ʻO Lovastatin (lovastatin tablet) kahi hua lāʻau lipid-ka mua o ka hana. ʻO kona hiʻohiʻona ka mea hiki ke hoʻopiha maikaʻi i ka hoʻokaʻawale ʻana i nā lua o ka hapa haʻahaʻa haʻahaʻa a me nā kumu no ka hoʻonui i ke kiʻekiʻe o ka mea.
Manaʻo nā kauka i ka lāʻau lapaʻau kekahi o nā stins pono, ʻo nā mea ikaika e kūlohelohe loa no ke kino kanaka. I nā wai liʻiliʻi, aia lākou i loko o kekahi mau meaʻai, no ka laʻana, ma loko o ka mauhere ʻōpū.
Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa i pani ʻia me ka pale pale. Hoʻololi ka kala i ka keʻokeʻo a me ka melemele, aia i ka calcium lovastatin, ke kōpaʻa palaoa, ka silika dioxide, ka lactose monohydrate, magnesium stearate. I loko o nā lāʻau lapaʻau, hiki ke kūʻai ʻia nā papa Lovastatin i loko o nā ʻano like ʻole: 20, 20 a 40 mg.
Ka hana lāʻau lapaʻau
Ma hope o ke komo ʻana i ka hana kūwaho a ke kanaka, hiki i nā papa ke hōʻono i nā kinemona, a ʻokiʻoki ʻia a hoʻoneʻe ʻia e nā paia o nā kino o nā papa gastrointestinal. ʻO ke kūpaʻa o ka absorption e hilinaʻi pololei i ka nui o ka lāʻau o ka lāʻau, ʻoi aku ka kiʻekiʻe, ʻo ka wikiwiki ka mea ikaika e komo i ke kahe koko.
Ma ke kahe koko, ua hoʻokumu ka huahana i nā paʻa paʻa me nā protein, kahi i hāʻawi ʻia i ka wikiwiki wikiwiki o nā ʻōnaehana a pau, kahi hopena therapeutic qualitative. Hoʻohana ʻia ka hoʻomaʻamaʻa ʻana i ʻelua ʻaoʻao o ka manawa hoʻokahi, e hana ana i ka lāʻau lapaʻau i kaulana loa i waena o statins.
I ka hoʻomaka, hoʻonāukiuki ʻo Lovastatin i ka hana o ke kolamu, ʻaʻole ia e ʻae i ka hoʻoneʻe hou ʻana i loko o ka mevalonate. I ka papa aʻe, hoʻonui ka catabolism i nā mea haʻahaʻa haʻahaʻa, triglycerides, a me ka kolamu kiʻekiʻe kiʻekiʻe.
No laila, loaʻa i ka lāʻau lapaʻau ka hopena therapeutic koke a lilo i kumu no ka pale ʻana i ka ulu kolamu. Ma muli o ka hana hoʻokūkū wikiwiki:
- ʻaʻole hoʻi iʻoi aku ma mua o hoʻokahi;
- ʻo ka hapalua ke ola-ʻekolu mau hola;
- Lā ka hopena ma kahi o 14 mau hola.
Ka hana ʻana o ka hana ikaika e hele mai ma o ka ʻōpū, ka koena ma o nā ʻōpū me ka urine.
Hōʻike ʻia ka hopena therapeutic paʻa ma hope o ʻelua mau pule o ka hoʻohana mau ʻana i ka lāʻau lapaʻau, hiki i ka mea puna ke piʻi i kona neʻe ma hope o hoʻokahi mahina a me ka hapa o ka mālama ʻana.
Me ka hoʻohana mau ʻana, ʻaʻole i emi ka hopena o Lovastatin.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
Ke hōʻike ʻia nei ka lāʻau Lovastatin no ka mālama ʻana i ka ʻano hypercholesterolemia mua. Hoʻohana ʻia ia me nā ala wale nō i ka hui pū me nā lāʻau lapaʻau ʻole (kūʻai kino, kaʻai ʻana).
Ua papa ʻia nā papa no ka mālama ʻana i ka hyperlipoproteinemia, i hoʻohui ʻia ʻo hypercholesterolemia, atherosclerosis o nā kīʻaha koko. Me ka hua lāʻau, ua hōʻike ʻia ke hoʻohana ʻana i nā momona momona unsaturated, kahi papa o nā vitamina a me nā minela.
Hoʻomaopopo ʻia kahi meaʻai a me ka hiʻona o ke ʻano kino me ka lāʻau lapaʻau. Hoʻohana ka hoʻohana ʻana i ka lāʻau lapaʻau i kahi liʻiliʻi liʻiliʻi o ka hoʻololi o ke ʻano type type 1 a me ka type 2 diabetes mellitus i nā puka paʻakikī.
Hiki ke hoʻohui ʻia ʻo Lovastatin me ka hoʻohana ʻana i nā lāʻau hoʻohiolo i ke kō, ua hōʻike ʻia no ka pale ʻana o nā maʻi o ka ʻōnaehana cardiovascular. Hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau me ka hiki ʻana o ka hoʻihoʻi hou ʻana:
- he poho;
- myocardial infarction;
- ʻōpalaola.
Lawe ʻia e nā maʻi maʻi maʻi me ka hopena o ka corasary revascularization, unstable angina pectoris, coronary artery maʻi.
Hoʻomaka lākou e lawe i nā lāʻau lapaʻau inā ʻaʻole i hāʻawi ʻia nā mea lapaʻau ʻole o ka lapaʻau i ka hopena i manaʻo ʻia. ʻAʻole e like me ka nui o nā statins i hoʻohana hoʻokahi i ka lā, hiki ke hoʻohana ʻia ka lovastatin ma nā kaulike like ʻole me ke anuanu o 12 mau hola.
ʻAʻole pono ka hopena mua o ka lāʻau lapaʻau ma mua o 10 mg, i ka wā e hiki mai ana (ma muli o ka palaka a me ka paʻakikī), hoʻonui ʻia ka nui o ka lāʻau i kēlā me kēia mau hebedoma 2-4. Hiki ke lawe ʻia ka nui o 80 mg ma ke ao.
ʻO ka emi nui ʻana o ka hana o nā momona like-momona o nā haʻahaʻa haʻahaʻa a me ka haʻahaʻa haʻahaʻa e pono ai ka hōʻemi ʻana i ka pauku ʻana o ka lāʻau. I kēlā me kēia pule, hōʻemi ʻia ka nui o ka lāʻau e 10 mg. Eia kekahi, hiki ke hoʻemi ʻia ka dosage ma ka hapalua, akā ke hoʻāpono ʻia kēia inā wale nō:
- lilo i ka inu waiona;
- ke hele ʻana i kahi papa o nā immunosuppressants;
- maʻi maʻamau maʻi o nā maʻi o nā etiology.
Ke lawe ʻia nei ka hōʻemi ʻia ʻana me ka wā lapaʻau me nā ʻaina antifungal, nā maʻi a me nā lāʻau lapaʻau e pili ana i nā anticoagulants.
ʻAʻole hiki iā ʻoe ke hoʻohui iā Lovastatin me ka cyclosporins, no ka mea i kēia hihia e paʻakikī ana ka hele ʻana i ka neʻe ʻana o ka mea ikaika ma ke kahe o ka mea maʻi.
ʻO nā kumulane, nā ʻinoʻino loa, loaʻaʻole
Me ka maʻi maʻi, kahi lāʻau kūʻē i ke kolamu kiʻekiʻe ʻaʻole kūpono no nā maʻi āpau. No laila, contraindications e pili ana ka intolerance pilikino i nā mea ikaika a i ʻole nā mea kōkua o ka lāʻau lapaʻau, ka hana kiʻekiʻe o nā transaminases i loko o ka ate, a me ka palau ole o ka ate.
ʻAʻole kuhikuhi nā kauka iā Lovastatin i ka manawa hāpai o kēlā me kēia manawa a i ka wā hānai, no nā keiki ma lalo o 18 makahiki. ʻAʻole i hōʻike ʻia ka palekana o ka hoʻohana ʻana i nā papa no nā poʻe maʻi o kēia kulana, ʻaʻole i aʻo ʻia ka hopena o ka mālama ʻana.
ʻO ka pinepine, hāʻawi ka lāʻau lapaʻau i nā hopena maikaʻiʻole. ʻO kekahi o lākou he myopathy. Inā e huki ana i nā hōʻeha a me nā nāwaliwali o nā ʻōpū o ke kua, pono ʻoe e ʻimi i ke kauka no ke aʻo ʻana. Ma ka hōʻoia ʻana i ka myopathy, ua kāpae ke ʻano o ka mālama ʻana, ua kuhikuhi ʻia ka mea maʻi.
ʻAʻole kāpae i ka ʻōnaehana hana i ka hōʻemi i ka libido, erectile dysfunction, gynecomastia. Ma ka ʻaoʻao o nā lālā o ka ʻike, ʻulaʻula hoʻi o ka maka, ua ʻike ʻia nā aniani aniani, nā lensa blurred.
ʻO nā hopena ʻē aʻe maikaʻi ʻole o ka mālama ʻana nā loli pathological i loko o ke akepū. No kēia kumu, me kahi predisposition i nā maʻi ʻalani, e koi ʻia kahi hōʻike biochemical o ka ate i kēlā me kēia mahina ʻekolu.
Me ka hoʻonui nui o ka hana o nā transaminases i nā pae koʻikoʻi, pono ia e hooki i ka lawe ʻana i nā papa. Eia kekahi, hoʻihoʻi i ka lāʻau lapaʻau e pono i nā hopena ʻaoʻao:
- ninini
- utuka
- nā ninia
- nā pulu ʻili;
- huu
Wahi a nā kauka, ʻo Lovastatin kahi lāʻau maikaʻi a palekana maikaʻi i kūpono no ka mālama ʻana a me ka pale ʻana i ka atherosclerosis o nā kīʻaha koko. ʻO ka manawa pinepine, ʻoi aku me ka hoʻohana ʻana i ka lōʻihi, hoʻolale maikaʻi ʻia ia e ke kino, he mea maʻamau ke haʻi ʻia i ka hoʻoulu ʻia ʻana o nā hopena maikaʻi ʻole.
Eia nō naʻe, ma 2012, ua hana ʻia kahi noiʻi e hōʻike ana i nā hopena ʻē aʻe. I waena o lākou ko nā mea hoʻomanaʻo hoʻomanaʻo, ka poina mahele, nā hoʻohuli a me nā hau.
Inā ua loaʻa i ka mea maʻi hānai i ka nui o ka nui o ka lāʻau, ua hoʻohālikelike ʻia ʻo ia i ka ʻomaʻi maʻi. Pono pono e inu i ka wai maʻemaʻe e hiki ai, e lawe i ka enterosorbents a me nā mea hoʻoikaika kino i nā ʻōlelo maʻamau. Hoakaka pū ʻia ka hoʻomaka ʻana o ka diuretics. ʻAʻole hāʻawi Hemodialysis i kahi hopena kūikawā, akā ua hōʻoia ʻia i nā hihia koʻikoʻi o ka maʻi overdose.
Ma hope o kahi overdose, ua hoʻomaka ka papa hana lua no ka mālama ʻana ma mua o 6 mau mahina a ma lalo o ka mākaʻi o ke kauka.
Nā Lovastatin analogues
| Ke poʻo inoa | He kumukūʻai ma nā rubles |
| Medostatin | 550 |
| Mevacor | 220 |
| Cardiostatin | 240 |
| Rovacor | 390 |
| Holartar | 190 |
| Lovacor | 280 |
| Lovasterol | 200 |
I ka manawa, no kekahi kumu, ʻaʻole kūpono ʻo Lovastatin no ka maʻi maʻi maʻi, ʻaʻole i loaʻa iā ia ka lāʻau lapaʻau ma kahi kīkī kokoke loa ia, pono ʻoe e lawe i mea hoʻokalakupua o ka lāʻau. Kēia mau lāʻau lapaʻau e like me ka mea ikaika, hiki ke hoʻohuli i ka lāʻau mua.
No Lovastatin, ke kumukūʻai kumukūʻai mai 180 a 300 mau rubles. I kekahi mau manawa, ʻoi aku ka maikaʻi o ka lāʻau lapaʻau ma mua o nā mea like. Hiki iā ʻoe ke kūʻai iā ia i loko o ka pānaehana apotika me ka loaʻa ʻole o ka lāʻau lapaʻau.
Hōʻike maikaʻi nā loiloi e pili ana i nā paila i ka nui.
Hoʻohui nūhou
ʻO ka hana like ʻana o ka lāʻau lapaʻau me nā mea antifungal e hoʻonāukiuki i ka hoʻomohala ʻana i ka myopathy, ka luku ʻana i ka nui o ka ʻiʻo. Hoʻopili pū ka ʻano pōpilikia o myopathy me ka hoʻohana ʻana i ka nui o ka wai o ko lākou niuki ʻana.
Inā lawe ka mea maʻi ma mua o Lovastatin me Warfarin, aia ke koʻikoʻi o ke kahe koko. Ke mālama nei me Colestiramin, ke emi nei ka bioavailability o ka lāʻau lapaʻau, no kēia kumu he mea nui e mālama i kahi wā o 2-4 mau hola ma waena o nā mea lapaʻau.
Ke hui pū ʻia ka lāʻau lapaʻau me nā anticoagulants, derivatives coumarin, piʻi nui ke koko a hoʻonui ka manawa prothrombin. Ua ʻike nā lāʻau lapaʻau i nā hihia i ka wā e ulu ai kahi maʻi maʻi maʻi hyperkalemia koʻikoʻi.
ʻO ka lāʻau lapaʻau e hōʻemi i ka hopena o nā maʻi o ka ʻōnaehana cardiovascular. Inā ua kū mua ʻia nā mea, lapaʻau e kōkua:
- hoʻoikaika i nā pā vascular;
- hoʻolaʻa haʻahaʻa haʻahaʻa;
- hoʻomaikaʻi i ka maikaʻi o ka mea maʻi.
I ka hihia o ka hina ʻana o nā keiki, lawe ʻia nā papa ma kahi nui loa o 20 mg. Hoʻohana ʻia i ka hui pū ʻana me nā lāʻau lapaʻau e hoʻopau i ke kūlohelohe, ʻaʻole iʻoi aku ma mua o 20 mg o ka mea i kēlā me kēia lā i hōʻike ʻia.
I ka wā o ka papa o ka maʻi, pono ka mea maʻi ma muli o ka papaʻai me ka kolamu hoʻohaʻahaʻa. Manaʻo ʻia mai kēlā manawa kēia manawa e nānā i ke kiko o ka momona o ka momona o ke koko, e hoʻokau i nā hōʻike o ke akepaʻa. He mea koʻikoʻi kekahi e nānā i ke ʻano laulā o ka mea maʻi. ʻO ka hōʻailona e pili ana i ka pono e kāpae i ke ʻano he mea ʻoluʻolu a me ka ʻehaʻī ʻana.
E haʻi nā loea i nā statins i loko o kahi wikiō ma kēia ʻatikala.
