ʻO ka aspart Insulin kahi mea hana hoʻonā ultra-pōkole e loaʻa ana me ka hoʻohana ʻana i ka biotechnology a me nā ʻano hana ʻenehana genetic. Kuhi ʻia e nā ʻano holoholona ʻano hoʻololi o Saccharomyces cerevisiae yeast, ka mea i kanu ʻia no kēia mau pahuhopu i loko o ka lāʻau lapaʻau. ʻO ka lāʻau lapaʻau e hōʻemi pono i ke kōpaʻa koko i nā mea maʻi me ka maʻi diabetes type 1, ʻoiai ʻaʻole ia e lilo i ka hopena alerine a ʻaʻole pale i ka ʻōnaehana.
ʻO ke kumu o ka hana
Hoʻomaopopo kēia lāʻau lapaʻau i nā ʻenehana insulin i loko o ka adipose tissue a me nā uaua uaua. Hōʻemi ka pae o ka glucose i ke koko ma muli o ka ʻike pono i nā ʻili e hoʻopili pono i ka glucose, ʻoi aku ka maikaʻi o ka komo ʻana i nā loko, ʻoiai ka helu o kona neʻe i loko o ke ate, ma kahi ʻē aʻe, e hoʻolōʻihi ana. ʻO ke kaʻina o ka hoʻokaʻawale i nā momona i ke kino ke hoʻoikaika a hoʻoulu i ke ʻano o ka hana ʻana o ka protein.
Hoʻomaka ka hana a ka lāʻau lapaʻau ma 10-20 mau minuke, a ʻo kona ʻike nui loa i ke koko ka mea i ʻike ʻia ma hope o nā hola 1-3 (ʻo 2 kēia ka wikiwiki e hoʻohālikelike ʻia i ka hormone kanaka). Kuhi ʻia kēlā ʻano monocomponent ma lalo o ka inoa kalepa ʻo NovoRapid (ma waho aʻe o ia mea, aia kekahi ʻelua o ka ʻōhua insulin lua, kahi ʻokoʻa i kona ʻano).
ʻO ka insulin Biphasic
ʻO ka aspart insulin o ka aspart ka mea e pili like i nā hopena o ka lāʻau lapaʻau ma ke kino. ʻO ka ʻokoʻa ka loaʻa iā ia o ka insulin hana pōkole (ʻo ia hoʻi ka aspart) a me ka hormone medium-acting (protamine-insulin aspart). ʻO ka hoʻohālikelike o kēia mau insulins i ka lāʻau lapaʻau e like me kēia: 30% he wikiwiki wikiwiki ka lāʻau a ʻo 70% ka lōʻihi.
Hoʻomaka maoli ka hopena nui o ka lāʻau i ka manawa kūpono ma hope o ka hoʻokele ʻana (i loko o 10 mau minuke), a me 70% o ke koena o ka lāʻau lapaʻau ka hoʻokumu ʻana i kahi ʻāpana o ka insulin ma lalo o ka ʻili. Hāʻawi hou ia i ka hana maʻalahi a hana i ka awelika a hiki i 24 mau hola.
Loaʻa ka lāʻau hoʻohui i lalo o ka inoa ʻo Novomix. ʻAʻohe mea kikoʻī pololei o kēia lāʻau, akā aia nā lāʻau e like me ke kumu no ka hana
Aia kekahi pūlima kahi e hui pū ai ka insulin manuahi (aspart) a me nā hormone hana lōʻihi (degludec). ʻO kāna inoa kālepa aʻo ʻo Ryzodeg. ʻO kēia lāʻau lapaʻau, e like me kekahi insulin like like like, hiki ke lawelawe ʻia i ka subcutaneously, e hoʻololi pinepine ʻia i ka wahi no nā inikini (i mea e pale ai i ka hoʻomohala ʻana o ka lipodystrophy). ʻO ka lōʻihi o ka hana o ka lāʻau lapaʻau ma ka lua o ke kau a hiki i 2 a 3 lā.
Inā pinepine ka mea maʻi e kau i nā ʻano o ka hormone like ʻole, a laila paha ke ʻoi aku i mua o ka hoʻohana ʻana i ka lua o ka laʻi a me ke kīpona. Hoʻemi kēia i ka nui o nā injections a kōkua i ka mālama pono ʻana i ka glycemia. Akā hiki i ka endocrinologist ke koho i ka hopena kūpono e pili ana i nā hopena o nā noiʻi a me ka ʻike hōʻike hoʻoweliweli.
Loaʻa a me nā ponoʻole
ʻO ka neʻe i ka aspart (biphasic a me hoʻokahi-phase) he ʻokoʻa i ka insanie kanaka maʻamau. I kekahi kūlana, ua hoʻololi ʻia ka prolama acid amino i loko me ia me ka aspartic acid (ʻike ʻia ʻo ka aspartate). Hoʻomaikaʻi wale kēia i nā waiwai o ka hormone a ʻaʻole i hoʻopilikia i kekahi me ke ahonui maikaʻi, ka hana a me ka allergenicity haʻahaʻa. Mahalo i kēia hoʻololi, hoʻomaka kēia lāʻau lapaʻau e hana wikiwiki ma mua o kāna mau kikowaena.
ʻO nā nāʻino ʻole o ka lāʻau lapaʻau me kēia ʻano insulin, hiki nō ke hoʻomaopopo, ʻoiai ʻaʻole hiki ke ʻike, akā he mau hopena paha.
Hiki iā lākou ke hōʻike iā lākou iho ma ke ʻano o:
- ka ʻāʻī a me ka ʻeha ma ke kahua hōʻola;
- paluanaluhi;
- nā pulu ʻili;
- maloʻo maloʻo;
- he hopena kūlohelohe.
Hiki ke lawelawe ʻia kēia insulin (one-kompon) ʻaʻole i ka subcutaneously wale nō, akā komo pū kekahi. Akā e hana wale kēia ma nā limahana lapaʻau i hiki i ke keʻena haukapila
Nā Hoʻohui
Nā 'ano no ka inika insulin + papaʻO nā hoʻohālikelike me ka hoʻohana o ka lāʻau lapaʻau ka intolerance kanaka, kūlohelohe a me nā haʻahaʻa koko haʻahaʻa (hypoglycemia). ʻAʻohe paʻa i nā loiloi e pili ana i ka hoʻohana ʻana o kēia insulin i ka wā hāpai a me ka lactation. Ua hōʻike ʻia nā hoʻokolohua holoholona preclinical ma nā dosis i ʻaʻole iʻoi aku ma mua o ka mea i ʻōlelo ʻia, ua pā ka lāʻau i ke kino ma ke ʻano like me ka insulin kanaka maʻamau.
I ka manawa like, a ʻoi aku ka nui o nā lawelawe hoʻokele ma mua o ka 4-8 mau manawa i loko o nā holoholona, ʻike ʻia nā kuhi hewa i ka wā mua, ka hoʻomohala ʻana o nā malenial congenital i loko o nā keiki a me nā pilikia e pili ana i ka hopena o ka hāpai ʻana.
ʻAʻole ʻike ʻia inā komo kēia lāʻau i ka waiū umauma, no laila ʻaʻole ʻia he wahine no nā umauma umauma i ka wā e mālama ai. Inā makemake ka mea maʻi i ka wā hāpai e inikini i ka insulin, a laila koho mau ʻia ka lāʻau lapaʻau mai ka hoʻohālikelike ʻana i nā pōmaikaʻi o ka makuahine a me ka loaʻa ʻana o nā kīpē.
Ma ke ʻano he kānāwai, i ka hoʻomaka ʻana o ka wā hāpai, pono ka hoʻēmi ʻana i ka insulin, a i loko o ka lua a me ke kolu o ka trimester, he hana hou ʻia ka lāʻau lapaʻau. Me ka maʻi maʻi gestational, ʻaʻole hoʻohana ʻia kēia mea hana. I kekahi hihia, ʻaʻole he endocrinologist wale nō, akā he mea pūpikiʻo obstetrician-gynecologist e kuhikuhi i kahi lāʻau lapaʻau like i ka wahine hāpai.
ʻO kēia ʻano hana o ka hormone i ka hapanui o nā maʻi he hoʻomanawanui ʻē aʻe nā maʻi e nā maʻi, a ʻoi paha ka hopena o nā ʻaoʻao mai kona hoʻohana ʻana.
Nui ʻano lāʻau me nā inoa kālepa like ʻole e pili ana iā ʻoe e koho i ke kaha ʻoi loa o ka injection no kēlā me kēia maʻi maʻi pākahi. Ke mālama pono nei i kēia lāʻau lapaʻau, pono e nānā i nā regimen i ʻōlelo ʻia e ke kauka a ʻaʻole poina e pili ana i ka mea ʻai, hoʻomaʻamaʻa a me ke ʻano kino.
