ʻAʻole i palena iki ka nui o nā lāʻau lapaʻau i hoʻohana ʻia i ka maʻi diabetes no ka lōʻihi.
Hāʻawi ʻo Pharmacology i kēia lā i kahi pālahalaha nui e kōkua i ka hoʻohaʻahaʻa o ke kō i ka diabetes type 2. ʻO kahi ʻāpana nui o lākou he synthesized art artially, as Pioglitazone (Pioglitazone).
Hōʻike, hoʻokuʻu i ke ʻano
Ke hele nei ka lāʻau lapaʻau i kūʻai ʻia i loko o nā pahu pahu pepa o nā papa 3 a i ʻole he 10 paha, aia i nā papa he ʻumikūmālua o kahi ʻaoʻao e puni ana a me ke keʻokeʻo. Hiki ke kau ʻia ka mea ola i loko o lākou me ka paʻa o 15, 30 a 45 mau mg.
ʻO ka waihona kumu o ka lāʻau, ka pioglitazone hydrochloride, e hōʻemi ana i ka hoʻowalewale ʻana o ka ate a me nā ʻōpala i ka hana o ka hormone, ma muli o ka nui o ka hōʻila o ka glucose, e māhuahua, a me ka hoʻoneʻe ʻana i ka ate i ka hōʻemi.
Ma kahi o ke kolamu nui, loaʻa pū kekahi mau māhele hou:
- lactose monohala;
- magnesium stearate;
- hydroxypropyl cellulose;
- kalepuleta carboxymethyl cellulose.
Ka hana lāʻau lapaʻau
ʻO Pioglitazone e pili ana i nā huila hypoglycemic waha e pili ana i ka thiazolidindine. Hoʻopili ʻia ka mea i ke kaohi o ke koko a me ka mololi metabolism. ʻO ka hōʻemi ʻana i ka pale o ke kino a me nā kao o ka ʻōpū i ka insulin, e alakaʻi ana i ka hoʻonui ʻana o ka lilo o ka glucose i hilinaʻi i ka insulin a me kahi hoʻemi ʻana i nā mea hoʻihoʻi mai ka ate.
Eia naʻe, ʻaʻole ia e hoʻolaha i ka hoʻoulu hou ʻana o nā β-cell o ka pancreas, kahi e mālama ai iā lākou mai ka wā wikiwiki. ʻO ka hopena o ka lāʻau i ka maʻi type 2 e alakaʻi i kahi kahe o ke koko o ka glucose a me ka hemoglobin glycosylated. Hiki i ka huahana ke hoʻohana wale ʻia a i ʻole me ka hoʻohui pū ʻana me nā lāʻau lapaʻau haʻahaʻa.
Ke kōkua nei ka hoʻohana ʻana i ka lāʻau lapaʻau e hoʻomaʻamaʻa i ka hana lipid metabolism, ke alakaʻi nei i ka hōʻemi o nā pae a me ka hoʻonui o HDL me ka hoʻopiʻi ʻole ʻana i ka kolamu a me LDL.
Lapaʻau lāʻau
ʻO ka hoʻopili ʻana o ka lāʻau ka mea i loko o ka nenehana digestive, me kēia hana e wikiwiki koke nei, e ʻae ana iā ʻoe e ʻike i nā mea ikaika i loko o ke koko i ka hapalua hola ma hope o ka lawe ʻana i ka lāʻau. ʻElua mau hola ma hope mai, ʻoi aku kona kiʻekiʻe ma mua o 80 pakeneka. Kūleʻa kaʻai me ka meaʻai i ke kaʻina o ka heo ʻana.
Hōʻike ʻia ka hopena o ka lāʻau i loko o ka pule mua o ka hoʻokomo maʻamau. ʻO ka hōʻiliʻili o nā mea lapaʻau i loko o ke kino e kū ʻole ʻia, ma hope o kahi lā a pau ia i ka hoʻopā ʻia ʻana ma o ka ʻāpana ʻana o ka kūnaehana a me ka lolo.
Nā hōʻailona a me nā contraindications
Kuhi ʻia ʻo Pioglitazone e like me ke ʻano o ka kaohi ʻana i ka maʻi diabetes 2 ʻano. Hiki ke hoʻohana ia e like me ka lāʻau hoʻokahi, ʻo ia ka mea i hōʻike pinepine ʻia i ka poʻe maʻi maʻi pākaha i keu nui ʻia a i ʻole iā contformicated ka mea ʻo Metformin.
ʻOi aku ka ikaika, hoʻohana ʻia ka lāʻau lapaʻau i loko o ka ʻoihana paʻakikī i nā hana e hiki mai nei.
- hui pū ʻia me nā lāʻau metformin a i ʻole sulfonylurea lāʻau;
- triple hui pū me nā hui ʻelua o nā lāʻau
E like me nā contraindications:
- ka huhū nui loa i nā mea āpau o ka lāʻau;
- ka mōʻaukala o nā ala cardiovascular;
- uha kapili āpau;
- maʻi mellitus type 1;
- diabetes ketoacidosis;
- ka hele mai o nā maʻi maʻa;
- ka loaʻa ʻana o ka hemro macroscopic o ka kumu maopopo ʻole.
I kēia mau hihia, ua hoʻololi ʻia ka lāʻau lapaʻau me nā analogue e loaʻa kahi ʻano like a me ka hana o ka hana.
Nā ʻōkuhi no ka hoʻohana
Hoʻonohonoho ʻia ka nui o ka lāʻau no kēlā me kēia maʻi pākahi. ʻO kēia ka hana o ke kauka, ka mea ma hope o ka maʻi maʻi, ke loiloi i ka pae o ka hōʻino o ka mea maʻi a hoʻomohala i kahi hoʻoponopono lapaʻau.
Wahi a nā ʻōlelo kuhikuhi, lawe ʻia ka lāʻau i hoʻokahi manawa i ka lā hoʻokahi, me ka ʻike ʻole ʻana o ka meaʻai. Akā, ʻoi aku ka maikaʻi o kēia hana i ke kakahiaka.
Hoʻolaha ʻia ka inapo hoʻomaka i ka 15-30 mg, hiki iā ia ke hoʻonui pinepine i 45 mg a me ka ʻaki ʻana, ʻo ia ke ʻano nui loa.
I ka hihia o ka hui pū ʻana me nā lāʻau lapaʻau hypoglycemic ʻē aʻe, e kau ʻia ana kahi nui o 30 a i kēlā me kēia lā, akā hiki ke hoʻoponopono ʻia e pili ana i ka heluhelu ʻana o ka glucometer a me ke ʻano o ka mea maʻi.
He mea nui loa ia e koho i ke kūpono kūpono i ka wā i lawe ʻia me ka insulin. Ma ke kānāwai, ua kuhikuhi ʻia ma 30 mg i kēlā me kēia lā, ʻoiai e hoʻemi ʻia ka nui o ka insulin.
E nānā ʻia ka hopena o ka ʻoihana i kēlā me kēia mahina ʻekolu ma o ka nānā ʻana no ka hemoglobin glycated. Inā ʻaʻohe hopena, e pau ka hoʻokipa.
ʻO nā maʻi maʻi a me nā Kuhina kūikawā
No nā poʻe kahiko, ʻaʻohe mau koi kūikawā dosage. Hoʻomaka pū kekahi me kahi liʻiliʻi, e hoʻonui mālie.
I ka wā hapai, ʻaʻole i ʻae ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana, ʻaʻole i maopopo loa kona hopena i ka ʻōpio, no laila ua paʻakikī ke wānana i nā hopena. I ka wā lactation, inā pono ka wahine i ka hoʻohana ʻana i kēia lāʻau lapaʻau, pono ʻo ia e hōʻole i ka hānai i ka pēpē.
ʻO nā mea maʻi me nā maʻi puʻuwai a me ka vascular e hoʻohana i ka liʻiliʻi liʻiliʻi, ʻoiai he mea pono ke nānā i ke kūlana o nā pilikia pilikia i ka wā o ka hoʻokele ʻana o Pioglitazone.
ʻO ka lawe ʻana iā Pioglitazone hiki ke hoʻonui i ka hōʻemi o ka hoʻomohala ʻana i ka maʻi kanesa i ka 0,06 pakeneka, e pili ana i ke kauka e hoʻomau i ka mea maʻi a ʻōlelo i ka hoʻemi ʻana i nā mea pilikia ʻē aʻe.
No nā poʻe maʻi me ka hikiʻole o ka puʻuwai pale, ua contraindicated ka lāʻau, a me ka hōʻemi ʻeha, hiki ke hoʻohana me ka mālama aka. I kēia hihia, pono ia e hoʻomalu i ka pae o nā enzyme o ka ate, inā ʻoi aku lākou i kēlā me kēiaʻano i ʻekolu mau manawa, ua hoʻopau ʻia ka lāʻau lapaʻau.
Video e pili ana i nā hopena o nā lāʻau lapaʻau maʻi ma ke kino:
Nā hopena ʻaoʻao a me ka overdose
ʻO ka hopena hopena nui e lawe ai i ka lāʻau lapaʻau he hypoglycemia, akā ʻike pinepine ʻia me kahi overdose a i ʻole ka hoʻohui maikaʻi ʻana me nā mea maʻi hypoglycemic ʻē aʻe. Hiki nō hoʻi ke hoʻohaʻahaʻa i ka hemoglobin a me nā anemia.
Hōʻike ʻia ka overdose o ka lāʻau i loko.
- ʻaʻai, māhuahua momona;
- hypersthesia a me ke poʻo;
- kuʻi ʻana i ka hoʻonohonoho ʻana;
- glucosuria, protenuria;
- vertigo;
- ua emi ka maikaʻi o ka hiamoe;
- erectile dysfunction;
- hoʻopōʻino i ka hana hoʻopili i ka ʻōpū o ka ʻōpū;
- ka hoʻokumu ʻana o nā tumors o nā ʻano like ʻole;
- maʻi hōʻino;
- hoʻonui mahuahua o nā ʻeha a me ka ʻike ʻana o ke ʻeha i nā lōpū.
Hoʻopili me nā lāʻau lapaʻau ʻē aʻe
Hiki i ka hoʻohanaʻana o ka pioglitazone ke hōʻemi i ka hopena o nā contraceptives.
ʻAʻole hoʻololi ka mea hana i kāna hana inā hoʻohana pū ʻia me Digoxin, Metformin, Warfarin Ifenprokumon. I ka manawa like, ʻaʻole e loli nā hiʻohiʻona. ʻO ka hoʻohana like ʻana o ka sulfonylureas me nā derivatives ʻaʻole i hoʻololi i ko lākou hiki.
ʻAʻole i ʻike ʻia ka hopena o Pioglitazone ma luna o nā hāmeʻa saluran kalima, cyclosporins, a me nā HMCA-CoA reductase inhibitors.
I ka manawa e hoʻohana pū ai me ka gemfibrozil, hoʻonui ʻia ka AUC o ka glitazone, e hoʻonui ana i ka pilina o ka manawa e pili ana i ke kumu o ʻekolu. I kēia hihia, pono ia e nānā i ke kūlana o ka mea maʻi a, inā pono, e hoʻoponopono i ka nui o ka lāʻau.
Hoʻohana like me ka rifampicin i ka hoʻonui i ka hana o ka pioglitazone.
ʻO ka hoʻomākaukau ʻana i kahi hana like
Hāʻawi ʻia nā analogs Pioglitazone ma luna o ka mākeke me ka nui o nā meaʻokoʻa.
ʻO nā mea hana e like me ka hoʻonohonoho like ʻana:
- Pioglar ʻōleʻa;
- Nā Lūkini Lūkini o Diaglitazone, Astrozone, Diab-Norm;
- Nā Papa ʻ Actlelo ʻ Actlelo;
- Kelemania hoʻomaʻemaʻe ʻo Amalvia;
- Pyoglitis;
- ʻO Piouno a me nā mea ʻē aʻe.
Aia kēia mau kālā āpau i ka hui o glitonezone hoʻomākaukau, aia pū kekahi me troglitazone a me rosiglitazone, kahi ʻano hana like ʻole, akā ʻokoʻa i ka ʻano kemika, no laila hiki ke hoʻohana ʻia inā hōʻole ʻia ka pioglitazone e ke kino. Loaʻa iā lākou kekahi pono ponoʻī a me nā mea e pono ai, i hiki ke loaʻa i nā ʻōlelo i nā lāʻau lapaʻau.
Eia kekahi, nā analogues e loaʻa i kahi waihona ʻokoʻa e hiki ke lawelawe me nā analogues: Glucofage, Siofor, Bagomet, NovoFormin.
He mea pono ia e like me nā ʻokoʻa o nā loiloi o nā poʻe maʻi i hoʻohana iā Pioglitazone a me kāna mau ʻano. No laila, e pili ana i ka lāʻau lapaʻau ponoʻī, pane nā mea maʻi i ka maikaʻi loa, e loaʻa ana i nā mea liʻiliʻi loa.
Hoʻomaʻamaʻa pinepine ʻia nā ʻike analogues e nā hopena maikaʻi ʻole, e like me ka paona ʻana, edema, a me ka hoʻolilo ʻana i nā pae hemoglobin.
E like me ka hōʻike ʻana, hōʻike pono ka lāʻau lapaʻau i ka hōʻemi o nā pae gula a hiki ke hoʻohana maikaʻi ʻia i ka mālama ʻana i ka maʻi diabetes 2 ʻano. Eia nō naʻe, he mea nui e koho i ke ʻano kūpono o ka lāʻau lapaʻau a me keʻano.
ʻO nā kumukūʻai maoli
Mai ka hiki ke hoʻolauna ʻia ka hāmeʻa ma lalo o nā inoa like ʻole, e pili ana i ka mea hana, ʻano nui ka nui o kāna kumukūʻai. Kuhi o Pioglitazone i loko o nā lāʻau lapaʻau ʻokoʻa i kona ʻano maʻa he pilikia, hana ʻia ma ke ʻano o ka lāʻau me nā inoa ʻē aʻe. Loaʻa ʻia ma lalo o ka inoa ʻo Pioglitazone Asset, ke kumukūʻai o ke ana ma ke ʻano o 45 mg ka 2 mano rubles.
Ma ke pioglar e kūʻai ʻo 600 a me kekahi mau rubles no 30 mau papa me ka nui o ka 15 mg a me ka liʻiliʻi o ke kumukūʻai ma mua o hoʻokahi kaukani no ka huina like me ka nui o ka 30 mg.
ʻO ke kumukūʻai o Aktos, ma nā ʻōlelo i kuhikuhi ʻia i kēia mau ʻano ikaika like, ka helu mai 800 a me 3000 rubles.
E kūʻai aku ʻo Amalvia i ka 900 rubles no kahi laʻa o 30 mg, a me Diaglitazone - mai 300 mau rubles no kahi maʻi o 15 mg.
ʻO ka holomua lāʻau lapaʻau hou e hiki i ka mea e hiki ai ke loaʻa i nā hopena i ʻoi aku ka nui o ka nānā ʻana a me ka hoʻoponopono ʻana i ke kō. ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau hou e hiki ke hoʻokō me kēia a me ka maikaʻi, ʻoiai ʻaʻole lākou me ka loaʻa ʻole o ka drawback, kahi āu e ʻike pono ai ma mua o ka hoʻomaka ʻana o ka lāʻau lapaʻau.
