ʻO Gluconorm kekahi o nā lāʻau i lawe ʻia e mālama i ka maʻi maʻi type 2. Loaʻa ka lāʻau i ka hopena hypoglycemic.
Loaʻa ka Gluconorm i ka pā pākau a manaʻo ʻia no ka hoʻokō waha.
ʻO ka ʻike nui, ka hoʻonohonoho ʻana a me nā ʻano hoʻohālikelike
ʻO Gluconorm kahi lāʻau lapaʻau hypoglycemic i kūkulu ʻia ma India. Hoʻopili i nā hopena hypoglycemic, kōkua ka lāʻau lapaʻau i ka hoʻohaʻahaʻa i ka koloka o ka kolamu ma ke koko o ka mea maʻi.
ʻAe ʻia ka wehe ʻana i nā kālā e like me ke koho ʻana o ka loea i hele mai i loko. Hoʻohana ʻia ka lāʻau lapaʻau no 3 mau makahiki mai ka lā i hana ʻia ai.
Pono pono e nānā i nā kūlana mālama o kēia lāʻau lapaʻau. Mālama ʻia ia ma kahi wahi pouli ʻole i ka loaʻa ʻole o nā keiki. ʻO ka mahana mālama mālama wela ʻo 20-230C.
Eia kekahi, ua hoʻokumu ʻia ʻo Gluconorm me nā blueberries i loko o ke ʻano o ka lāʻau lapaʻau, ʻaʻole ia he lāʻau lapaʻau, akā, lawe ʻia ma ke ʻano inu wai.
ʻO nā mea nui o ka lāʻau lapaʻau ʻo Metformin Hydrochloride a me Glibenclamide. ʻO nā ʻike o ka waiwai mua ma ka 1 papa he 400 mg, ka lua - 2,5 mg. ʻO ka cellulose i loko o nā microcrystals a me ka siloneid colloidal i kēia manawa e like me nā mea hou i ka pūnaehana o ka hoʻomākaukau. Kuhi ʻia nā māla o ke croscarmellose, diethyl phthalate a me ka glycerol.
I waena o nā mea ʻē aʻe o ka lāʻau, ua hoʻomaopopo ʻia ka sodium carboxymethyl starch, magnesium stearate a me cellacephate. I kekahi mau kikoʻī, talc me ke kōkō palaoa a me ka gelatin i ka hoʻonohonoho ʻana o nā lāʻau.
Hoʻokahi kahi pahu o nā papa he 1-4 nā palaka. I loko o ka pahuhopu hiki ke lilo i 10, 20, 30 mau papa o ka lāʻau lapaʻau. Ke keʻokeʻo a nā papa o ka lāʻau lapaʻau a loaʻa kahi ʻano biconvex a puni. I ka wā hoʻomaha, hiki paha i nā papa ke kiko hina.
ʻAʻole i loaʻa i nā ʻula huapula ʻo Gluconorm ka mea i hōʻike i nā papa i loaʻa i nā papa. Hana ʻia ia mai nā mea kanu kūlohelohe a kūʻai ʻia ma ke ʻano o nā ʻeke peke. Hoʻolālā ʻia ka papa no ka komo ʻana no 3 mau pule.
Pharmacology a me ka pharmacokinetics
He ʻelua kumumanaʻo Gluconorm: Glibenclamide a me Metformin. ʻO nā mea ʻelua e hana i ka hui hui pū ʻana, e hoʻonui ana i ka pono o ka lāʻau lapaʻau.
ʻO Glibenclamide kahi makahiki 2 o ka kōmūlani sulfonylurea. Ma muli o kāna hana, hōʻeuʻeu ʻia ka hoʻohuihui insulin, a hoʻonui nui ʻia ka insulin i nā cell target.
Hoʻololi ʻo Glibenclamide i ka hoʻokuʻu ʻana i ka insulin a hoʻonui i kona hopena ma ka hoʻopio ʻana o ka glucose i ka puhaka, a me nā ʻiole. Ma lalo o ka hana a kahi mea kikowaena, e iho ana ke kaʻina o nā hōʻiliʻi i nā momona.
ʻO ka metformin kahi waiwai nunui. Ma muli o kāna hana, ke hoʻoneʻe nei ke kahe o ka glucose i ke koko o kahi mea maʻi, a hoʻonui ʻia ka glucose i nā kino peripheral.
Hoʻonui ka waiwai i ka hoʻoemi o ke kaʻoli o ke kolamu o ke koko. Ma muli o ka hana a Metformin, ua emi ka nui o nā mea make i loko o ka ʻōpū a me nā ʻili. Hoʻopili nui ka mea kanu i ka hana o ka glucose i loko o ke kao.
ʻO Glibenclamide lāua ʻo Metformin, kahi ʻāpana o ka lāʻau lapaʻau, he pharmacokinetics ʻokoʻa.
ʻO ka hoʻopili ʻana o ka glibenclamide ma hope o ka hoʻoilo ʻana mai ka ʻōpū a me nā ʻōpū, hiki i ka 84%. Hiki i ke ana o ke kikoo loa o kahi mea i hiki i ke hola a ʻelua paha. Hoʻopili maikaʻi ke ʻano o nā mea me nā protein koko. ʻO ka 95 ka%. ʻO ka hapa haʻahaʻa o nā hapalua he 3 hola, ʻo ka lōʻihi loa he 16 hola. Hoʻopili ʻia ka waihona laea e nā keiki, kekahi ma nā ʻāpana o nā ʻāpana.
ʻO ka bioavailability o loaʻo Metformin ʻaʻole iʻoi aku ma mua o 60%. ʻAno ʻai nui ʻia i ka lohi ʻana o nā metformin. ʻO kahi waiwai i lawe ʻia ma luna o kahi ʻōpū ʻawae e hoʻopili ʻia mai ka ʻōpū a me ka ʻōpū.
ʻAʻole e like me Glibenclamide, he palena liʻiliʻi kona e kaoli ana i ke koko. Ke hoʻopio ʻia nei e nā ʻōpū. 30% o nā mea i hiki ke hele ma i nā feces o ka mea maʻi. ʻO ka hoʻopau hapa-hapalua ke ola i 12 mau hola.
Nā hōʻailona a me nā contraindications
ʻO ka hōʻailona nui no ka lawe ʻana i kēia lāʻau lapaʻau ka hele ʻana o ke ʻano maʻi type II i ka mea maʻi. Pēlā nō, ʻo ka lāʻau lapaʻau i kauoha ʻia ai me ka ʻole o ka hopena kūpono o ka mālama ʻana me ka meaʻai, hoʻomaʻamaʻa a me nā maʻi e pili ana i ka lawe ʻana i ka Metformin me Glibenclamide.
Hoʻomaopopo ʻia ka lāʻau lapaʻau no nā poʻe maʻi me he kō koko koko maʻamau a kūpaʻa, akā nāna nō e pono ke hoʻololi i ka maʻi me Glibenclamide a me Metformin.
He helu nui o nā contraindications kekahi o nā lāʻau lapaʻau.
- pūpū hema;
- ka hoʻohemo ʻana i loko o ke kōpaʻa koko koko (hypoglycemia);
- ʻike kiʻekiʻe i nā māhele o ka lāʻau lapaʻau;
- ʻ Ilelo diabetes Mellitus;
- lāleʻa hemahema;
- hapai
- hana ʻole ʻole ʻoia i ka hana ma muli o nā maʻi;
- ketoacidosis;
- ka hoʻohana ʻana o ka miconazole;
- ke kino o ke kahe ana o ke kino;
- hana ʻole naʻau;
- liilii;
- nā maʻi āpau;
- maʻi koma maʻi;
- pilikia ʻole;
- myocardial infarction;
- hana ka hoʻokele kaʻa kaʻa;
- lactic acidosis;
- mea ʻona make kino;
- ke aho hanu;
- precoma hoʻokaʻawale;
- maʻi maʻi phi.
Nā ʻōkuhi no ka hoʻohana
Lawe ʻia ka lāʻau lapaʻau me ka papa ʻaina. No kēlā me kēia maʻi maʻi pākahi, ua hoʻokumu ʻia kahi kapuahi o Gluconorm.
Hana ʻia ka lāʻau lapaʻau i nā hana he nui. I ka hoʻomaka mua ʻana, lawe ʻia ka papa ʻaina 1 i ka lā maʻamau i kēlā me kēia lā. Ma muli o kēia hoʻolālā e 14 mau lā. I ka wā e hiki mai ana, e kau ʻia ka nui o ka hoʻoponopono i ke ʻano o ka maʻi a me nā hōʻailona o ke kō i loko o kona koko.
Ke loli nei i ka lapaʻau, lawe ka mea maʻi i nā papa ʻelua o ka lāʻau. ʻO ka papa kiʻekiʻe loa i kēia lā he 5 papa.
ʻO nā maʻi maʻi a me nā Kuhina kūikawā
Lā ʻia kēia lāʻau lapaʻau no nā wahine hāpai. ʻAʻole hiki ke ʻoluʻolu a lawe i ka lāʻau lapaʻau i ka wā o ka hoʻolālā ʻana o ka hāpai ʻana.
ʻAʻole pono nā Gluconorm e lawe ʻia e nā wahine lactating, no ka mea, ke komo ikaika ʻo Metformin i ka waiū umauma a hiki ke hoʻopilikia i ka olakino o ka pēpē. I kēia mau pilikia, ua hōʻike ʻia ke hoʻololi pono o ka lāʻau me ka inika insulin.
ʻAʻole ia ke kauoha ʻia i ka lāʻau maʻi no nā maʻi maʻi ʻoi aku o kona mau makahiki he 60 mau makahiki. I ka hui pū me nā ukana koʻikoʻi, hiki i Gluconorm ke hana i ka lactic acidosis i kēia māhele o ka poʻe.
Pono ka lāʻau lapaʻau e mālama pono e nā maʻi e loaʻa ana:
- lawa adrenal;
- fiva;
- maʻi ʻehā.
No ka lāʻau lapaʻau, ua hāʻawi ʻia i nā ʻōlelo aʻoaʻo he nui:
- i ka wā o ka mālama ʻana, mālama pono ʻia ka nui o ka glucose o ke koko ma luna o ka ʻōpū ʻole a ma hope o ka pāʻina;
- Hoʻolālā ʻia ka lāʻau hoʻōla a me ka wai ʻawa;
- pono ia e hoʻololi i ka lāʻau lapaʻau me ka inika insulin inā ua hōʻeha nā mea maʻi, nā maʻi, ka maʻi, ke kuni, nā hana mua;
- 2 mau lā ma mua o ka hoʻolauna ʻana o kahi mea radiopaque e loaʻa ana i ka iodine i loko o ke kino o ka mea maʻi, pono ia e kāpae i ka lawe ʻana i ka lāʻau (ma hope o 2 mau lā, hoʻomau ʻia ke ʻano);
- ka hui pū ʻana o Gluconorm me ka ethanol e hoʻonāukiuki ana i ka hypoglycemia, loaʻa nō hoʻi i ka wā o ka hoʻokē ʻai a lawe i nā lāʻau anti-inflammatory o kahi ʻano like ʻole o ka steroid;
- pili ka lāʻau i ka hiki i ka mea maʻi ke holo i kahi kaʻa (pono ʻoe e hōʻole ma ka holo ʻana i ka kaʻa i ka wā o ka mālama ʻana me ka lāʻau lapaʻau).
Nā hopena ʻaoʻao a me ka overdose
Ma ke kaʻina o ka mālama ʻana me kahi lāʻau lapaʻau, hiki i ka mea maʻi ke loaʻa i nā hopena ʻokoʻa:
- ka hōʻemi o ka glucose o ke koko (hypoglycemia);
- ua hōʻemi i ka momona;
- leukopenia;
- āhāhuʻe
; - ka ʻeha ma ka ʻili;
- lactic acidosis;
- holo pālahalaha me ka luaʻi;
- thrombocytopenia;
- mea momona
- urticaria;
- ka hopena hanu me ke kuni ʻana i ka maka a me ka tachycardia, ma ke ʻano he pane ʻana i ka ʻimi like ʻana o ka waiʻona;
- ʻeha ka ʻōpū
- anemia
- nā kuʻi;
- fiva;
- ka hōʻemi o ka naʻau;
- ke helehelena o ke kahe o ka protein i ka urine;
- jaundice
- hepatitis i nā hihia maʻamau.
;ʻO kahi overdose o ka lāʻau hiki ke hōʻike ʻia e:
- lactic acidosis;
- hypoglycemia.
ʻO ka acidact lactic hoʻonāukiuki i nā kīwaha o ka naʻau, hoʻopuka, a me ka ʻeha o ka ʻōpū. Hoʻomaopopo nā hōʻailona o ka maʻi i ka haʻalele koke i ka lāʻau a hoʻonoho i ka mea maʻi i kahi haukapila. ʻO ka koho kūpono e hoʻomaʻamaʻa hou aku ai he hoʻomaʻemaʻe koko extrarenal (hemodialysis).
Hiki i ka Glibenclamide ke hana i ka hypoglycemia ma ka maʻi. Ke loaʻa ke kaumaha, nā ʻeha. Nā huaʻōlelo i hōʻike ʻia: pallor, coordination conaired, sweating, loss ofness.
Hoʻokuʻu ʻia ka hypoglycemia ma ke ʻano maʻalahi a me ka maʻalahi ma o ka lawe ʻana i ka wai hilo i nā mea maʻi. I nā pilikia koʻikoʻi, hopu ʻia ʻo ia me ka hopena o glucose he 40%. Hoʻolaha ʻia ka hoʻomaka ʻana me ka hana a me ka intramuscularly.
Nā Kūleʻa Kūʻai a me nā Analog
ʻO nā hiʻohiʻona o ka launa pū me nā lāʻau lapaʻau ʻē aʻe ke ʻano o ka lāʻau lapaʻau.
- hoʻālaʻi ka hopena o ka ethanol a me nā gluconorm;
- nā lāʻau lapaʻau cationic (Vancomycin, Morphine, Quinine, Amiloride) hoʻonui i ka ʻike o Metformin e 60%;
- kahalaha, like me clonidine, furosemide,
Danazole, Morphine, paʻakai lithium, estrogens, Baclafen, Glucagon, hormones thyroid, Phenytoin, Epinephrine, Chlortalidone, hoʻōla nikotinika, Triamteren, Acetazolamide me ka hoʻohaʻahaʻa nui ʻana i ka hopena o ka lāʻau lapaʻau; - Cimetidine, hui āpau o hypoglycemic, Tetracycline, Ethionamide, Guanethidine, fibrates, antifungals, enalapril, Theophylline, Cyclophosphamide, salicitates, Pentoxifylline, Pyridoxine, Reserpine, anabolic steroid hoʻonui i ka lāʻau antidiabetic;
- me ka calcium chloride me ka ammonium klorida, a me ka mea nui ascorbic acid, e hoʻoikaika ai i ka hana pono o ka lāʻau;
- Hoʻopilikia ka Furosemide i ke kahe o ke metformin ma ke kuhikuhi o kona hoʻonui e 22%.
Danazole, Morphine, paʻakai lithium, estrogens, Baclafen, Glucagon, hormones thyroid, Phenytoin, Epinephrine, Chlortalidone, hoʻōla nikotinika, Triamteren, Acetazolamide me ka hoʻohaʻahaʻa nui ʻana i ka hopena o ka lāʻau lapaʻau;I waena o nā mea kikoʻī nui o ka lāʻau lapaʻau:
- Metglib Force;
- Glibomet;
- Huhu;
- Kūkākūkā;
- Metglib;
- Bagomet Plus.
ʻO nā mea wikiō e pili ana i ka hoʻohaʻahaʻa ʻana i ke kō o ke koko ma ke ʻano maʻi diabetes type 2.
ʻO nā manaʻo hoʻomanawanui
Nā loiloi maʻi maʻi maʻi maʻi e pili ana i ka Gluconorm i loaʻa ka hopena maikaʻi loa i ka lawe ʻana i ka lāʻau lapaʻau, akā naʻe, ʻo nā mea hoʻopihapiha i ʻōlelo ʻia, ma waena o ka nausea a me nā poʻo o nā loiloi pinepine e hālāwai nei, e ʻoki ʻia ana e ka hoʻoponopono hoʻoponopono ʻia.
Maikaʻi ka lāʻau lapaʻau, hoʻohaʻahaʻa ia i ke kō. ʻOi hou loa, ʻaʻole i loaʻa iaʻu kekahi hopena like ʻole i kākau pinepine ʻia e pili ana. ʻO ke kumu kūʻai kūpono. Kau i nā Gluconorm i kahi e mau nei.
Svetlana, 60 makahiki
Ua nui wau i ka maʻi maʻamau i ka maʻi maʻamau no nā makahiki he nui. Ua kuhikuhi iā ke kauka hele ʻana iā Gluconorm. I ka wā mua, aia nā hopena ʻaoʻao: pinepine ka maʻi, aia ka maʻi ʻana. Akā i ka wā e hiki mai ana mākou i hoʻoponopono iho i kēia maʻa, a ua hala nā mea a pau. He maikaʻi loa ka mea hana inā hoʻohui ʻoe i kāna hana me kahi meaʻai.
Tatyana, 51 ona makahiki
Kūpono loa ka Gluconorm. I koʻu hihia, ua kōkua hou wau e hoʻoponopono hou i ke kaumaha. ʻO ka lāʻau lapaʻau e hōʻemi i ka momona. ʻO nā mea liʻiliʻi, e hōʻike wau i nā hopena hopena. Nui nā mea o lākou. I kekahi manawa, maʻi ko kuʻu poʻo a maʻi.
Eva, 43 makahiki
ʻAʻole i ka manawa ma mua, ua hana kahi endocrinologist i kahi maʻi maikaʻiʻole - type 2 type diabetes. Ua kuhikuhi ʻia ʻo Gluconorm e hoʻoponopono i ke kōʻai koko. ʻO ka hauʻoli piha loa i ka mālama ʻana. Me ke kōʻai gula nui, hiki i ka lāʻau lapaʻau ke hōʻemi i kona pae i 6 mmol / L. Aia kekahi mau hopena ʻaoʻao, akā ua hoʻopau ʻia lākou. Pono ke ʻai.
ʻO Anatoly, 55 makahiki
ʻO nā kumukūʻai o ka gluconorm ma nā wahi like ʻole o ka'āina ʻē. ʻO ka kumukūʻai kumukūʻai ma ka'āina he 212 mau rubles. ʻO ka kumukūʻai o ka lāʻau lapaʻau he 130-294 mau rubles.
