ʻO Zaltrap kahi lāʻau antitumor i hoʻohana ʻia i ka mālama ʻana i ke kanesa colorectal cancer i nā pākeke, ke hāʻawi ʻole ʻo chemotherapy i kahi hopena therapeutic ma muli o ke pale kiʻekiʻe o ka hoʻoulu aiʻole ka hihia o kona hoʻemi.
Inoa Kūʻai ʻole honua
ZALTRAP.
ʻO Zaltrap kahi lāʻau antitumor i hoʻohana ʻia i ka mālama ʻana i ke kanesa colorectal cancer i nā pākeke.
ATX
L01XX - nā lāʻau lapaʻau antitumor.
E hoʻokuʻu i nā palapala a me ka ʻano
ʻO ka paʻa ʻana mai kahi e hoʻonā ʻia ai ka hopena o ka infusion. Loaʻa i nā pahu kiko kahi 4 ml a me 8 ml. ʻO ka nui o nā mea nui o aflibercept he 25 mg ma 1 ml. ʻO ke koho lua he ʻōnaehana sterile paʻa i hoʻomākaukau ʻia no ka hoʻokō intravenous. ʻO ke kala o ka hoʻonā a i ʻāmi ʻole a i ʻole kahi pulu ʻala.
ʻO ka mea nui ka ʻōnaehana aflibercept. Nā mea kū'ē: sodium phosphate, citric acid, hydrochloric acid, sucrose, sodium chloride, sodium hydroxide, wai.
Ka hana lāʻau lapaʻau
Laka aku ʻo Aflibercept i ka hana o nā mea nānā, ke kuleana no ka hoʻokumu ʻana i nā kīʻaha koko hou e hānai ana i ka maʻi ʻa a hoʻoiho i kona ulu ulu ʻana. Ke waiho nei me ka loaʻa ʻole o ke koko, hoʻomaka ka neoplasm e hōʻemi i ka nui. ʻO ke kaʻina o ka ulu a me ka hoʻokaʻawale o kāna mau cell atypical i pani.
Laka aku ʻo Aflibercept i ka hana o nā mea hoʻopale, e kuleana ana i ka hoʻokumu ʻana o nā moku koko hou.
Lapaʻau lāʻau
ʻAʻohe ʻikepili i ka metabolism o ka protein aflibercept. Ua like ia, e like me kekahi kīmala ʻē aʻe, ua māhele ʻia ka māhele nui o ka lāʻau lapaʻau i loko o nā waikona amino a me nā peptides. ʻO ka pau hoʻopau hapa-ola a hiki i ka 6 lā. ʻAʻole hoʻohālikelike ʻia ka prototein ma o nā keiki me ka urine.
Nā hōʻailona no ka hoʻohana ʻana
Hoʻohana ia i ka hui me ka waikawa folinic, Irinotecan a me Fluorouracil no ka chemotherapy of metastatic colorectal cancer me ka pale kūʻē kūʻokoʻa i nā lāʻau antitumor. Ua hoʻohālikelike ʻia no ka mālama ʻana i nā ʻikepili.
Nā Hoʻohui
ʻAʻole pāpā ʻia no ka hoʻohana ʻana i ka lāʻau lapaʻau i loko o ia mau hihia:
- huhū;
- hypertension o ka arterial type, i ka wā hiki ke mālama ʻia e ka lāʻau lapaʻau;
- Wili 3 a me 4 o ka paʻa naʻau paʻakikī;
- ka mea maʻi i ka hypersensitivity i nā ʻāpana ʻokoʻa o ka lāʻau;
- pilikia kaumaha ʻole.
Hoʻopau i nā makahiki - nā mea maʻi ma lalo o ka 18 mau makahiki o ka makahiki.
Me ka mālama pono
ʻO ka mālama mau ʻana i ka kūlana o ke olakino i ka poʻe maʻi me ka hōʻeha ʻole o ka pilikia, ka lāʻau hypertension arterial, maʻi o ka naʻau coronary, a me nā kumu mua o ka ulu ʻana o ka naʻau e koi. Me ka mālama aka, ua kuhikuhi ʻia ka lāʻau lapaʻau no nā mea maʻi a me kahi kūlana maikaʻi o ke olakino olakino, inā ʻaʻole iʻoi aku ka nui o ka helu ma mua o 2 mauʻaoʻao.
Pehea e lawe ai iā Zaltrap
Ka hoʻokō ʻana i loko o loko - infusion no 1 hola. ʻO ka awelika nui ka 4 mg no ka kilo o ka paona kino. Hoʻonohonohoʻia ka mālamaʻana ma ke kumu o ka hoʻoponopono regotherapeutic:
- lā mua o ka hana maʻi: infravenous infusion me kahi Y-shaped catheter e hoʻohana ana iā Irinotecan 180 mg / m² no 90 mau minuke, Kalai maloʻo Calcium no 120 mau minuke i kahiʻu o 400 mg / m² a me 400 mg / m² Fluorouracil;
- ka hala ʻana o ka infusion hope loa he 46 mau hola me kahi ala o Fluorouracil 2400 mg / m².
Ka hoʻokō ʻana i loko o loko - infusion no 1 hola.
Hoʻomaka ka pōkole i kēlā me kēia 14 lā.
Me ka maʻi diabetes
ʻAʻole pono ke hoʻoponopono ʻia.
Nā hopena ʻona o Zaltrap
ʻO nā hihia pinepine o ka pākia, proteinuria, stomatitis, dysphonia, a me nā maʻi urinary tract ua hōʻike ʻia. I nā maʻi he nui, hoʻemi ka makemake, ʻaihue nā ihu, hōʻemi ʻia ka paona. Ua hoʻonuiʻia ka momona, asthenia.
Nā hōʻailona hoʻohālikelike mai ka papa hana hanu: dyspnea o nā ʻano paʻakikī, rhinorrhea, ka huhū ʻana o nā sinuses e hele pinepine ana.
Mai ka musculoskeletal a me ka hoʻopili pili
Hoʻokumu kekahi mau maʻi i ka osteonecrosis ʻā.
ʻŌpala Gastrointestinal
ʻO ka maʻi paleha, ka ʻōpū o ka hōʻoli ʻana o ka ikaika like ʻole, ka hoʻomohala ʻana o nā ʻōpū hemorrhoids, ka hoʻokumu ʻana o fistulas i loko o ka anus, ʻūpā, ka palupalu liʻiliʻi. Hiki i ka ʻūhā niho hiki, stomatitis, ke ʻeha ma ka ʻāʻī, ka pūpū. ʻO nā fistulas i loko o ka meahana a me ka hoʻokaʻawale ʻana o nā pā i hiki pinepine ʻole ke hele, kahi e hiki ai i ka make o ka mea maʻi.
Hoʻohālikelike nā hōʻailona mai ka papa hanu: pinepine ka dyspnea i loaʻa.
Hematopoietic mau hui
ʻO ka maʻamau pinepine ka leukopenia a me ka neutropenia o ka ʻano paʻakikī.
Pūnaehana pīhoihoi waena
Aneane mau nō nā poʻo o kēlā me ke ʻano o ka ikaika o ke kala ʻana.
Mai ka pūnaehana urinary
I ka manawa pinepine - proteinuria, ʻaʻole anuā - ka hoʻomohala ʻana o ka maʻi nephrotic.
Ma ka ʻāpana o ka ʻili
Itching, ʻulaʻula a me ke kaulua, urticaria.
Mai ka pūnaehana genitourinary
ʻO nā maʻi, nā leka i nā kāne a me nā wahine.
I nā maʻi he nui, ʻo ka lawe ʻana iā Zaltrap hiki i ka thromboembolism.
Mai ka pūnaehana cardiovascular
Pahu i loko o ke kō, ke koko. I ka nui o nā mea maʻi: thromboembolism, ischemic attack, angina pectoris, nui ka hopena o ka neʻe ʻana o myocardial infarction. Kēia: ka wehe ʻana o ka hemorrhage craniocerebral, hoʻokahe koko, ka ʻuwī ʻana i ke koko i loko o ka ʻeha gastrointestinal, ʻo ia ke kumu o ka make.
Ma ka ʻāpana o ka ate a me ka pāpaʻi biliary
ʻO ka hoʻomohala ʻana o ka hana hema ʻole.
Mai ka ʻaoʻao o ka metabolism
I ka nui o nā manawa, aia ka hemahema o ka makemake, pinepine - dehydration (mai ka maʻalahi a paʻakikī).
Allergies
ʻO ka hopena hypersensitivity koʻikoʻi: bronchospasm, koʻikoʻi iki o ka hanu, ka pīhoihoi anaphylactic.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻohe ʻikepili i ka hoʻopaʻa ʻana o ka hopena hiki o ka lāʻau lapaʻau ma ka nānā ʻana i ka maka. Manaʻo ia e hōʻole i ke kaʻa a hana a me nā hana paʻakikī inā loaʻa i nā mea maʻi mai nā ʻaoʻao o ka nūnaehana kikowaena, nā maʻi psychomotor.
Ma mua o kahi hāmeʻe o ka maʻi hou (i kēlā me kēia 14 mau lā), pono e hoʻomaʻamaʻa i ke koko.
Nā ʻōlelo kikoʻī
Ma mua o kahi hāmeʻe o ka maʻi hou (i kēlā me kēia 14 mau lā), pono e hoʻomaʻamaʻa i ke koko. Hoʻohana wale ʻia ka lāʻau lapaʻau i loko o kahi papa hoʻomaha no kahi pane manawa kūpono i nā hōʻailona o ka hiʻona, perforation o nā pā o ka ʻeha gastrointestinal.
ʻO nā mea maʻi me kahi kūkala olakino olakino e pili ana i 2 mau kālā a i ʻole e loaʻa i kahi hopena maikaʻiʻole. Pono lākou i nā mālama lapaʻau mau no ka manawa kūpono o ka hōʻino ʻana i ke olakino.
ʻO kahi hoʻokumu o fistulas e pili ana i ko lākou wahi e hōʻike nei no ka hoʻopau koke ʻana i ka hoʻomehana. Hāʻawi ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau ma ka mālama ʻana i nā mea maʻi i loaʻa i ka nui o ke kaʻina holoʻokoʻa (a hiki i ka hōʻō ʻana o nā hōʻeha).
Pono nā kāne a me nā wahine o ka hānau keiki ʻana e hoʻohana i nā ʻano like ʻole o ka contraception i loko o ʻeono mahina (ʻaʻole emi iho) ma hope o ka make hope o Zaltrap. ʻae ʻia ka ʻona ʻana o kahi keiki.
ʻO ka hoʻonā Zaltrap he hyperosmotic. Hoʻokomo kona kāpili i ka hoʻohana ʻana i nā lāʻau lapaʻau no ka pili o intraocular. Hoʻole ia i ka hoʻolaha ʻana i ka hoʻonā i loko o ke kino vitreous.
Hoʻohana i ka wā kahiko
Aia ka pilikia nui o ka hoʻomohala ʻana i ka maʻi lōʻihi, ka dizz, ka wikiwiki nui a me ka dehydration i nā maʻi i nā makahiki o 65 makahiki a keu aku. Pono e hoʻokau ʻia ke ʻano saltrap ma lalo o ka nānā ʻana o nā limahana olakino. I ka hōʻailona mua o ka maʻa a i ʻole nā dehydration, hele pono ka loaʻa ʻana o ka hōʻailona maʻi.
Pono e hoʻokau ʻia ke ʻano saltrap ma lalo o ka nānā ʻana o nā limahana olakino.
Koha i na keiki
ʻAʻole paʻa i ka palekana o Zaltrap i nā keiki.
Hoʻohana i ka wā hāpai a me ka lactation
ʻAʻole ʻike nā ʻikepili ma ka hoʻohana ʻana o Zaltrap i nā wahine hāpai a lactating. Hāʻawi ʻia i nā hopena kūpono ʻole o ka hopena i ke keiki, ʻaʻole ka lāʻau antitumor i kuhikuhi ʻia no kēia mau maʻi o nā maʻi. ʻAʻohe mea e pili ana i ka paʻa ʻana o ka lāʻau i loko o ka waiū umauma. Inā kūpono, e hoʻohana i kahi lāʻau lapaʻau i ka mālama ʻana i ka maʻi maʻi i ka wahine hānai, pono e hoʻopau ʻia ka lactation.
Ke noi no ka hana renal haukapole
Hoʻohana ʻia ka hoʻohana ʻana o Zaltrap i nā maʻi me nā maʻi liʻiliʻi a me ke kaulike. ʻAʻohe ʻike e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka maʻi koʻikoʻi o ka renal.
Hoʻohana no ka hana lawelawe lēwa
ʻAʻohe ʻikepili i ka hoʻohana ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka hōʻeha hepatic koʻikoʻi. ʻAe ʻia ka lāʻau lapaʻau o nā mea maʻi me ka maikaʻi o ka puʻuwai, akā me ka mālama nui a paʻa i lalo o ka mākaʻi ʻana o ke kauka.
ʻAe ʻia kahi hoʻokolohua o nā maʻi me ka puʻuwai koʻikoʻi.
Kaihua o Zaltrap
ʻAʻohe ʻike e pili ana i ka makeʻana o ka lāʻau lapaʻau ma mua o 7 mg / kg i mālama ʻia i kēlā me kēia 14 mau lā a i ʻole 9 mg / kg i kēlā me kēia lā 21 i ka hopena o ke kino.
Hiki i kahi overdose ke hōʻike i ka hoʻonui ʻia ʻana o ka nui o nā hōʻailona ʻaoʻao. Hoʻōla - mālama mālama maʻi, mālama mau i ke kahe o ke koko. ʻAʻohe antidote.
Hoʻopili pū me nā lāʻau ʻē aʻe
Ke hana nei i nā haʻawina pharmacokinetic a me kahi hoʻohālikelike hoʻohālikelike i hōʻike ʻole aku i ka pilina o ka pharmacokinetic o Zaltrap me nā lāʻau lapaʻau ʻē aʻe.
Hoʻolaha ka waipuna
ʻO ka inu ʻawaʻawa i ka wā maʻi e pāpā ʻia loa.
Nā kuʻina
Hoʻomoe me kahi ʻano like ʻole o ka hana: Agrelide, Bortezovista, Vizirin, Irinotecan, Namibor, Ertikan.
He lāʻau lapaʻau ʻo Irinotecan me ka like o nā hana like.
Waihue huaʻōlelo waiho nā huaʻōlelo
Ma ka hāʻawi wale ʻana i kahi papa lāʻau mai kahi kauka.
Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?
Hoʻokuʻu ʻia ka hana kūʻai OTC.
Kūʻai
Mai ka 8500 kahakaha. i kēlā me kēia pahu.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
I ke kūlana mahana mai +2 a + 8 ° C.
ʻO ka lā kau
3 mau makahiki Hoʻohana hou ʻia ka lāʻau lapaʻau.
Mea hana
Sanofi-Aventis Deutschland GmbH, Kelemānia.
Hoike Mai
Ksenia, 55 makahiki, Moscow: "ʻO ke aʻo iā Zaltrap i kuhikuhi ʻia i koʻu makuakāne no ka mālama ʻana i ka maʻi cancer. He maikaʻi ka lāʻau lapaʻau, kūpono akā hiki nō nā hopena ʻē aʻe. hopohopo, akā hōʻike nā loiloi i ke ʻano maikaʻi o ka hōʻemi ʻana i ka neoplasm. "
Eugene, he 38 makahiki, ʻo Astana: "Ua loaʻa iaʻu nā hopena he nui mai Zaltrap. He kūlana weliweli wau: nausea, luaʻi, hopohopo mau, nāwaliwali nui. Akā, hana koke ka lāʻau lapaʻau ma ka ʻōpala. ke ola nei no keia ehaeha. "
ʻO Alina, 49 makahiki, ʻo Kemerovo: "He lāʻau lapaʻau nui ia, ʻaʻole au e like me ka noho pū me ia ma hope o ka chemotherapy. Akā ʻo ia he mea kūpono nō. I ka 1 mau papa, ua pau nā huki o kuʻu. Ua ʻōlelo ke kauka he wā ka hue. ʻOi aku.
