C-PEPTIDES I KA MAʻI DIABETES - HOʻOHIʻONA O KA MAʻI MAʻI

Send

Me kēlā me kēia ʻano maʻi o ka maʻi mellitus, ʻo ka nānā ʻana i kona kūlana ka mea nui loa no ka mea maʻi

ʻO ka mea mua, nānā ia i nā glucose i nā plasma. Hiki ke hoʻomaʻamaʻa ʻia kēia ʻano me ke kōkua o nā mea nona ka maʻi diagnostic - glucometer. Akā ʻaʻole emi iki ka mea nui o ka loiloi ʻana o C-peptide - kahi hōʻailona o ka hana insulin i ke kino a me ka metabolism. Hana ʻia ʻo ia ʻano hōʻike ma ke kikowaena: pono e hana ʻia ke kaʻina hana no ka poʻe maʻi me ka maʻi o nā ʻano ʻelua.

He aha kahi C-peptide

Hāʻawi ke ʻepekema lapaʻau i ka wehewehe i kēia manawa:

ʻO C-peptide kahi pīpī paʻa o kahi mea i hoʻokaʻawale i ke kino o ke kanaka - proinsulin.

Hoʻokaʻawale ʻia ka C-peptide a me ka insulin i ka wā o ka hoʻokumu ʻana o ka hopena: pēlā, ke hōʻike nei ka pae o C-peptide ma ke ʻano he nui o ka insulin.

ʻO nā kūlana nui e kau ʻia ai kahi huakaʻi no C-peptide.

ʻO ka hoʻowalewale ʻana o ka maʻi mellitus o ka maʻi ʻokoʻa a me ka ʻano ʻokoʻa o ka maʻi II a me ke ʻano type II;
Ka hana ʻana o ka insulinoma (kahi momona paha a malignant o ka pancreas);
Ka ʻike ʻana o nā koena o ka kaila pancreatic i loaʻa ma hope o kona neʻe ʻana (no ke kanesa o ke kino);
Diagnosis o ka maʻi ate;
Diagnosis o ka polycystic ovary;
ʻO ka nānā aku i nā pae insulin i ka maʻi o ka naʻau;
ʻO ka loiloi o ka mālama ʻana no ka maʻi diabetes.

Pehea ka C-peptide synthesized ma ke kino? ʻO Proinsulin, ka mea i hoʻoili ʻia i loko o nā pancreas (ʻoi aku ka pololei, ma ka β-cell a me nā pulupulu pancreatic), he kaula polypeptide nui e loaʻa ana i nā koena asam amino 84. I kēia kūlana, hoʻihoʻi ka waiwai i ka hana hormonal.

ʻO ka hoʻololi ʻana o ka proinsulin ka hana i ka insulin e like me ka neʻe ʻana o ka proinsulin mai nā ribosomola i loko o nā wahi i loko o nā mea i hoʻopaʻa ʻia e nā mea kuʻuna o ka hoʻokaʻawale o nā molekala. Ma ka manawa like, he 33 mau koena o ka waikawa amino, i ʻike ʻia ʻo ka ʻae ʻana o ka peptide a i ʻole C-peptide, e pani ʻia mai kahi kihi o ke kaulahao.

I loko o ke koko, no laila, aia kahi hopena i waena o ka nui o C-peptide a me insulin.

No ke aha e makemake ai au i kahi hoʻokolohua C-peptide?

No kahi ʻike maopopo o ke kumuhana, pono ʻoe e hoʻomaopopo i ke kumu e hana ai nā limahana o ka C-peptide, a ʻaʻole ma ka insulin maoli.

I kēia mau mea, e hāpai ana i kēia:

ʻO ka hapalua o ke ola o ka peptide i ke kahe koko e ʻoi aku ka lōʻihi ma mua o ka insulin, no laila ua paʻa ka hōʻailona mua;
ʻO ka loiloi immunological no C-peptide hiki iā ʻoe ke ana i ka helu ʻana o ka insulin a hiki ke kū i ke kua ʻana o ka noho ʻana o ka lāʻau lapaʻau synthetic i loko o ke koko (ma nā ʻōlelo olakino - ʻaʻole i hele a "C-peptide" me insulin);
Hāʻawi ka loiloi no C-peptide i kahi loiloi kūpono o ke kiʻekiʻe o ka insulin a hiki i ke alo ʻana o nā antibimies autoimmune i loko o ke kino, ka mea e tupu ai i nā mea maʻi me ka maʻi diabetes type II.

ʻAʻohe mea hoʻomākaukau no ka lāʻau lapaʻau lāʻau i ka C-peptide, no laila, ʻo ka hoʻoholo ʻana o kēia pūhui i loko o ka serum koko e hiki ai iā mākou ke loiloi i ka hana ʻana o nā cell beta pancreatic i nā mea maʻi e hoʻomālamalama ana. ʻO ka pae o ka basal C-peptide, a ma ka manaʻo koʻikoʻi o kēia waiwai ma hope o ka ukana ʻana i ka glucose, hiki iā ia ke hoʻoholo i ka loaʻa o ka naʻau (a i ʻole pale ʻana) o ka mea maʻi i ka insulin. Pēlā, ua hoʻonohonoho ʻia nā hana kala ʻana a i ʻole ka exacerbation a hoʻoponopono ʻia nā hana therapeutic.

Me ka exacerbation o ka maʻi mellitus o ka maʻi mellitus (ʻoi aku ka ʻano I), he haʻahaʻa nā kiko o C-peptide i loko o ke koko: ʻo ia kahi hōʻike mau no ka nele o ka insulin endogenous (loko). ʻO ka haʻawina o ka ʻike ʻana o ka peptide pili i hiki i ka loiloi ʻana o ka huna ʻana o ka insulin i nā kūlana kulekele.

Hiki ke loli ka haʻahaʻa o ka insulin a me C-peptide inā loaʻa i ka mea maʻi i nā maʻi ʻeha a me nā maʻi ʻeha.

Ka metamine i ka nui o ka insulin i ka parenchyma ate, a hoʻopili ʻia ka C-peptide ma o nā keiki. No laila, ʻo nā kuhikuhi o ka nui o C-peptide a me ka insulin e lilo i mea nui no ka wehewehe pono o ka ʻikepili i nā maʻi o nā puʻupaʻa a me nā pūpū.

Pehea ka loiloi o C-peptide

Lawe ʻia kahi hōʻike koko no ka C-peptide ma kahi ʻōpū ʻole, ke ʻole kahi alakaʻi kūikawā mai ka endocrinologist (pono e nīnau ʻia kēia loiloi inā āu i manaʻo ai i kahi maʻi metabolic). ʻO ka manawa o ka wikiwiki ma mua o ka hāʻawi ʻana i ke koko he 6-8 mau hola: ʻo ka manawa maikaʻi loa no ka hāʻawi ʻana i ke koko i ke kakahiaka ma hope o ke ala ʻana.

ʻAʻole ʻokoʻa nā ka hoʻāʻo ʻia ʻana o ke koko mai ka mea maʻamau: ʻiʻoki ʻia ka vein, hoʻākoakoa ʻia ke koko i kahi ʻōpala ʻole. Inā hematomas puka ma hope o venipuncture, kuhikuhi ke kauka i kahi mea hoʻomehana mahana. Holo ʻia ke koko lawe ʻia ma kahi centrifuge, hoʻokaʻawale i ka serum, a ʻōeloʻi, a ʻike ʻia i loko o ka hale hana ma lalo o kahi mikroscope e hoʻohana ana i nā reagents.

Hele ia ma luna o ka ʻōpū ʻawaʻawa ka pae o C-peptide i ke koko e pili ana i ke kumu a i ʻole ma kona palena palena. ʻAʻole hāʻawi kēia i nā kauka i kahi kumu kūpono no kahi maʻi maʻi. I ia mau kūlana hoʻokolohua hoʻāʻo.

E like me nā mea e hoʻoulu ai, hiki ke hoʻopili ʻia nā ʻano hana penei:

Kui o kahi insulin antagonist - glucagon (no nā kānaka me ka hypertension, ua hoʻohālikelike ʻia kēia hana;
ʻO ka pāʻina maʻamau ma mua o ka hoʻoilo ʻana (e ʻai wale ʻia nā ʻāpana "ʻai liʻiliʻi").

ʻO kahi koho kūpono no ka maʻi maʻi ke hana ma kahi o nā hōʻike 2:

ka helu ʻai wikiwiki
hoʻoulu.

I ka nānā ʻana i kahi ʻōpū ʻole, hiki iā ʻoe ke inu i ka wai, akā, pono ʻoe e hōʻalo i ka lawe ʻana i nā lāʻau lapaʻau e hoʻopilikia ai i ka pololei o ka hopena hoʻoili. Inā hiki ʻole ke hōʻoka ʻia nā lāʻau lapaʻau no nā kumu olakino, pono e hōʻike ʻia kēia ʻoiaʻiʻo ma ka palapala ʻōlelo.

ʻO ka manawa haʻahaʻa helu haʻahaʻa he 3 mau hola. Hoʻonohonoho ʻia ka Archive i mālama ʻia ma -20 ° C no 3 mau mahina.

He aha nā hōʻailona o ka loiloi no C-peptides

ʻO nā leʻa i ka pae o C-peptide i serum e pili ana i ka dinamics o ka nui o ka insulin i ke koko. ʻO ka ʻenehana peptide wikiwiki e noho ana mai ka 0.78 a i ka 1.89 ng / ml (ma ka ʻōnaehana SI, 0.26-0.63 mmol / l).

No ka ʻikeʻana i ka insulinoma a me kona hoʻokaʻawale ʻana mai ka hypoglycemia wahaheʻe (ʻoiaʻiʻo), ʻo ke ʻano o ka pae o ka C-peptide i ka pae o ka insulin e hoʻoholo.

Inā helu hoʻokahi a emi mai paha kēia waiwai, ʻo ia ka mea i hōʻike ai i ka hoʻonui ʻia o ka insulin o loko. Inā ʻoi aku ka nui o nā kuhikuhi ma mua o ka 1, ʻo ia ka hōʻike o ka hoʻokomo ʻana i ka insulin waho.

Piʻo kiʻekiʻe

ʻO ke kūlana i ke kiʻekiʻe o ka C-peptide i hāpai ʻia e hōʻike i nā ʻōkuhi i lalo:

ʻAno maʻi II;
Insulinoma;
ʻO ka maʻi Herenko-Cush (maʻi neuroendocrine i hoʻokumu ʻia e ka adrenal hyperfunction);
ʻO ka holo ʻole o ka pūpū;
ʻO ka maʻi ʻeha (cirrhosis, hepatitis);
ʻŌnuʻi lime Polycystic;
ʻO ke kāne male momona;
Hoʻohana lōʻihi o ka estrogens, glucocorticoids, nā lāʻau lapaʻau āpau.

Hiki i kahi kiʻekiʻe o C-peptide (a no laila insulin) ke kuhikuhi i ka hoʻomaka ʻana o ka pulu hoʻohaʻahaʻa waha. ʻO ia paha kekahi hopena a kahi maʻi pancreas a i ʻole nā hoʻololi ʻana i nā cell beta.

ʻO ka haʻahaʻa haʻahaʻa

Hoʻolaha ka hoʻohālikelike ʻana me ka pae maʻamau o C-peptide i ka wā e:

ʻAno maʻi type 1;
Hoopaea hypoglycemia;
Hoʻoweliweli ʻoi ka hōʻemi ʻana i ka maʻi pancreatic.

C lawelawe ʻo peptide

Hiki i nā mea heluhelu ke nīnau i ke kumu loiloi: no ke aha e pono ai mākou i ka C-peptides i ke kino?

A hiki i kēia manawa, i manaʻoʻiʻo ʻia kēia ʻāpana o ka huina o ka waikawa amino i hana ʻole ai i ka biologically a he mea ala o ka hoʻokumu ʻana i ka insulin. Akā ʻo nā haʻawina hou e nā endocrinologists a me nā maʻi maʻi maʻi i alakaʻi i ka hopena ʻaʻole pono i ka waiwai a hana i loko o ke kino, ka mea maʻamau no nā poʻe maʻi me ka maʻi maʻi maʻi.

E like me nā hōʻike i hoʻopaʻa ʻole ʻia, ʻo ka hoʻokaʻawale ʻokoʻa o ka C-peptide i ka wā o ka inikini insulin no ka poʻe maʻi me ka maʻi maʻi e ʻae i ka hōʻeha ʻana i nā hōʻeha koʻikoʻi o ka maʻi e like me ka nephropathy (dysal function), neuropathy a me angiopathy (hōʻino i nā ʻeha a me nā kīʻaha koko, kēlā me kēia).

Aia he hiki ke hiki mai i ka hoʻomākaukau ʻana o ka C-peptide e hui pū me ka insulin i ka maʻi maʻi maʻi, akā, i kēia manawa a hiki i nā hopena kūpono a me nā hopena o nā hanana ke hoʻoholo ʻia i loko o ka hauoli. Ke hele mai nei nā noiʻi nui ma kēia kumuhana.

Send