Aia ʻo Glimecomb i ka hui o nā lāʻau antidiabetic i hui pū. Hoʻohālikelike ʻia e kekahi ʻokoʻa, kūʻoko ʻole ma Rusia hui o nā mea ikaika. ʻO ka lāʻau lāʻau ka metformin a gliclazide. ʻO ka hopena piha o kēia mau mea e hiki ai ke hōʻemi i ka wikiwiki a me ka glycemia postprandial e 3 mmol / l, me ka ʻole o ka hoʻopili ʻana i ke kaumaha o ka maʻi maʻi
Loaʻa maikaʻi koʻikoʻi o Glimecomb ma luna o nā mea hui pūpili kaulana e loaʻa ana i ka metformin a me glibenclamide ka liʻiliʻi o ka hōʻemi o ka hypoglycemia. Hoʻopuka ʻia ʻo Glimecomb e ka hui ʻo Akrikhin ma kahi o Moscow.
Nā hōʻailona no ka koho
ʻO nā derivatives o Sulfonylurea (PSM) ka nui o nā lāʻau lapaʻau ʻano 2 no nā maʻi maʻi ma hope o ka metformin. Hoʻohui ʻia ka hui ʻana o PSM a me ka metformin no kēlā mau mea maʻi i ka ʻai ʻana i ka mea laʻai haʻahaʻa-haʻahaʻa, hākinakina, a me ka metformin i hāʻawi ʻia i ka makemake i makemake ʻia i ke kō. Hoʻopili kēia mau mea i nā pili ʻo pathogenesis nui o nā maʻi diabetes type 2: ke kūʻē kiʻekiʻe o ka insulin a me ka nele o ka insulin, no laila ua hāʻawi lākou i nā hopena maikaʻi loa i ka hui pū ʻana. ʻO Glyclazide, kahi mea i hoʻohana ʻia ka lāʻau Glimecomb, he PSM no 2 mau hanauna a ua manaʻo ʻia ʻo ia kekahi o nā mea palekana loa i kāna hui.
Hiki ke kuhikuhi i nā papa Glimecomb:
- I ka wa i pau ai ka mālama ʻana o ka hāʻawi mua ʻana i ka uku no ka maʻi diabetes.
- Ma hope koke o ke ʻano o ka maʻi maʻi, inā he kiʻekiʻe ka nui o ka glycemia.
- Inā ʻaʻole eʻaʻa ka maʻi maʻi i ka metformin i kahi nui nui.
- No ka hōʻemi ʻana i ka nui o nā papa i nā maʻi e lawe ana i ka gliclazide a me ka metformin.
- ʻO nā maʻi Diabetic ka poʻe glibenclamide (Maninil a me nā mea hoʻohālike) a me kāna hui pū me ka metformin (Glibomet et al.) E hoʻomehana pinepine i ka hypoglycemia koʻikoʻi.
- ʻO nā mea maʻi me ka pilikia ʻole kahi e pāpā ai ka glibenclamide.
- Me ka maʻi maʻi paʻakikī e ka maʻi naʻau coronary. Ua hōʻike ʻia ʻaʻole i pili ka gliclazide i ka myocardium.
Wahi a nā haʻawina, ʻoi aku no hoʻokahi malama o ka mālama ʻana me Glimecomb, e hoʻemi ana ka wikiwiki o ka wikiwiki e ka awelika o 1.8 mmol / L. Me ka hoʻohana mau ʻana o ka lāʻau lapaʻau, hoʻonui ʻia kona hopena, ma hope o 3 mau mahina ua hōʻemi ke 2.9. Kaola mau ʻekolu malama i hoʻoneʻe i ka glucose i ka hapalua o nā mea maʻi me ka decellensated diabetes mellitus, aʻo ka make ma mua o 4 mau papa i ka lā. ʻO ka loaʻaʻana o ka paona a me ka hypoglycemia koʻikoʻi, koi ana i ka hoʻokipa ʻana, ʻaʻole i hoʻopaʻa ʻia me kēia lāʻau lapaʻau.
ʻO ka maʻi maʻi a me nā hoʻohaʻahaʻa manaʻo e hana ia i ka wā ma mua
- Ka hana maʻamau o ke kō -95%
- Hoʻokuʻuina o ka pua thrombosis - 70%
- Hoʻopau i kahi puʻuwai ikaika -90%
- Hoʻopau i ke kiʻekiʻe o ke koko - 92%
- ʻO ka hoʻonuiʻana i ka ikehu i ka wā, hoʻomaikaʻi i ka hiamoe i ka pō -97%
Lapaʻau Glimecomb
ʻO ka hui pū ʻana o PSM a me ka metformin i manaʻo ʻia he kuʻuna. ʻOiai ka uluʻana o nā loea hypoglycemic hou, ke hoʻomau nei nā hui maʻi ʻona honua a me ke Kuhina o ke Ola o ka Lūkini Kūwaho e hōʻike i kēia hoʻohui e like me ka mea e hoʻomaʻamaʻa loa ʻia. Hoʻohana a Glimecomb e hoʻohana a kūpono. ʻO kāna mau huahana ke kūpono a palekana.
Hoʻolāleʻa ʻo Glyclazide i ke ʻano type type 2 i ka hana ʻana i kāna iho ponoʻī, a hoʻomaka e hana i ka hana mua o kāna hiili, i ka wā i komo ai ke kō i ke koko. Ma kēia hana e hiki ai iā ʻoe ke hoʻemi wikiwiki i ka glycemia ma hope o ka ʻai ʻana, e hoʻomohala ana i nā glucose i nā kino peripheral. Mālama ʻo Glyclazide i ka hoʻomohala ʻana o ka angiopathy: pale i ka thrombosis, hoʻomaikaʻi i ka microcirculation a me ke ʻano o nā paia o nā kīʻaha koko. Ua hōʻike ʻia ka hopena maikaʻi o ka gliclazide ma ke ala o ka retinopathy a me ka nephropathy. ʻAʻole alakaʻi nā papa gula Glimecomb i ka nui o ka insulin i ke koko, no laila ʻaʻole lākou e hoʻoulu i ka paona. Ua hōʻike pū nā ʻōlelo aʻo i ka hiki i ka gliclazide e hoʻomaikaʻi i ka naʻau o ka insulin, akā i kēia hihia ua mamao loa ia i ka metformin, kahi alakaʻi i ka hakakā me ka pale ʻana i ka insulin.
ʻO ka Metformin ka lāʻau lapaʻau wale nō no nā ʻano maʻi āpau āpau me ka loaʻa ʻole. Ke hoʻoulu nei i ka hoʻololi o ka glucose mai nā kahe koko i nā ʻāpana, pale i ka hana o ka glucose ma o ka ate, hoʻohemo i kona kō ʻana mai loko mai o nā ʻāpana. Ke kūleʻa nei ka lāʻau lapaʻau i nā pilikia o ka lipid metabolism, kahi ʻano no ka type 2 o ka maʻi. Ma muli o nā loiloi maikaʻi o ka maʻi maʻi, hoʻohana ʻia ka metformin no ka hoʻolilo kaumaha. ʻAʻole ia e kumu i ka hypoglycemia, i ka wā e hoʻohana ʻia e like me nā ʻōkuhi. ʻO nā hemahema o kēia māhele o Glimecomb ka piʻi nuiʻana o nā hopena kūpono ʻole i ka digestive tract.
ʻO nā pharmacokinetics o nā māhele o ka lāʻau lapaʻau:
| Nā Pālani | gliclazide | metformin | |
| Bioavailability,% | a hiki 97 | 40-60 | |
| Nā hola hana koʻikoʻi ma hope o ka hoʻokele ʻana | 2-3 mau hola | 2 mau hola i kau ʻia ma kahi ʻōpū ʻole; 2,5 hola inā lawe ʻoe i ka lāʻau lapaʻau i ka manawa like me ka meaʻai, e like me ke kuhikuhi ʻana i nā ʻōlelo aʻoaʻo. | |
| Half-ola, hola | 8-20 | 6,2 | |
| Ke hoʻihoʻi nei ala,% | nā pōpō | 70 | 70 |
| nā ʻāpana | 12 | 30 a | |
ʻĀnō
ʻO ka lāʻau Glimecomb ke koho i loaʻa i kahi koho dosage hoʻokahi - 40 + 500, ma kahi papa 40 mg o glyclazide, 500 mg o metformin. No ka loaʻa ʻana o ka hapalua wai, hiki ke hoʻokaʻawale ke papa, aia ma luna o ke kau.
Inā ʻaʻole i lawe ka mea maʻi me ka metformin ma mua, e noʻonoʻo ʻia ka papa 1 i ka hoʻomaka ʻana. ʻAʻole hiki i ka 2 mau pule hou aʻe ke hoʻonui hou iā ia, no laila hiki iā ʻoe ke hōʻemi i ka hōʻeha o ka hoʻowalewale i ka hoʻowalewale ʻana. ʻO nā mea maʻi e ʻike mua ana i ka metformin a ʻae ʻia iā ia maikaʻi, hiki ke hoʻonohonoho koke ʻia i nā papa 3 Glimecomb. Hoʻoholo ʻia ka ʻona i makemake ʻia e ke kauka, i ka nānā ʻana i ka pae glycemia o ka mea maʻi a me nā lāʻau lapaʻau ʻē aʻe nāna e lawe ai.
Inā hāʻawi ʻole ka lāʻau hoʻomaka i ka hopena i makemake ʻia, e hoʻonui mālie ia. I mea e pale ai i ka hypoglycemia, ʻo ka manawa ma waena o ka hoʻoponopono o ka hoʻoponopono ʻana ma kahi o ka hebedoma. ʻO ka hiʻona nui loa he 5 papa. Inā ma kēia hewa, ʻaʻole ʻo Glimecomb e hāʻawi i ka uku no ka diabetes mellitus, aia kekahi lāʻau lapaʻau haʻahaʻa e hoʻohālikelike ʻia i ka mea maʻi.
Inā loaʻa ka maʻi i ka pale ʻana i ka insulin, hiki ke inu a Glimecomb i ka maʻi diabetes me ka metformin. Hoʻohana ʻia ka nui o nā papa i kēia hihia a ʻo ke kumu nui o ka metformin ʻaʻole iʻoi aku i ka 3000 mg.
Nā rula no ka lawe ʻana i ka lāʻau Glimecomb
No ka hoʻomaikaʻiʻana i ka hoʻomanawanui o ka metformin a pale i ka hāʻule kī nui i ka kō, nā wai ʻaiʻai Glimecomb i ka manawa like me ka meaʻai a i ʻole ia ma hope. Pono ke kūleʻa ʻia ka meaʻai a pono ke loaʻa i nā calcium, ʻoi aku ka paʻakikī i ka nānā ʻana. ʻO ka hoʻoholo ʻana e nā loiloi, a hiki i ka 15% o nā maʻi maʻi e manaʻoʻiʻo ʻo ka lawe ʻana iā Glimecomb a me nā lāʻau hoʻemi haʻahaʻa i hoʻohiolo ʻana i ke kō. A ke kumu, lawe lākou i nā inikua kiʻekiʻe o nā lāʻau lapaʻau, e hoʻonui ana i kā lākou hopena a me nā kumukūʻai o ka mālama ʻana, hoʻopiʻi i ke kōpaʻa galloping, a ma mua o nā ʻōhumu o ka maʻi maʻi.
I kēia manawa ʻaʻole kahi papa lāʻau papa hoʻokahi no ka maʻi diabetes e hiki ke hoʻololi i ka ʻai. Me nā maʻi type 2, hōʻike ʻia nā meaʻai me ke kīkī wikiwiki ʻana, me ka kaohi ʻana o nā hāmeʻa maloʻo hāwau, a me ke ʻano haʻahaʻa o ka calorie - nā meaʻai no ka maʻi diabetes type 2. Hoʻokomo ʻia ka regimen mālama i ka hana maʻamau o ka paona a me ka hana i hoʻonui ʻia.
E hōʻoia i ka hopena like o Glimecomb i ka lā, ua hoʻokaʻawale ʻia ka nui i ʻōlelo ʻia i loko o 2 mau wai - kakahiaka a me ke ahiahi. Wahi a nā loiloi, ʻike pono ʻia nā hopena hopena maikaʻi loa i nā maʻi i lawe i ka lāʻau lapaʻau ʻekolu mau manawa (ma hope o kēlā me kēia pāʻina), ʻoiai ke kīnā nei i nā ʻōlelo i hāʻawi ʻia no kēlā koho.
Nā hopena hopena
ʻO ka hapa nui paha o nā hopena e hiki ke hoʻonā ʻia inā e hahai ʻoe i nā lula no ka lawe a hoʻonui i ka nui mai nā ʻōkuhi. ʻOi ka wehe ʻana o Glimecomb ma muli o ka intolerance e koi pinepine ʻia.
| Nā hopena hopena ʻole o ka lāʻau lapaʻau | ʻO ke kumu o nā hopena ʻokoʻa, ka mea e hana ai i ka wā e kū ai |
| Hypoglycemia | Hoʻokumu me kahi papa lāʻau i koho ʻia ʻole a i ʻole ʻo ia e ʻai. I mea e pale ai, e hoʻohele ʻia ka ʻai i nā lā a pau o ka lā, pono ke loaʻa nā ʻōleʻaleʻa i kēlā me kēia. Inā hele mai ka hypoglycemia i ka manawa like, hiki i kahi kīkiki liʻiliʻi e pale aku. Kū pinepine i ka wai o ka kō - kahi manawa e hōʻemi ai i ka nui o Glimecomb. |
| Lactic acidosis | ʻO kahi hoʻopiʻi kaumaha ʻole kumu, ke kumu he overdose o ka metformin a lawe paha i ka Glimecomb i nā maʻi e maʻi ai. I nā maʻi keiki, koi ʻia ka mākaʻikaʻi pinepine o kā lākou hana. He mea pono kēia e hoʻopau i ka lāʻau lapaʻau i ka manawa inā ʻike ʻia kahi papa koʻikoʻi o ka nele o ka lawaʻole. |
| ʻO ka manaʻo kuʻuna i ka pālahalaha huehue, luaʻi ʻole, ka maʻiʻaʻai, ka hoʻāʻo ʻana o ka metal. | ʻO ka hopena like kēia mau hopena like i ka hoʻomaka ʻana o ka metformin. I ka hapanui o nā maʻi, ua nalowale lākou i nā mea nona iho i 1-2 mau pule. E hoʻomaikaʻi i ka hoʻomanawanui o Glimecomb, pono lohi e hoʻonui lohi i kona ʻano, e hoʻomaka ana mai ka hoʻomaka. |
| Hoʻokomo ka naʻau, ke hoʻololi ʻana i ka hana o ke koko | Pono e kāpae i ka lāʻau lapaʻau, ma hope o ka hala ʻana o kēia kipi iā lākou iho, ʻaʻole pono ka lāʻau lapaʻau. |
| Hoʻopiʻi ʻike ʻia | He wā pōkole lākou, ʻike ʻia i ka maʻi maʻi maʻi me ka hoʻokaʻa gula mua. I mea e pale aku ai iā lākou, pono ke hoʻonui ʻia ka pā o Glimecomb e pale lohi i ka hāʻule ʻana i lalo o ka glycemia. |
| Allergic hopena pili | Kuhi loa pinepine ʻole. Ke hele mai lākou, e aʻo ʻia e hoʻololi i Glimecomb me kahi mea laʻa. Ma ka maʻi hika me ka allergy i gliclazide i hoʻohoka ʻia loa o ka hopena like me nā PSM ʻē aʻe, no laila ke hōʻike nei lākou i ka hui pū ʻana o ka metformin me nā gliptins, no ka laʻana, ʻo Yanumet a i ʻole Galvus Met. |
Nā Hoʻohui
ʻAʻole hiki iā ʻoe ke inu i ka Glimecomb:
- maʻi type type 1;
- hypoglycemia. ʻAʻole hiki i ka lāʻau lapaʻau ke inu a hōʻemi ke koko koko i ke ʻano maʻamau;
- nā pilikia maʻi koi, nā maʻi koʻikoʻi a me nā hōʻeha e koi ana i ka insulin. ʻO kahi hihia o ka lactic acidosis i ka wā ma mua;
- hanau, hanau mai;
- X-ray me nā yodino i hoʻohālikelike ʻia;
- ka molololi ana i kekahi o na mea o ka aapaa;
- renal, hana hōʻoki o ka naʻau, hypoxia, a me nā maʻi e manaʻoʻi paha i hoʻopiʻi ʻia kēia mau maʻi;
- inu waiu, hoʻokahi helu kiʻekiʻe o ka waiʻona.
I nā maʻi me nā maʻi hormonal, maʻi maʻi makua me ka hana mau loa ʻana, hoʻonui ʻia ka hopena o ka ʻaoʻao, no laila ke lawe ʻana iā Glimecomb, pono lākou e makaʻala i ko lākou olakino.
Ka kuʻikahi me nā lāʻau lapaʻau ʻē aʻe
Hiki ke hoʻonui ʻia a hopena paha nā hopena o Glimecomb i ka wā i lawe ʻia ai me nā lāʻau lapaʻau ʻē aʻe. ʻO ka papa inoa o nā mea pili i ka lāʻau lapaʻau he nui loa, akā ʻo ka mea pinepine ka hoʻololi ʻana i ka hana pono ʻaʻole he koʻikoʻi ka maʻalahi a hiki ke hoʻoponopono maʻalahi ma ka hoʻololi ʻana i ka dosage.
| Hoʻopilikia i ka hopena o ka glimecomb | Hoʻomākaukau |
| Hoʻemi i ka hana, hiki i ka hyperglycemia. | ʻO Glucocorticoids, ʻo ka nui o nā hormones, me nā ʻukui; ʻO nā lāʻau lapaʻau adrenostimulants, nā maʻi epilepsy, diuretics, ka waikika nicotinic. |
| Loaʻa iā lākou kahi hopena hypoglycemic, hiki ke koi ʻia ka hoʻēmi ʻana ma o Glimecomb. | ʻO nā pale o ACE, sympatholytics, antifungal, anti-tuberculosis lāʻau lapaʻau, NSAIDs, fibrates, sulfonamides, salicylates, steroid, microcirculation stimulants, vitamin B6. |
| Hoʻonui i ka hopena o ka acidosis lactic. | ʻAi keke. ʻO ka hapa nui o ka metformin i ke koko ka mea i ka wā e lawe ai i ka furosemide, nifedipine, glycosides cardiac. |
He aha nā mea e hoʻololi aku ai
ʻAʻole i loaʻa iā Glimecomb nā kikowaena piha i hoʻopaʻa ʻia ma ka Russian Federation. Inā ʻaʻole pono ka lāʻau i ka lāʻau lapaʻau, ʻelua mau lāʻau me nā mea hoʻoikaika like e hiki ke hoʻololi iā ia:
- Aia i loko o Metformin i ka Glucofage kumu i hana ʻia ma Farani, Siofor Kelemania, Russian Metformin, Merifatin, Gliformin. Loaʻa nā koho āpau i nā 500 mg. No nā mea maʻi me ka hoʻohaʻahaʻa ʻole o ka metformin, ʻoi aku kahi ʻano o ka lāʻau lapaʻau ka ʻoluʻolu, ka mea e hōʻoia ai i ke komo like ʻana o ka mea i loko o ke koko a hoʻemi nui ʻia ka hopena o nā hopena. Eia kēia mau lāʻau Metformin Long Canon, Metformin MV, Formin Long a me nā mea ʻē aʻe.
- ʻO Gliclazide kekahi mea kaulana i ka hypoglycemic kaulana. ʻO ka waihona mea he ʻāpana o ka Glidiab Lūkini a me Diabefarm. Hoʻololi ʻia ʻo Gliclazide i kēia manawa i ke kiʻi i makemake ʻia. Hiki i kona hoʻohana ʻana ke hoʻemi i ka hoʻolimalima a me ka paʻakikī o ka hypoglycemia. Kuhi ʻia ka gliclazide i loko o ka hoʻomākaukau no ka Diabefarm MV, Diabeton MV, Gliclazide MV, Diabetalong, etc. A kūʻai ʻia, pono ʻoe e hoʻolohe i ka dosage, pono ʻoe e hoʻokaʻawale i ka papa ma ka hapalua.
Nui Nui nā hui analog o Glimecomb ma ka mākeke Lūkia. ʻO ka hapa nui he hui pū ʻana o ka metformin me glibenclamide. ʻAʻole palekana kēia mau lāʻau ma ka glimecomb, ʻoiai e hoʻonā pinepine lākou i ka hypoglycemia. ʻO kahi mea maikaʻi maikaʻi no ka Glimecomb Amaril (metformin + glimepiride). I kēia manawa, ʻo kēia ka nui o ka lāʻau lapaʻau paʻa ʻelua me PSM.
Kūʻai
ʻO ke kumu o kahi pākahi o 60 mau papa o Glimecomb mai 459 a 543 rubles. ʻO Gliclazide a me ke metformin mai ka mea hana like e kūʻai ʻia nā 187 rubles. no kēlā mau la like (60 papa o Glidiab 80 mg kumukūʻai 130 mau rubles, 60 papa. Gliformin 500 mg - 122 mau rubles). ʻO ke kumukūʻai o ka hui pū ʻana o ka mākaukau mua o gliclazide a me ka metformin (Glucofage + Diabeton) he mea e pili ana i 750 rubles, ʻelua mau mea i kahi ʻano i hoʻololi ʻia.
