Hoʻokomo ʻia ka Therapy no ke ʻano type mellitus type 2 ʻaʻole wale ma luna o ka meaʻai kūikawā, akā aia nō hoʻi i ka waiwai o ka waiwai o nā huahana synthet i kūpono no ka maʻi.
Pono lākou e hoʻokō pono i nā helu glycemia maʻamau.
I waena o nā lāʻau lapaʻau he nui i hāʻawi ʻia e ka mākeke lāʻau lapaʻau, kuhikuhi pinepine nā poʻe maʻi i nā papa Glibomet.
ʻO ka ʻike nui e pili ana i ka lāʻau lapaʻau, hoʻokuʻu i ke ʻano a me ka ʻano
ʻO Glibomet nā kuleana o ka lāʻau hypoglycemic i lawe ʻia ma ke alo. Ke hana ʻia ka lāʻau lapaʻau e ka hui Kelemania ʻo BERLIN-CHEMIE / MENARINI. ʻOkoʻa ʻo Glibomet ma Rūsia, ʻoi aku ka 100 o nā lāʻau lapaʻau o kēia ʻoihana ke kākau inoa ʻia, ka mea i hoʻohana nui ʻia i ka mālama ʻana i nā maʻi he nui a ua hoʻokele ʻia i loaʻa i ka hilinaʻi o nā maʻi.
Kele ʻia ka lāʻau lapaʻau i ke ʻano o nā papa i pani ʻia me ka ʻulaʻula keʻokeʻo. Loaʻa iā lākou āpau i 2 mau hiʻohiʻona ikaika a me nā huina o nā mea kōkua.
Aia ka papa o ka lāʻau lapaʻau:
- ʻO Glibenclamide (2.5 mg) a me Metformin Hydrochloride (400 mg) nā mea nui;
- pākaʻi palaoa (57) mg;
- cellulose (kanu polysaccharide) - 65 mg;
- silicon dioxide (ka meaʻai hoʻohui E551) - 20 mg;
- gelatin - 40 mg;
- Glycerol - 17.5 mg;
- talc (maina) - 15 mg;
- Diethyl phthalate (0.5 mg) a me 2 mg Acetylphthalyl cellulose - aia i loko o kaʻili o nā papa.
Hiki i ka pōkole ke 40, 60 a 100 mau papa.
Pharmacology a me ka pharmacokinetics
Mahalo i nā mea i loaʻa i loko o ka hoʻomākaukau, hōʻemi ka lāʻau lapaʻau i ka hōʻailona glucose i loko o ke koko o ka mea maʻi.
ʻO ka hana lāʻau lapaʻau o ka waiwai Glibenclamide:
- Hoʻonui i ka ʻili o ka insulin, a hoʻonui hoʻi i ka hoʻokuʻu i ka hormone;
- Hoʻonui ka hoʻonui ʻana i ka hiki i ka insulin i loko o ke kino;
- hoʻonui i ka hopena o ka insulin ma ka glucose;
- hoʻololo i ke kaʻina o ke lipolysis.
Kūmole hana ia Metformin:
- kōkua i ka hoʻonui ʻana i ka naʻau o ka insulin, a hoʻomaikaʻi pū i kona hopena;
- hoʻohaʻahaʻa i ke komo ʻana o nā glucose i loko o ka ʻōpū, hoʻomaikaʻi i kona komo ʻana e nā kino ʻē aʻe;
- e hāʻawi i ka kaohi ʻana o gluconeogenesis;
- pili pono i ka lipid metabolism, ke alakaʻi i ka kaumaha.
Hiki ke hoʻokō i ka hōʻemi i ka glycemia ma hope o kahi pōpoki ma hope o 2 mau hola a mālama i nā hola 12.
Hoʻohālikelike ka hopena o ka lāʻau pharmacological o nā hiʻohiʻona e nā hiʻohiʻona o ka maʻa, hoʻoulu, ka hoʻokūkū a me ka hoʻōho o nā mea nui.
Hoʻolālā:
- Ke kaʻina a me ka hoʻoili ʻana. ʻO ka piʻi lōʻihi loa o ka waihona hiki i ka mau hola 2 ma hope o ka hoʻokele ʻana. Hoʻololi koke ka māhele mai ka digestive tract (gastrointestinal tract). ʻO ka pilina o nā mea me nā protein plasma e loaʻa i ka 97%.
- ʻO ka metabolabol ka hopena e kokoke loa i ka palupalu.
- ʻAno hānau. Hana ʻia nā hana hana e kēia mau keiki. Lawe ʻia ka ʻoihana a pau me ka ʻoi a me ka bile ma o ka urine. ʻO ka hoʻopau hoʻopau hapa-ola e lawe 10 hola.
Metformin:
- ʻO ka hoʻopili a me ka hoʻonui ʻana i nā ʻili o ka māhele e hele wikiwiki a maʻalahi.
- ʻO ka excretion o ka māhele mai ke kino e loli ma o nā ʻōpū a me nā puʻu. ʻO ka pau hoʻopau hapa-ola e 7 hola.
Nā hōʻailona a me nā contraindications no ke hoʻohana
Hoʻomaopopo ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana me ka maʻi diabetes type 2, i ka wā eʻai ai a me ka lāʻau ʻana me nā lāʻau ʻē aʻe he mea ʻole ʻole.
Nā pālua:
- hypersensitivity o kekahi o nā lāʻau o ka lāʻau;
- maʻi type type 1;
- gestational puka o ka maʻi diabetes;
- lactic acidosis;
- ketoacidosis;
- coma (hypoglycemic a hyperglycemic);
- pilikia hooili;
- kalawai o ka pūpū, nā pēpē;
- gangrene
- ka heleʻana o nā maʻi lēʻeha;
- interventable kaʻaila, hele pū ʻia me ka pohō nui o ke koko;
- nā ʻeha a puhi paha;
- kekahi mau koi e koi ana i ka hoʻohana ʻana o ka hana insulin;
- leukopenia;
- porphyria;
- nā loli dystrophic;
- mai ka waiʻona make;
- wā hōʻeha;
- keiki, opio malalo o 18 makahiki;
- hapai
Nā ʻōkuhi no ka hoʻohana a me nā ʻōlelo aʻoaʻo kūikawā
Lawe ʻia nā papa papa me ka ʻai. Pono e koho ʻia ka nui o ka lāʻau e ke kauka, i ke ʻano o ke kaʻina o ka pakanā o nā kalapona a me ke glycemia i ka mea maʻi.
Hoʻomaka pinepine ka lāʻau lapaʻau i ka papa hoʻokahi. Aia ma muli o nā hopena o ka lapaʻau, ʻokoʻa paha ke ʻano. ʻO ka nui o nā papa i ʻae ʻia i kēlā me kēia lā he 6, no ka mea he pilikia ia e lawe iā lākou ma kahi kiʻekiʻe kiʻekiʻe. Hoʻoholo ʻia ka maikaʻi o ka regimen mālama i koho ʻia e ka waiwai glucose i loaʻa.
He mea nui ia i nā poʻe maʻi e pili i nā ʻōlelo aʻo a ke kauka e pili ana i ka meaʻai, ke ʻano o ka hoʻokele ʻana a me ka nui o ka lāʻau. Me ka maʻi decompensated, ka pōloli, ka inu ʻawaʻawa, ka nui o ka hana o ka ʻōpū, a me nā mea hōʻike ʻē aʻe o ka hypoxia, pono e mālama ʻia nā papa me ka mālama nui ma muli o ka loaʻa ʻana o ka waʻawa lactic acidosis. ʻO kēia ke kumu o ka hōʻiliʻili o ka metformin, ma muli o ke kahi o ka lactate e ʻike i ke koko.
ʻO ka ʻaeʻana i nā kālā e pili ana i ka hana kauoha mai nā hoʻokaʻina koko no ka mea hana:
- Hoʻokahi makahiki i ka hana o ka hana maʻamau (i nā maʻi me ka maʻi o ka maʻi maʻi);
- ʻoi aku ka nui ma mua o 2 mau manawa i kēlā me ka poʻe me HBV (congenital adrenal hyperplasia) a i nā maʻi maʻi ʻelemakule paha.
Nā ʻōlelo kikoʻī:
- hoʻohana me ka akahele me ka diuretics;
- Mai lawe i ka lāʻau lapaʻau i ʻelua mau lā ma mua o ka hoʻokolokolo ʻana a X-ray a i ʻole nā hoʻohana ʻana me ka hoʻohana ʻana i ka anesthesia, e pani ʻia me ka insulin a me nā lāʻau ʻē aʻe;
- hoʻomau hou i ka hana ma hope o 48 mau hola mai ka manawa o kahi paʻa ʻana ma lalo o ke ʻano o ka hana maʻamau o nā pēpē.
- mai lawe i ka wai ʻawa me ka lāʻau lapaʻau i mea e pale ai i ka hypoglycemia a i ʻole ka hopena i nā ʻano ʻano like ʻole i kūleo i ka papa o ke ʻano inu ʻona;
- ʻO ka lāʻau lapaʻau e hōʻemi i ka helu o nā hopena psychomotor, hiki i ka mea ke hoʻopilikia i ka hoʻokele.
ʻO ka maʻi maʻamau ʻo mellitus kekahi o nā maʻi i loaʻa i ka mea maʻi. Ma mua o nā ala'ē aʻe, he mea nui ka lawe i ka lāʻau lapaʻau me ka mālama nui.
He hui kūikawā o nā maʻi:
- hāpai a ʻeha paha lactating makuahine (ua hoʻohālikelike ʻia ka lāʻau);
- nā mea maʻi me ka hana aho lēwa (e pāpā ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana);
- nā poʻe me nā pilikia o ke keiki (me ka hana mai 135 mmol / l i nā kāne a ma luna o 100 mmol / l i loko o nā wahine, ua pāpā ʻia ka lāʻau lapaʻau).
ʻAʻole ʻōlelo ʻia ka lāʻau lapaʻau e hoʻohana ʻia e nā mea maʻi ma mua o 60 mau makahiki o ka makahiki, mai ka mea a lākou e hana ai i ka hana kino kino, hiki iā lākou ke hoʻomohala i ka acidosis lactic
Nā hopena ʻaoʻao a me ka overdose
ʻO ka lawe ʻana i ka lāʻau lapaʻau hiki ke kumu i ka hopena ʻino:
- e pili ana i ka hoʻowalewale ʻana - i ka hoʻouka ʻana o ka ʻuwaa a me ka luaʻi ʻana, nalowale a i ʻole ka pau ʻana o ka momona, ʻeha kūwaho;
- mai ka ʻōnaehana uila - leukopenia, a me nā anemia a me pancytopenia;
- e pili ana i ka palupalu, pilikia o ke poʻo;
- itching, urticaria, erythema;
- hypoglycemia aiʻole lactic acidosis;
- palpitations puʻuwai.
Me kahi overdose o ka lāʻau lapaʻau, ʻike maikaʻi ka maikaʻi o ka mea maʻi, ulu ka hypoglycemia. I kēia hihia, pono ʻoe e ʻai i ka momona. ʻO ka holomua o hypoglycemia hiki i ka nalowale o ka pale pono ʻana a me ka ʻike. I kēia kūlana, ʻaʻole hiki i ka mea maʻi ke ʻai, no laila, e noi ʻia ka glucose me ka intravenous.
Hoʻopili pū kekahi me nā lāʻau lapaʻau a me nā hōʻailona
Hoʻohui ʻia ka hopena hypoglycemic o ka lāʻau ma lalo o ka mana o nā mea pena e like me:
- Hōʻailona i nā kāne dermarin;
- Salicylates;
- Nā MAO inhibitors;
- nā kumuhana phenylbutazone;
- Sulfonamides;
- Miconazole;
- Feniramidol;
- Ethanol
No ka hōʻemi ʻana i ka hopena o ka hoʻohana ʻana i ka lāʻau lapaʻau e pili ana i ka:
- Kūkākūkā
- Thaizide diuretics;
- ʻāpā aelike (waha);
- nā hormones e mālama i ka lau thyroid gland;
- ʻAhakaline.
Inā ʻaʻole i kūpono ʻo Glibomet no kekahi mau kumu, aia ka nui o nā mea hoʻohālikelike, ʻokoʻa i ka hoʻonohonoho ʻana a me nā kumukūʻai.
ʻO nā mea nui:
- Kalepui Met;
- ʻO Glimecomb;
- Avandaglim;
- Janumet;
- Avandamet;
- ʻO Combogliz.
He mea nui ia e hoʻomaopopo he kauka wale nō e hana i kahi hoʻoholo e pili ana i ka loli ʻana o Glibomet me nā lāʻau ʻē aʻe.
He wikiō ma ke ʻano e hoʻemi ai i ke kō koko koko ma ka home:
ʻO nā manaʻo hoʻomanawanui a me nā kumukūʻai lāʻau lapaʻau
Mai nā loiloi o nā mea maʻi, hiki ke hoʻoholo ʻia e lālau ʻia ka lāʻau lapaʻau me ka akahele, no ka mea, ua nui ka hopena o ka ʻaoʻao, pono nō hoʻi e nīnau i kahi loea ma mua o ka lawe ʻana i ka lāʻau.
Ua hoʻomaka wau e lawe i ka lāʻau lapaʻau e like me ka mea i kuhikuhi ʻia e ke kauka. I ka lā mua o ke mālama ʻana, ua ʻelua ia i nā hōʻailona o ka hypoglycemia, ʻoiai ʻaʻole i loli kāna kīʻaha. ʻAʻole hiki iaʻu ke hele koke i ke kauka, no laila ua hoʻoholo pilikino au ʻaʻole e hoʻāʻo hou i ka hana hou ʻana a hoʻi i ka lawe ʻana i nā lāʻau o mua.
Svetlana, 33 makahiki
Ua ʻoluʻolu loa wau iā Glibomet. Me kona kōkua, hiki i ka hoʻokohala i ka pae o ke kō. Ma hope o ka heluhelu ʻana i nā ʻōkuhi, i ka manawa mua ua makaʻu ʻo ia i ka papa inoa nui o nā hopena ʻoli, akā hoʻoholo ia e hilinaʻi i ke kauka. Ua ʻoluʻolu ka hopena.
Egor, 46 mau makahiki
I ka makahiki i hala ua lawe wau i kēia mau pala. ʻAʻole kūpono kēia lāʻau lapaʻau iaʻu, no ka mea, ua kūlohelohe ka mea metallic i loko o koʻu waha i ka manawa a pau a i kekahi manawa he lago wau.
Nikita Alexandrovich, 65 makahiki
Hōʻemi ka mea momona i ke kō, akā i ka wā o kona komo ʻana, ʻaʻole hiki iā ʻoe ke hele i kahi kīmaki, ʻaʻole like me nā kīʻaha nui. Makemake ʻo Glybomet i kahi meaʻai maʻamau no ka mea ʻaʻohe hypoglycemia.
Irina, 48 makahiki
ʻO ke kumu o ka lāʻau lapaʻau e like me 350 rubles no 40 mau papa.
