ʻO Bagomet ka lāʻau lapaʻau me ka hiki o hypoglycemic hiki, ke hoʻohana ʻia no ka hoʻopiʻi ʻana no ka non-insulin-dependence diabetes mellitus (DM), inā ua lawa ka hopena o ka sulfonylurea.
ʻO nā hiʻohiʻona lāʻau o Bagomet
ʻO Bagomet kahi lāʻau lapaʻau hypoglycemic e hoʻohaʻahaʻa i ke kōʻai wikiwiki a me kāna hana ma hope o ka ʻai. ʻAʻole pili ka lāʻau lapaʻau i ka synthesis o nā insulin. Ma waena o nā hopena hopena o nā hihia o ka hypoglycemia ʻaʻole paʻa. Aia nā hopena Therapeutic ma hope o ka pale ʻana i ka glycogenolysis a me ka gluconeogenesis, e hoʻonāukiuki ana i ka hoʻokuʻu ʻana o glycogen i loko o ka puʻuwai.
Hoʻonui ka Bagomet i ka hana o ka enzyme e hoʻomaikaʻi ana i ka synthly glycogen, hoʻonui i ka hiki ke kahe o ka transporter glucose membrane. Hoʻomaikaʻi ka lāʻau lapaʻau i ka hana lipid metabolism - me ka diabetes type 2 loaʻa kahi manawa e waiho i ke kaupaona.
Hoʻohālikelike ʻo Bagometua me kāna mau hoa i nā ʻōlelo o ka wikiwiki a me ka hoʻokaʻawale kūpono ʻana.
Ke hoʻoluhi ʻia, ua hoʻokomo koke ʻia ka lāʻau lapaʻau mai ke kaʻe ʻana o ka huina, hiki i ke ana nui loa i loko o ʻelua a me ka hapa hola. Hoʻowalewale i ka hiki o ka lāʻau lapaʻau ʻokoʻa kūʻai o ka meaʻai. ʻO ka hōʻailona o ka bioavailability o Bagometua e loaʻa i ka 60% o ka nui o ka nui o ka lāʻau i hāʻawi ʻia i nā kino.
E like me nā hopena o nā noiʻi pharmacokinetic, hiki iā mākou ke manaʻo e neʻe koke ke ʻano o ka lāʻau ma loko o nā kiko, e pili ana i ka plasma. ʻAʻole nā mea i paʻa i ka lāʻau i hoʻopaʻa ʻia i nā protein, hiki iā ia ke komo i loko o nā kaila ʻulaʻula, akā i loko o ke koko ka liʻiliʻi a lākou hoʻohālikelike i ka plasma.
Ua hōʻoia ʻia nā mea hoʻokalakupua ʻaʻole ka hoʻohālikelike o ka lāʻau i loko o ke kino - e hoʻohālikelike ana nā keiki i kona kūlana mua. I kēia hihia, ʻeono a me ka hapalua hola ka hapa o ka hapalua. Hōʻalo ʻia ka puka o Bagomet e ka filtration glomerular ikaika a me ka exule tubule renal, no laila, aia ka poʻe maʻi āpau me nā māka renal.
Ua hoʻonui ʻia ka hapalua ola, ʻo ia ka mea ke hōʻea ka hōʻiliʻili o ka lāʻau.
Nā hōʻailona a me ke ʻano o ka hoʻohana
Hana ʻia ʻo Bagometua no ka mālama ʻana i nā maʻi maʻi me ka maʻi kūʻokoʻa i ka insulin a me ka ʻōmole (me ka ʻike ʻole o ka ketoacidosis a me ka pane ʻole ʻana i ka mālama ʻana me ka sulfonylureas).
Pono ka lāʻau lapaʻau no ka hoʻohana ʻana i loko. E hoʻopulu i ka papa ʻaina me ka wai. Hoʻohā pinepine ʻia kēia me ka meaʻai a i ʻole lā ma hope. ʻO ka dosis kumu mua he 500-100 mg / lā, e pili ana i ka pae o ka glycemia. Hiki iā ʻoe ke hoʻoponopono i ka hewa ma hope o ʻelua pule o ka hana maʻamau a me ka nānā ʻana i nā hōʻailona glycemic.
Inā ʻaʻole i hana a ke kauka i kahi hoʻoholo pilikino e pili ana i ka mea maʻi, a laila ua kuhikuhi ʻia ka laʻana therapeutic maʻamau mai 1500 a 2000 mg. ʻAʻole hiki ke hoʻonui i ka lōʻihi loa. Inā hoʻonāukiuki ka lāʻau lapaʻau i nā pilikia o ka papaʻa, hiki iā ʻoe ke uha i ka maʻamau maʻamau i kēlā me kēia lā ma 2-3 mau manawa.
Me ka hoʻolālā paʻakikī "Bagomet a me ka hoʻomākaukau ʻana i ka insulin", ʻo ka nui maʻa ka manawa 1500 mg / lā. No nā papa me ka hiki ke lōʻihi ka lōʻihi, ʻo ka nui loa ka momona o kēlā me kēia lā he 850 mg -1000 mg. Me ka hoʻomanawanui maʻamau, ke kū nei lākou ma kahi mālama mālama 1700 mg / lā, a me ka palena - 2550 mg / lā. Ma ka hana paʻakikī me nā lāʻau lapaʻau hoʻohaʻahaʻa ʻē aʻe, ua kau ʻia kahi papa hoʻokahi (850 mg a i ʻole 100 mg).
I ka wā pākeke, ʻo Bagomet e lawe ma mua o 1000 mg / lā. Hiki iā ʻoe ke kākau i kahi lāʻau lapaʻau no nā keiki ma mua o 10 mau makahiki. Pono nā keiki, ʻoiai nā pākeke, e hoʻomaka i kahi papa o ka mālama ʻana me ka 500-850 mg / lā. I ke wā kamaliʻi, ʻo ka nui loa o ka nui o kēlā me kēia lā he 2000 mg.
Nā hopena hopena
Ma keʻano maʻamau, ʻae maikaʻi ʻia ka lāʻau lapaʻau e ka hapa nui o nā maʻi, akā, e like me nā lāʻau lapaʻau, hiki paha nā hopena kūpono.
| ʻO nā mea mana e hoʻopaʻi ʻia ai ka hewa | Nā ʻano hana ʻino |
| ʻŌnaehana nenoaiu |
|
| Pahe koko | Megaloblastic anemia |
| Nā hui genitourinary | ʻO ka nele o Renal ma muli o ka hoʻouka ʻole i ka puka ʻana i Bagomet. |
| ʻŌnaehana Endocrine | Hypoglycemia (wale nō inā ʻoi aku ka nui o ke ʻano). |
| Allergy | Hoʻohui a me nā rashes i ka ʻili. |
| Hāpai |
|
Ua hōʻike ka ʻike mua ʻana i ka pono o Bagomet e hoʻonāukiuki i ka mutagenicity, carcinogenicity a me ka teratogenicity. Hōʻoia ʻia kona hopena kūmau i ka hana hoʻohuli.
Nā Hoʻohui
ʻAʻole ia e noʻonoʻo ʻia e lawe i ka Bagomet me nā maʻi ʻē aʻe:
- ʻO ke koholupa ketoacidosis, maʻi koma maʻi a me nā kūlana kūpuna;
- Nā pilikia pilikia;
- Nā ala wili Cardiac, ʻoiai ma ka puʻuwai puʻuwai;
- ʻO nā maʻi kahe koko Cerebral;
Lactic acidosis;
- Hoʻinoʻe i ke alakaʻi, huehue;
- Hoʻolauna hana a Renal;
- Hōʻike kiʻekiʻe i nā meaʻai o ka hoʻolālā Bagomet;
- Nā hana e koi ai i ka hoʻololi ʻana o nā papa me nā inikini insulin;
- ʻAno hema ʻole;
- ʻO ka hapai a me ka umauma;
- X-ray e hoʻohana ana i ka iodine e like me ke kaawale (laʻa - no 2 mau lā ma mua a ma hope o ka hoʻokolokolo);
- Hypogalogy meaʻai;
- ʻAkahi (ma hope o 60 mau makahiki), ʻoi aku me nā kaumaha nui e hoʻowalewale i ka lactic acidosis;
- Hānau (a hiki i ke 10 mau makahiki).
Nā ʻōlelo hāpai
ʻAʻole i hōʻoia i nā hoʻokolohua haukapila i ka waiwai mutagenic a me teratogenic o Bagomet, akā ʻaʻole lākou i kuhikuhi no nā wahine hāpai. Hiki i ka lāʻau lapaʻau ke komo i loko o ka waiū umauma, inā ʻaʻohe ala ʻē aʻe iā Bagomet, pono ke hoʻoneʻe ʻia ke keiki i ka hānai hana.
Nā hopena hoʻopuka lāʻau lapaʻau
Hoʻonuiʻia nā pono hypoglycemic Bagometua e sulfonamides, insulin, acarbose, non-steroidal anti-inflammatory drug, ACE a me MAO inhibitors, oxytetracycline, β-blockers.
ʻO nā Glucocorticosteroids, GOK, epinephrine, glucagon, nā lāʻau lapaʻau thyroid, sympathomimetics, thiazide a me "loop" diuretics, phenothiazine a me nā kumulamu a me ke kinikini ʻo nikotinic e pale i kāna hana.
ʻO ka hoʻopau ʻana o Bagomet mai nā ʻōpū i pale ʻia e ka cimetidine. Loaʻa ka hopena anticoagulant o nā derivatives Coumarin pale iā Bagometua.
ʻO ka hoʻohana pinepine ʻana i ka waiʻona e hoʻonāukiuki i ka acidosis lactic. ʻO kona mau hiʻohiʻona he puna kahi i loko o ke ʻano wela o ke kino, myalgia, ʻoluʻolu i loko o ka ʻōpū o ka ʻōpū, nā ʻōpū o ke dyspeptic, ka pōkole o ka hanu, nā kīwaha, nāwaliwali. Ma nā kānalua mua o ka mea i hōʻeha ʻia, ka hale hoʻokipa a i hoʻomālamalama ʻia ke kaʻi e ka nānā ʻana o ka neʻe o ka lactate i nā io a me nā ʻili.
Nā hōʻailona āpau
Inā ʻoi aku ka nui o nā dosis o Bagomet, a ʻoi aku ka hopena o ka maikaʻi o ka coma a hiki i ka make. Hoʻopilikia ʻia nā hopena like ʻole e ka hoʻonui nui o ka lāʻau i loko o ke kino me nā pilikia me ka hoʻopā ʻana o nā pēpē. E ulu ka pilikia ma kekahi mau hola a ua ukali ʻia e nā ʻano ʻano:
- Nā maʻi Dyspeptic;
- Hypothermia;
- Hoʻowahāwahā i ke kaniʻana o nā neʻe i loko o ke alo;
- ʻEha i loko o ʻōpū;
- Myalgia;
- Nā manaʻo o ka hoʻonohonoho hoʻonohonoho;
- Pahu a me ka comic koma.
Inā ma ka liʻiliʻi o kekahi mau papa inoa i hōʻike ʻia, pono e ʻoki koke ʻia ka Bagomet, a hiki i ka hale maʻi ke hōʻulu ʻia i ka haukapila.
E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana, nā kūlana mālama
Hiki i nā papa waiho i nā ʻano like ʻole a me nā kala, hilinaʻi ʻia ma ke ʻano: ke keʻokeʻo, ka puni a me ka convex - 500 mg kēlā me kēia, i ke ʻano o nā capsules - 850 mg ʻĀwili i kahi kala a me 1000 mg i ke keʻokeʻo. ʻO nā mea hope loa he mau lōʻihi. ʻO kahi hiʻohiʻona o ka puka hoʻokuʻu i ka laina hoʻokaʻawale a me kahi hōʻailona o ka mea hana, ua hoʻopili ʻia ma nā papa āpau.
Aia ka papa hoʻokahi mai ka 500 a 100 mg o ka mea hanahana metformin hydrochloride hoʻohui me nā mea waiwai i loko o ke ʻano o ka sodium croscarmellose, povidone, stearic acid, mais kō, ka lactose monohala.
Pono e hoʻokomo i ka pahu kōkua mua me nā lāʻau lapaʻau i kahi wahi hiki ʻole i nā keiki, i ke ana a hiki i 25 ° C. E mālama i ka Bagometua ʻole i ʻelua makahiki.
ʻLelo a me nā kikoʻi o ka lāʻau lapaʻau
Hoʻokomo pūnū ka ʻatikala iā Bagometua i hui pū ʻia nā hui (nā lāʻau antidiabetic waha) a me nā mea ikaika (metformin) coincide.
- Methamine;
- NovoFormin;
- Formmetin;
- ʻ Formlelo.
ʻO nā mea hoʻohālikelike o Bagometua nā lāʻau lapaʻau ma kahi o kahi maʻi e like me ke kūlana i hoʻopaʻa ʻia i ka hōʻike, i kēia hihia ʻo ka maʻi maʻi maʻi 2.
- Avandia
- Apidra
- Baeta;
- Glemaz;
- ʻO Glidiab;
- Kuʻulaka;
- Kūkulu;
- Lymphomyozot;
- Levemir Penfill;
- Levemir Flekspen;
- Kaukaʻikaʻi;
- Methamine;
- NovoFormin;
- Piroglar;
- Formmetin;
- ʻ Formlelo.
Me ka hoʻomaʻamaʻa paʻakikī me nā lāʻau ʻē aʻe o kahi hopena like, he mea nui ia e noʻonoʻo i ka hopena o ka hypoglycemia. Hiki i ka lāʻau lapaʻau ke hoʻonāukiuki i ka hoʻonohonoho ʻana a hoʻolōʻihi i nā hoʻonaninani psychomotor, no laila i ka hana ʻana me nā hana kūpono a i ʻole ke kaʻa ʻana, ʻoi aku ka maikaʻi o ka haʻalele ʻana i ka lāʻau lapaʻau. Pono ka hoʻohana ʻana o Bagometina i ka hana kūpono i kahi meaʻai haʻahaʻa-kaohi ka kaohi o ka nui o nā hāmeʻe i loko o ke koko.
Hōʻikeʻike e pili ana iā Bagomet
E pili ana i ka lāʻau Bagomet, ʻo ka loiloi o nā kauka he maikaʻi loa. Wahi a nā poʻe akamai, ʻo ka lawe ʻana i kēlā lāʻau lapaʻau kaulana e hāʻawi i ka kaomi glycemic paʻa i nā puna koko no nā hola 12. Kūpono ʻo ia mau manawa iā ia kekahi mau pōmaikaʻi: hiki iā ʻoe ke hōʻemi i ka pinepine o ka lawe ʻana i ka lāʻau lapaʻau, hoʻomaikaʻi i ka nānā ʻana o nā kaʻina metabolic. Ma ka manawa like, ʻo ka hoʻokaʻawale ʻana o ka mea hana mai ka digestive tract e hoʻomaikaʻi ʻia a hōʻemi ʻia ka hopena o ka hoʻoulu ʻana i nā hopena ʻino.
ʻAʻole hiki i ka wehewehe ʻana o ka lāʻau lapaʻau ke lilo i alakaʻi ma ke ʻano. Ma mua o ke kūʻai ʻana, pono ʻoe e kamaʻilio i kahi endocrinologist, a ma mua o ka lawe ʻana i ka lāʻau Bagomet, heluhelu i nā ʻōlelo kuhikuhi no ka hoʻohana ʻana mai ka mea hana. Hāʻawi ʻia ka ʻike e pili ana iā Bagometua no ka familiarization aoao me kona mau kaha a ʻaʻole he kumu no ka hoʻoikaika ponoʻī iā ʻoe iho. ʻO ka hoʻoponopono kaulike kūpono, e noʻonoʻo ana i ka hōʻeha o ka maʻi maʻi maʻi maʻi, ka maʻi pili a me ke ʻano nui o ke olakino o kahi maʻi maʻi, hiki ke hoʻomohala ʻia e kahi loea.
