Siofor no ka lilo ʻana o ka momona, hoʻomaʻamaʻa ʻana i ke ʻano maʻi diabetes like 2 a me kona pale ʻana

ʻO Siofor ka lāʻau kaulana loa i ka honua no ka pale a me ka mālama ʻana i ka maʻi type 2. Siofor ka inoa kālepa no ka lāʻau lapaʻau e hoʻohana ai i nā metformin ikaika. Māhuahua kēia lāʻau lapaʻau i ka naʻau o nā cell i ka hana o ka insulin, i.e., hōʻemi i ka pale ʻana i ka insulin.

Mālama kēia lāʻau lapaʻau i ka kolamu a me nā triglycerides i ke koko, e hoʻemi i ka hōʻemi o ka maʻi cardiovascular, a he mea nui loa - e kōkua ana i ka nalo ʻana o ke kaumaha.

Miliona miliona nā mea maʻi me ka diabetes type 2 i ke ao holoʻokoʻa e lawe iā Siofor. Hāʻawi kēia ia iā lākou e mālama i ke kō koko koko maikaʻi, ma kahi o ka hahai ʻana i ka ʻai. Inā hoʻomaka e mālama ʻia nā maʻi diabetes 2 like i ka manawa, hiki i ka Siofor (Glucophage) ke kōkua i ka hana me kaʻole o ka inikua o ka insulin a lawe i nā lāʻau ʻai e hoʻemi ana i ke kō koko.

Nā ʻōkuhi no ka lāʻau Siofor (metformin)

Aia kēia ʻatikala he "kāwili" o nā ʻōlelo kuʻuna mana no Siofor, ka ʻike mai nā nūpepa olakino a me nā loiloi o nā mea maʻi e lawe ana i ka lāʻau. Inā ʻoe e ʻimi i nā kauoha no Siofor, e ʻike ʻoe i ka ʻike a pau pono me mākou. Manaʻo mākou i hiki iā mākou ke hāʻawi i ka ʻike e pili ana i kēia mau papa inoa ʻia i ʻike ʻia i ka palapala e kūpono loa iā ʻoe.

Siofor, Glucofage a me kā lākou mauʻikepili

ʻO ka Glucophage kahi lāʻau lapaʻau mua. Ke hoʻokuʻu ʻia nei e kahi hui nā mea i hoʻolālā ai i ka metformin ma ke ʻano he lāʻau lapaʻau no ka maʻi maʻi type 2. ʻO Siofor kahi hoʻohālikelike o ka hui Kelemānia Menarini-Berlin Chemie. ʻO ia nā moʻolelo metformin kaulana loa ma nā ʻāina e ʻōlelo nei ʻo Rūsia a ma Europa. He kūpono lākou a loaʻa i ka hana maikaʻi. Kūkākūkā lōʻihi - kahi lāʻau lapaʻau lōʻihi. E hōʻeha ia i nā hana digestive ʻelua mau manawa ma mua o ka metformin maʻamau. Hōʻailona ka lōʻihi o ka Glucophage e hoʻohaʻahaʻa i ke kōpī maikaʻi i ka maʻi diabetes. Akā, ʻoi aku ka nui o kēia lāʻau lapaʻau. ʻO nā koho ʻē aʻe papa hana āpau i kākau ʻia ma luna o ka papa i hoʻohana pinepine ʻia. ʻAʻohe nui o ka ʻikepili i ko lākou hopena.

Nā hōʻailona no ka hoʻohana ʻana

Kākau 2 type mellitus (non-insulin-depend), no ka mālama a me ka ʻohi. Hoʻohui kūikawā me ka hana momona, inā ʻaʻole pono ka hopena a me ka hoʻonaʻauao kino me ka lāʻau ʻole.

No ka mālamaʻana i ka maʻi maʻi, hiki ke hoʻohana ʻia ʻo Siofor e like me ka monotherapy (ʻo ia wale nō ka lāʻau lapaʻau), a me ka hoʻohui pū ʻana me nā papa wai e hoʻohiolo ana i ka wai a i ʻole insulin.

Nā Hoʻohui

Nā maʻi hoʻohālikelike i ka wā e koho ai i ka siofor:

• Inā hoʻohana i ka maʻi diabetes mellitus (ʻo koe wale nō no nā hihia o ka momona. Inā loaʻa iā ʻoe ka maʻi laʻa 1 me ka huʻihuʻi - lawe ʻia ʻo Siofor e pono, e kipa i kāu kauka);
• pau ka hoʻopau ʻana i ka huna ʻana o ka insulin e ka pancreas i ke ʻano maʻi mellitus type 2;
• diabetes ketoacidosis, maʻi koma maʻi;
• ʻO ka hana hoʻopili a me ka pae hana ma loko o ke koko ma luna o 136 μmol / l i nā kāne a ma luna o 110 μmol / l i nā wahine a i kahi kānana filtration glomerular (GFR) ma lalo o 60 ml / min;
• ka hana paʻa ʻaʻe
• cardiovascular gagal, myocardial infarction;
• ke aho hanu;
• anemia
• nā hopena ʻoi e hiki ke kōkua i ka hana ʻoi aku ka hopena (dehydration, ka maʻi ākea, nā neʻe, ka hoʻomaka ʻana o nā iodine-hoʻohālikelike i nā mea);
• ʻO nā haʻawina x-ray me ka iodine-i hoʻohālikelike ʻia - pono ka hoʻopau ʻana i ka manawa kuʻuna o ka siophore;
• hana, hōʻeha;
• nā maʻi catabolic (nā kūlana me nā hana hoʻolōʻihi i hoʻonui ʻia, no ka laʻana, me ka hihia o nā maʻi ʻōpū);
• lāleʻa hemahema;
• lactic acidosis (me ka neʻe o ka mua);
• hapai a me ka lactation (umauma) - mai lawe iā Siofor i ka wā hāpai;
• kaʻai ʻana me ka nui o ka palena o ke ʻano caloric intake (e emi iho ma mua o 1000 kcal / lā);
• makahiki o na keiki;
• hypersensitivity i nā ʻāpana o ka lāʻau.

A kuhikuhi ʻia ke aʻo e kau ʻia nā papa metformin me ka mālama ʻana i nā poʻe i ʻoi aku o 60 mau makahiki mai ka wā e hana nei lākou i ka hana kino koʻikoʻi. No ka mea he ulu nui o kēia mahele o nā mea maʻi me ka lactic acidosis. Ma ka hoʻomaʻamaʻa, ʻike ka hopena o kēia hoʻonāukiuki i ka poʻe me kahi maʻi hānai maʻi i ke kīwī.

Siofor no ka lilo momona

Ma ka Pūnaewele, hiki iā ʻoe ke ʻike i nā loiloi maikaʻi loa mai ka poʻe e lawe iā Siofor no ka hoʻoluhi kaumaha. ʻAʻole ʻōlelo ka ʻōlelo ʻānō no kēia lāʻau lapaʻau e hiki ke hoʻohana ʻia ka lāʻau lapaʻau ʻaʻole wale no ka pale ʻana a i ʻole mālama ʻana i ka maʻi maʻi, akā e nalo wale nō ke kaumaha.

Eia naʻe, hōʻemi kēia mau penikala i ka makemake a hoʻomaikaʻi i ka metabolism no laila ʻo ka hapa nui o ka poʻe e "nalo" i kekahi mau paona. E hoʻomau ka hopena o Siofor no ka hoʻolilo ʻana a hiki i ke kanaka ke lawe, a laila e hoʻi hou ka momona.

ʻOiaʻiʻo, ʻo Siofor no ka lilo ʻana o ka mea kaumaha, ʻo ia kekahi o nā palekana palekana ma waena o nā paila āpau no ka lilo ʻana o ka mea kaumaha. Loaʻa nā hopena ʻaoʻao (koe wale nō ka puhipuhi, ke nānā ʻana a me ka lemulewa) Eia kekahi, ʻoi aku ka nui o ka lāʻau lapaʻau.

Siofor no ka hoʻoluhi momona - nā paila kūpono no ka hoʻolilo ʻana, ʻoi loa ka palekana

Inā makemake ʻoe e hoʻohana Siofor e nalowale i ke kaumaha, e ʻoluʻolu e heluhelu i ka ʻāpana "Contraindications". E hoʻoponopono ʻia nō ia e nīnau aku i kekahi kauka. Inā ʻaʻole me ka endocrinologist, a laila me kahi maʻi gynecologist - ua kuhikuhi pinepine lākou i kēia lāʻau lapaʻau no ka maʻi polycystic ovary syndrome. Lawe i nā hoʻāʻo a ke koko a me ka waiū paha e nānā ai i kāu hana maʻamau a pehea e hana ai kou puʻuwai.

Ke lawe ʻoe i nā paila e hōʻemi i ke kaumaha o ke kino - i ka manawa like ʻoe pono e pili pono i kahi meaʻai. Hoʻokipa ʻia, i kēlā mau kūlana, ke kuhikuhi ʻia kahi mea ʻai haʻahaʻa "ʻona" haʻahaʻa. Akā ʻo ka pūnaewele Diabet-Med.Com no ka hopena maikaʻi loa e hōʻike ana i ka hoʻohana ʻana iā Siofor no ka hoʻolilo ʻana i ka momona kaumaha me kahi mea ʻai me nā mea haʻawina o nā pore i ka meaʻai. ʻO kēia paha ka Dukan, Atkins meaʻai a me nā haʻahaʻa haʻahaʻa haʻahaʻa o Dr. Bernstein no nā maʻi maʻi. ʻO kēia kīʻaha āpau he momona, olakino a me ka pono no ka hoʻolilo ʻana.

ʻAʻole eʻoi aku iʻoi aku ma mua o ka lāʻau i ʻōlelo ʻia ʻia i ʻole e ulu ka lactic acidosis. ʻO kahi hoʻopiʻi pinepineʻole kēia, akā make. Inā ʻoe e pākuʻi i ka nui o ka dosage i ʻōlelo ʻia ʻia, ʻaʻole ʻoe e nalowale i ke kau wikiwiki, a ʻike ʻoe i nā hopena ʻaoʻao no ka gastrointestinal tract piha. Hoʻomaopopo ka hoʻonui ʻana iā Siofor i kahi hiki ʻole i kahi hāpai hāpai ʻole.

Ma ka Pūnaewele Pūnaewele Rūkia, hiki iā ʻoe ke ʻike i nā loiloi he nui o nā wahine e lawe iā Siofor no ka hoʻoluhi ʻana i ke kaumaha. ʻOkoʻa loa nā loiloi o kēia lāʻau lapaʻau - mai ka hoihoi ana i ka maikaʻi ʻole.

Loaʻa i kēlā me kēia kanaka ke kaohi o kāna iho, ʻaʻole like ka mea ʻē aʻe. ʻO ke ʻano o kēia ka hopena o ke kino iā Siofor. Inā ʻaʻole ʻoe e hoʻolālā e lawe i nā lāʻauʻai i ka manawa like e like me kaʻai haʻahaʻa, a laila ʻaʻole e manaʻo e lilo i ka nui o ka momona e like me ka mea kākau o ka loiloi ma luna nei. Waʻi ʻia i ka minus 2-4 kg.

Malia paha, ua ukali ʻo Natalia i kahi meaʻai haʻahaʻa-haʻahaʻa, ʻaʻole ia e kōkua i ka emi ʻana o ka paona, akā no ka mea, ke pale ʻole i ka momona kaumaha. Inā ua hoʻohana ʻo ia i ka meaʻai liʻiliʻi haʻahaʻa, ʻokoʻa loa ka hopena. He mea momona wikiwiki a maʻalahi ka Siofor + protein me ka maikaʻi, a me ka ʻole o ka pōloli.

ʻO ke kumu kumu o ka ʻōpū o ke ʻano he maʻi hoʻomaha, he mea ʻole i ka maʻi maʻi. Ua hānau ʻia ke kanaka ma kahi e neʻe ai. ʻO ka hana pilikino he mea nui iā mākou. Inā ʻoe e alakaʻi i kahi ala e noho ai, a ma hope o ke mau makahiki he 40 mauʻano maʻi degenerative, me ka ʻohi ʻana a me ka osteochondrosis, e hiki mai ana. ʻO ke ala wale nō e lohi ai iā lākou ʻo ka aʻo ʻana e pehea e hoʻōho ai me ka leʻaleʻa, a hoʻomaka e hana. Ma waho o ke neʻe ʻana, ʻaʻohe mea kōkua e kōkua, me ka glucosamine a me ka chondroitin. ʻAʻohe mea e mākaʻikaʻi ʻo Siofor. Hana ʻoiaʻiʻo ʻo ia i kāna hana, me ke kōkua ʻana no ka nalo ʻana i ke kaupaona ʻana a kāohi i ka maʻi diabetes.

ʻO kahi mea ʻē aʻe i ka pālākeke haʻahaʻa-kalaiwa, kākā, ke kalaiwa i ke olakino e kuhikuhi ai i nā kauka no nā maʻi āpau. Akā, wikiwiki koke ʻo Elena. ʻOiai mālama ʻo ia i ka nalo momona. Akā no ka ʻai hewa, ʻaʻohe kumu o ka lawe ʻana i ka Siofor, ʻaʻole no ka nalowale ʻana i ke kaumaha, ʻaʻole hoʻi no ka hoʻōho maʻamau i ke kō koko.

Ua hoʻonui mālie ʻo Natalya i kahi pane a hoʻomaikaʻi iā ia no kēia hiki iā ia ke hōʻalo i nā hopena ʻaoʻao. Hele i kahi meaʻai hoʻohaʻahaʻa-liʻiliʻi - a ʻaʻole ʻoe e kaupaona, akā lele a lele i lalo, hāʻule.

Siofor no ka hoʻopaʻa ʻana i ka maʻi maʻamau ʻo 2

ʻO ke ala maikaʻi loa e pale ai i ka maʻi maʻamau ʻo 2 ke huli nei i kahi ola olakino. Ma keʻano kūikawā, hoʻonui i ka hoʻoikaika kino a hoʻololi i ke ʻano kai. ʻO ka mea pōʻino, ʻo ka hapa nui o nā mea maʻi i ka nohona o kēlā me kēia lā ʻaʻole i hahai i nā ʻōlelo hāpai no ke hoʻololi ʻana i ko lākou ola.

No laila, nīnau nui ka nīnau i ka hoʻolālā ʻana i kahi hoʻolālā no ka hoʻopaʻa ʻana i ka maʻi maʻamau ʻo type 2 e hoʻohana ana i ka lāʻau. Mai 2007, ua hoʻopuka kūkākūkā ka poʻe loea Kaleponi o ʻAmelika Hui Pū ʻIa e pili ana i ka hoʻohana ʻana o Siofor no ka pale ʻana i ka maʻi maʻi.

Ke hōʻike nei i kahi 3 mau makahiki i hōʻike ʻia ka hoʻohana ʻana o Siofor a i Glucofage e hōʻemi i ka hopena o ka hoʻouluʻana i ka maʻi maʻi ma o 31%. No ka hoʻohālikelike: inā ʻoe e hoʻohuli i kahi koina olakino olakino, a laila e emi ka palena iki e 58%.

No ke hoʻohana ʻana i nā papa metformin no ka pale ʻana i manaʻo ʻia wale nō i nā mea maʻi me ka maʻi koʻikoʻi o ka maʻi maʻi. Hōʻuluʻulu ʻia kēia pūʻulu i ka poʻe ma lalo o ka makahiki o 60 me ka obesity ka mea pū kekahi i ʻole a i ʻole nā ​​ʻoi aku paha:

• hemoglobin kūlia glycated - ma luna o 6%:
• hypertension arterial;
• ka pae haʻahaʻa o ka "maikaʻi" kolamu (kiʻekiʻe kiʻekiʻe) i ke koko;
• hoʻokiʻekiʻe kaila triglycerides;
• aia ka lā hewa type 2 ma nā pili pili.
• hui kino kino ʻia ma mua o a i ʻole ka 35.

I kēlā mau mea maʻi, hiki ke kūkākūkā ʻia ke koho ʻana o Siofor no ka pale ʻana i ka maʻi diabetes ma kahi kaha o 250-850 mg 2 mau manawa i ka lā e hiki ke kūkākūkā. I kēia mau lā, ʻo Siofor a i kāna ʻano Glucophage wale nō ke ʻano he mea pono ke pale aku i ka maʻi maʻi.

Nā ʻōlelo kikoʻī

Pono ʻoe e nānā i ka hana o ka ʻā a me nā hana ma mua o ka koho ʻana i nā papa metformin a laila ma kēlā me kēia 6 mahina. Pono ʻoe e nānā i ke kiʻekiʻe o ka lactate i ke koko 2 mau manawa i hoʻokahi makahiki a keu paha paha.

Ma ka mālamaʻana i ka maʻi maʻi, ka hui pū me ka siofor me nā derogatives o ka sulfonylurea e loaʻa i ka hopena o ka hypoglycemia. No laila, pono i ka mālama ponoʻana i nā pae glucose koko i nā manawa he nui i ka lā.

Ma muli o ka pilikia o ka hypoglycemia, ʻaʻole i ʻōlelo ʻia nā mea maʻi e lawe i ka siofor a i ka glucophage paha e hana i nā hana e pono ai ka huli ʻana a me ka wikiwiki psychomotor.

Nā hopena hopena

10-25% o nā mea maʻi e lawe ana iā Siofor me nā hoʻopiʻi o nā hopena maikaʻi mai ka hoʻopili ʻana, ma ka hoʻomaka ʻana o ke ʻano. ʻO kēia ka ʻoma "ʻōpala" i loko o ka waha, ka nalo ʻana o ka momona, ka ʻeha ʻana, ka ʻūhū a me ke kīkī, ka ʻōpū o ka ʻōpū, ke kuʻi a hiki hoʻi i ka luaʻi.

No ka hōʻemi i ka pinepine a me ka ikaika o kēia mau hopena, pono ʻoe e lawe i siofor i ka wā a ma hope o ka ʻai ʻana, a hoʻonui i ka nui o ka lāʻau lapaʻau. ʻO nā hopena ʻaoʻao mai ka gastrointestinal tract ʻaʻole kumu kumu e hoʻopau ai i ka mālama Siofor. No ka mea ma hope o kekahi manawa maʻamau lākou e haʻalele, a me ka papa like ʻole.

ʻO ka maʻi o ka metabola: loaʻa pinepine loa (me ka overdose o ka lāʻau, i mua o nā maʻi concomitant, kahi i hoʻohālikelike ʻia ai ka hoʻohana ʻana o Siofor, me ka waiʻona make), hiki i ka acidact lactate ke ulu. Pono kēia e hoʻomaʻemaʻe koke i ka lāʻau lapaʻau.

Mai ka pūnaehana hematopoietic: i kekahi mau hihia - meememia megaloblastic. Me ka lōʻihi o ka mālama ʻana me ka siophore, hiki i ka hiki ke hoʻomohala ʻia ka B12 hypovitaminosis (he kīnā paʻa ʻole). Kēia loa loaʻa nā hanana kūlohelohe - kahi ʻupalu kino.

Mai ka ʻōnaehana endocrine: hypoglycemia (me kahi overdose o ka lāʻau).

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua ʻike ʻia ka nui o ka metformin (ʻo ia ka ikaika o Siofor) ma ka plasma koko ua loaʻa ma hope o nā hola he 2 mau hola. Inā ʻoe e lawe i nā paila me ka meaʻai, a laila emi iki ka hoʻohuihui ʻana a emi iho. ʻO ka piʻi loa o ka metformin i ka plasma, ʻoi aku ma ka nui loa o ka nui, ʻaʻole iʻoi aku ma mua o 4 μg / ml.

ʻO nā ʻōlelo i ʻōlelo ʻia he kūleʻa kūlohelohe maoli ka poʻe maʻi ma kahi o 50-60%. ʻAʻole paʻa ka lāʻau lapaʻau i nā protein plasma. Hoʻopau ʻia ka mea ola i ka urine holoʻokoʻa (100%) i loli ʻole. ʻO ia ke kumu i kuhikuhi ʻole ʻia ai ka lāʻau no nā poʻe maʻi e hōʻemi ana ka maʻi filtration renal glomerular i ka haʻahaʻa o 60 ml / min.

ʻO ka hoʻomaʻemaʻe o ka hana hakahaka o ka metformin ma mua o 400 ml / min. Loaʻa ia ma ka helu filtration glomerular. ʻO kēia ke neʻe i ka siofor mai ke kino ʻaʻole ma ka kānalua glomerular wale nō, akā ma o ka ʻono a me nā mea hoʻonaʻauao ʻē aʻe i nā papa renal proximal.

Ma hope o ka lawelawe waha, ua piha ka hapalua o nā ola he 6.5 mau hola. Me ka hiki ʻole o ka renal, hōʻemi ka nui o ka hoʻonuiʻana i ka siofor ma kahi o ka emi ʻana o ka hoʻomaʻamaina ma ka hana. No laila, ʻoi aku ka lōʻihi o ka hapalua-a ke piʻi nei ke ʻano o ka metformin i ka plasma koko.

Hoʻopau anei ʻo Siofor i ka calcium a me ka magnesium mai ke kino?

Ke hopohopo nei ʻo Siofor i ka emi o ka magnesium, calcium, ka make a me ke keleawe i ke kino? Ua hoʻoholo ʻo nā loea Loma e ʻike. Ua aʻo ʻia kā lākou aʻo ʻana he 30 ka poʻe 30-60, ka mea i hoʻohālikelike i ka maʻi diabetes type 2 ʻaʻole naʻe i mālama ʻia no ia ma mua. Ua hoʻonohonoho ʻia lākou i Siofor 500 mg 2 mau manawa i kahi lā. ʻO Siofor wale nō i hoʻonohonoho ʻia mai nā papa e nānā i kona hopena. Hana paʻa nā kauka i nā huahana a nā mea ʻai e ʻai ai he 320 mg o ka magnesium i kēlā me kēia lā. ʻAʻole i kuhikuhi ʻia nā papa lāʻau Magnesium-B6 i kekahi.

Kūkulu ʻia kekahi pūʻulu mana o ka poʻe olakino, ʻaʻohe maʻi maʻi maʻi maʻi. Hana lākou i nā hoʻokolohua like i hoʻohālikelike ʻia i kā lākou hopena me nā mea maʻi.
ʻO nā mea maʻi o ka maʻi diabetes type 2 ka mea i loaʻa ʻole ka hemahema, cirrhosis o ke ake, ka maʻi noʻonoʻo, ka hapai ʻana, ka maʻi maʻi ʻana, a me ka mea nāna i lawe i nā lāʻau diuretic, ʻaʻole i ʻae ʻia i ke ʻano o ka hoʻopaʻa ʻana.

ʻO ka haʻahaʻa o ka magnesium i ke koko o nā poʻe maʻi me ka maʻi maʻamau type 2, ke hoʻohālikelike ʻia me nā poʻe olakino. ʻO ka hemahema o Magnesium i ke kino kekahi o nā kumu o ka maʻi maʻi. Ke ulu ka lolo i ke kō, e hoʻoneʻe ana nā keiki i ka nui o ke kō i loko o ka pāʻai, a ma muli o kēia, ke piʻi aʻe nei o ka magnesium. I waena o nā poʻe maʻi maʻi maʻi i hoʻomohala i nā hoʻopiʻi, aia ka mea nui o ka nui o ka magnesium ma mua o ka poʻe i loaʻa ka maʻi maʻi ʻole me ka hoʻopiʻi ʻole. ʻO ka Magnesium kahi o nā mea e ʻoi aku ai i ka 300 o nā enzyme e hoʻoponopono i ka kaohi o ka protein, nāʻaina a me nā mea e hoʻoweliweli ana. Ua hoʻohālikelike ʻia ka hoʻonui ʻana o ka magnesium i ka pale ʻana i ka insulin i nā poʻe maʻi me ka metabolic syndrome a maʻi paha. A ka lawe i nā kīʻaha magnesium, ʻokoʻa iki, akā hoʻonui mau i ka hoʻololi ʻana o nā sel i nā insulin. ʻOiai ke ala nui loa e mālama ai i ka pale ʻana i ka insulin he haʻahaʻa kaʻai iki, aia ka poʻe āpau a ma hope ona e kahi laulā ākea.

ʻO Zinc kekahi o nā mea iʻike nui ʻia ma ke kino o ke kanaka. Pono ia ma mua o 300 mau kaʻina hana i loko o nā pūpū - ka hana enzyme, synt synthesis, hōʻailona. Pono Zinc no ka hana ʻana i ke keʻa ka hana, mālama i ka pale kaulike, hoʻokaʻawale i nā ʻōpio manuahi, hoʻolohi i ka wā kahiko a pale i ka maʻi kanesa.

ʻO ka Copper kekahi mea hele aihue koʻikoʻi, kahi o nā pūnaehana nui. Eia nō naʻe, komo pū nā kīpana keleawe i ka hana o nā ʻekikua hāmeʻa reaktika (free radical free), no laila, he oxidants. ʻO nā hemahema a me ke keleawe nui loa i ke kino ke kumu nā maʻi like ʻole. I kēia hihia, ʻoi aku ka nui o ka keu. ʻO ka maʻi diabetes type 2 kahi maʻi metabolic maʻi e hoʻomohala ai i nā radical free he nui, kahi e hoʻoneʻe ai i ke kaumaha o ka oxidative e hōʻino i nā ʻili a me nā kīʻaha koko. Hōʻike nā hōʻike ma ke ʻano he pinepine ka nui o ke kino o ka maʻi diabetes me ke keleawe.

Nui nā ʻōmole ʻē aʻe i hoʻonohonoho ʻia no ka maʻi maʻi 2. ʻO ka metformin kaulana kaulana loa, i kūʻai ʻia ma lalo o nā inoa Siofor a me Glucofage. Ua hōʻike ʻia ʻaʻole ia i alakaʻi i ka lilo momona, akā kōkua i ka nalo momona, hoʻomaikaʻi i ke kolamu koko, a me kēia āpau me ka hopena ʻole o ka hopena. Hoʻololi ʻia ʻo Siofor a i ʻole glucophage e ʻōlelo koke ʻia, ma ka manawa ua hōʻike ka mea maʻi i ka maʻi type 2 a i ʻole ka metabolic syndrome.

Ua hoʻoholo nā kauka Loma e pane i kēia mau nīnau aʻe:

• He aha ka pae maʻamau o nā minela a me nā ʻokiʻoki i ke kino o nā mea maʻi i hoʻohālikelike ʻia me nā maʻi maʻi type 2? Mea kiʻekiʻe, haʻahaʻa a maʻamau paha?
• Pehea e hoʻohana ai ka metformin i ka magnesium o ke kino, ke kōlepa, ka zinc a me ke keleawe?

E hana i kēia, ua ana lākou i kā lākou maʻi maʻi maʻi:

• ka ʻikeʻana o ka koni, calcium, kele a me ke keleawe i ka ʻaila koko;
• nā ʻike o ka magnesium, calcium, zinc a me ke keleawe i loko o kahi lawelawe o 24 i ka urine;
• ka pae o ka magnesium i loko o nā kaila koko ʻula (!);
• a me ka "maikaʻi" a me ka "ʻino" kolamu, triglycerides, hookeai i ke koko koko, ka glycated hemoglobin HbA1C.

Nā maʻi maʻi maʻi maʻi āpau i hoʻomākino i ke koko a me nā hoʻāʻo:

• i ka hoʻomaka ʻana o ke hoʻopaʻa ʻana;
• a laila hou - ma hope o 3 mau mahina o ka lawe ʻana i ka metformin.

ʻO nā mea e loaʻa ai nā mea i loko o ke kino o nā mea maʻi me ka diabetes type 2 a me nā poʻe olakino

ʻIke mākou i nā mea maʻi me ka maʻi maʻi i ka haʻahaʻa o nā konupora a me ka zinc i loko o ke koko, ua hoʻohālikelike ʻia me nā poʻe olakino. He nui nā ʻatikala ma nā papa puke lapaʻau ʻ -lelo Pelekane i mea e hōʻike ai i ka haʻahaʻa o nā magnesium a me nā zinc kekahi o nā kumu o ka maʻi diabetes 2. ʻO ka paia keleawe hoʻokahi. No ka ʻike ʻoe, inā ʻoe e lawe i ka zinc i loko o nā papa a i ʻole nā ​​capsules, e saturates i ke kino me ka zinc a i ka manawa like ka haʻalele i ke keleawe mai loko aku. Heʻuʻuku ka poʻe i ʻike he ʻelua pālua nā mea hoʻohui. Akā, ʻaʻole ʻoe e pono e halihali i kahi ʻole kīkē keleawe. Lawe i ka zinc i nā papa 2-4 manawa i ka makahiki.

Hōʻike nā hopena o ka hōʻike ʻana i ka lawe ʻana i ka metformin ʻaʻole i hoʻonui ka hapa o nā mea ʻimi a me nā minela i loko o ke kino. No ka mea o ka excretion o ka magnesium, zinc, keleawe a me ka calcium i ka urine i ka poʻe maʻi me nā maʻi type type 2 ʻaʻole i hoʻonui ma hope o 3 mau mahina. E kūʻē i ke kūleʻa o ka mālama ʻana me nā papa Siofor, ua hoʻonui ʻia ka maʻi diabetes i ka ʻike magnesium i ke kino. Hoʻonohonoho ka poʻe kākau o ke aʻo i kēia i nā hana a Siofor. Uaʻike wau i ka pili ʻole o nā lāʻau maʻi maʻi i ka mea me ia, akā maʻalahi wale nō, ua ʻai nā mea noiʻi i nā meaʻai maikaʻi loa ke nānā aku nei nā kauka.

Ua nui aku ke keleawe i loko o ke koko o nā maʻi maʻi i ka poʻe olakino, akā ʻo ka ʻokoʻa me ka pūʻulu mana i ʻike ʻole ʻia. Eia naʻe, ʻike nā kauka Lūkini ʻoi aku ka nui o ke keleawe ma ka kaila koko, ʻoi aku ka paʻakikī o ka maʻi maʻi. E hoʻomanaʻo ua pili i ka noiʻi ʻana i nā mea maʻi 30 me nā maʻi maʻi type 2. Ma hope o 3 mau mahina o ka lapaʻau, ua hoʻoholo lākou e haʻalele iā 22 o lākou ma Siofor, a ua hoʻohui hou ʻia he 8 papa - sulfonylurea derivatives. No ka mea ʻaʻole i hoʻohaʻahaʻa ʻo Siofor i kā lākou holi. ʻO ka poʻe e hoʻomau ʻia e mālama ʻia me Siofor he 103.85 ± 12.43 mg / dl o ke keleawe ma ka kaila koko, a me nā poʻe e pono e kuhikuhi i ka deronati sulfonylurea i nā 127.22 ± 22.64 mg / dl.

Ua hōʻoia a kākau ʻia nā mea kākau o ke noiʻi i kēia mau pilina e pili ana i kēia:

• ʻO ka lawe ʻana iā Siofor ma 1000 mg i ka lā ʻaʻole e hoʻonui i ka excretion o ka calcium, magnesium, zinc a me ke keleawe mai ke kino.
• ʻO ka maknesium i ke koko, ʻoi aku ka maikaʻi o ka heluhelu glucose.
• ʻOi aku ka nui o ka magnesium i loko o nā sela koko, ʻoi aku ka maikaʻi o ka hana ʻana o ke kō, a me ka hemoglobin glycated.
• ʻO ka keleawe hou aku, ʻoi aku ka maikaʻi o ka hana o ke kō, ka glycated hemoglobin, kolamu a me triglycerides.
• ʻO ke kiʻekiʻe o ka pae kiʻekiʻe o ka hemoglobin glycated, ʻoi aku ka nui o ka zinc i loko o ka urine.
• ʻAʻole ʻokoʻa ka pae o ka calcium ma ke koko i nā mea maʻi me ka maʻi diabetes type 2 a me nā poʻe olakino.

Ke huki nei au i kou nānā ʻana i kahi hōʻoia ʻana o ke koko no ka magnesium plasma, ʻaʻole ia he hōʻike i ka pau ʻole o kēia minima. Hōʻoiaʻiʻo e hana i kahi kikoʻī o nā kikoʻī o nā magnesium i loko o nā kōpela koko. Inā ʻaʻole hiki ʻole kēia, a ke manaʻo nei ʻoe i nā ʻike o ka hemahema o ka magnesium i ke kino, a laila e lawe wale i nā papa meli me ka huaʻai B6. Mālama ʻole ia inā ʻaʻohe maʻi koʻikoʻi kāu. I ka manawa like, ʻaʻohe hopena o calcium i ka maʻi diabetes. ʻO ka lawe ʻana i nā papa pākuʻi me nā vitamin B6 a me nā zinc capsules i nā manawa he nui aku ka nui ma mua o ka calcium.

Ka hana lāʻau lapaʻau

Siofor - nā papa ʻaina no ka hoʻohaʻahaʻa i ke kōhi koko mai ka pūʻulu biguanide. Hāʻawi ka lāʻau lapaʻau i kahi emi ʻana o ka glucose i ke koko ʻelua ma ka ʻōpū ʻole a ma hope o ka ʻai ʻana. ʻAʻole ia e kumu i ka hypoglycemia, no ka mea, ʻaʻole ia e hoʻoulu i ka huna huna o ka insulin. Kiwi ʻia ka hana o ka metformin e pili ana i kēia mau hana penei:

• kaohi ʻana i ka nui o ka hana glucose i loko o ke akea ma o ke kaohi ʻana i ka gluconeogenesis a me ka glycogenolysis, ʻo ia hoʻi, ua mālama ka siofor i ke kūmole o ka glucose mai nā waikena amino a me nā "ʻona kumu", a pale pū i ka hoʻihoʻi ʻia mai nā hale kūʻai glycogen;
• ka hoʻomaikaʻi ʻana i ka glucose i loko o ka pā peripheral a me kāna hoʻohana ʻana ma laila ma o ka hoʻohaʻahaʻa ʻana i ke kū ʻana o ka kū i ka insulin, ʻo ia hoʻi, ua nui ka naʻau o nā ʻili o ke kino i ka hana o ka insulin, a no laila ʻoi aku ka maikaʻi o nā ʻili i loko o ko lākou iho;
• e lohi ana i ka lilo ʻana o ka glucose i loko o nā ʻāpana.

ʻO ka mālama iki o ka hopena o ka glucose i ka koko, siofor a me kāna mea ikaika e metformin e hoʻomaikaʻi ai i ka lipid metabolism, hoʻohaʻahaʻa i nā triglycerides i ke koko, hoʻonui i nā kiko o ka "maikaʻi" kolamu (kiʻekiʻe kiʻekiʻe) a hoʻohaʻahaʻa i ka hoʻoliʻiliʻi o "kino" haʻahaʻa haʻahaʻa kolé i ka koko.

Hoʻololi maʻalahi ka metformin molekue i loko o ka lipid bilayer o nā membranes cell. Hoʻopilikia ka Siofor i nā membranes, me nā:

• ka hoʻokae ʻana o ke kaulahao o ka mitochondrial;
• ka hoʻonui ʻana o ka hana tyrosine kinase o ka mea nāna e hopu i ka insulin;
• ka hoʻoweliweli ʻana o ka unuhi ʻana o ka hoʻonaninani o ka glucose transporter GLUT-4 i ka membrane plasma;
• hoʻōla o ka AMP-hoʻāla i ka protein kinase.

Hoʻokomo ka hana o ka physiological o ka membrane i ka mea hiki ke hoʻoliʻiliʻi i nā hāmoa i ka lipid bilayer. ʻO ka hoʻonui nui aʻe o nā membrane rigidity ka mea maʻamau o ka maʻi mellitus o ke ʻano, e hiki ai i nā pilikia o ka maʻi.

Ua hōʻike nā noiʻi e hoʻonui ana ka metformin i ka kaila o nā membrane plasma o nā nui o ke kanaka. ʻO ka mea nui ka hopena o ka lāʻau i ka membito mitochondrial.

Hoʻonui ka Siofor a me Glucofage i ka hoʻonaninaniʻana i ka insulin i ka hapanui o nā ʻōpū mākala o nā iwi, a ma kahi ʻano liʻiliʻi - ka kiko adipose. Ua ʻōlelo ka ʻōlelo aʻo e ho'ēmi ana ka lāʻau lapaʻau i ka loaʻa ʻana o ka glucose i loko o ka ʻōpū ma o 12%. Ua hōʻike ʻia nā miliona o nā poʻe maʻi e hōʻemi ana kēia mea lāʻau i ka momona. E kū'ē i ke kua o ke kaohi aku i nā paila, ʻaʻole nui ka koko, ua emi ka hopena o ke ʻano o nā kaha koko.

Glucophage a siofor: he aha e koho ai?

ʻO ka lōʻihi ka Glucophage he hana hou no ka metformin. Ka ʻokoʻa ia i ka siofor ma ia manawa he hopena lōʻihi. ʻAʻole hoʻokomo koke ka lāʻau mai ka papaʻaina, akā me ka lohi. I ka Siofor konoho, ua hoʻokuʻu ʻia ʻo 90% o ka metformin mai ka papa ma loko o 30 mau minuke, a i ka lōʻihi glucophage - e lohi iki, e hele me 10 mau hola.

He like ka Glucophage e like me kahi siophore, akā no ka hana lōʻihi. ʻO nā hopena liʻiliʻi a me nā mea maʻalahi ke lawe, akā ʻoi aku nā kumu keu.

Inā ʻaʻole e lawe ka mea maʻi i ka siofor, akā lōʻihi ka lōʻihi o ka glucophage, a laila e lohi ka pehu o ka metformin i loko o ke koko koko.

Loaʻa nā pōmaikaʻi o ka glucophage ma luna o siofor "maʻamau".

• ua lawa e lawe i kahi i hoʻokahi lā;
• nā hopena hopena mai ka gastrointestinal tract me ka nui o ka nui o ka metformin e hoʻomohala i 2 mau manawa a emi pinepine;
• ʻoi aku ka maikaʻi o ke kō o ke koko ma ka pō a i ke kakahiaka ma kahi ʻōpū ʻole;
• ʻaʻoleʻoi aku ka hopena o ka hoʻohaʻahaʻa i ke kiʻekiʻe o ka glucose koko ma mua o kahi siofor "maʻamau".

He aha ke koho e - siofor a i ka glucophage lōʻihi paha? Pane: inā ʻaʻole ʻoe e ʻae i ka siofor ma muli o ke koko, ihi a i ʻole nā ​​maʻi ʻaʻa, e hoʻāʻo iā glucophage. Inā maikaʻi nā mea a pau me ka Siofor, e hoʻomau iā ia, no ka mea, ʻoi aku ka nui o ke kālai ʻana o ka glucophage. Ma muli o ke ʻano lapaʻau maʻi maʻi maʻi ʻo Dr. Bernstein e ʻoi aku ka maikaʻi o ka glucophage ma mua o ka lāʻau paila metformin. Akā ua manaʻo nui ʻia nā haneli haneli o nā mea maʻi e hana ikaika ka siofor maʻamau. No laila, ʻoi aku ka uku no ka glucophage ma ke ʻano, e hoʻemi wale i ka huhū.

Nā ʻāpana o nā papa Siofor

Hoʻonoho ʻia ka nui o ka lāʻau i kēlā me kēia manawa, e pili ana i ka pae o ka glucose i ke koko a pehea e hoʻomanawanui ai ka mea maʻi. He nui nā mea maʻi e hoʻokuʻu i ka hoʻouka ʻana o Siofor ma muli o ka palupalu, ke nānā ʻana, a me ka ʻeha ʻeha. Hoʻomaʻo pinepine, ʻo kēia mau hopena ʻaoʻao i ke koho wale ʻia ma ke koho pono ʻole.

ʻO ke ala maikaʻi loa e lawe ai iā Siofor me kahi hoʻonui lohi i ka pāʻai. Pono ʻoe e hoʻomaka me kahi haʻahaʻa haʻahaʻa - ʻaʻole iʻoi aku ma mua o 0.5-1 g i kēlā me kēia lā. ʻO kēia nā papa 1-2 o ka lāʻau lapaʻau o 500 mg a i hoʻokahi papa o Siofor 850. Inā ʻaʻohe hopena mai ka gastrointestinal tract, a ma hope o 4-7 mau lā e hiki ai iā ʻoe ke hoʻonui i ka momona mai 500 a 1000 mg a i ʻole 850 mg a 1700 mg i kēlā me kēia lā, i.e. me ka papa pākahi ma kēlā me kēia lā.

Inā i kēia manawa ke loaʻa nā hopena mai ka gastrointestinal tract, a laila pono ʻoe e "hoʻihoʻi" i ka wai i ka mea ma mua, a ma hope e hoʻāʻo e hoʻonui. Mai nā ʻōlelo aʻoaʻo no Siofor, ʻike ʻoe i kāna ala mau ʻo 2 mg mau lā, 1000 mg kēlā me kēia. Akā pinepine ka lawa e lawe i 850 mg 2 mau manawa i ka lā. No nā mea maʻi o ke kino nui, ʻo ke kūpono kūpono loa 2500 mg / lā.

ʻO ka palena loa o Siofor 500 o kēlā me kēia lā he 3 g (6 mau papa), Siofor 850 he 2.55 g (3 mau papa). ʻO ka awelika o kēlā me kēia lā o Siofor® 1000 he 2 g (2 mau papa). ʻO kona mau momona nui loa i kēlā me kēia lā he 3 g (3 mau papa).

E lawe ʻia nā papa metformin i kekahi ʻano me ka ʻai, me ka ʻaʻa ʻole ʻana, me ka nui o ka wai. Inā ʻoi aku ka nui o ka make i kēlā me kēia lā ma mua o 1 papa, hoʻokaʻawale iā ia i 2-3 dosis. Inā ʻaʻole ʻoe e lawe i ka pulu, a laila ʻaʻole pono ʻoe e uku no kēia ma o ka lawe ʻana i nā papa hou i hoʻokahi manawa.

Pehea ka lōʻihi e lawe iā Siofor - hoʻoholo kēia e ke kauka.

Ke keu

Me kahi overdose o Siofor, hiki i ka lactate acidosis ke ulu. Nā ʻehaʻeha: nāwaliwali koʻikoʻi, ka hoʻopiʻi ʻana o ka ʻōpū, ka hiamoe, ka lua, ka luaʻi, ka maʻi ʻana, ka ʻeha o ka ʻōpū, ke kū ʻana o ke kai, ka hōʻemi ʻana i ke koko, ka reflex bradyarrhythmia.

Loaʻa paha nā ʻōhumu o ka maʻi me ke kaniʻuhū, nā haunaele a me ka nalowale o ka ʻike ʻana, wikiwiki ka wikiwiki. ʻO ka hōʻailona o ka acidact lactic acidatic he hōʻailona. ʻO kahi hoʻopiʻi maikaʻiʻole kēia e hiki ai i ka make. Akā inā ʻaʻole ʻoe e pākuʻi i ka pākuʻi a me kou mau hina ka maikaʻi o nā mea āpau, a laila pono ke hiki ke hiki.

Hoʻohui nūhou

He waiwai waiwai kēia lāʻau lapaʻau. ʻO kēia kahi manawa kūpono e hoʻohui pū me ia me nā mea ʻē aʻe e hoʻohaʻahaʻa i ka paila o ka glucose i ke koko. Hiki ke kuhikuhi ʻia ʻo Siofor i hoʻohui ʻia me kekahi kīpoki maʻi 2 ʻano ʻē aʻe a i ʻole insulin.

Hiki ke hoʻohana ʻo Siofor i ka hui pū me nā lāʻau e like me kēia:

• nā huna huna (sulfonylurea derivatives, meglitinides);
• thiazolinediones (glitazones);
• nā kinikini hinu (analogues / agonists o GLP-1, inhibitors o DPP-4);
• nā lāʻau e hōʻemi ai i ka komo ʻana o nā calcium (acarbose);
• insulin a me kona mau mele.

Aia kekahi hui o nā lāʻau lapaʻau e hiki ke hoʻonui i ka hopena o ka metformin ma ka hoʻohiolo ʻana i ke kō koko koko, inā hoʻohana ʻia i ka manawa like. ʻO kēia nā derivatives sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Ke ʻōlelo nei nā ʻōlelo iā Siofor e hiki ai i kekahi mau pūʻulu ke hōʻemi i kona hopena i ke hoʻohaʻahaʻa ʻana i ke kōpaʻa koko inā hoʻohana nā lāʻau i ka wā like. ʻO kēia nā GCS, nā contraceptives waha, epinephrine, sympathomimetics, glucagon, nā thyroid hormon, deriviazine derivatives, nicotinic acid derivatives.

Hiki iā Siofor ke hoʻonāwaliwali i ka hopena o nā anticoagulants kūlohelohe. Hoʻololi ʻo Cimetidine i ke kāpae ʻana o ka metformin, e hoʻonui ai i ka hopena o ka lactic acidosis.

Mai inu i ka wai ʻona ke lawe ʻana ʻoe i Siofor! Me ka hoʻohana like pū me ka ethanol (waiʻona), hiki i ka hōʻeha ke kūkulu i kahi hoʻopiʻi weliweli - hoʻonui ka lactic acidosis.

Hoʻonui ka Furosemide i ka nui o ka piʻiʻana o ka metformin i ka plasma koko. Ma kēia hihia, hōʻemi ʻo metformin i ka nui o ke koikoi o ka furosemide i ka pili koko a me kona mau hapalua.

Hoʻonui ka Nifedipine i ka hoʻopili a me ka kaila o ka metformin i loko o ke koko koko, e hoʻopau i kāna excretion.

ʻO nā lāʻau lapaʻau cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin), kahi i hūnā ʻia i loko o nā ʻāpana'āpana, hoʻokūkū i nā ʻōnaehana hoʻouluo tubular. No laila, me ka hoʻomohala lōʻihi, hiki iā lākou ke hoʻonui i ke kahe o ka metformin i ka plasma koko.

I loko o kēiaʻatikala, ua kūkākūkā mākou i nā kikoʻī penei:

• Siofor no ka lilo momona;
• ʻO nā papa metformin no ka pale ʻana a me ka mālama ʻana i ka maʻi type 2;
• I nā hihia kahi e pono ai e lawe i kēia lāʻau lapaʻau no ka maʻi maʻi i ka maʻi type 1;
• Pehea e koho ai i kahi dosage no laila ʻaʻohe mea hoʻonāukiuki.

No ka maʻi type 2, mai palena ʻoe iā ʻoe iho i ka lawe ʻana iā Siofor a me nā pilola ʻē aʻe, akā e hāhai i kā mākou papahana maʻi diabetes type 2. E make koke nei mai ka hōʻeha ʻana o ka puʻuwai a i ʻole hōʻeha paha ka hapa hapa o ka pilikia. A ʻo ka lilo ʻana i kahi mea i mālamalama i kahi maʻi moe no ka hoʻopiʻi ʻana i ka maʻi diabetes. E aʻo mai iā mākou pehea e hoʻomalu ai i ka lolo me ka ʻole o ka 'makeʻai "make, hoʻopau ʻana i ka hoʻonaʻauao kino, a ma 90-95% o nā hihia ʻaʻole he inikua insulin.

Inā he nīnau e pili ana i ka lāʻau lapaʻau Siofor (Glucofage), a laila hiki iā ʻoe ke nīnau iā lākou i nā ʻōlelo, pane koke ka luna o ka pūnaewele.