʻailona e hoʻomaopopo ai i ke kauka i ka manawa e pili ana i ka hopena o ke kino e hoʻoponopono i ka regimen mālama. I waena o nā hopena makemake pinepine loa:

  • Nā kiʻekiʻe kāwili;
  • Nā maʻi Dyspeptic;
  • Nā māpala e like me migraine;
  • ʻO nā ʻōpū o ke mele o nā neʻe i loko o ke alo;
  • Nā maʻi ʻeha;
  • Hoʻemi i ka maikaʻi o ka hiamoe;
  • ʻO ka hōʻike o ka pancreatitis a me nā ala āpau o ka pancreas;
  • Hāʻule;
  • ʻO ka hōʻemi momona, anorexia;
  • ʻO nā maʻi ʻeha ma ka ʻili.

Hiki ke hoʻohālikelike ʻia ka loaʻa ʻana o nā hopena ʻehā ma kahi ʻōpiopio WHO:

  • Pā pinepine pinepine (> 1 / 0,1);
  • I nā manawa pinepine (> 0.001, <0.1);
  • Auhea (> 0.001, <0.01).

Hōʻike ʻia nā hōʻike o nā helu lapaʻau i ka papa iʻa.

Nā hopena hopenaʻO ke alapine o nā hopena ʻaoʻao me nā algorithm therapeutic ʻē aʻe
metformin, sitagliptinmetformin, sitagliptin, pūʻulu SMmetformin, sitagliptin, rosiglitazonemetformin, sitagliptin, insulin
24 pule24 pule18 pule24 pule
Keʻikepili hana
Hoemi ka koko kokopinepine
Pūnaehana pīhoihoi waena
Laumapa

Ka moemoe hewa

pinepinepinepinepinepine
ʻŌpala Gastrointestinal
ʻO ka maʻi palaualelo hoʻohālikelike

Kahula

ʻEha ka ʻōpū

Lohea

pinepine

pinepine

pinepine

pinepine

ʻO nā kaʻina hana pā
Hypoglycemia

pinepine pinepinepinepinepinepine pinepine

Pehea e hoʻopili ai

ʻO ke kipa "kipa" ma ka inoa o ka lāʻau lapaʻau e hōʻike ana i ka noho ʻana o ka metformin i loko o kāna hui, akā lawe ʻia ka lāʻau ma ke ʻano like me ke kuhikuhi ʻana iā Januvia, kahi lāʻau lapaʻau e pili ana i ka sitagliptin me ka metformin.

Hoʻopili ke kauka i ka dosage, a lawe i nā lāʻau me ke kakahiaka a me ke ahiahi me ka meaʻai.

I kekahi mau kūlana, pono e mālama nui kekahi i ka mālama ʻana iā Yanumet.

  1. ʻO ka pancreatitis acute. Hiki i ka Sitagliptin ke hiki ke hoʻoikaika i kāna mau hōʻailona. Pono ke kauka i ka mea maʻi: inā he ʻeha ma loko o ka ʻōpū a i ʻole hypochondrium ʻākau, pono ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau.
  2. Lactic acidosis. ʻO ke kūlana koʻikoʻi a ʻaʻole loa e uluhua iki i ka hopena o nā mea momona, a hoʻopau ʻia ka mālama ʻana inā puka mai nā hōʻailona. Hiki ke hoʻomaopopo ʻia e ka pōkole o ka hanu, ka ʻeha o ka epigastric, ka hoʻoluliluli, nā hoʻololi i ke kulu ʻia o ke koko, nā mākēkē o nā io, nā asthenia, a me nā pilikia o ka gastrointestinal.
  3. Hypoglycemia. Ma lalo o nā kūlana maʻamau, e kū'ē ana i ke ʻano o Yanumet, ʻaʻole ia i hoʻomohala. Hiki ke hoʻonāukiuki e ka nui o ka hoʻoikaika kino, haʻahaʻa haʻahaʻa (a i ka 1000 kcal / lā) ka mea kanu, pilikia me nā kelepa adrenal a me ka puluitary kelepona, inu ʻona, a me ka hoʻohana ʻana o β-blockers. Hoʻopili i nā hopena o ka hypoglycemia i ke kuʻaloli hoʻomehana me ka insulin.
  4. Palapala Renal. Hoʻopilikia ka uluʻana o ka hoʻomoʻi lactic acidosis me ka maʻi maʻi o ka lolo, no laila he mea nui loa e nānā i ka creatinine. Kūpono maoli nō kēia no nā maʻi maʻi maʻi, ʻoiai paha ko lākou hoʻomaʻemaʻe kino paha he asymptomatic.
  5. Hypersensitivity. Inā hele ke kino me nā maʻi alerine, hoʻopau ʻia ka lāʻau lapaʻau.
  6. Hoʻolā hewa. Inā he papa hoʻolālā ka maʻi lolo, ʻelua mau lā ma mua o ka haʻalele ʻana o Janumet a hoʻoneʻe ʻia ka mea maʻi i ka insulin.
  7. Nā huaʻai Iodine. Inā hoʻokomo ʻia ka ulia papa iodine me Yanumet, hiki ke hoʻonāukiuki i ka maʻi o nā keiki.

Ma mua o ke kuhikuhi ʻana i kahi papa, pono ke maʻi ma kahi maʻi maʻi maʻa. Inā aia nā hōʻailona o ka acidosis i loko o ke koko a me nā hoʻāʻo urine, hoʻōla ʻia ka lāʻau lapaʻau.

Ua aʻo ʻia ka hopena o Yanumet i nā wahine hāpai i nā luna o ka honua holoholona. I nā wahine hāpai, ʻaʻole i hoʻopaʻa ʻia nā maʻi hoʻomohala i ka wā e lawe ai i ka metformin. ʻAʻole lawa ia mau hoʻoholo manaʻo no ka kuhikuhi ʻana i ka lāʻau lapaʻau i nā wahine hāpai. Kūleʻa i ka insulin ma ka hoʻolālā hoʻolālā o ka hāpai ʻana.

Hele pū ʻo Metformin i ka waiū umauma, no laila, ʻaʻole i kuhikuhi ʻia ʻo Yanumet no ka lactation.

ʻAʻole ke kipi ʻo Metformin i ka hana ʻana i nā kaʻa a i ʻole nā ​​mea kikowaena paʻakikī, a hiki i ka synagliptin ke hōʻeha i ka nāwaliwali a me ka hiamoe, no laila, ʻaʻole i hoʻohana ʻo Januvia inā he wikiwiki a me ke ʻano kiʻekiʻe o ka makaʻala.

Nā hopena o kahi overdose

No ka pale ʻana i ka metformin overdose, ʻaʻole hiki iā ʻoe ke hoʻohana iā ia ma kahi o Yanumet. ʻO kahi overdose o ka lāʻau lapaʻau he pōʻino me ka lactic acidosis, ʻoi aku me ka nui o ka metformin. Ke hele nei nā hōʻailona o kahi overdose, hoʻohana ʻia ke ʻano maʻi hōʻailona e pale i ka hoʻokaʻalā.

No ke aha e hoʻomohala ai i nā mea paʻakikī Metformin me Yanuvia, Galvus, Onglyza, Glybyuryd, inā hiki iā ʻoe ke hoʻohana i nā mea hana like ʻole ma ka hoʻopulapula ʻoiaʻiʻo. Ua hōʻike ʻia nā hoʻokolohua ʻepekema me kekahi ʻano mālama mana no ka maʻi type 2, ua loaʻa ʻo Metformin (ʻoiai ke hoʻololi nei i ka insulin). Eia nō naʻe, i ka hoʻohana ʻana i ʻelua mau mea ikaika me kahi ʻano like ʻole o ka hana, hiki ke hoʻonui ʻia ka lāʻau lapaʻau a hiki iā ʻoe ke hana me nā lāʻau pā me kahi haʻahaʻa haʻahaʻa.

ʻO ka mea nui wale nō ke kāohi i ka nui o ka metformin i ka pōkole (500 mg, 850 mg a 1000 mg) i mea e pale aku ai i nā maʻi maʻamau. No nā poʻe maʻi e poina e inu i kēlā me kēia ʻano kīpī i ka manawa, ʻo ka manawa ka lawe i nā mea āpau a lākou e loaʻa ai i kahi manawa maikaʻi nui e pili nui ana i ka palekana a me nā hopena o ka mālama ʻana.

Hoʻohui nūhou

Hiki ke hōʻemi i nā metformin e ka diuretics, glucagon, corticosteroids, thyroid hormones, phenothiazines, oral contraceptives i loko o nā papa, phenytoin, ka waikika nicotinic, sympathomimetics, calcium antagonist, isoniazid. Ma nā hoʻokolohua, ʻoi aku ka nui o ka nifedipine i hoʻonui i ka hoʻowalewale o ka metformin i nā poʻe hui ola i loko o ka hoʻopaʻa ʻana, ʻo ka manawa e hiki ai i ka pae kiʻekiʻe a i ka hapalua-ola mau like.

E hoʻonui ʻia nā waiwai hypoglycemic e ka insulin, nā mea kanu o ka hui sulfonylurea, acarbose, MAO a me ACE inhibitors, NSAIDs, oxytetracycline, clofibrate derivatives, cyclophosphamide, β-blockers. ʻO kahi hoʻohana hoʻokahi o ka furosemide e nā poʻe ola olakino i ka hoʻokolohua i hoʻonui ʻia ke kao a me ka hāʻawi ʻana i ka metformin e 22% a 15%, kekahi. ʻAʻole i loli nui ka maikaʻi o ka hoʻomaʻemaʻe ʻana i nā waiwai. ʻAʻohe ʻike e pili ana i ka hoʻomehana hui lōʻihi me ka furosemide a me ka metformin.

ʻO nā lāʻau lapaʻau e hūnā ʻia i loko o nā tubule e hakakā no nā ʻōnaena o ka halihali, no laila, me ka hoʻohana wā lōʻihi e hiki iā lākou ke hoʻonui i ka nui o ka hoʻokaumaha ʻana o ka metformin e 60%.

Hoʻololi ʻo Cimetidine i ka hoʻonuiʻana o ka metformin, ka hōʻiliʻili o nā lāʻau lapaʻau i ke koko e hoʻonāukiuki i ka waikena.

He kue like ʻole ʻo Yanumet me ka waiʻona, e hoʻonui ana hoʻi i ka waʻa o ka acidosis.

Ke aʻo nei i ka hopena o nā lāʻau lapaʻau o nā hui ʻē aʻe (metformin, simvastatin, glibenclamide, warfarin, rosiglitazone, contraceptives), ʻaʻole i hoʻoikaika maoli ka synagliptin. Ua hoʻonui ʻia ka plasma plasma o ka digoxin i ka 18% i ka manawa i lawe pinepine ʻia me ka sitagliptin.

ʻO ka loiloi o nā hopena o ka 858 o nā mea ola olakino ma ka hoʻokolohua i lawe i nā ʻano 83 o nā lāʻau lapaʻau concomitant, 50% o nā mea i hoʻopuka i nā ʻōpū, ʻaʻole i hoʻopaʻa i ka hopena nui o ka ʻili ʻana a me ka hoʻolilo ʻana i ka sitagliptin.

Nā hōʻike a me nā kumukūʻai

ʻO Yanumet kahi lāʻau lapaʻau maikaʻi loa: ma ka awelika, ke kumukūʻai ma ke keena lāʻau lapaʻau mai nā ʻāpana a ʻelua a ʻekolu paha mau rubles i ka pahu me nā pahu 1-7 (14 mau papa i hoʻokahi blister). Hana lākou i ka lāʻau mua ma Sepania, Switzerland, ka Netherlands, USA, Puerto Rico. I waena o nā kikowaena, kūpono wale ʻo Velmetia i ka hoʻopili. ʻO ka hana pono a me nā code o ka lāʻau lapaʻau ATC e like nō:

  • Douglimax;
  • Glibomet;
  • Kūleʻa;
  • Avandamet.

ʻO Glibomet ka hoʻopili me ka metformin a me nā glibenclamide, nāna e hāʻawi me ka hypoglycemic a me nā mana hypolipidemic.Hoʻohālikelike nā ʻōkuhi no ka hoʻohana ʻana me nā loiloi no Yanumet. Hoʻokumu ʻia ʻo Douglimax e pili ana i ka metformin a me glimepiride. ʻO ka mīkini o ka hōʻike a me nā hōʻike e like like me Yanumet. He hele a glimepiride a me ka pioglitazone ka huakaʻi, he hopena antidiabetic a me nā hōʻailona like. ʻO Avandamet, kahi hui o metformin + rosiglitazone, he mau waiwai hypoglycemic hoʻi.

ʻO ke koho ʻana i kekahi o nā lāʻau lapaʻau i hōʻike ʻia a i ʻole nā ​​mea ʻē aʻe i kū i ka hoʻokūkū o ka ʻaha loea.
Ke lāʻau lapaʻau pilikino, ʻoi aku me nā maʻi like ʻole, ʻaʻole ke alakaʻi i nā mea maikaʻi. Kahi ʻia ka ʻikepili i loko o ka ʻatikala mai nā kumu ākea ākea, ʻaʻohe kumu no ka hoʻopaʻa ʻana i ke ake a me ke alakaʻi wale nō.

Inā ʻaʻole kūpono ʻo Yanumet

ʻOkoʻa paha nā kumu no ka hoʻololi ʻana i ka lāʻau lapaʻau: no kekahi, ʻaʻole kōkua ke lāʻau lapaʻau i ka ʻāpono kūpono, no ka mea, ke hoʻolilo ʻia ka hopena i ʻole ka hopena.

Ke hoʻohālike ʻole ʻia ka hoʻohana ʻana o ka lāʻau lapaʻau no ka mea hoʻohuukui, ke hoʻololi ʻia nei e nā inikini insulin. ʻAʻole like ia nā papa ʻē aʻe i kēia hihia. ʻO ka mea ʻē loa, mai ke ʻano he hiki ʻana i ka lāʻau lapaʻau huakaʻi, ua hana ka pancreas, a me ka ʻano kiʻekiʻe o ka maʻi diabetes type 2 i hele i ka maʻi diabetes type 1.

ʻOiai nā papa e pili ana i kēia mau lā ʻaʻole pono ia inā e nānā ʻole ʻoe i ke kauoha ʻana o ka endocrinologist e pili ana i kaʻai haʻahaʻa-carb a me nā ukana i pau.

Hōʻike pinepine ʻia nā hopena ʻaoʻao e ka metformin, sitagliptin i kēia hanohano ʻaʻole pōʻino. Wahi a kona hiki i nā lāʻau lapaʻau, ʻo Metformin kahi lāʻau lapaʻau kūʻokoʻa, ma mua o kou ʻimi ʻana i kahi kuapo, pono ia e hana nui i nā hana e hiki ke hoʻopili pono. E hala ka pilikia o ka dyspeptic i ka manawa, a mālama ka metformin i kahi maʻamau o ke kō me ka ʻole o ka luku ʻana i ka pancreas a me nā ʻōpala. Hāʻawi ʻia nā hopena hopena ʻole e hāʻawi ʻia e Janumet ma mua o a ma hope o ka ʻai ʻana, akā i ka wā e ʻai ai.

I mea e hoʻopakele ai i ke kālā, hiki iā ʻoe ke kahakaha iā Janumet a i ka ʻoviavia wale nō me ka metformin mā. I loko o ka pūnaewele olakino, ʻoi aku ka maikaʻi e koho i nā hana Glyukofazh a i nā Siofor paha ma kahi o nā mea hana hale.

ʻO nā maʻi maʻi a me nā kauka e pili ana iā Yanumet

E pili ana i ka lāʻau lapaʻau Janumet, hui pū nā loiloi o nā kauka. Wahi a nā kauka: ʻo ka mea pono nui o kāna mau ʻāpana (ʻoi aku hoʻi i kahi sitagliptin) ʻaʻole lākou e hoʻonāukiuki i ka hypoglycemia. Inā ʻaʻole ʻoe e hōʻino maikaʻi i ka regimen i kuhikuhi ʻia a hahai i nā ʻōlelo aʻoaʻo e pili ana i ka hoʻonaʻauao a me ke aʻo ʻana no nā maʻi, e haʻahaʻa loa nā hōʻailona o ka mika. Inā pilikia ka pilikia o ka epigastrium a me nā hopena ʻē aʻe i makemake ʻia, pono e hoʻokaʻawale i kēlā me kēia lā i kēia me nā 2 wai i mea e hōʻemi ai ke kaumaha ma ke kino. Ma hope o ka hoʻololi ʻana, hiki iā ʻoe ke hoʻi i ke aupuni i hala aku nei, inā he ʻoi aku ke kiʻekiʻe o ka kōpō ma mua o nā mea i manaʻo ʻia, he hiki ke hoʻoponopono ʻia e ka lāʻau lapaʻau.

E pili ana iā Yanumet, he hoʻopaʻapaʻa nā loiloi maʻi maʻi, no ka mea, e ala ʻia aʻe ka maʻi like i kēlā me kēia. ʻO ka hapa nui, ʻeha nā maʻi o nā pākeke i nā hopena ʻokoʻa, no ka mea, ʻo ke akepaʻa, a me ke kino holoʻokoʻa, ua nalo loa nā maʻi maʻi concomitant.

ʻO Olga Leonidovna, ʻO St. Petersburg "Ua aʻo wau e pili ana iā Yanumet mai kahi kamaʻāina. Ua hoʻolōʻihi ʻo ia iā ia i kahi manawa lōʻihi a ʻoliʻoli i nā hopena. ʻAʻole i ola ke kūʻai mai i kaʻu mau mea i manaʻo ʻia: ua heluhelu wau i nā ʻōlelo aʻoaʻo i pōmaikaʻi ka lāʻau lapaʻau no nā keiki maʻi maʻi, a loaʻa iaʻu kahi maʻi pyelonephritis. ʻAʻole wau i wiwo ʻole e lawe, hāʻawi wau i kekahi i kamaaina. Ke ʻimi nei wau e aʻo i nā ʻōlelo aʻo a pau ma ka Pūnaewele. ”

Amantai, Karaganda “Ua kuhikuhi mai kuʻu kauka iaʻu iā Janumet. Ua lawe wau i 2 papa i kēlā me kēia lā no 2 mau makahiki (50 mg / 500 mg), ua hauʻoli wau a ʻelua hoʻi i nā hopena: maʻamau ke kō, a ʻo ka mea maʻamau ua hoʻomaʻamaʻa ke ʻano. ʻAʻole maʻalahi ke lāʻau, akā, i koʻu manaʻo, kekahi o ka maikaʻi loa. ʻ lākou ke hiki iā ʻoe ke kanu i nā pōpoki, maikaʻi, no laila lākou pilikia ai i kekahi chemistry. ʻO kahi hoʻohui hou o ke kaupaona ʻana o ka 7 kg. ʻ sayslelo ke kauka mai nā lāʻau lapaʻau. "

He ʻōlelo kaulana ʻo Endocrinologists: "ʻO ke aʻai a me ka meaʻai - hoʻōki e kūʻē i ka maʻi maʻi." ʻO nā poʻe a pau e ʻimi nei i kahi pōpana kupaianaha, a manaʻoʻiʻo ʻoi i nā lāʻau hou, kahi pānaʻi hou a i ʻole nā ​​lāʻau lapaʻau e hoʻōla mau i ka maʻi diabetes me ka ʻole o ka hoʻoikaika nui, e hoʻomanaʻo pinepine.

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