ʻO nā maʻi āpau kekahi mau lula e pālahalaha aku. ʻO ke kumu a me ka hōʻeha ʻana he hapakolu, aia ma ka lua ka nui o nā maʻi ʻino, a ua lawe ʻia nā maʻi o ka ʻōnaehana ma ka palma.
Hoʻopili lākou i ka infarction myocardial koʻikoʻi; ischemic and hemorrhagic stroke; thrombosis urena hohonu loa o nā ʻoi aʻe i lalo; atherosclerosis. ʻAʻole kēia he papa inoa piha o nā maʻi, nā mea maʻamau wale nō. Hōʻike lākou āpau i kahi pilikia o ke olakino a me ke ola kanaka.
ʻO ia ke kumu o ka hana ʻana i nā lāʻau lapaʻau no ka mālama ʻana i nā maʻi o ka puʻuwai a me nā maʻi vascular i ka nui o ka palahalaha loa, a aneane loa kēlā me kēia hui a pau o nā lāʻau lapaʻau i kēlā me kēia mea o kēia hopena.
Nā kumu o ka maʻi Cardiovascular
Hoʻokumu nā maʻi Coronary i nā kumu like ʻole. Aia nā mea i hiki ʻole ke hoʻololi ʻia - ka wahine, ka makahiki a me ka moʻomeheu. A aia nā pilikia e hiki ke hoʻololi e pale i ka hoʻomohala ʻana o ka pathology.
Aia nā kumu hoʻoponopono:
- Ka ulaula - ka huʻihuʻi maikaʻi ʻana i ka loiloi o ke kino kanaka. Ke komo lākou i ka kahe ma o ka pūnaewele alveolar dense, noho lākou ma ka intima o nā moku, ke komo i ka pā, i hoʻokomo pū ʻia i ka membrane cell, hana ia i mea e pīhoihoi ai, a ʻike ʻia nā microcrack. Nā pākela, ka mea e pani kokoke ai i ka hemahema, ʻoiai e hōʻike ana i nā kumu coagulation, pili i kēia mau hōʻeha. A laila e hoʻopili ʻia nā lipids i kēia wahi, ʻuʻulu a hōʻiliʻili a hoʻopaʻa ʻia i ka lumen. No laila e hoʻomaka i ka atherosclerosis, e alakaʻi i ka hoʻomohala ʻana o ka maʻi naʻau coronary a, ma hope aku, i ka myocardial infarction;
- ʻOi momona. Hoʻokaʻawale ʻia ka momona i ka wā o ka malnutr e hoʻopōlohelohe pinepine ʻia, hoʻopuni mua ʻia ma nā ʻōpū. Ma muli o kēia, ua pilikia kā lākou hana, e ʻeha ka naʻau a me nā moku nui. He mea nui ia e hoʻomaopopo, me ka obesity, hoʻonui i ke kiʻekiʻe o ka lipoproteins haʻahaʻa haʻahaʻa a hoʻemi i ka pae o ka lipoproteins density kiʻekiʻe, e hāʻawi i ka hōʻike o ka maʻi;
- ʻO ka Hypodynamia - alakaʻi i ka nāwaliwali o ka ʻiʻo i ke kākoʻo i ka leo vascular, e hoʻoneʻe i ka intima i kahi palupalu a me ka atrophy. Ke alakaʻi nei kēia i nā hemahema i loko o nā paia vascular;
- Hoʻinoʻa i ka waiʻona - alakaʻi i ka hoʻoinu nui i ke kino, pili i nā moku koko me ka luku ʻana i nā hepatocytes. Loaʻa ia he hopena ma ka vena cava, ka moku nui hepatic. Hōʻiliʻili nā ketui i ka paia o ka pā o ka moku, ʻokiʻoki a me ka deforming.
Ma lalo o ka mana o kēia mau mea e pili ana i ka hopena o ke kanaka, a me ke koʻikoʻi, ka luhi a me nā maʻi e pili ana, e ulu ana ka atherosclerosis - ka pilina mua o nā maʻi coronary.
Me ia, hana ka pāla i nā paia o nā kīʻaha koko mai ka kolamu, aia i ke kaʻina o ka ulu ʻana o ke kahe koko.
Nā Hana Hoʻomaʻi Atherosclerosis
He pilikia koʻikoʻi kēia maʻi, ma ka ulu ʻana o nā pākeke ʻekolu ma hope o 50 mau makahiki. ʻO ia ke kumu i holo pono ai i nāʻoihana lāʻau lapaʻau ma ka hoʻokumu ʻana o ka lāʻau lapaʻau i ka atherosclerosis.
Eia nō naʻe, ke hoʻohana mua nei i ke ala pale mua. ʻO ka hoʻonui ʻana i ka hoʻāla kino, ma ka liʻiliʻi a i hoʻokahi hora o ka lā (a hiki paha ke hāpai ʻia a i ʻole nā ʻoluʻolu hoʻohana, a brisk hele a hele a hele paha i ka lewa hou), e hōʻemi ana i ka hoʻokumu ʻana i ka atherosclerosis e 40% Inā hoʻololi ʻoe i ka meaʻai, a hoʻohui pū i ia mea, i ka ʻokoʻa, ka cereals, nā huaʻai a me nā mea kanu, a laila e emi ka pilikia ma kahi o 10%. ʻO ka haʻalele ʻana i ka hūʻena e lawe i ka hapaʻumi o ka hopena.
Inā kūpono ʻole kēia mau hana āpau, ua kau ʻia nā lāʻau lapaʻau i ka papa o ke ʻano. ʻO nā lāʻau lapaʻaka lipid hou me ka hopena i hōʻoia ʻia i hana ʻia he kanakolu mau makahiki wale nō ma mua, ma mua o ka mālama ʻia ʻana o nā hōʻaiʻe wahine wahine - estrogens, acid acidotinic, sequestrants o nā momona momona. Hōʻike lākou i kahi hopena kūmole - ka make mai ka maʻi coronary nui me ka nui.
I ka makahiki 1985, ʻo ka ʻoihana lapaʻau Kelemania ʻo Pfizer i hōʻeha i ka lāʻau hou - Atorvastatin. Hoʻokumu ʻia me ia, me ka hoʻohui o nā pūhui mea kōkua, ua hana mua ka lāʻau lapaʻau mua me ka hopena anticholesterolemic like, ʻo Liprimar. Kāohi ʻo ia i ka hoʻoneʻe o ka enima HMG-CoA, hoʻokaʻawale i ka hoʻolālā o ke kāpili ʻana o ke kolesterol i loko o ka ate i ka papa o ka hoʻokumu ʻana o ka mua o ke kolamu - mevalonate.
I ka hoʻohālikelike maʻalahi ʻana i ka makapō, ua hōʻike ʻia ka hopena hopena o ka atorvastatin. A ʻo kahi hopena, ua ʻike ʻia kahi hāʻule ma kahi o nā lipoproteins haʻahaʻa haʻahaʻa i ka 40%.
Inā he maʻi hypertension arterial, Atorvastatin ma ke ʻano o 5 i 20 milligrams no ʻekolu mau makahiki o ka monotherapy e hōʻemi i ka hopena o ka hoʻomohala ʻana i ka myocardial infarction e ka 35%.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau Liprimar
Ua loaʻa i nā liprimar nā ʻōlelo kikoʻī no ka hoʻohana.
Ma mua o ka hoʻohana ʻana i kēia lāʻau lapaʻau e hōʻemi i ka nui o nā lipid i ke kaila koko, pono e kamaʻilio mau ʻoe i kāu kauka.
Aia nā hōʻike āpau no ka hoʻohana ʻana i ka lāʻau lapaʻau i hōʻike ʻia i nā kuhikuhi i ka hoʻohana ʻana i ka lāʻau lapaʻau.
Nā mea nui e hōʻike ʻia:
- ka hiki ʻana o kahi hypertension arterial i loko o nā maʻi - ka mahuahua o nā kaha hoʻonaninua mai 160/100 mm Hg a iluna;
- angina pectoris, ke kolu o ka papa hana;
- myocardial infarction i ke kala ʻana;
- maʻalahi (hoʻonui LDL), kāwili (hoʻonui ʻia LDL a me VLDL) a i ʻole familial (hoʻoilina, malignant) hypercholesterolemia ma mua o 6 mmol / l, kahi i hoʻoki ʻole ʻia e ka loli ʻano;
- atherosclerosis.
I ka hoʻohālikelike ʻia me ka lāʻau lapaʻau me ka lāʻau lapaʻau, pono ʻoe e pili i kahi meaʻai, hoʻomaʻamaʻa a hāʻawi i nā hana maikaʻi ʻole.
Lawe ma ke ʻano me ka ʻole o ka haki ʻana a papa ʻole i kahi papa. Ininu i ka nui o ka wai. ʻO ka ʻōmai hoʻomaka no ka ʻike mua ʻia he hypercholesterolemia he 10 mg i kēlā me kēia lā, ma hope o kahi malama e nānā ana i ka dinamics o ka lapaʻau, hoʻoponopono ʻia ka lāʻau i luna, inā pono. Me ka hypercholesterolemia familial, ʻoi aku ka nui o ke ʻano, a he 40-80 mg. Pono ʻia nā keiki he 10 mg wale nō i ka lā.
ʻO ka palena kiʻekiʻe loa i kēlā me kēia lā he 80 mg. I ka wā o ka mālama ʻana, pono ia e hoʻomalu i ka mālama ʻana i nā enzyme o ka ate, inā ʻoi aku lākou i ʻoi aku ma mua o nā manawa 3, hoʻopau ʻia ʻo Liprimar.
Aia kekahi nui o nā hopena ʻokoʻa mai ka hoʻohana ʻana i ka lāʻau, nā mea nui:
- Neuropathy, nā hiamoe o ka hiamoe, ke kaumaha, nā paresthesias.
- ʻO ka ʻeha ʻanui, twitching, myositis.
- Ka hoʻohaʻahaʻa ʻana i ka momona, nausea, hoʻonui ʻia i ke kino, ka ʻeha ʻana, ka maʻi o ka pancreas.
- Ka huhū o nā ate, Jaundice, stagnation o ka bile.
- Allergy, urticaria.
ʻO Liprimar ka liʻiliʻi o nā contraindications, ʻo ka mea nui ka intolerance e lactose a i ʻole ka mea ikaika o ka atorvastatin. Hoʻohana me ka makaʻala ʻana i nā mea maʻi me nā maʻi pūpū a me nā maʻi, nā keiki ma lalo o 14 makahiki o nā makahiki, a me nā wahine lactating.
I ka wā hāpai, ʻaʻole ʻōlelo ʻia ka lāʻau lapaʻau.
ʻO ka ʻokoʻa ma waena o ka kumu a me nā derivatives
ʻAʻole wale ʻo Liprimar ka lāʻau lapaʻau mai ka helu i kekahi o nā statins, ʻoiai naʻe, me ka kānalua, e like me nā noi ʻana ma nā maʻi maʻi, ʻo ia kekahi o nā mea maikaʻi loa. Ma waena o 1985 a me 2005, ʻoiai ke palekana nei ka pale patent, ʻo ia wale nō kekahi. Akā ua loaʻa i kāna ʻano hoʻohālike, a hoʻomaka e hoʻohālikelike nā analogue, nā mea i kapa ʻia ʻo generics. Loaʻa lākou āpau i ka hopena maʻamau me ka Atorvastatin, a, nā mea ʻenehana, pono ke ʻano like me ka hopena therapeutic.
Eia naʻe, ma muli o ka kūpaʻa o nā kānāwai o nā'āina he nui i ka hoʻopaʻa ʻana i nā hoʻokolohua lapaʻau, ʻo ka mea wale nō i pili ai lākou me ka mea kumu. Wahi a nā palapala i ʻae ʻia e like, i mea e hana ai i kahi inoa kālepa hou, pono wale nō ʻoe e waiho i kahi palapala i ka like o ka kūlohelohe i ke komisina. Akā ʻo ka pilikia ke ala e hiki ai i kēia mau mea ke hoʻōla ʻia, a ʻo kēia ke alakaʻi i ka hoʻololi i nā waiwai. ʻO kēia ka hopena o ka hopena therapeutic e emi, a i ʻole ka liʻiliʻi.
I kēia manawa, nui aku ka nui o ka inoa ʻo Liprimar i nā inoa kālepa, ʻoi aku lākou a pau i atorvastatin he mau mea ikaika. ʻO ka mea kaulana loa o lākou ʻo Atorvastatin (hana-Lūkini) a me Atoris (mea hana - Slovenia). Loaʻa lāua a kūʻai aku i nā mea i loko o nā mākeke, akā aia nā ʻokoʻa ma waena o lākou.
Hiki ke ʻike ʻia ka ʻokoʻa mua ma ka hale kūʻai - ʻo ia ke kumukūʻai ma ke ʻano o 10 mg:
- Liprimar - 100 ʻāpana - 1800 rubles;
- Atoris - 90 mau ʻāpana - 615 mau rubles;
- Atorvastatin - 90 mau ʻāpana - 380 mau rubles.
Ke kū aʻe nei ka nīnau, no ke aha e ʻokoʻa ai ke kumukūʻai a pehea e hiki ai ke hoʻololi ʻia ʻo Atorvastatin. Hele ʻo Liprimar i ka ʻimi noiʻi piha, loaʻa i ka patent, a he nui nā kumuwaiwai e hana ai a hoʻolaha. No laila, ʻo ka ʻoihana ke kau i ke kumukūʻai kiʻekiʻe e like me ke uku no ka pono kūpono, hōʻike ʻia i ka wā he ʻumi makahiki.
ʻO Atoris, i hana ʻia ma Slovenia, he loiloi ʻelua mau makahiki ʻōpiopio, kahi i hōʻike ʻia ai e hoʻēmi ana ia i ka lipoproteins haʻahaʻa haʻahaʻa ma 5% ma mua o ka mea o ka mea kumu, akā ʻaʻole ka hopena a ka hopena therapeutic a hiki ke hoʻohana ʻia he analogue o Liprimar.
ʻAʻole i hele ʻo Domor Atorvastatin i nā wāwae āpau o nā hoʻokolohua lapaʻau, a ua hōʻoia wale ʻia kona kūlike kemika, no laila he mea ʻala loa ia. Eia naʻe, ʻike ʻole ʻia kona hopena ma ke kino no kekahi, e hana selly, ʻo ia, hiki ke kōkua i kekahi kanaka a hōʻino kekahi. Ke kūʻai ʻia nei e nā poʻe hiki ʻole ke kūʻai i ka lāʻau lapaʻau i hoʻopuka ʻia.
Hiki ke loiloi ʻia ka hopena o nā lāʻau ma hope o ka hoʻokele ʻana. Eia nō naʻe, no ka hoʻokō ʻana i ka hopena, pono ke lawe ʻia ʻo Liprimar i ʻelua mau pule, Atoris ʻekolu, a me nā papa ʻelua ʻelua o Atorvastatin. Hiki i kēia ke hōʻeha i nā ate.
I mea e pale ai i kēia, ʻoi aku ia e lawe i nā lāʻau hepatoprotectors i ka ʻokoʻa.
Pehea e hoʻohui ai i nā statins?
Hoʻopiliʻia nā derivatives o atorvastatin, aia kekahi mau mea ikaika i ka mākeke lāʻau i hoʻohana ʻia no ka atherosclerosis. ʻO kēia nā kumuhana o losartan, he inhibitor angiotensin 2, no ka laʻana, ʻo ka lāʻau Lozap. ʻAʻole ʻo ia ka hana nui i ka hoʻouka ʻana i ka LDL cholesterol, akā i ka hoʻohaʻahaʻa ʻana i ke kaomi, no laila e hoʻohana pinepine ʻia nā wahi moe me nā moena. Eia nō naʻe, aia ka hopena o Lozap i nā hepatocytes, no laila, ʻo ka poʻe me nā hōʻailona o ka hiki ʻole o ke akeʻa e kūkākūkā i kahi kauka ma mua o ka hoʻomaka ʻana i ka mālama ʻana. Hōʻike ʻia nā hopena maikaʻi loa e hui pū ʻia me nā statins e nā kanaluna hāpana kalima, no ka laʻana, ʻo Amlodipine.
I kahi hihia o kahi hopena alū i Liprimar, pono e hoʻohana i nā mea analogs a ua hoʻololi no ka atorvastatin. ʻO kēia ka rosuvastatin a simvastatin. ʻO lākou, e like me nā statins ʻē aʻe, pili ka hopena i ka pae o ka enzyme redmase HMG-CoA a loaʻa nā lāʻau lapaʻau like like.
Eia nō naʻe, i ka papa o ka noiʻi ua loaʻa i ka Rosuvastatin he nephrotoxicity, ʻo ia hoʻi, hiki ke hoʻopilikia i ka renal parenchyma, hoʻoweliweli i ka hoʻomohala ʻana o ka hana ʻole i ka renal.
Hoʻolaha ʻo Simvastatin i ke kiʻekiʻe o ka lipoproteins haʻahaʻa haʻahaʻa e 9% ma mua o Liprimar, e hōʻike ana i kona haʻahaʻa haʻahaʻa. ʻO kēia ke kumu ʻo Liprimar i noho a alakaʻi i ka mākeke kūʻai mai nā pūʻulu o nā statins, i hōʻoia ʻia ʻaʻole wale nō e nā hopena o ka noiʻi a me nā makahiki he nui o ka ʻike ma ka hoʻohana ʻana i nā atherosclerosis, akā hoʻi i nā manaʻo kūpono mai nā maʻi.
Hoʻākāka ʻia ʻo Atorvastatin i kahi wikiō ma kēia atikala.
