Gentadueto kekahi o nā lāʻau lapaʻau e hoʻohana ʻia ai no ka mālama ʻana i ka maʻi maʻi. Loaʻa ia i kahi hopena hypoglycemic mau a hiki iā ʻoe ke mālama i kahi pae glucose maʻamau no ka manawa lōʻihi o ka manawa.
Inoa Kūʻai ʻole honua
INN: Linagliptin + Metformil
Gentadueto kekahi o nā lāʻau lapaʻau e hoʻohana ʻia ai no ka mālama ʻana i ka maʻi maʻi.
ATX
A10BD11
E hoʻokuʻu i nā palapala a me ka ʻano
Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa kiʻi ʻoniʻoni. ʻO ka mea hana nui: linagliptin 2,5 mg a me metformin hydrochloride i loko o kahi waihona o 500, 850 a i ʻole 1000 mg. Ua hōʻike ʻia nā mea ʻē aʻe: arginine, mais starch, copovidone, silicon dioxide, magnesium stearate. Hoʻokumu ʻia ka membrane kiʻiʻoniʻoni e ka titanium dioxide, ka melemele a me ka ʻulaʻula o ka hao, propylene glycol, hypromellose, talc.
Nā Kūlana 2.5 + 500 mg: biconvex, oval, i kālai ʻia me kahi kiʻi o kaʻula ʻula. Ma ka lima ʻē aʻe ua loaʻa i ka kahakaha ʻana o ka mea hana, a ma ka ʻaoʻao ʻē aʻe kahi kākau "D2 / 500".
ʻO nā papa he 2,5 + 850 mg like a like, hoʻokahi wale nō ke kala o ke kapa kiʻi ʻulaʻula māmā, a me nā papa o 2,5 + 1000 mg ke kala o ka pink pink shell.
Ka hana lāʻau lapaʻau
ʻO Linagliptin kahi mea pale i ka hoʻoliʻi o ka huina DPP-4. Hoʻōlele ʻo ia i ka incretins a me kahi glucose-e hilinaʻi i ka insulinotropic polypeptide. Hoʻokomo ka incretins i ka mālama ʻana i nā pae glucose koko maʻamau. Hoʻohālikelike ka mea hana i nā pūnaehana a hoʻonui i ka ʻike o incretins. Hoʻopili ʻia ka hiʻona ʻana o ka glucose Glucose, a ua emi ka hoʻokaʻawale ʻana o glucose, e hoʻomaʻamaʻa i ka waiwai o ka glucose.
ʻO kahi metformin kahi biguanide. He hopena hoʻomanawanui. ʻO ka emiʻana o ke kaohiʻana o ka plasma. I kēia hihia, ʻaʻole hoʻoikaika ʻia ka hana ʻana i ka insulin, no laila e ulu wale ka hypoglycemia i nā hihia loaʻa ʻole wale aku. Hoʻemi ʻia ka synthesis o ka naʻau ma muli o ke kaohi ʻana o ka glycogenesis a me nā gluconeogenesis. Ma muli o ka hoʻonui nui o ka insulin o ka ʻenehana helehelena, ʻoi aku ka maikaʻi o ka hoʻohana ʻana i nā glucose e nā hanana.
Hoʻomoe ka Metformin i ka synthesis glycogen i loko o nā hale.
Hoʻomoe ka Metformin i ka synthesis glycogen i loko o nā hale. Loaʻa iā ia ka hopena maikaʻi o nā hana lipid metabolism. Hoʻemi i ke kūlike o ka cholesterol a me ka triglycerides i ke koko. ʻO ka hoʻohana ʻana o ka linagliptin me ka derivatives sulfonylurea a me ka metformin e hōʻemi ana i ka HbA1c (e ka 0.62% hoʻohālikelike ʻia me ka placebo; ʻo ka HbA1c mua ʻo 8.14%).
Lapaʻau lāʻau
Hoʻopuka koke ʻia nā mea ikaika mai ka pale ʻana. Hoʻopili ʻia nā ʻāpana a me nā wili. ʻO ka bioavailability a me ka hiki ke hoʻopili i nā paena o ka protein he haʻahaʻa loa. Hele mai ka hana ma hope o ka filalation renal i loli nui ʻole.
Nā hōʻailona no ka hoʻohana ʻana
ʻO nā hōʻike kuhikuhi no ka hoʻohana ʻana i kēia lāʻau lapaʻau ka:
- ka mālama ʻana i ka maʻi mellitus type 2 i nā mea maʻi me ka mana glycemic kakaho me ka nui o ka nui o ka metformin;
- hui pū me nā lāʻau ʻē aʻe a me ka insulin i ka pākeke me ka pathology maʻi, inā ʻaʻole ka hāʻawi ʻana o ka metformin a me kēia mau lāʻau i ka mana glycemic control;
- ka maʻi o ka poʻe i lawe mua i ka metformin a me linagliptin i hoʻokaʻawale.
ʻO kahi hōʻike maʻamau no ka hoʻohana ʻana i kēia lāʻau lapaʻau ka mālama ʻana i nā maʻi diabetes type 2 i ka poʻe maʻi me ka ʻike glycemic hikiʻole me ka nui o ka nui o ka metformin.
Hoʻohana ia e like me ka hoʻohui a me nā hana kino e hoʻomaikaʻi ai i ka mana glycemic i ka poʻe me nā ʻano type 2.
Nā Hoʻohui
Hōʻāpā loa ia e hoʻohana i ka lāʻau lapaʻau i ia mau ʻano:
- maʻi mellitus type 1;
- hypersensitivity i nā ʻāpana kūʻokoʻa;
- diabetes ketoacidosis;
- lactic acidosis;
- kūlana o ke comic maʻiʻai;
- pilikia hōʻeha;
- nā maʻi e hoʻonāukiuki i ka hypoxia kūloko: decompensation o ka hapa ʻole o ka puʻuwai puʻuwai, pōkole o ka hanu, hōʻeha puʻuwai puʻuwai;
- pūpū hema;
- inu pia.
Me ka mālama pono
Pono e mālama pono i nā maʻi āpau ma mua o 80 mau makahiki.
Pehea e lawe ai iā Gentadueto?
Kuhi ʻia ka lāʻau lapaʻau no ka mālama ʻana ma ka waha. I mea e hōʻemi ai i ke ʻano o nā hopena i makemake ʻole ʻia, e noi ʻia nā papa e lawe ʻia me nā meaʻai.
Hoʻohana ʻia i ka maʻi maʻi
ʻO ka lā helu o kēlā me kēia lā he 2.5 mg + 500 mg, 2.5 mg + 850 mg a i ʻole 2.5 mg + 1000 mg. E inu ʻelua i nā papa i kēlā me kēia lā. Hoʻoholo ʻia ka makeʻe i ke ʻano o ka hōʻeha ʻana i nā maʻi lapaʻau o ka maʻi a me ka hiki ʻana o kēlā me kēia mau mea ikaika i ke kino. ʻAʻole pono e kiʻekiʻe loa ka nui o ka nui ma kēlā me kēia lā ma mua o 5 mg + 2000 mg.
Hoʻomaʻomaʻo ʻaoʻao ʻaoʻao Gentadueto
ʻO ka manawa pinepine, me ka hoʻohana pū ʻana o ka metformin me ka linagliptin, hele mai nā maʻi hānō. Ke lawe nei i ka linagliptin me metformin i hui pū me nā derivatives sulfonylurea, hele pinepine ka hypoglycemia. Hoʻoulu pū ia i ka wā e lawe ai i ka linagliptin, metformin me ka insulin.
Nā hōʻailona maʻamau o nā hōʻailona ʻino:
- nasopharyngitis;
- hui kūʻai;
- ua hōʻemi i ka momona;
- nā ninia
- ninini
- ʻili nā pehu i hui ʻia e ka ʻeha;
- hoʻonui i nā pae lipase koko;
- hypoglycemia;
- constipation
- hana aho pili ole;
- lactic acidosis;
- hoʻowahāwahā ʻaʻa;
- ʻeha ka ʻōpū.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻole pili.
Nā ʻōlelo kikoʻī
Wahi a nā noiʻi, inā e hoʻohui pū i ka lāʻau me nā derivatives o sulfonylurea, hele mai ka hopena hypoglycemic ma mua o ka hopena pletebo. ʻO ka lāʻau ponoʻī aneane ʻaʻole loa e hoʻouka i ka hypoglycemia. Inā hoʻohana pono ʻole, hiki i ka lactic acidosis ke kū mai, kahi e hoʻoweliweli ʻia i nā ola o ke kanaka.
ʻO ka hana pinepine ʻana o ka metformin i ka mālamaʻana i ka hoʻōla o ka waiʻona hiki ke alakaʻi i ka hoʻomohala ʻana i ka acidosis lactic, ʻoi aku me ka pōloli lōʻihi, maln lako, a i ʻole hemahema maʻemaʻe.
Hoʻohana i ka wā kahiko
Pono ʻia ka lāʻau lapaʻau no ke kuhikuhi ʻana i nā kānaka mai 65 mau makahiki. Akā i ka manawa like, pono ʻoe e kiaʻi mau i ka hana o ka kidney, no ka mea i ka makahiki he nui, ua kiʻekiʻe nā mōʻaukala o ke kūkulu ʻana i nā ala no nā keiki, kahi o ka hoʻohana ʻana i ka metformin.
Koha i na keiki
ʻAʻole hoʻohana ʻia ka lāʻau lapaʻau ma ka hoʻomaʻamaʻa pediatric.
Hoʻohana i ka wā hāpai a me ka lactation
ʻAʻole hiki iā ʻoe ke lawe i nā pōpoki i ka wā gestational. I mea e hōʻalo ai i nā pilikia o ka hōʻino o ka maʻi hōʻiliʻili o ka intrauterine, pono ʻoe e hoʻololi i ka insulin maʻamau i ka wā hiki.
ʻAʻole lawa ka noiʻi nui pehea e wikiwiki ai ka waiwai ikaika i ka waiū umauma, akā aia kahi pilikia no ka pēpē. No laila, no ka manawa o kēlā ʻano lapaʻau ʻoihana, ʻoi aku ka maikaʻi o ka haʻalele ʻana i ka umauma.
Ke noi no ka hana renal haukapole
Me ka clearance hana kiʻekiʻe, ua hoʻohālikelike ka lāʻau. Hoʻopili ʻia kēia pili i ka hiki ʻole o ka hana renal me kahi papa maʻi.
Hoʻohana no ka hana lawelawe lēwa
I ka pīhoihoi paʻa, ʻaʻole i ʻae ʻia ka lāʻau lapaʻau, no ka mea ka mea e lawe ai i ka lāʻau lapaʻau mai ka ʻōnaehana hepatobiliary, hiki i ka maʻi hepatitis a me nā maʻi hōʻiliʻili o ke ake.
ʻO ka overdose Gentadueto
ʻAʻohe ʻikepili ma ka overdose. Ma nā hoʻokolohua lapaʻau, ʻaʻole i ʻike ʻia kahi overdose o ka linagliptin. Me kahi pākahi hoʻokahi o ka metformin, ʻaʻole i ʻike ʻia ka hypoglycemia, akā aia nā hihia o ka acidosis lactic. ʻO ka hoʻoneʻe lactic acid kahi kūlana paʻakikī e pono ai ke mālama ʻoihana i ke ʻano maʻi. Hoʻokuʻu ʻia ka Metformin e ka hemodialysis.
Hoʻopili pū me nā lāʻau ʻē aʻe
Hoʻololi hou ka hana o ka lāʻau a me nā mea hana i hoʻokaʻawale aku i kahi loli i ka pharmacokinetics o ka lāʻau. Hiki iā ʻoe ke hoʻohana i ka lāʻau lapaʻau i hui pū me Glibenclamide, Warfarin, Digoxin a me kekahi mau lāʻau lapaʻau e ʻekepona.
Hoʻohui hui like ʻole
ʻAʻole hiki iā ʻoe ke hoʻohana i ka lāʻau e hui pū me ka ritonavir, rifampicin a me kekahi mau mea hoʻohālikelike waha.
ʻAʻole hiki iā ʻoe ke hoʻohana i ka lāʻau lapaʻau i hui pū me ka ritonavir.
ʻAʻole i hāʻawi ʻia
ʻAʻole ia e hoʻohui i hoʻohui i ka lawe ʻana i nā papa me thiazolidinediones a me kekahi mau deronioma sulfonylurea, no ka mea kōkua lākou i ka hōʻemi nui o ka glucose a hoʻonāukiuki i ka glycemia.
ʻO nā hui e koi ana i ka mālama
Hoʻohana me nā lāʻau lapaʻau cationic ikaika, no ka laʻana, cimetidine. I kēlā mau kūlana, pono ia e nānā i nā hana o nā ʻōnaehana tubular renal a kiaʻi pono i ka nui o ke kala i ka plasma koko.
Hoʻolaha ka waipuna
ʻAʻole hiki iā ʻoe ke hoʻohui i ka lawe ʻana i nā peni me ka waiʻona, no ka mea hoʻemi ʻia ka hopena therapeutic, a hoʻonui ka hopena o ka lāʻau lapaʻau ma ka nū a me nā mea hoʻoweliweli.
ʻAʻole hiki iā ʻoe ke hoʻohui i ka lawe ʻana i nā peni me ka waiʻona, no ka mea hoʻemi ʻia ka hopena therapeutic.
Nā kuʻina
He nui nā mea hoʻohālike e like me kēia lāʻau lapaʻau i ka mea hoʻokahi a i ʻole nā hopena a me nā hopena therapeutic:
- Avandamet;
- Amaryl;
- Douglimax;
- Velmetia;
- Janumet;
- Vokanamet;
- ʻO Galvusmet;
- Glibomet;
- ʻO Glybophor;
- Kūkākūkā;
- Duotrol;
- Dianorm-M;
- Dibizid-M;
- Casano;
- ʻAliʻi
- Sinjardi;
- Hōʻailona.
Waihue huaʻōlelo waiho nā huaʻōlelo
Pono ke ʻano lāʻau lapaʻau e kūʻai no.
Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?
Hūnā.
He Mau Pololei
ʻAʻole loaʻa ka ʻike o ka ikepili, mai I kēia manawa ke kau nei ka lāʻau lapaʻau i kahi hōʻoia hou.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Pono e ʻimi i kahi maloʻo a pouli hoʻi, i kahi mahana ʻaʻole kiʻekiʻe aʻe ma mua o + 25 ° C.
Pono e ʻimi i kahi maloʻo a pouli hoʻi, i kahi mahana ʻaʻole kiʻekiʻe aʻe ma mua o + 25 ° C.
ʻO ka lā kau
ʻAʻole iʻoi aku ma mua o 3 mau makahiki mai ka lā i hoʻopuka ʻia ai i hōʻike ʻia ma ka pōpoki mua. Mai hoʻohana ma hope o kēia manawa.
Mea hana
ʻOihana hana: Beringer Ingelheim Pharma GmbH & Co. KG, Kelemānia.
Nā Hōʻike Polike Hou
Irina, 37 makahiki, Ivanovo
ʻO kahi lāʻau maikaʻi maikaʻi e kōkua i ka mālama i ka pae o ka kō ma ke ʻano he 12 mau hola. He kaumaha kēia i kēia manawa ʻaʻole hiki ke loaʻa iā ia i loko o nā lāʻau lapaʻau, pono e koho i nā lāʻau ʻē aʻe me ka hopena like.
Vladimir, 64 makahiki, Murmansk
Lawe au i kēia lāʻau lapaʻau i mau makahiki a hiki i kona puka ʻana. Mālama ʻia ka Sugar iā ia, ʻaʻohe ʻano hopena, kūpono ia e hoʻopuka. I kēia manawa pono wau e ʻimi i kahi hakahaka.
Yaroslav, 57 makahiki, Chelyabinsk
Ua hoʻohana i kēia lāʻau lapaʻau i ka hui pū me ka insulin. Maʻeha ka huakaʻi. Naʻu nō e hoʻololi i kahi lāʻau lapaʻau hou.
