ʻO Aprovel kahi lāʻau lapaʻau i hoʻolālā ʻia e mālama i ka hypertension a me ka nephropathy. ʻAe ʻia ia e hoʻohana i ka lāʻau lapaʻau no ka maʻi maʻi. I kēia hihia, ʻaʻole ka hopena o ka lāʻau i ka haʻaleleʻana i ka maʻi ma hope o ka hoʻokuʻu ʻana o ka hōʻola. Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa, e hiki ai i nā kauka ke kāohi i ka lāʻau. Hiki i nā maʻi maʻi ke hoʻoponopono i ka hoʻoponopono ʻia o ka lāʻau lapaʻau i ka manawa kūpono no lākou.
Inoa Kūʻai ʻole honua
Irbesartan.
ʻO Aprovel kahi lāʻau lapaʻau i manaʻo ʻia no ka mālamaʻana i ka hypertension arterial a me nephropathy.
ATX
C09CA04.
E hoʻokuʻu i nā palapala a me ka ʻano
Loaʻa ka lāʻau lapaʻau i nā papa hana enteric-coated. Aia ka lāʻau o ka lāʻau lapaʻau i ka 150, 300 mg o ka mea ikaika - irbesartan. Hoʻohana ʻia nā mea kōkua i ka hana hana:
- waiū waiū;
- huki;
- colloidal dehydrated silicon dioxide;
- magnesium stearate;
- kahi sodium a ʻaihoe.
ʻO ka membrane kiʻiʻoniʻoni e loaʻa ana ka mika carnauba, macrogol 3000, hypromellose, titanium dioxide a me ka waiū waiū. Aia nā papa papa i kahi ʻano lula ʻo biconvex a ua keʻokeʻo.
Ka hana lāʻau lapaʻau
Hoʻokumu ʻia nā hana a Aprovel ma irbesartan, kahi ʻano antagonist e pili ana i ka ʻili o ka pehu angiotensin II. Ma muli o ke kaohi ʻana o ka hana receptor, e emi ana ka ʻike o ka ald testosterone i ka plasma koko. ʻAʻole loli ka pae o ka wai o ka sodium ma ka serum koko inā ʻaʻole hōʻino ka mea maʻi i ka lāʻau lapaʻau a lawe wale ia i ka dosage i kēlā me kēia lā.
I ka hopena o ka hana a ka pūhui kemika, ua ʻike ʻia kahi emi ʻana i ke kahe koko (BP). I kēia hihia, ʻaʻohe emi o ka puʻuwai puʻuwai. Me kahi pākahi hoʻokahi a i ka 300 mg, ka hāʻule ʻana o ke kahe koko i hilinaʻi nui ʻia ma ka ʻimi i lawe ʻia. Me ka hoʻonui ʻana o ka maʻamau i kēlā me kēia lā o ka hana ikaika, ʻaʻohe loli nui i nā ʻōnaehana koko.
Loaʻa ka hopena hypotensive kiʻekiʻe e 3-6 mau hola ma hope o ka lawe ʻana i ka paila. Hoʻomaʻa ka hopena therapeutic no 24 mau hola. Ma hope o kahi lā mai ke lawe ʻana i kahi kapu hoʻokahi, hoʻoneʻe wale ke kahe koko i ka 60-70% wale nō o ka nui loa.
Hoʻolaha ka hopena pharmacological o Aprovel i kahi manawa o 7-14 mau lā, ʻoiai ke nānā aku nei ka nui o nā waiwai kiʻekiʻe o ka hopena therapeutic ma hope o 4-6 mau pule. I kēia hihia, e hoʻomau ka hopena hypotensive. Ke hoʻokuʻu ʻia ka mālama ʻana, e hoʻi ka neʻe o ke koko i kona pae mua.
Lapaʻau lāʻau
Ma hope o ka lawelawe waha, ua komo koke ka lāʻau i loko o nā ʻōpū liʻiliʻi e 60-80% o ka nui i lawe ʻia. Ke komo nei i ke kahe, hiki i ka mea hana ke hoʻopili i ka protein plasma e 96% a, hoʻomaikaʻi ʻia i ka punawai i hoʻomohala ʻia, ka mea i kola ʻia i nā kiko āpau.
Loaʻa ka waiwai hana i ka paila plasma kiʻekiʻe loa ma hope o 1.5-2 mau hola ma hope o ka hoʻokele ʻana.
ʻO ka hoʻopauʻana hapalua-ola e hana iā 11-15 mau hola. ʻOi ka liʻiliʻi o 2% o ka hana ikaika i kona ʻano kumu i hoʻopuka ʻia ma o ka urinary system.
Nā hōʻailona no ka hoʻohana ʻana
Pono ʻia ka lāʻau lapaʻau no ka mālama ʻana a me ke pale ʻana i ke koko kiʻekiʻe e like me ka monotherapy a i ʻole pū me nā lāʻau ʻē aʻe me nā hopena antihypertensive (beta-adrenergic blockers, thiazide diuretics). Kuhi nā kauka lāʻau lapaʻau iā Aprovel no ka nephropathy i mua o ka maʻi diabetes type 2, i hele pū me ka hypertension arterial. I kahi kūlana, ʻaʻole i lawe ʻia ka monotherapy, akā e kuhikuhi ʻia ana ka mālama ʻana i ka hōʻemi ʻia e hōʻemi i ke koko.
Nā Hoʻohui
ʻAʻole ʻae ʻia ka lāʻau lapaʻau a pāpā ʻole ʻia paha no ka hoʻohana ʻana i kēia mau hihia:
- hoʻonui nui ʻana o nā kopa i nā mea hoʻonohonoho o ka lāʻau;
- hemahema ka lactose, lactase;
- ka lawe hewaʻana o monosaccharides - galactose a me kaʻula;
- uha wīwī ikaika.
Ma muli o ka hemahema o nā haʻawina hoʻokolohua kūpono loa, ua pāpā ʻia ka lāʻau lapaʻau no ka poʻe ma lalo o ka 18 mau makahiki o ka makahiki.
Me ka mālama pono
A hāpai ʻia ka mālama ʻana i kēia mau pilikia:
- stenosis of aorta or mitral valve, renal arteries;
- kidney transplanting;
- CHD (ka maʻi naʻau coronary);
- me ka nele o ka renal, pono ia e kāohi i ka pae o ka paʻakai a me ka mea hana i loko o ke koko;
- cerebral arteriosclerosis;
- kaʻai ʻai ʻole paʻakai, me ka hele ʻana o ka maʻi ʻaʻa;
- pae mai i ka cardiomyopathy pae;
- hypovolemia, kahi hapa o ka sodium ma ke kua o ka lāʻau lapaʻau me ka diuretics.
Pono e nānā pono i ke kūlana o nā mea maʻi ma ka hemodialysis.
Pehea e lawe ai iā Aprovel
Pono ʻia ka lāʻau lapaʻau no ka hoʻoponopono ʻana ma ka waha. I ka manawa like, ʻo ka wikiwiki a me ka ikaika o ka pāpaʻi ʻana ma nā kaʻe liʻiliʻi, he kūʻokoʻa kū i ka ʻaʻa o ka meaʻai. Pono ʻawaʻawa nā papa me ka moʻolelo ʻole. ʻO ka dosage maʻamau ma ka pae mua o ka mālamaʻana he 150 mg i kēlā me kēia lā. Loaʻa nā mea maʻi nona ka hypertension therapy hou i ka lāʻau antihypertensive 300 mg i kēlā me kēia lā.
Me ka emi ʻole o ke kahe o ke koko, ua hoʻohui ʻia ka mālama ʻana me Aprovel, beta-blockers, calcium antagonist ion e hoʻokō i nā koina.
He mea nui e hoʻomanaʻo e hoʻomau ʻia ka make a me ka lōʻihi o ke kau ʻana i nā lāʻau lapaʻau e pili ana i nā hiʻohiʻona pilikino o ka mea maʻi, ka ʻikepili a me ka hōʻoia kino kino.
Lawe i ka lāʻau lapaʻau no ka maʻi maʻi maʻi
ʻO ke kamaʻilio ʻana no ka maʻi pālolo ʻano 1 e kamaʻilio pū me kāu kauka, ka mea e pale aku i ka hoʻohana ʻana o Aprovel a i ʻole e hoʻokō i ka hoʻoponopono ʻia o ka lā maʻamau. Ma ke ʻano 2 non-insulin-dependant diabetes, ʻo ka nui ka mea i mālama ʻia, ʻo 300 mg i hoʻokahi lā.
ʻO ka maʻi me nā maʻi maʻi maʻi ka nui o ka ulu ʻana o ka ulu ʻana i ka hyperkalemia.
Pehea e hōʻole ai i kou ʻae ʻana
ʻO ka ʻaihie kāpae ʻia ma hope o kahi o ka pau ʻana o ka hopu ʻana iā Aprovel ʻaʻole i ʻike ʻia. Hiki iā ʻoe ke hoʻololi koke i kahi lāʻau lapaʻau ʻē aʻe a paʻa paha i ka lawe ʻana i ka lāʻau lapaʻau.
Nā hopena ʻona o Aprovel
ʻO ko ka palekana o ka lāʻau lapaʻau ua hōʻoia ʻia i loko o nā hoʻokolohua lapaʻau i hoʻohele ʻia ai ka poʻe 5,000. Ua hōʻeha nā manawaleʻa 1300 i ke koko koko kiʻekiʻe a ua lawe i ka lāʻau lapaʻau no 6 mau mahina. No nā 400 maʻi, uaʻoi aku ka lōʻihi o ka lāʻau i hoʻokahi makahiki. ʻO nā mea i nā hopena o ka hopena ʻaʻole i hilinaʻi ma ka dosis i lawe ʻia, ka wahine a me nā makahiki o ka mea maʻi.
I kahi noi hoʻokele paʻa plebo, ua loaʻa i nā mea hana 1965 ka hana neʻe irbesartan no 1-3 mau mahina. I ka 3,5% o nā hihia, ua hoʻohaumia nā mea maʻi e haʻalele i ka mālama ʻana me Aprovel ma muli o nā lēwa ʻehā o ka hana ʻōnaehana. Ua hōʻole ʻo 4.5% e lawe i kahi placebo, no ka mea ʻaʻole lākou i hoʻomaikaʻi.
ʻŌpala Gastrointestinal
Hōʻike maikaʻi ka hōʻike ʻana i ka hāhai ʻana o ka huina.
- huehue, constipation, flatulence;
- naki, holo
- ka hoʻonui ʻana i nā hana o nā aminotransferases i nā hepatocytes;
- dyspepsia;
- puʻuwai.
Ma ka ʻaoʻao o ka palau a me ka tractary tract, hiki i ka hepatitis ke piʻi, he piʻi ʻana ka nui o ka plasma o ka bilirubin, e alakaʻi ana i ka jaundice cholestatic.
Pūnaehana pīhoihoi waena
ʻO nā hoʻonāukiuki i ka kamaʻilio neuronal ma muli o ka hoʻohana ʻana i nā lāʻau antihypertensive i hōʻike pinepine ʻia e like me ka dizziness a me ke poʻo. Ma nā kīʻaha pilikia ʻole, hilahila, ka malaise laulā, nā māka ʻana o ka ʻōpū, ka nāwaliwali o ka naʻau, a me ka vertigo. Ua lohe kekahi poʻe maʻi i ka tinnitus.
Mai ka papa huhū
ʻO ka hopena wale nō o ka ʻoihana hanu he uwa.
Mai ka pūnaehana genitourinary
I nā mea maʻi me ka hopena o ka hoʻomohala ʻana o ka hana ʻole o ka pūpū, hiki i nā lolo ke hana i ka ulu.
Mai ka pūnaehana cardiovascular
Hōʻike pinepine nā Orthostatic hypotension.
Allergies
I waena o nā hōʻikeʻike o ka hopena kūloko, aia nā:
- ʻO ka makeʻe o Quincke;
- pehu ana pane;
- ʻehole, ʻeha, erythema;
- urticaria;
- angioedema.
Hiki i nā mea maʻi i ka hopena anaphylactic e pono i kahi hoʻokūkū allergy. Inā maikaʻi ka hopena, pono e hoʻokaʻa ʻia ka lāʻau lapaʻau.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻole pili pono ka lāʻau lapaʻau ma ka hana cognitive o kahi kanaka. Ma kēia hihia, hiki ke hoʻomohala hou i ka hopena maikaʻi ʻole mai ka pūnaehana waena a me ke kaʻa o ke kaʻa, no ka mea ʻo ia e hōʻike e pale ʻole i ke kaʻa, hana me nā ʻoihana paʻakikī a mai nā hana ʻē aʻe e koi ai i ka pane wikiwiki a me ka neʻe ʻana i ka wā o ka lāʻau lapaʻau.
Nā ʻōlelo kikoʻī
ʻO ka poʻe maʻi me ka hana pono ʻole o ka ʻōnaehana cardiovascular a i ʻole me ka nui o ka renal function he nui ka hoʻonui ʻia ʻana o ka ulu ʻana o ka hypotension, oliguria, a me ka hoʻonui i ka hauoli i loko o ke koko. Me ke kahe nui ʻana o ke kahe koko ma muli o ischemia, hiki mai i ka myocardial infarction a i ʻole cerebral vascular stroke.
Hoʻohana i ka wā hāpai a me ka lactation
Lā ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i ka wā o ka gestation. E like me nā lāʻau'ē aʻe e pili ana i ka ʻōnaehana renin-angiotensin-aldosterone, komo pono ka irbesartan i ka pale placental. Hiki i ka mea kūpono ke hoʻopili i ka hiki ʻana o intrauterine i kekahi manawa o ka hāpai ʻana. I kēia hihia, ua excreted ʻo irbesartan i ka umauma umauma, i pili me ia e pono e pani i ka lactation.
Koho noi ʻana i nā keiki
ʻAʻole ia e hōʻike i nā maʻi ma lalo o ka makahiki 18, no ka mea, ʻaʻohe mea e pili ana i ka hopena o ka lāʻau lapaʻau ma ka hoʻomohala ʻana i ka wā kamaliʻi a me nā ʻōpio.
Hoʻohana i ka wā kahiko
ʻAʻole koi ʻia ka hoʻoponopono hou ʻana i kēlā me kēia lā no ka poʻe ma hope o 50 mau makahiki.
Ke noi no ka hana renal haukapole
ʻO 2% wale nō o ka lāʻau lapaʻau e haʻalele i ke kino ma o nā keiki, no laila ʻaʻole pono nā kānaka me nā pathologies e hōʻemi i ka dosis.
Hoʻohana no ka hana lawelawe lēwa
I ka hoʻohaunaele koʻikoʻi o nā hepatocytes, lawe ʻia ka lāʻau ʻaʻole mālama ʻia.
ʻO 2% wale nō o ka lāʻau lapaʻau e haʻalele i ke kino ma o nā keiki, no laila ʻaʻole pono nā kānaka me nā pathologies e hōʻemi i ka dosis.
ʻOukiā o Aprovel
Ma nā haʻawina loiloihana, i ka wā e lawe ʻia ai ka 900 mg i kēlā me kēia lā e ka pākeke no 8 mau hebedoma, ʻaʻohe hōʻailona o ka hoʻomāoino o ke kino.
Inā hoʻomaka nā hōʻailona lapaʻau o ka overdose i ka wā o ka hōʻino ʻana i ka lāʻau lapaʻau, a laila pono ʻoe e ʻimi i ke kōkua olakino a kāpae i ka lawe ʻana i ka lāʻau. ʻAʻohe mea kūlike kūpono, no laila, ke kuhikuhi nei ka mālama ʻana i ke kāpae ʻana i ke kiʻi hōʻailona.
Hoʻopili pū me nā lāʻau ʻē aʻe
Me ka hoʻohana like ʻana o Aprovel me nā lāʻau lapaʻau ʻē aʻe, ua ʻike ʻia nā hopena aʻe:
- Synergism (hoʻonui i nā hopena therapeutic o nā lāʻau ʻelua) i hui pū me nā lāʻau antihypertensive, inhibitor channel kalima, thiazide diuretics, beta-adrenergic blockers.
- Nā kikowaena serum i loko o ke koko e piʻi me ka heparin a me nā lāʻau hoʻomohala pili.
- Hoʻonui ʻo Irbesartan i ka uluʻana o ka lithium.
- I ka hui pū me nā lāʻau anti-inflammatory non-steroidal, ʻo ka nui o ka hōʻemi o ka pilikia ʻole i hoʻonui ʻia, hoʻonui ʻia ka hyperkalemia, a no laila, pono ke nānā ʻia ka hana o ka pūpū i ka wā o ka lāʻau lapaʻau.
ʻAʻole pili ka mea koʻikoʻi o Aprovel i ka hopena therapeutic o Digoxin.
Hoʻolaha ka waipuna
Hoʻowai ʻia ka ʻeka ʻo Antihypertensive e lawe pū ʻia i nā huahana wai inu. Hiki i ka Ethyl alkohol ke hoʻoulu i ka hōʻiliʻili o nā ʻāpana koko ʻulaʻula, ka hui pū me ia e hiki ke hoʻopili i ka lumen o ka moku. He paʻakikī ka kahe ʻana o ke koko, ka mea e hoʻonui ai i ka nui o ka puʻuwai a me nā hoʻonui o ke kaomi. E pale aku i ke ʻano o ka lāʻau lapaʻau, hiki i kēia kūlana ke hōʻohi i ka vascular.
Nā kuʻina
I waena o nā mea kikoʻī, ʻo ka hana a ka mea e kau ai i ka māhele ikaika o ka ʻōpala o ke abbesartan, aia nō ka lāʻau lapaʻau o ka hoʻoili ʻana a me ka Lūkini. Hiki iā ʻoe ke hoʻololi i nā papa Aprovel me nā lāʻau lapaʻau i lalo iho:
- Irbesartan
- Ibertan;
- Firmastoy;
- Irsar;
- Irbesan.
He mea nui e hoʻomanaʻo e ma mua o ka hoʻololi ʻana i kahi lāʻau hou he pono ia e kamaʻilio pū me kāu kauka. Hoole ia ka lono
Waihue huaʻōlelo waiho nā huaʻōlelo
Kūʻai ʻia ka lāʻau lapaʻau e ka lāʻau lapaʻau.
Kumukuai no aprovel
ʻO ka kumukūʻai kumukūʻai o ka pahu pahu kāwili i loaʻa iā 14 mau papa o 150 mg ka mea ʻokoʻa mai 310 a 400 mau rubles.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Pono e hoʻokomo i ka lāʻau lapaʻau i kahi wahi hiki ʻole ke hiki i ka mālamalama a me nā keiki i ke ana a hiki i 30 ° C.
ʻO ka lā kau
3 mau makahiki
Mea hana
ʻO Sanofi Winthrop Ahahui, Palani.
Nā Hōʻikeʻike Aprovel
ʻO nā ʻōlelo kūpono e pili ana i ka hopena o ka lāʻau lapaʻau ma nā ʻikepili nui o nā hui pūnaewele e kōkua i ka hoʻoikaika ʻana i ke kūlana ʻo Aprovel i ka mākeke pharmacological.
Cardiologists
Olga Zhikhareva, cardiologist, Samara
ʻO kahi hopena e pono ai no ka hoʻohaʻahaʻa i ke koko. Hoʻohana wau i ka hoʻomaʻamaʻa lāʻau ma ke ʻano he monotherapy a i ʻole ka hōʻea ʻo ka paʻakikī. ʻAʻole wau i nānā i ke kīnā. ʻAʻole ʻōlelo ka mea maʻi e lawe i kahi ʻoi aku ma mua o ka manawa o kēlā me kēia lā.
Antonina Ukravechinko, cardiologist, Ryazan
Loaʻa maikaʻi maikaʻi nā kālā, akā manaʻo wau e makaʻala i kēlā poʻe maʻi i loaʻa i ka stenosis valve aortic aortic. Ke papa paʻa loa nā keiki a me nā wahine hānai e lawe i nā papa Aprovel. I waena o nā hopena hopena, ua loaʻa nā hopena kūlohelohe. I ka manawa like, ʻoiai me nā hopena maikaʻi ʻole mai ke kino, ua kōkua ka lāʻau lapaʻau i ka hōʻemi ʻana i ke koko kiʻekiʻe.
Inā hoʻomaka ʻia nā hōʻailona lapaʻau o ka overdose o ka lāʻau lapaʻau, a laila pono ʻoe e ʻimi i ke kōkua olakino.
ʻO nā maʻi maʻi
Kairo Airam, 24 makahiki, Kazan
Ua loaʻa iaʻu kahi maʻi hypertension. I ke kakahiaka kakahiaka nui ia i ka 160/100 mm Hg. ʻAniā. Lawe ʻo ia i nā lāʻau he nui e hoʻemi i ke kahe koko, akā ua kōkua wale nā papa Aprovel. Ma hope o ka noi ʻana, e maʻalahi koke ka hanu ʻana, kani ka leo o ke koko ma nā heiau. ʻO ka mea nui ʻo ka hopena ma hope o ka haʻalele ʻana i ka lāʻau i ka manawa lōʻihi. Pono ʻoe e inu i nā papa a kipa pinepine aku i kāu kauka. ʻAʻole au i ʻike i nā hopena ʻaoʻao.
Anastasia Zolotnik, 57 makahiki, Moscow
ʻAʻole kūpono ka lāʻau i koʻu kino. Ma hope o ka loaʻa ʻana o nā paila, ka palupalu, ka huhū a me ka hōʻeha nui. Ua hoʻāʻo wau e hoʻomaʻamaʻa i hoʻokahi pule, no ka mea, ua hoʻemi ʻia ke kaumaha, akā ʻaʻole i haʻalele i ka pehu. Pono wau i hele i ke kauka e koho i kekahi lāʻau lapaʻau. ʻO wau makemake, ʻaʻole i kū mai ka syndrome withdrawal, ʻaʻole e like me nā ala ʻē aʻe e hoʻohaʻahaʻa i ke koko.
