ʻO Galvus kahi lawena hypoglycemic i hoʻolālā ʻia e kāohi i ka glycemia i nā maʻi maʻi type 2. ʻO ka hana ikaika o ka lāʻau lapaʻau ʻo vildagliptin. Hoʻokuʻu ʻia ka lāʻau lapaʻau i ke ʻano o nā papa. Loaʻa nā lāʻau lapaʻau a me nā maʻi hānai i hōʻike maikaʻi mai Galvus.
Ka mana ikaika i ka hana hoʻokūkū o ka insulin a me ka glucagon. Ke ʻōlelo nei ka European Antidiabetic Association e haʻi aku ʻo Galvus i ka monotherapy i ka hoʻohana ʻana i ka wā e contraindicated wale nō ʻo ka metformin i ka mea maʻi. No nā maʻi maʻi e pili ana i ka insulin me ka maʻi type 2, kōkua ʻo Galvus i ka hōʻemi ʻana i ka nui o nā poplite a me ka nui o ka insulin i paʻi ʻia.
Nā hiʻohiʻona Pharmacological
Ua kapa ʻia nā hone e pili ana i nā hāmeʻa a hua nā ʻili i ka wā e komo ai nā mea momona. ʻO kēia mau hormone he insulinotropic, hoʻokomo i ka mea huna o ka insulin, no ka mea, ʻo 60% o kāna hana e kūpono pono i ka hopena o ka incretins. ʻIke ʻia kēia mau ʻano i ka makahiki 1960, i ko lākou aʻo ʻana e hoʻoholo i ka neʻe ʻana o ka insulin i ka plasma.
ʻO Glucan-like peptide-1 (GLP-1) kahi mea kaulana loa, ʻoiai ʻo ia ka hoʻemi ʻana o kona neʻe i ka maʻi diabetes 2. ʻO kēia ka mea i hōʻea i kahi papa hou o nā lāʻau lapaʻau e hoʻonui ai i ka ʻike o nā hormones like i ka injection o ka syntatic analogue o GLP-1, e like me Baeta a i Victoza, a i ʻole nā huaʻōlelo e like me Galvus a i kāna analogue Januvius. ʻAʻole wale ka neʻe ʻana o ka DPP-4 e hoʻonui i ke kahe o ka lua o nā hormones, akā ua pale aku nō hoʻi i kā lākou degradation.
ʻO ka mea kūpono iā Galvus
No nā poʻe maʻi me ka maʻi o ka maʻi helu 2, hiki ke hoʻohana ʻia ka lāʻau lapaʻau:
- No ka monotherapy, i ka hui pū me kahi meaʻai haʻahaʻa-low a me ka lawa ʻana o ka naʻau uaua;
- Ma ka hana paʻakikī ma waena o nā metformin, inā ʻaʻole i lawa ka hopena;
- ʻO ke ʻano hou no nā lāʻau lapaʻau e like me Galvus e pili ana i ka metformin a me vildagliptin;
- ʻO ka hoʻohui i nā mea āpau hypoglycemic ʻē aʻe, inā ʻaʻole maikaʻi ka hoʻoponopono ʻana o ka mālama mua ʻana;
- Me kahi lāʻau triple me ka insulin a me ka metformin, inā he meaʻai, hoʻomaʻamaʻa a me nā insulin me ka metformin ʻaʻole i lawa.
Nā ʻōkuhi no ka hoʻohana
Hoʻoholo ʻia ka ʻākala e ka endocrinologist i hoʻokahi, ke nānā ʻana i ke ʻano o ka maʻi a me ke kūlana olakino maʻamau o ka maʻi maʻi. ʻAʻole pili ʻia ka hoʻohana ʻana i nā papa i ka pāʻina kakahiaka, ʻo ka mea nui ka inu i ka lāʻau lapaʻau me ka wai pono. I ka loaʻaʻana o nā hopena kumu ʻole no ka gastrointestinal tract, ʻoi aku ka maikaʻi e hoʻohana i ka lāʻau lapaʻau me ka meaʻai.
Inā hoʻokomo i ka maʻi diabetes 2, hiki ke hāʻawi koke iā Galvus. Ka nānā ʻole o ka regimen mālama (paʻakikī a monotherapy paha), lawe ʻia nā papa ma loko o kahi huina 50-100g / lā. Lawe ʻia ke ʻano kiʻekiʻe (100 mg / lā) i nā mahele koʻikoʻi o ka maʻi maʻi. I ka wā mālama, me nā ʻaina hypoglycemic ʻē aʻe, ua kuhikuhi ʻia ka 100 mg / lā.
ʻO kahi mahele o 50 g / lā. lawe ʻia i hoʻokahi manawa, ma ke kakahiaka, pono ka hoʻokaʻawale ʻana o ka nui o ka 100 mg i 2 mau waʻa - like, i ke kakahiaka a me ke ahiahi. Inā pau ka hoʻokipa ʻia o Galvus, pono e lawe ʻia ka pōpoki i kēlā me kēia manawa, akā pono e mālama ʻia nā palena ʻokoʻa.
Inā me ka monotherapy hiki iā ʻoe ke lawe i 100 mg / lā, a laila me ka lāʻau paʻakikī, hoʻomaka me 50 mg / lā, no ka laʻana, me ka metformin: 50 mg / 500 mg, 50 mg / 850 mg, 50 mg / 100 mg.
Me ka uku uku kōpē piha, nā lāʻau lapaʻau hou hypoglycemic (metformin, insulin, sulfonylurea derivatives, etc.) i kuhikuhi i ka hoʻohui.
Inā ke hana nei nā lolo maʻi a me ka puʻupaʻa i nā kuhi hewa, hōʻemi ʻia ka nui o ka nui ma ka 50 mg / lā., No ka mea ua hōʻoki ʻia ʻo Galvus e nā keiki, e hana ana i ka uku hou ma luna o ka mana excretory.
Nā hōʻailona āpau
Inā ʻaʻole ʻoi aku ka maʻamau o kēlā me kēia lā ma mua o 200 mg / lā, e hoʻololi ʻia nā maʻi maʻi Galvus me nā hopena ʻole. ʻO ka overdose me nā hōʻailona kūpono e ʻike ʻia i ka wā e hoʻopau ʻia ma mua o 400 mg / lā. Hōʻike pinepine ʻia nā Myalgia (ʻehaʻeha o ka naʻau), me ka liʻiliʻi - ka paresthesia (i ke ʻano maʻalahi a transistor), ʻāʻī, ke kuapo, ka piʻi ʻana o ka lipase i ʻelua mau manawa e like me ka VGN.
Inā ʻoi aku ka nui o ka Galvus ma mua o ʻekolu mau manawa (600 mg / lā), aia he ala o ka ʻūhā ʻana o ka wāwae, paresthesia a me ka piʻi o ke kiʻekiʻe o ALT, CPK, myoglobin a me C-reactive protein. ʻO nā hopena hōʻike āpau, e like me nā hōʻailona, e nalowale ana i ka hoʻopau ʻia o Galvus.
ʻO Galvus: nā kikowaena
Wahi a ke ʻano loiloi ikaika, e like nō nā lāʻau Vildaglympin a me Galvus Met e like me Galvus, a ʻo covia a me ʻOnglisa coincide e like me ka code ATX-4. Ua hōʻike ʻia nā noi ʻana o nā lāʻau lapaʻau a me nā loiloi maʻi e hoʻohuli ʻia kēia mau lāʻau.
Nā hanana pōʻino
ʻO kahi hoʻohana lōʻihi no Galvus e hele pū me nā hopena ʻaoʻao:
- Nā ʻōpū a me ka nalowale o ka hoʻonohonoho ʻana;
- Tremor o nā lima a me nā wāwae;
- Nā maʻi Dyspeptic;
- Keʻokiʻoki, nā puhaka a me nā ʻalihi o ka ʻili o kahi kumu alaka;
- Hoʻowahāwahā i ke kaniʻana o nā neʻe i loko o ke alo;
- ʻO ka pale kūleʻa
- Kekahi papa hana nā hana;
- Hepatitis, pancreatitis a me nā maʻi ʻē aʻe o ka ate a me ka pancreas;
- Kāwāwā a me ka hamo.
ʻO contectedicated ʻo Galvus
ʻO nā hoʻohālikelike no ka hoʻohana ʻana o Galvus he nui nā maʻi a me nā kūlana.
- Ka hoʻomanawanui ʻana o ka pilikino i nā mea o ka lāʻau, kūlohelohe;
- Hoʻolaha ka hana a me ka ʻōnaehana excretory;
- ʻO nā kūlana e hoʻonāukiuki i ka hana kuhi o ka ʻōpū (ke kanaka, ka maʻi ʻeha, ke kīwaha, aʻaila);
- Nā maʻi o ka puʻuwai a me nā moku koko;
- Nā pilikia pilikia;
- ʻO ke ketoacidosis Diabetic, coma, a me nā kūpuna, ke unuhi ʻia ka maʻi diabetes i nā insulin;
- Lactic acidosis, hoʻonui i loko o ka lactic acid;
- ʻLelo a me ka lactation;
- ʻAno maʻi type 1;
- Hoʻopukuhū ʻole a hōʻino paha i ka waiʻona;
- ʻO kaʻai koʻikoʻi nui me kahi waihona calorie o 1000 Kcal / lā;
- Hoʻopili i nā makahiki: a hiki i ka 18 mau makahiki o ka makahiki, ʻaʻole i kuhikuhi ʻia kahi metabolite, ma hope o 60 makahiki - me ka akahele;
- Ma mua o ka hana (2 mau lā ma mua a ma hope), i ka pō o ka hoʻolauna o nā mea hoʻohālikelike a i ʻole loiloi radiographic;
- ʻO kekahi o nā contraindications koʻikoʻi no Galvus ʻo ka lactic acidosis, no laila, me ka pale o ka palaka a me ke aloha ʻole ʻole, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau.
Ma nā maʻi hānai o nā makahiki pākeke, hiki i ke hoʻohui ʻana me ka metformin ka mea, e hoʻonui ai kēia i ka heluna o nā pilikia, no laila, ua kuhikuhi ʻia ʻo Galvus ma lalo o ka mālama koʻikoʻi maʻi.
ʻO nā hiʻohiʻona o ka mālamaʻana o Galvus i kekahi mau helu o ka maʻi maʻi
ʻAʻohe mea hilinaʻi i ka hopena o ka lāʻau lapaʻau ma ke olakino o ka makuahine a me ka mahele, no laila, i ka wā hapai, ʻaʻole i kuhikuhi ʻia. ʻO ka hoʻonui hoʻonui nui o nā kōoʻa i ka wahine hāpai e hoʻonui i ka nui o ka hoʻomohala ʻana i nā maʻi nui a me ka make o kahi keiki. I ka maʻi maʻamau i nā wahine hāpai, maʻi maʻamau ka glycemia e ka insulin.
Ua hōʻike ʻia nā haʻawina ʻoiai he dosis o Galvus, ʻoi aku ka nui ma mua o ka manawa 200, ʻaʻole ia i hoʻonāukiuki i nā loli pathological i ke kūlana olakino o ka wahine hāpai a i loko o ka wahine hāpai. Ua hoʻopaʻa ʻia kekahi hopena like me ka hoʻohana ʻana i ka metformin a me Galvus ma kahi māhele o 10: 1.
ʻAʻole i aʻo ʻia ka nīnau i ka hiki o ka ulu ʻana o ka metala i loko o ka waiū umauma, no laila, me ka ʻaʻa umauma, ʻaʻole hoʻi i kuhikuhi ʻia ʻo Galvus.
ʻO ka ʻike ʻo Galvus ka mālama ʻana i nā keiki maʻi me ka maʻi 2 o ka maʻi (ʻo ka nui o nā mea maʻi e hoʻonui koke nei i kēia lā), inā no ke ʻano o kona hopena a me nā hopena maikaʻi ʻole, ʻaʻole i lawa.
No laila, ua kauoha ʻia ka pakanā i loko o ke ʻano maʻi type 2 mai ka makahiki 18.
Pono nā maʻi o ka wā ʻelemakule (ma hope o 60 mau makahiki) e kaohi i ka hopena o ka nui o Galvus a me kā lākou mau mea nui, no laila inā he pōpilikia, e hoʻomaopopo koke i ke kauka. I kēia manawa, hoʻonui ka hopena o nā hoʻopiʻi a me nā hopena kūponoʻole, ʻoiai ua hoʻowalewale ʻia ka hopena hoʻohui.
Nā manaʻo loea
Pono ke hoʻomaopopo ʻana i ka maʻi diabetes no nā hopena āpau o ka lāʻau hou iā ia.
ʻO Galvus kahi hana antidiabetic, akā ʻaʻole ia he mea hoʻohālike o ka insulin. No laila mea e hoʻohana pinepine ai kona hoʻohana ʻana i ka mālama maʻamau i ka hana naʻau. Hiki ke wehewehe ʻia kēia e ka mea ʻoi ke kumu koʻikoʻi ikaika o Galvus e hoʻonui i ka hana o aminotransferases. Ma waho aʻe, ʻaʻole ia i hōʻike ʻia i loko o nā mau kikoʻī, akā he loli ʻole ka loli i ka hana o ke akeʻa a hiki i ka hoʻomohala ʻana o ka hepatitis. I kēlā me kēia hihia, nā hōʻike maʻi maʻi mai ka pūʻulu hoʻomalu i hōʻike i kahi hopena like. I nā hōʻailona mua o ka maʻi pancreatitis (hoʻomau ʻia ke kaumaha o ka ʻōpū), pono e hoʻopau koke i ka lāʻau. ʻOiai ma hope o ka hoʻihoʻi ʻana i ka olakino maʻi, ʻaʻole i kuhikuhi hou ʻia ʻo Galvus.
ʻO Galvus nā maʻi kanikela hilinaʻi nui me ka maʻi type 2 e kuhikuhi wale ʻia me ka hoʻomākaukau ʻana me ka hoʻomākaukau ʻana no ka insulin.
ʻO ke kaumaha pinepine a me ka neʻe ʻana a hoʻoluhi i ka hoʻohaʻahaʻa nui i ka hopena o Galvus. Wahi a nā maʻi maʻi maʻi, pinepine ka nui o ko lākou kino me ka nalowale o ka hoʻonohonoho ʻana a me ka maʻi nausea. No laila, ʻaʻole i kauoha ʻia ka lawe ʻana i kahi kaʻa a hana paha i ka hana ʻalike ma ia mau ʻano.
Ma mua o nā hoʻokolohua o kekahi ʻano, ua hoʻopaʻa ʻia ʻo Galvus a me nā mea o nā kikowaena, no nā lā ʻelua. ʻO nā mea hoʻohālikelike e hoʻohana nei i ka maʻi maʻi maʻamau e loaʻa i ka iodine. Ka pilina me vildagliptin, hana ia i ka ukana nui ma luna o ka pehu a me ka ʻōnaehana excretory. E kūʻē i ke kua o kahi weliweli i kā lākou hana, hiki mai paha ka lactic acidosis.
ʻO ka papa papa mua o ka puʻuwai naʻau (ka hoʻonohonoho ʻana o NYHA) me nā hāmeʻa maʻamau hikiʻole i nā hoʻololi o ka maʻi Galvus. Ka lua papa e pili ana i ka hoʻopili ʻana i ka hana ʻāʻī o ka hiki ke pale i ka pōkole o ka hanu, nā nāwaliwali, a me nā tachycardia, ʻoiai ke noho malū nei ua ʻole nā mea like ʻole.
No ka paleʻana i ka pilikia o ka hypoglycemia, me ka mālama hoʻohui me ka hoʻomākaukau ʻana i ka sulfonylurea, ua koho ʻia ʻo ka popole ʻoi ka nui.
Nā hopena hoʻopuka lāʻau lapaʻau
I ka hana paʻakikī me ka hoʻohui o metformin, glibenclamide, pioglitazone, ramipril, amlodipine, digoxin, valsartan, simvastatin, warfarin a Galvus, ʻaʻohe hopena nui o ka maʻi i hōʻike ʻia mai kā lākou pilina.
ʻO ka hui hui pū me nā thiazides, glucocorticosteroids, sympathomimetics, ke hoʻoneʻe nei nā hormones thyroid i ka hopena hypoglycemic o vildagliptin.
Nā mea hoʻohālikelike o ka angiotensin-hoʻohuli i ka enzyme me ka hoʻohana pākuʻi e hoʻonui i ka paʻakikī o ka angioedema.
ʻAʻole hana hōʻole ʻo Galvus me kēlā mau hōʻailona, no ka mea, hele ka edema i kāna iho.
ʻAʻole hoʻololi ka lāʻau lapaʻau i ka helu metabola me ka hoʻohana ʻokoʻa me ka hoʻohana ʻana i nā huina CYP3A4, CYP1A2, CYP2C8, CYP3A5, CYP2C9, CYP2C19, CYP2D6, CYP2E1.
Nā kānāwai mālama
I loko o ke pūnaewele kūʻai lapaʻau, kūʻai aku ʻo Galvus e ka lāʻau lapaʻau. Hiki iā lākou ke hoʻokaʻawale ʻia e ka ʻaoʻao beveled a me nā hōʻailona ʻelua ʻelua: nā pōkole ʻo FB a me NVR. Ma ka papa i hiki i 7 a 14 mau papa o 50 mg. I loko o ka pahu keʻokeʻo mai nā pilima a he ʻumikumamālua.
Mālama ʻia ka lāʻau lapaʻau i nā kūlana wela a hiki i ka 30 ° C ma kahi wahiʻeleʻele, me ka ʻole o nā keiki. ʻO ke ola hoʻomaha o Galvus a hiki i ka 3 makahiki. Pono nā papa hana i hoʻopau ʻia.
Hōʻikeʻike i nā kauka a me nā maʻi
Kuhi pinepine ʻia kēia waha hypoglycemic aelike i ka maʻi maʻi ma hope o ka maʻi. No laila, i nā loiloi ma nā papa kūkala he nui nā nīnau i ka endocrinologist ma mua o nā pane.
ʻO ka hōʻike ʻana i kēlā mau hōʻike, ua ʻike nā kauka i ka maʻi maʻi i ke ola holoʻokoʻa. ʻAʻole hiki iā Galvus, ʻaʻole kekahi mea e hoʻonaninani nā antidiabetic e hoʻoponopono i ka mika o ka glucose i kahi pae maʻamau mau loa. Ke hoʻomau mau nei ke kūlana olakino i ka maʻi maʻi, e piʻi pololei ana ka nui o nā loli ʻē aʻe i ka pae o ka uku o ka maʻi diabetes. ʻAʻohe mea hōʻailona hōʻailona no ka maʻi maʻi maʻi maʻi. ʻO ka hoʻoponopono maikaʻi ʻana i ka meaʻai, ka hoʻihoʻi ʻana o ke ola holoʻokoʻa me ka mālama mālama pono e hiki ke hoʻolōʻihi i ka hoʻolālā ʻana o nā hoʻopiʻi ʻana a mālama i ka maikaʻi o ke ola me ka maʻi diabetes ma kahi pae maʻamau.
ʻAʻole ka loaʻa nā penikala āpau i Galvus ma ke kumukūʻai o 800 rubles. no 28 pcs., he nui nā poʻe e ʻimi nei i kahuli nona, ʻoiai ʻo Januvia (1400 rubles) a ʻo Onglisa (1700 rubles) ʻaʻole naʻe i kūpono i kēlā me kēia. A ʻo nā mea e hoʻomau nei i ka hoʻohana ʻana i ka makaʻala e neʻe lohi ka hilo i ke kīloi a he pau ka hana o ka hoʻomaʻamaʻa ʻana.
