Aia ʻo Gabagamma i ka hui o nā lāʻau antiepileptic. ʻO ke kumu ke gabapentin kahe ikaika, he hopena anticonvulsant. ʻAʻole i like me nā lāʻau ʻē aʻe me kahi hopena like, ʻaʻole pili ʻo Gugsamma capsules i ka metabolism o ka gamma-aminobutyric acid. Ma ka hoʻomaʻamaʻa lāʻau lapaʻau, ʻae ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i nā mea maʻi ma mua o 12 mau makahiki e hoʻopau i nā hapa ʻāpana, mai nā makahiki 18 mai makahiki - no ka mālama ʻana i ka ʻeha neuropathic.
Inoa Kūʻai ʻole honua
Gabapentin.
Aia ʻo Gabagamma i ka hui o nā lāʻau antiepileptic.
ATX
N03AX12.
E hoʻokuʻu i nā palapala a me ka ʻano
ʻO ka lāʻau lapaʻau i hana ʻia i ke ʻano o nā kapeta, i kālai ʻia me ka lāhula gelatin, no ka hoʻoponopono waha.
Nā ʻatikā
Loaʻa nā waihona o nā lāʻau lapaʻau i ka 100, 300 a i 400 mg o ka hana ikaika o ka gabapentin. Hoʻohana ʻia nā mea ʻē aʻe no ka hana ʻana i ka pōpoki waho:
- talc;
- waiū waiū;
- ʻōpala palaoa;
- titanium hone.
Wahi a ka dosage, hoʻokaʻawale ka ʻupala i ka kala: i ka mua o 100 mg o gabapentin, ke keʻokeʻo nei ka gelatin, ma ka 200 mg he melemele ma muli o kahi ka wai e kau ai ma ka oxide iron, 300 mg ka ʻona. I loko o nā peke he keʻokeʻo.
ʻO ka lāʻau lapaʻau i hana ʻia i ke ʻano o nā kapeta, i kālai ʻia me ka lāhula gelatin, no ka hoʻoponopono waha.
ʻAʻohe mea hana
ʻAʻole hana ʻia ka lāʻau lapaʻau ma nā ʻano papa.
Ka hana lāʻau lapaʻau
Hoʻohālikelike ke ʻano o ke kumuhana o ka gabapentin e like me nā neurotransmitters GABA (gamma-aminobutyric acid), akā, ke ʻano ikaika o Gabagamma e like me nā waiwai pharmacological. ʻAʻole ke kikowaena o nā lāʻau lapaʻau me ka aminalon e like me nā lāʻau ʻē aʻe (barbiturates, derivatives o GABA, Valproate) a ʻaʻole i loaʻa nā hiʻohiʻona GABA-ergic. ʻAʻole pili ʻo Gabapentin i ka wawahi a me ka hū o ka waika γ-aminobutyric.
Ma nā haʻawina loiloi, ua hōʻike ʻia e pili ana ka waiwai ikaika i ka delta subunit o nā kalima kalepa, ma muli o ke kahe o nā kaila o ka calcium. I ka hopena, ʻo Ca2 + e hana i ka hana koʻikoʻi i ka hoʻokumu ʻana o ka ʻeha neuropathic. I ka like me ka kaohi o nā kanaleka, mālama ʻo gabapentin i ka paa ʻana o ka huehue glutamic i nā neurons, no laila ʻaʻole i make ka nui o ka nerve. Hoʻonui ka hoʻonuiʻana o GABA, ka hoʻokuʻu ʻana o nā neurotransmitters o ka hui monoamine.
Me ka hoʻokūkū waha, hoʻomaka ka ʻili o waho e hoʻoneʻe ma lalo o ka hana o nā enzymes intestinal, a hoʻokuʻu ʻia ka gabapentin i ka wahi kokoke o ka pānaʻi liʻiliʻi.
Lapaʻau lāʻau
Me ka hoʻokūkū waha, hoʻomaka ka ʻili o waho e hoʻoneʻe ma lalo o ka hana o nā enzymes intestinal, a hoʻokuʻu ʻia ka gabapentin i ka wahi kokoke o ka pānaʻi liʻiliʻi. Hoʻokomo ʻia ka waiwai ikaika e microvilli. Hoʻokomo ʻo Gabapentin i ke kahe koko, kahi e loaʻa ai i ka plasma kiʻekiʻe loa i loko o nā hola 2-3. He mea nui e hoʻomanaʻo e emi ka bioavailability me ka hoʻonui ʻana i ka dosis a hiki i ka awelika o 60%. ʻAʻole ʻai ka ʻai i ka hoʻopiha a me ka helu ʻana o ka lāʻau.
ʻO ka hoʻopauʻana hapa-hapalua ke ola i nā hola he 5-7. Loaʻa ka lāʻau lapaʻa i nā kikowaena kūlike me ka pākahi. ʻO ke kiʻekiʻe o ka paʻa ʻana o ka gabapentin i nā protein protein i haʻahaʻa - emi mai ka 3%, no laila ke kāhea ʻia ka lāʻau lapaʻau i loko o nā ʻāpana i kahi ʻano ʻole. Hoʻopili ʻia ka lāʻau lapaʻau me ka hoʻohana ʻana i ka ʻōnaehana urinary i kāna ʻano mua, me ka ʻole o ka loli ʻana i ka hepatocytes.
He aha ia e hoʻōla ai
Aia ka lāʻau i ka pūʻulu o nā lāʻau antiepileptic. No nā mea maʻi ma mua o 12 mau makahiki, ua kau ʻia ʻo Gabagamm ma ke ʻano o ka hui ʻana i ke kūpaʻa mahele, i hiʻohiʻona ʻia me ka ʻole a me ka ʻole o ka generalization. No nā pākeke, ua kuhikuhi ʻia nā papa no ka neuralgia postherpetic a me nā ʻeha hōʻeha e kūʻē i ke kua ʻana o ka neuropathy diabetic.
No nā mea maʻi i ʻoi aku ma mua o 12 mau makahiki, ua hoʻopaʻa ʻia ʻo Gabagamm ma ke ʻano o ka hui hoʻohui ʻana i nā pale kikowaena.
Nā Hoʻohui
ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau inā he ala nui o ka hiki ʻana o nā kiko o ka mea maʻi i nā mea pili o Gabagamma. Ma muli o ka nui o ka lactose i ka hoʻopili, hoʻohālikelike ʻia ka lāʻau no ka hoʻohana ʻana i nā mea maʻi me ka nele o ka ʻāina me ka waiū o ka waiu me ka galactose, me ka loaʻa ʻole o ka lactase a me ka malabsorption o monosaccharides.
Me ka mālama pono
ʻAʻole ia he kūpono ʻole a mālama ʻia paha i ka wā e lawe ai i nā mea maʻi me nā maʻi o kahi psychotic a i ʻole ka pale ʻole.
Pehea e lawe ai iā Gabagamma
Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ka manaʻo ʻole o ka meaʻai. Inā makemake ʻoe e kāpae i ka lāʻau lapaʻau, pono ʻoe e ho'ōki me ka hoʻohana ʻana iā Gabagamma i kahi holoʻokoʻa o ka hebedoma. Hōʻalo ʻia ka lāʻau lapaʻau me ka piʻi ʻana o ka hana ma ka hihia a pau ʻole o ka mea maʻi, hoʻohaʻahaʻa ke kino o ke kino a i ʻole ke ʻano koʻikoʻi o ka mea maʻi, me ka nāwaliwali o ka hōʻola hou ʻana ma hope o ke hoʻololi ʻana. I kēlā kūlana, pono e hoʻomaka me ke ʻano o ka 100 mg.
Hoʻokumu ʻia ka regimen lapaʻau e ka mea hele i ke kauka e hilinaʻi ana i ke kūlana o ka mea maʻi a me ke kiʻi olakino o nā papa holo.
| ʻO ka maʻi | Hōʻike hoʻohālikelike |
| ʻO ka maʻi Neuropathic ma nā maʻi maʻi | ʻO ka dosis maʻamau o kēlā me kēia lā i ka manawa mua o ka lapaʻau e hōʻea i 900 mg me ka pinepine o ka hoʻokele 3 mau manawa i ka lā. Inā kūpono, hiki ke hoʻonui ʻia i ke ʻano o kēlā me kēia lā a hiki i ka 3600 mg. Hoʻomaopopo ʻia e hoʻomaka i ka mālama ʻana me ka hoʻohaʻahaʻa ʻana i ka waʻa e like me ka papa hana maʻamau: 300 mg 3 mau manawa i ka lā. Ma kēia hihia, pono e hoʻopiʻi nā mea maʻi me ke kino nāwaliwali i kēlā me kēia lā i 900 mg no 3 mg no 3 mau lā e like me ke hoʻoponopono hou ʻia ʻana o ka maʻi.
|
| ʻO nā mea hōʻeha lehulehu i nā poʻe ma mua o 12 mau makahiki | Hoʻomaopopo ʻia e lawe mai ka 900 a 3600 mg i kēlā me kēia lā. Hoʻomaka ka lāʻau lapaʻau i ka lā mua me kahi kaha o 900 mg, hoʻokaʻawale ʻia i 3 pūpē. No ka hōʻemi ʻana i ka pilikia o nā kīwaha o nāu, ʻaʻole ka lōʻihi ma waena o 12 mau hola. I nā lā aʻe o ke ʻano lapaʻau, hiki i ka nui hōʻemi ke kiʻekiʻe (3.6 g) hiki. |
Me ka maʻi diabetes
ʻAʻole pili ka lāʻau lapaʻau i ka kiʻekiʻe o ke kōpaʻa plasma a ʻaʻole ia e hoʻololi i ka huna ʻana o ka hormonal i ka insulin e nā beta beta o ka papa pancreas, no laila, ʻaʻohe kumu e haʻalele i ka regimen lapaʻau i ʻōlelo ʻia i mua o ka maʻi mellitus.
Nā hopena hopena
ʻO nā hopena ʻaoʻao ma ka hapanui ke loaʻa me kahi regimen koho kūpono ʻole a ʻokoʻa paha mai nā ʻōlelo loea. Loaʻa paha ka hoʻomohala ʻana i ka lāʻau lapaʻau, hoʻonui i ka luhiluhi, ʻeha ma nā ʻano ʻāpana o ke kino.
Mai ka musculoskeletal a me ka hoʻopili pili
ʻAʻole pili ka lāʻau lapaʻau i ka ʻōnaehana musculoskeletal, akā me ka hōʻino ʻole i ka ʻōpala o ke ʻano, nā hōʻeha ma nā ʻeha a me nā ʻili, hiki i nā iwi nui ke piʻi.
Hematopoietic mau hui
Me ka loli o nā ʻāpana o ka ʻōnaehana hematopoietic, hiki mai paha nā kuʻuna thrombocytopenic, i hele pū me ka bruising, kahi hōʻemi o ka helu o nā mea i hoʻokumu ʻia i ke koko.
ʻŌpala Gastrointestinal
Hōʻike nā ʻano maikaʻi ʻole i ka digestive tract e nā ʻano mea penei:
- eha epigastric;
- anorexia;
- ʻōpulū, ʻaʻā, ʻaʻa;
- huehū o ka hana noke;
- nā hana hoʻonui a hepatocytic aminotransferases;
- jaundice e kū'ē ana i kahi kūlana o ka hyperbilirubinemia;
- lōkohu
- dyspepsia a waha maloʻo.
Pūnaehana pīhoihoi waena
Me ka emi o ka pūnao, hiki nō:
- ʻʻAla
- ka haʻalele ʻana i ka hoʻopunipuni o ke neʻe;
- choreoathetosis;
- nalowale o na pulu;
- nā hana hoʻonaninani;
- lilo ana o ka mana noʻonoʻo-psycho;
- ka hoʻololi ʻana i ka hana cognitive, ka manaʻo noʻonoʻo;
- aloha.
I nā hihia pinepine, ulu ka amnesia, hoʻonui i ka piʻi o nā mea hoʻokele epileptic.
Mai ka papa huhū
Loaʻa paha kahi hoʻomohala o ka pōkole o ka hanu, nā maʻi pneumonia. Me ka pānaʻi nāwaliwali nāwaliwali, hiki ke hoʻomohala ʻia nā maʻi pāpaʻi, maʻi maʻi viral, pharyngitis, a me ka ulu ʻana o ka ihu.
Ma ka ʻāpana o ka ʻili
I nā hihia kūikawā, hiki i nā huehue, peripheral edema, erythema, hōʻeha a me nā rashes ke hele mai.
Mai ka pūnaehana genitourinary
I nā hihia pinepine, hiki i nā mea maʻi hiki ke hoʻomohala i nā maʻi o ka urinary, hōʻemi iho i ka erectis, enuresis (urinary incontinence), a me nā hopena o ka pēpē.
I nā hihia pinepine, hiki i nā mea maʻi hiki ke hoʻomohala i ka maʻi o ka urinary tract.
Mai ka pūnaehana cardiovascular
Malia paha ke uluʻana o nā hōʻailona o ka vasodilation, hoʻonui i ka naʻau nui a hoʻonui i ke koko.
Allergies
Inā pili ka mea maʻi i nā hopena alaka, hiki iā ia ke hoʻomohala iā Quincke edema, kahi anaphylactic shock, angioedema, Stevens-Johnson syndrome a me ka hopena kino.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
I ka ʻike ʻana i ka hopena o ka hopena o ka maikaʻi ʻole i ka pūnaehana neʻe o ka pūnaehana (CNS) i ka manawa o ka lāʻau lapaʻau, pono ia e hoʻokaʻawale i ka hana me nā mea paʻakikī paha a paʻakikī paha, ka lawe ʻana i kahi kaʻa a i ka hana i nā hana e koi ai ka wikiwiki a me ka wikiwiki o ka hopena o ka mea maʻi.
Nā ʻōlelo kikoʻī
ʻOiai ʻaʻole e hoʻoneʻe i ka maʻi kanalapa i ka wā o ka lāʻau lapaʻau me ka gabapentin, aia kahi hopena o ka hoʻihoʻi ʻana o nā kīʻaha mākeke i nā mea maʻi me kahi mahele ʻāpana o ka hana hoʻoikaika. He mea nui ia e hoʻomanaʻo he pono ʻole ka lāʻau i ka hakakā me ka epilepsy abscess.
Me ka hui pū ʻana me Morphine, pono ʻia e hoʻonui i ka dosis o Gabagamma ma hope o ke kūkā ʻana i kahi kauka. Ma kēia hihia, pono mau ka mea maʻi ma lalo o ka mālama mālama olakino pono e pale i ka hoʻomaka ʻana o nā hōʻailona o ke ʻano hōʻeha o ka pūnaehana nerve waena (ma ka hiamoe. Me ka hoʻolālāʻana o nā hōʻailona o nā hōʻeha o ka ʻōnaehana o ka iwi, pono ia e hoʻemi i ke ʻano o nā lāʻau ʻelua.
Me ka hui pū ʻana me Morphine, pono ʻia e hoʻonui i ka dosis o Gabagamma ma hope o ke kūkā ʻana i kahi kauka.
I ka hoʻomaka ʻana o nā haʻawina ʻoihana, hiki ke hoʻopaʻa ʻia kahi hopena maikaʻi ʻole no ka hiki ʻana mai o ka proteinuria, no laila, i ke koho ʻana iā Gabagamma e hui pū me nā anticonvulsants, pono e noi i nā limahana ʻo ka mea hana hou e hana i nā loiloi i kahi ala kūikawā e hoʻopau ai i ka wai o sulfosalicylic.
Hoʻohana i ka wā kahiko
ʻAʻole pono nā poʻe i ʻoi aku o 60 mau makahiki i ka hoʻoponopono hou ʻana i ka nui.
Nā leka iā Gabagamma i nā Keiki
ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau i nā keiki a me nā ʻōpio i lalo o ka 18 mau makahiki o ka makahiki, me ka ʻokoʻa wale nō o nā hihia kīmiʻi.
Hoʻohana i ka wā hāpai a me ka lactation
ʻAʻole i hele ʻia nā haʻawina hoʻokolohua ma ka hopena o ka lāʻau i ka hoʻomohala ʻana i ka embryonic. No laila, ua kuhikuhi ʻia ka gabapentin i nā wahine hāpai i nā hihia koʻikoʻi loa, i ka wā o ka hopena maikaʻi o ka lāʻau a i ʻole ka weliweli i ka ola ʻana o ka makuahine i ʻoi aku i ka nui o ka hōʻino o ka maʻi fetus.
Ua koho ʻia ʻo Gabapentin i nā wahine hāpai i nā hihia koʻikoʻi.
Hiki ke hoʻonui ʻia ka mea ikaika ma ka waiū o ka makuahine, no laila e haʻalele ʻia ka nui o ka hānai ʻana i ka wā o ka lāʻau lapaʻau.
Ke noi no ka hana renal haukapole
I mua o ka hala ole o ka renal, hoʻoponopono ʻia ka nui o ka hoʻoponopono ʻia ma muli o ke kāpae ʻana o ka creinine (Cl).
| Cl, ml / min | Ka helu 'ana i kēlā me kēia lā i 3 pākēneka |
| oi aku ma 80 | 0.9-3.6 g |
| mai 50 a hiki i ka 79 | 600-1800 mg |
| 30-49 | 0.3-0.9 g |
| mai 15 a hiki 29 | 300 mg e kuhikuhi ʻia me kahi lō 24 mau hola. |
| malalo o 15 |
Ke keu
Me ka hōʻino ʻana o ka lāʻau lapaʻau ma muli o hoʻokahi pānaʻi o kahi nui nui, ʻike ʻia nā hōʻailona o kahi overdose:
- ʻʻAla
- hana maʻi ʻike ʻia i hōʻike ʻia e kahi kaʻawale o nā mea;
- maʻiʻo ʻōlelo;
- makehewa;
- hiamoe
- nā ninia
Hiki paha ke hoʻonui a hoʻonui paha i nā hopena ʻē aʻe. Pono ka poʻe i lawe ʻia i ka hale hoʻomaha no ka palapa gastric, i hoʻolako ʻia ua lawe ʻia nā capsules ma ke alo o nā hola 4 i hala. Hoʻokuʻu ʻia kēlā me kēia hōʻailona o kahi overdose ma o ka mālama kino ʻana. He ʻola a hemodialysis.
Me kahi overdose o ka lāʻau lapaʻau, hiki ke hiamoe.
Hoʻopili pū me nā lāʻau ʻē aʻe
Me ka hoʻohana ʻana o Gabagamma me nā lāʻau ʻē aʻe, e kū aʻe ana nā hopena penei:
- Inā lawe ʻoe i ka Morphine 2 mau hola ma mua o ka hoʻohana ʻana i ka gabapentin, e hoʻonui paha ʻoe i ka hoʻoilo ʻana o nā mea ma ka hopena o 44%. I kēia hihia, ua ʻike ʻia ka hoʻonui ʻia ma ka paepae ʻeha. ʻAʻole paʻa ka manaʻo koʻikoʻi.
- I ka hui pū ʻana me nā antacids a me nā hoʻomākaukau e loaʻa ana i nā paʻakai me ka paʻakai konane, hoʻemi ʻia ka bioavailability o gabapentin e 20%. No ka hōʻalo ʻana i ka hopena therapeutic, ʻoi ʻia e lawe i nā capsules Gabagamma ma hope o 2 mau hola ma hope o ka lawe ʻana i antacids.
- ʻAʻole hoʻoemi ka Probenecid a me ka cimetidine i ka hoʻonui excretion a me ka serum pae o ka mea ikaika.
- Phenytoin, contraceptives waha, phenobarbital a me ka carbamazepine, ʻaʻole i pili i ka pili o ka plasma o gabapentin.
Hoʻolaha ka waipuna
I loko o ka wā o ka lāʻau lapaʻau, pale ʻia i ka inu ʻawa. ʻO ka Ethanol i ke ʻano o nā mea inu wai i hoʻoiho ikaika ia i ka ʻoihana sentral a me nā hoʻomaikaʻi ʻana i nā hopena ʻaoʻao.
Nā kuʻina
ʻO nā mea kikoʻī o ka lāʻau lapaʻau e loaʻa:
- Katena
- Gabapentin;
- Neurontin;
- Tebantin;
- Convalis.
Ke hoʻohuli nei i kahi lāʻau lapaʻau hou ke ʻae ʻia ma hope o ke kūkākūkā olakino me ka haʻahaʻa haʻahaʻa o Gabagamma a i ʻole me ka ʻano o nā hopena maikaʻi ʻole.
E like me ka analogue, hiki iā ʻoe ke hoʻohana iā Neurontin.
ʻO kaʻenehana hoʻomaha ʻo Gabagamma mai ka lāʻau lapaʻau
ʻAʻole kūʻai ʻia ka lāʻau lapaʻau me ka loaʻa ʻole o ka lāʻau lapaʻau.
Hiki iaʻu ke kūʻai me ke kī ʻole
Ma muli o ka hoʻonui nui o ka minamina o ka pūnaehana neʻe i waena a me ka ʻike mai o nā hopena maikaʻiʻole mai nā kino ʻē aʻe, ua palena ʻole ka kūʻai kūʻokoʻa o Gabagamma.
Kumukūʻai Gabagamma
ʻO ka kumukūʻai maʻamau o ka lāʻau lapaʻau e like me 400 a 1150 rubles.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Manaʻo ʻia e mālama i ka anticonvulsant i nā mahana a hiki i + 25 ° C ma kahi wahiʻoluʻolu me ka haʻahaʻa haʻahaʻa.
ʻO ka lā kau
3 mau makahiki
ʻO Gabagamma mea hana
Werwag Pharma GmbH & Co. KG, Kelemānia.
Manaʻo ʻia e mālama i ka anticonvulsant i nā mahana a hiki i + 25 ° C ma kahi wahiʻoluʻolu me ka haʻahaʻa haʻahaʻa.
Nā Hōʻikeʻike iā Gabagamma
Izolda Veselova, 39 makahiki, St.
Ua kuhikuhi ʻia nā kāloti Gabagamma e pili ana me ka neuralgia 2 mau lālā. Ua ʻōlelo ke kauka ua kau ʻia ka hala ʻana ma muli o ke ʻano o nā hopena maikaʻi. I koʻu hihia, pono wau e lawe i ka 6 mau kapika i ka lā. Pono e hana i ka hoʻonui hoʻonui ʻana: i ka hoʻomaka ʻana o ka hoʻōla, ua hoʻomaka me ka 1-2 mau pōmaika no 7 lā, ma hope o ka hoʻonui ʻia ʻana o kēia ʻauʻau. Manaʻo wau he mea kūpono ia no ka hoʻopaʻapaʻa. ʻAʻole wau i nānā i kekahi mau hopena i ka wā e mālama ai. Ua pani nā pāpale.
ʻO Dominika Tikhonova, 34 makahiki, Rostov-on-Don
Lawe ʻo ia iā Gabagamma e like me ka mea i kuhikuhi ʻia e ka neurologist i pili me ka neuropathy trigeminal. ʻAʻole maikaʻi ʻole ʻo Carbamazepine i koʻu kūlana. Ua kōkua nā Capsules i nā hoʻopunipuni mua. ʻO ka papa o ka lāʻau lapaʻau ua mau no 3 mau mahina mai Mei 2015. ʻOiai ke ala maʻi maʻamau, ua hala ke ʻeha a me nā hōʻailona o ka pathology.ʻO ke drawback wale nō ke kumukūʻai. No nā 25 mau kōneka aʻu e uku ai iā 1200 rubles.
