Ke aʻo ʻia nei nā statins a me nā mellitus mellitus i kēia manawa a nā kumu ʻepekema mai nā wahi a puni. Ua nui nā noiʻi i hoʻohana i ka hopena pletebo i hiki ke hōʻoia i ka poʻe statins i hōʻemi iki i ka hopena o ka hoʻomohala ʻana i ka maʻi cardiovascular.
I ka manawa like, aia kekahi mau ʻike o ka hōʻike e hōʻike ana i ka pono no nā statins i ke kaila diabetes mellitus e hiki ke hoʻonui i ka maʻi ʻonanika. ʻO ka mea maʻamau, i ka maʻi lolo, he nui ka nui o ke kō koko koko, ma muli o kahi āu e lawe ai i ka Metformin a hoʻololi i nā sartans.
I kēia manawa, hoʻomau nā kauka he nui i ka lāʻau lapaʻau no ka maʻi maʻi maʻi. Pehea kēia mau hana a nā kauka a hiki paha i ka poʻe maʻi me ka maʻi maʻi e lawe statins?
Pehea e pili ai nā statins i ke kino?
ʻO Cholesterol he pūhui kai loko kūlohelohe e pili ana i ka hana o nā wahine wahine a me nā kāne male kāne, hāʻawi i kahi pae maʻamau o ke kahe i loko o nā sela o ke kino.
Eia nō naʻe, me ka nui o ka mea i loko o ke kino, kahi maʻi maʻi nui - hiki i ka atherosclerosis ke ulu. Hoʻopilikia kēia i kahi hana kuʻuna i ka hana maʻamau o nā moku koko a hōʻeha pinepine i nā hopena koʻikoʻi, no ka mea e hiki ai i kekahi ke hōʻeha. Hoʻomaʻamaʻa pinepine ka mea maʻi ma muli o ka hōʻiliʻili o nā kolamu kolesterol.
ʻO nā statins he lāʻau lapaʻau lāʻau lapaʻau e hoʻohaʻahaʻa i nā lipids koko a i ʻole ka kolamu a me nā lipoproteins haʻahaʻa haʻahaʻa - kahi ala o ka kolamu. ʻO nā lāʻau lapaʻau Therapyutic he synthetic, semi-synthetic, kūlohelohe, e pili ana i ko lākou ʻano kumu.
ʻO ka hopena lipid-hoʻohaʻahaʻa loa i hoʻopiʻi ʻia e atorvastatin a me ka rosuvastatin o ka puka synthetic. Aia ia mau hōʻike i nā kumu hōʻike nui loa.
- ʻO ka mea mua, kāpae nā statins i nā enzymes e hana i ke kuleana nui i ke kaʻe o ka cholesterol. Mai ka nui o nā lipine endogenous i kēia manawa ke 70 i ka pakeneka, ʻo ke ʻano o ka hana a nā lāʻau lapaʻau ke noʻonoʻo pono i ka hoʻopau ʻana i ka pilikia.
- Eia kekahi, kōkua ka lāʻau lapaʻau i hoʻonui i ka nui o nā mea taliaina no ka lawe aku i ka cholesterol i nā hepatocytes. Hiki i kēia mau mea ke hoʻopili i nā lipoproteins e hoʻoheheʻe i loko o ke koko a hoʻoiho iā lākou i loko o nā pūpū o loko, ma hea ke kaʻina hana ka hemo ʻana i nā huahana aʻai ʻole o nā mea ʻino mai ke koko.
- Hoʻokomo i nā statins e ʻae i nā momona i hoʻohuihui ʻia i loko o nā loko, a e hōʻemi ana i ka pae o ka exogenous cholesterol.
Ma kahi o nā hana pono nui, loaʻa ka statins i ka hopena pleiotropic, ʻo ia hoʻi, hiki iā lākou ke hana ma kekahi mau "ʻimi" i ka manawa hoʻokahi, e hoʻomaikaʻi ana i ke ʻano maʻamau o kekahi kanaka. Ma keʻano kūikawā, ʻike ka mea maʻi i nā lāʻau lapaʻau ma luna nei e loaʻa i ke ʻano olakino nei:
- E holomua nā kūlana o ka linu i loko o nā kīʻaha koko;
- Ke emi nei ka hana o ke kaʻina o nā maʻi;
- Hoʻomaʻa ʻia nā ʻoka koko;
- Hoʻokuʻu ʻia nā hui kuʻi e hāʻawi ana i ka myocardium me ke koko;
- I ka myocardium, e hoʻoulu ʻia ka ulu o nā moku koko hou;
- Hoʻomau nā wahi myocardial hypertrophy.
ʻO ia, hiki iā mākou ke ʻōlelo maluhia i nā statins i kahi hopena lapaʻau maikaʻi loa. Ke koho nei ke kauka i ka dosis kūpono loa, ʻoiai ʻo ka liʻiliʻi liʻiliʻi hiki ke loaʻa kahi hopena therapeutic.
ʻO ka mea nui ka helu liʻiliʻi loa o ka hopena o ka hopena i ka mālama ʻana i nā statins.
ʻO nā statins a me kā lākou ʻano
I kēia mau lā, nui nā kauka e manaʻo nei he hoʻohaʻahaʻa ka kaohi ʻana i ke koko i ka maʻi type type 2 he mea nui ka hiki ʻana i ke ola. No laila, ua hoʻohālikelikeʻia kēia mau lāʻau, e like me Sartans, me nā lāʻau lapaʻau e like me Metformin. Hoʻohui pinepine ʻia nā statins me ke kolamu maʻamau e pale ai i ka atherosclerosis.
Hoʻohālikelike ʻia nā lāʻau lapaʻau o kēia pūʻulu e ka mea hoʻonohonoho, ke ʻano, nā hopena ʻaoʻao. Hōʻalo ka poʻe kauka i ka mea hope loa, no laila, lawe ʻia ka lāʻau lapaʻau ma lalo o ka mālama ʻana o kekahi kauka. ʻO kēia ka nui mau o nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol koko.
- Hoʻohui ʻia ka lāʻau Lovastatin me ka hoʻohana ʻana i nā pehu e hana ana i ka hana fermentation.
- ʻO ka lāʻau like ʻole ka lāʻau lapaʻau simvastatin.
- ʻO ka lāʻau Pravastatin he ʻano like a me ka hopena.
- ʻO nā lāʻau lapaʻau piha piha i ka Atorvastatin, Fluvastatin, a me Rosuvastatin.
ʻO ka maʻi ʻāpono hou loa a hoʻohana ʻia ka rosuvastatin. Wahi a nā helu helu, ʻo ka cholesterol i loko o ke koko o kahi kanaka ma hope o ka mālama ʻana i kēlā lāʻau lapaʻau no ʻeono mau pule e hoʻemi ʻia ana e 45-55 paona. Ua manaʻo ʻia ʻo Pravastatin i ka lāʻau lapaʻau liʻiliʻi loa, ʻo ia hoʻi e hoʻohaʻahaʻa i ka cholesterol ma o 20-35 pakeneka wale nō.
He ʻokoʻa nā kumukūʻai o nā lāʻau lapaʻau mai kēlā me kēia, ma muli o ka mea hana. Inā kūʻai ʻia nā papa he 30 o Simvastatin i kahi hale kūʻai i kahi 100 mau rubles, a laila hoʻohālikelike ke kumukūʻai o Rosuvastatin mai 300 a 700 rubles.
Hiki ke hoʻokō ʻia ka hopena therapeutic mua ma mua o hoʻokahi mahina o nā lāʻau lapaʻau maʻamau. E like me nā hopena o ka lapaʻau, hoʻemi ʻia ka hana o ka kolamu ma ka pepeke, ke hoʻoneʻe ʻia nei ka ʻike ʻana mai o ka cholesterol i loko o nā palu mai nā huahana i lawe ʻia.
Hōʻike ʻia nā kumuhana no ka hoʻohana ʻana:
- atherosclerosis;
- maʻi puʻuwai, ka hoʻoweliweli o ka puʻuwai puʻuwai;
- diabetes mellitus i mea e pale ai a hoʻoemi paha i nā hoʻopiʻi olakino.
I kekahi manawa ke nānā ʻia nā ʻano o nā kaha atherosclerotic me ke kolamu.
I kēia hihia, hiki ke ʻōlelo ʻia i ka lāʻau lapaʻau no ka mālama ʻana.
ʻO ka maʻi mellitus a me nā maʻi cardiovascular
Me ka maʻi o ka maʻi maʻi, he nui ka hopena o nā hopena maikaʻi ʻole i ke kahua o ka ʻōnaehana cardiovascular. ʻOi aku ka maʻi diabetes ʻelima a ʻumi mau manawa e hoʻomāhuahua i ka maʻi naʻau ma mua o nā poʻe me ke koko koko maʻamau. ʻO 70 pakeneka o kēia mau maʻi ma muli o nā hoʻopiʻi ʻana he hopena make.
Wahi a nā ʻelele o ka American Heart Association, ʻo ka poʻe me ka maʻi maʻi a me ka poʻe i loaʻa i ka maʻi ʻalapau coronary i like me ka nui o ka make ma muli o kahi ulia cardiovascular. No laila, ʻaʻole ka maʻi koʻikoʻi ʻo ka maʻi diabetes ma mua o ka maʻi puʻuwai ischemic.
Wahi a nā helu helu, ʻike ʻia nā maʻi naʻau coronary ma ka 80 pakeneka o ka poʻe me ka maʻi maʻi lā 2. Ma ka 55 ka nui o nā hihia i loko o ia mau kānaka, e make ana ka make ma ka myocardial infarction a ma ka 30 pakeneka ma muli o ka hōʻeha. ʻO ke kumu no kēia nā mea maʻi i nā mea pilikia kūikawā.
ʻO kēia mau mea pilikia no ka maʻi maʻi me:
- Hoʻopili i ke kōpaʻa koko;
- Ke kū mai nei o ke kū'ē o ka insulin;
- Hoʻonui ka naʻau insulin i ke koko o ke kanaka;
- Ke hoʻomohala ʻana o ka proteinuria;
- ʻO ka hoʻonui i nā puʻupuʻu koi i nā hōʻailona glycemic.
Ma keʻano holoʻokoʻa, hoʻonui ka hopena o ka hoʻomohala ʻana i ka maʻi cardiovascular me:
- lawe ʻia e ka moʻomeheu;
- kekahi makahiki;
- ka hele ʻana mai o nā hana ʻino;
- nele i ka hoʻoikaika kino;
- me ka maʻi hypertension;
- hypercholesterolemia;
- dyslipidemia;
- maʻi mellitus maʻiʻi.
ʻO ka hoʻonui ʻana i ka ʻike o ka cholesterol ma ke koko, kahi hoʻololi i ka nui o nā lipher atherogen a me antiatherogenic nā mea kūʻokoʻa e hoʻonui ai i ka hopena o ka hoʻomohala ʻana i nā maʻi o ka ʻōnaehana ponoʻī. E like me nā hōʻike ʻepekema like ʻole, ma hope o ka maʻamau o kēia mau hōʻailona, ua emi ka nui o nā pathologies.
Kuhi ʻia he hopena maikaʻi ka maʻi diabetes ma nā kīʻaha koko, he mea kūpono ʻole ke koho i nā statins e like me ke ʻano lapaʻau. Eia nō naʻe, ʻo ke ala kūpono kēia no ka mālama ʻana i ka maʻi, hiki i nā mea maʻi ke koho i ka Metformin a i nā statins i hoʻāʻo ʻia i nā makahiki ʻoi aku ka maikaʻi?
ʻO nā statins a me ka maʻi diabetes: kūlike a me nā pono
Ua hōʻike ʻia nā noiʻi hou ʻana i hiki ai i nā statins a me ke ʻano type type 2 ke kūpono. ʻO nā lāʻau like ʻole e hoʻemi i ka morbidity wale nō, akā make pū ma muli o nā maʻi cardiovascular ma waena o ka poʻe me ka maʻi maʻi. ʻO ka Metformin, e like me nā statins, he hopena ʻē aʻe i ke kino - e hoʻohaʻahaʻa ana i ke kahe koko.
ʻO ka pinepine, ʻo kahi lāʻau i kapa ʻia ʻo Atorvastatin e kau ʻia ma ka hoʻopaʻa ʻepekema. I kēia lā hoʻi, ua loaʻa ka lāʻau lapaʻau Rosuvastatin i ka mea kaulana. ʻO kēia mau lāʻau āpau he statins a loaʻa i ka kumu synthetic. Ua alakaʻi ʻia nā ʻepekema ʻana i kekahi mau ʻano o nā noiʻi, me CARDS, PLANET a me TNT CHD - DM.
Ua hana ʻia ka noiʻi CARDS me ke komo ʻana o nā maʻi maʻi o ka maʻi like lua, ma nā haʻina haʻahaʻa lipoprotein haʻahaʻa ʻaʻole i kiʻekiʻe mai ka 4.14 mmol / lita. Ma waena o nā mea maʻi e pono ke koho i ka poʻe ʻaʻohe i nā pathologies i ke kahua o nā maʻi peripheral, cerebral a me ka coronary.
ʻO kēlā me kēia kanaka i komo i ka aʻo ʻana he mea liʻiliʻi loa ka i loaʻa o kahi pōpilikia:
- He koko kiʻekiʻe;
- Retinopathy Diabetic;
- Albuminuria
- I nā huahana kikowaena.
Ua lawe nui ka mea maʻi i ka atorvastatin i ka nui o 10 mg i kēlā me kēia lā. ʻO ka mahele e lawe ʻia ka mea e waiho i kahi placebo.
Wahi a ka hoʻokolohua, ma waena o ka poʻe i lawe i ka statins, ua hoʻemi ʻia ka hopena o ka ulu ʻana i kahi hōʻeha ma kahi o 50 pakeneka, a me ka hopena e hoʻomohala i ka myocardial infarction, unina kaina, ka make koke ʻana o ka make coronary e ka 35 pakeneka. I ka loaʻa ʻana o nā hopena kūpono a ʻike ʻia nā pōmaikaʻi, ua pau nā haʻawina i ʻelua mau makahiki ma mua o ka hoʻolālā.
I ka papa o ka haʻawina PLANET, ua hoʻohālikelike a me ke aʻo ʻia nā mea nephroprotective e loaʻa ana iā Atorvastatin a me Rosuvastatin. ʻO ka hoʻokolohua PLANET mua i hōʻike aku i nā mea maʻi i hōʻike ʻia me ka maʻi type I a me ke ʻano type type 2. ʻO nā mea komo ma ka hōʻike PLANET II he poʻe me ka glucose koko maʻamau.
Hāʻawi ʻia kēlā me kēia o nā mea maʻi i hoʻoliʻi ʻia e nā kiʻekiʻe kiʻekiʻe o ka kolala a me ka proteinuria - i hiki ke kūmua i ka protein. Ua māhelehele ʻia nā poʻe āpau i ʻelua mau hui. Ua lawe ka pūʻulu mua i 80 mg o atorvastatin i kēlā me kēia lā, a ua lawe ka lua ma kahi o 40 mg o rosuvastatin. Ua mālama ʻia nā haʻawina no 12 mahina.
- E like me kahi hōʻikeʻike ʻepekema hōʻike, i nā poʻe maʻi me ka maʻi diabetes i lawe i Atorvastatin, ua hoʻemi ka nui o ka protein i ka urine e 15 pakeneka.
- ʻO ka hui e lawe ana i ka lāʻau ʻelua e hōʻemi i ka pae o ka protein i ka 20 pakeneka.
- Ma keʻano holoʻokoʻa, ʻaʻole i nalowale ka proteinuria mai ka lawe ʻana iā Rosuvastatin. I ka manawa like, aia ka mea lohi i ka pae o ka filtration glomerular rate o ka urine, ʻoiai nā kālā mai ka hoʻohana ʻana o Atorvastatin e like me ka loli ʻole.
ʻO ka PLANET aʻu i aʻo ai i loaʻa i ka 4 pakeneka o nā poʻe e pono e koho i ka rosuvastatin, he kūleʻa renal failed, a he mea pālua pū kekahi serum creatinine. I waena o nā kānaka. lawe ʻana i ka atorvastatin, ʻike ʻia ka maʻi i loko o ka hapa pākēneka o ka maʻi o ka maʻi wale nō, ʻaʻole naʻe i ʻike ʻia kahi loli i ka creatinine serum.
No laila, ua hoʻohuli ʻia ka lāʻau lapaʻau Rosuvastatin, i hoʻohālikelike ʻia me ka analogue, ʻaʻohe waiwai pale no nā keiki. Hoʻokomo ʻia ka lāʻau lapaʻau i nā mea maʻi me ka maʻi maʻi o kēlā me kēia ʻano a me ka hiki ʻana mai o ka proteinuria.
Ke hōʻike mua nei i kahi papa o TNT CHD - DM i ka hopena o ka atorvastatin i ka hopena o ka hoʻomohalaʻana o kahi pilikia cardiovascular ma ka maʻi arter coronary a me ke ʻano type type 2. Pono ka poʻe maʻi e inu i ka 80 mg o ka lāʻau lapaʻau i kēlā me kēia lā. Ua lawe ka hui kahi lāʻau i kēia lāʻau lapaʻau ma kekahiʻano o 10 mg i kēlā me kēia lā.
Wahi a nā hopena o ka hoʻokolohua, ua hoʻohuli ʻia ka hopena o nā hoʻonāukiuki ma ka papa o ka ʻōnaehana cardiovascular ma ka 25 pakeneka.
He aha nā statins pilikia
Eia kekahi, ua hana i nā mea ʻepekema Kepani i kekahi mau hoʻokolohua ʻepekema, ma muli o kahi hiki ke kiʻi i ka hopena heterogeneous. Ma kēia hihia, pono i nā kānaka ʻepekema ke noʻonoʻo pono i nā mea e lawe i kēia mau lāʻau lapaʻau no nā maʻi maʻi type 2.
ʻO kēia ma muli o ka lawe ʻana i nā statins, aia nā hihia o ka decompensation o ka maʻi mellitus o ka maʻi maʻi, a me ka hopena ua hana ʻia ka hohonu hohonu o nā lāʻau lapaʻau.
Ua hoʻāʻo ka ʻepekema o Iepani e hoʻopaʻa pehea e Atorvastatin i ka nui o 10 mg e pili ana i ka paʻa ʻana o ka hemoglobin glycated a me ke kō koko. ʻO ke kumu ke kūpono o ka glucose i loko o nā mahina ʻekolu i hala.
- Ua hoʻokō ʻia ka hoʻokolohua ʻekolu mau mahina he 76, nā maʻi maʻi i hōʻike ʻia me ke ʻano maʻi type 2 i komo i loko o ia mea.
- Ua hōʻike ʻia ka noiʻi ʻana i ka nui o ka hoʻonui ʻana i nā mea laʻa.
- Ma ka noiʻi ʻelua, ua mālama ʻia ka lāʻau lapaʻau ma ka lāʻau like i nā poʻe me ka maʻi a me ka dyslipidemia.
- I loko o kahi hoʻokolohua o ʻelua mau mahina, ua ʻike ʻia kahi emi ʻana o ka neʻe o ka lipher atherogen a me ka hoʻonui pinepine ʻana i ka hemoglobin glycated.
- No ka mea hoʻi, ua hōʻike kekahi mau maʻi i ka hoʻonui ʻana i ka pale o ka insulin.
Ma hope o ka loaʻa ʻana o ia mau hopena, hana ka poʻe ʻepekema ʻAmelika i kahi ʻano loiloi nui. ʻO kā lākou pahuhopu, ʻo ia ke ʻike i ka hopena o ka statins i ka metabolism a me ke kau ʻana i ka hopena o ka maʻi diabetes i ka wā e mālama ai me nā statins. Ua pili kēia me nā haʻawina ʻepekema mua e pili ana i ka hoʻomohala ʻana o ka maʻi type 2.
Wahi a nā hopena o nā hoʻokolohua, hiki ke loaʻa i nā ʻikepili i hōʻike ʻia i waena o nā kumuhana 255 i hoʻokahi hihia o ka hoʻomohala ʻana i ke ʻano o ka maʻi mellitus type 2 ma hope o ka terapi. I ka hopena, ua noi mai nā poʻe ʻepekema i kēia mau lāʻau hiki ke hoʻopilikia i ka metabolism.
Hoʻohui ʻia, ua ʻike ʻia ka helu makenika no kēlā me kēia maʻi pākēnē i nā maʻi āpau he 9 mau mea e pale ai i ka pōʻino o cardiovascular catastrophe.
No laila, i kēia manawa hikiʻole ke hoʻoponopono pono i pehea e hoʻohana ai a, i ʻole, ka hōʻino ʻana o nā statins i nā maʻi maʻi maʻi. Eia kekahi, paʻa nā kauka i kahi holomua nui o ka neʻe ʻana o ka lipids koko ma nā mea maʻi ma hope o ka hoʻohana ʻana i nā lāʻau. No laila, inā naʻe e mālama ʻia me nā statins, pono e nānā pono i nā pae o nā kalowa.
He mea nui hoʻi ia e ʻike i nā lāʻau i mea maikaʻi loa a lawe i ka lāʻau maikaʻi wale nō. ʻO ka mea kūikawā, e laʻa e koho i nā statins i ʻāpana o ka hui hydrophilic, ʻo ia hoʻi, hiki iā lākou ke hoʻoheʻe i ka wai.
I waena o lākou ʻo Rosuvastatin a me Pravastatin. Wahi a nā kauka, ua liʻiliʻi ka hopena o kēia mau lāʻau i ka hoʻoliʻoliʻoli. Hoʻonui kēia i ka hopena o ka hoʻomehana a pale i nā pilikia o ka hoʻomohala ʻana i nā hopena maikaʻi ʻole.
No ka mālamaʻana a me ka pale ʻana i ka maʻi maʻi ʻoi aku ka maikaʻi e hoʻohana i nā ʻano i hōʻoia ʻia. No ka hoʻohaʻahaʻa i ka kolamu koko, pono ia e hoʻoponopono i ka meaʻai, me ka hoʻomohala ʻana o ke ʻano maʻi mellitus type 2, ua makemake ʻia e lawe i ka lāʻau lapaʻau ʻo Metformin 850, i hōʻike ʻia he nui, a i ʻole sartans.
Ua wehewehe ʻia nā statins i ke wikiō ma kēia ʻatikala.
