ʻO Roxera kahi ʻelele o kahi hui o nā lāʻau lapaʻau e pili ana i ka lipid metabolism. ʻO ka mea hana nui o Roxers ʻo rosuvastatin, kahi e pale ai i ka enzyme e hoʻololi ai i ka cholesterol.
ʻO ke kumu o ka noi o rosuvastatin he hepatocytes, kahi i synthesize ʻia ka cholesterol a hoʻokaʻawale nā kikoʻī atherogenic o nā lipoproteins. ʻO ka hana o ka hana e hoʻonui ai i ka nui o ka hopena o ka mea hoʻoponopono i ka hepatocytes no LDL, a laila e hoʻonui ai i ka naʻau a me ka nalowale o ka LDL, no laila ke kāohi nei i ka hoʻohuihui ʻana o ka lipoproteins atherogenic.
Mahalo i Roxer, kolamu, hōʻuluʻulu ʻo atherogenic, hōʻemi a me ka triglycerides (TAGs), a me ka piʻi ʻana o nā haʻawina anti-atherogenic o nā lipoproteins e hoʻonui.
Kahi hopena therapeutic i haʻi ʻia ma kahi hebedoma ma hope o ka hoʻomaka ʻana o ka hoʻokele. I loko o ʻehā mau wiki o ka mālama ʻana, ua hoʻokō ʻia ka hopena o ka lā nui, ʻoiai ua lawe ʻia ka lāʻau lapaʻau.
ʻO ka lāʻau lapaʻau e pono ai e kuhikuhi e ka mea kauka e komo i nā hiʻohiʻona pilikino o ka mea maʻi.
ʻO ka lāʻau lapaʻau ponoʻī e Roxeroy hiki ke alakaʻi i kahi pūʻali o nā hopena maikaʻi ʻole, e komo pū ana me ka rhabdomyolysis a me ka hala ʻole.
Pharmacokinetics a me ka lāʻau lapaʻau
Loaʻa i ka lāʻau lapaʻau ka iwakālua mau pakeneka. ʻO ka hoʻololi a me ka hoʻohana ʻana i ka lāʻau lapaʻau ka mea e lawe ʻia e nā pūnao ʻili.
Ma kahi o 90% o Roxers e hui pū ana me nā protein plasma, kūikawā me ka albumin. ʻAʻole loli ia ʻo Pharmacokinetics i ka wā i lawe pinepine ʻia ai.
Ma kahi o 90% o ka rosuvastatin i hoʻoiho ʻia i loko o kāna ʻano i hana ʻia ma ka hana o ka digestive tract. Hoʻonohonoho iki kahi hapa o ka lāʻau lapaʻau i loko o nā tubula renal.
ʻO nā mea noi no ke koho ʻana iā Roxers ʻo:
- hypercholesterolemia mua;
- nā hemahema o nā lipids;
- genetic hypercholesterolemia;
- hypertriglyceridemia;
- atherosclerosis;
- ʻoiai he lāʻau lapaʻau no ka pale mua o nā maʻi cardiovascular catastrophes i nā mea maʻi me nā hōʻailona ʻole o ka maʻi coronary heart disease, akā i ka mālama kiʻekiʻe.
Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa me kahi pūpū pale.
Aia i ka papa papa ʻia i kēia maʻa e pili ana: 5 milligrams, 10 milligrams, 15 milligrams, 20 milligrams, 30 milligrams, 40 milligrams.
Koho ʻia ka ʻāuna ma ke ʻano a me ka hōʻino o ka maʻi. Hoʻokumu ka hopena therapeutic i ke ʻano a me ke kūpaʻa o ka lāʻau lapaʻau.
Hoʻokaʻawale ka ʻokoʻa a me ke ʻano o ka huaʻala. I nā hoʻokolohua lapaʻau, ʻike ʻia ka lāhui Mongoloid me ka Caucasoid, i hōʻike i ka nui o ka plasma o ka rosuvastatin.
ʻO nā papa Roxer i loaʻa ka kaola kalalau lactose, no kēia mea ua pāpā ʻia ka lāʻau lapaʻau no nā poʻe maʻi me ka nele o ka lactase, a me ka maʻi laʻi o ka malabsorption.
Ma muli o ka huki ʻana, hiki ke hōʻeha i ka ʻeha a me nā hopena ʻē aʻe, e koi pono ka nānā ʻana a me ka akaʻapaʻa i ka wā e lawe aku ai i ka mīkini a me ka hoʻomā ʻana i nā mīkini pono.
ʻO ka hana maʻamau a me ka kūpono o ka lāʻau lapaʻau e pale i ka hoʻolālāʻana o nā hopena maikaʻiʻole. He mea nui ia e lawe i ka lāʻau lapaʻau i ka hopena kūpono e hiki ai i ka hōʻalo ʻana i ka pōpilikia a me nā pōpoki, ʻo ka mea aia i kēia mau mea nā huaka a ka rosuvastatin.
Pono ke kauka komo e koho i nā maʻi kūpono wale nō, akā ʻo ka hui pū ʻana kekahi o nā lāʻau lapaʻau ma waena o lākou iho. ʻO kēia ma muli o ka loaʻaʻana o ka hapa nui o ka poʻe maʻi me ka atherosclerosis concomitant pathological pathology.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
Lawe ʻia ʻo Roxer e like me nā ʻōlelo a nā kikoʻi o ka pepa i hoʻohana ʻia.
Pono ʻia ka lāʻau lapaʻau no ka hoʻohana pono ʻana. Hoʻole ʻia i ka ʻalā a me ka wili i ka lāʻau lapaʻau. Pono ka papa paʻi i kona ʻano mua, holoi ʻia me ka nui wai. Hōʻike ʻia i kēlā me kēia manawa, me ka manaʻo o kahi kaiʻai.
Hoʻomaopopo wale ka hopena o ka lāʻau inā he ukali kekahi meaʻai kūikawā. I ka hoʻomakaʻana o nā pena, 5 milligrams o ka huahana i kuhikuhi i kēlā me kēia lā. Ke ke koho nei i ka hoʻoponopono reged, lawe ʻia nā pae kolikoli plasma a me ka noʻonoʻo ʻana i ka hopena kūpono paha o ke kolo cardiovascular catastrophes. Eia kekahi, e hoʻolohe i ka pilikino pilikino o nā hopena ʻaoʻao.
Hiki iā ʻoe ke hoʻonui i nā pona ma hope o ka mahina mai kahi o ka hoʻomaka ʻana o ka mālama ʻana. Kūpili ʻia ka nui o 40 mg me ka nui o nā hopena i hoʻohālikelike ʻia me nā haʻahaʻa haʻahaʻa o ka mea. Hāʻawi ʻia ia i ka hoʻonui ʻana i ka wai hoʻoneʻe no hoʻokahi mahina a lawe wale ʻia i nā mea maʻi me kahi kiʻekiʻe o ka hypercholesterolemia a me ke ʻano koʻikoʻi o ka hoʻomoʻa ʻana i nā catastrophes cardiovascular. Hoʻomaka ʻia ka hana ma lalo o ka mākaʻi o kahi kauka.
Ma hope o kahi mahina o ka mālama ʻana a i ʻole he mea hoʻololi paha i ka hopena o ka lāʻau lapaʻau, pono pono e hana i kahi kiʻi lipid. No ka poʻe maʻi me ka hiki ʻole o ka maikaʻi ʻole o ka hakahaka o ka renal (ʻoi aku ka hana ʻana o ka creinine ma mua o 30 milliliters i hoʻokahi minuke), ʻaʻole ʻae ʻia ka hoʻohana ʻana o ka lāʻau lapaʻau.
ʻAʻole hiki ke kuhikuhi ʻia ʻo Rosuvastatin i nā maʻi me ka maʻi maʻi ma ka manawa koʻikoʻi. ʻO nā mea maʻi ma mua o 65 mau makahiki e pono e hoʻomaka e lawe me kahi liʻiliʻi haʻahaʻa no kēlā me kēia lā.
Nā Hōʻino hewa a me ke kaupena
ʻO nā hopena ʻinoʻino e hilinaʻi pololei loa i ka maʻa o ka lāʻau a me nā hiʻohiʻona pilikino o ka mea maʻi.
Hoʻopili ʻia nā hopena kūpono e like me ka pinepine o ka hanana a me nā ʻano o nā hōʻike.
ʻO ka hopena maʻamau e hōʻike i nā hopena hypersensitivity (ka edema Quincke, urticaria, anaphylactic shock); poʻomanaʻo ʻʻAla polyneuropathy; mau kuhi ʻana o nā hana hoʻomanaʻo. ʻO ka hoʻonāukiukiʻana o ka pēpē gastrointestinal ma ke ʻano o ka constipation, e ukali ʻia e ka maʻi maʻi, ka ʻūhā a me ka luaʻi, ʻeha a me ka ʻeha i loko o ka ʻōpū, ʻaʻole i hoʻokaʻawale ʻia; ate dystrophy ate, hepatitis me ka maʻi icteric koʻikoʻi; Maʻiʻo Stevens-Johnson; nā kino ʻeha; myopathy a me ka luku ʻana o ka ʻoi ʻana; ʻāwili eha lilo ana o ka protein ma ka urine; nalowale o na kihe koko uwila i ka uila; asikoic kūlana; dysfunction hormone thyroid.
Ma muli o ke kaona nui o ka lāʻau lapaʻau, hōʻike ka mea hana i kahi mau palena i ka hoʻohana ʻana o Roxers. ʻO nā palena nui:
- ʻO ka hana ikaika o ka hepatitis a i ʻole nā papa hepatic ʻē aʻe.
- ʻO kahi pale hoʻokū maikaʻi.
- Myopathy
- Hōʻike ʻia me cyclosporin cytostatic.
- Hoʻohana maʻalahi me nā fibrates.
- ʻO ka wā hāpai a me ka lactation.
- Ka lule a lactose.
- Nā makahiki o nā keiki.
- Hoʻolaha kūʻokoʻa i ka lāʻau.
ʻO ka lawe ʻana i ka lāʻau lapaʻau i ka wā o ka hāpai a me ka lactation, ua hoʻohālikelike maoli ʻia. Hoʻohui ʻia ka Contraindication me ka hana teratogenic kiʻekiʻe o ka waiwai.
Rosuvastatin ua contraindicated i ka poʻe ma lalo o 18 makahiki o kona mau makahiki. Me ka mālama aka, pono e kuhikuhi ʻia ka lāʻau i ka poʻeʻelemakule.
Ua hoʻopaʻa ʻia kekahi koho koho o ka waiwai holoʻokoʻa no ka renal dysfunction, ʻoiai ua loaʻa iā rosuvastatin kahi hopena nephrotoxic. Ke lawe nei i kahiʻoi aku ma mua o 30 mg no ka lā o ka mea o ka hana, pono ka nānā ʻana i kahi hana maʻamau.
ʻO ka lāʻau lapaʻau ka myotoxic. Ua hoʻomaopopo ʻia ka Myalgia a me ka hōʻeha ʻana o ka naʻau inā hoʻohui ʻia me nā lāʻau lapaʻau lipid haʻahaʻa. Inā loaʻa i ka mea maʻi ka hōʻeha ʻeha, nāwaliwali, nā pūpili i hui pū ʻia me ka maʻi hauā laula, e ʻike koke ʻia ke kauka hele mai. He mea nui hoʻi e hoʻoholo i ka hoʻoili ʻia ʻana o ka phosphokinase creatine i loko o ke koko.
Hoʻopili ʻia ka Therapy me ka hoʻonui nui ʻana i ka phosphokinase creatine a i ʻole ka holo ʻana o kahi hōʻailona o ka hōʻeha o ka naʻau, ka haʻalulu a me ka nāwaliwali.
ʻO ke kikowaena o Roxers me nā lāʻau lapaʻau ʻē aʻe
Hōʻike ʻia nā Roxers e kekahi mau lāʻau lapaʻau me nā lāʻau lapaʻau ʻē aʻe.
I ka wā e hoʻohana ai i ka lāʻau lapaʻau me nā mea hana ʻē aʻe, pono e noʻonoʻo ʻia nā pilina ma waena o lākou.
Me nā lāʻau lapaʻau e hiki mai ana, aia ka hopena i ka hopena pharmacokinetic:
- Antimetabolite "Tsisklosporin". Me ka hoʻohana pū ʻana o nā lāʻau lapaʻau, ʻike nui ʻia ka nui o ka nui o ka rosuvastatin i loko o ka plasma.
- Warfarin. ʻO ka hoʻokahuli pūlohelohe ʻana o nā lāʻau e hōʻeha i ka mea maʻi. Hoʻohui ka hoʻokele me nā kūlohelohe anticoagulants i ka piʻi ʻana o ka rosuvastatin a me nā pālua i ka pae o ka mana o ka honua.
- Ezetimibe. ʻO ka hoʻohana pinepine ʻana i kēia mau lāʻau like ʻole e hoʻonui i ka iʻa o nā mea ʻelua i ke koko. Akā e hoʻonui paha ka ezetimibe i ka hopena o ka hopena myotoxic.
- ʻO nā lāʻau lapaʻau e pili ana i ka lipid. Me ka hoʻokūkū like, ua hoʻomaopopo ʻia kahi kaualua o ka neʻe ʻana o Rosuvastatin i ka plasma. Hoʻohui kēlā hui like i ka nui o ka hiki ʻana o ka holomua o ka pololi mākēpū.
- ʻO nā lāʻau lapaʻau antiretroviral: kūlohelohe o ka manawa immunodeficiency virus inhibitor. Hoʻopili kēia hui like i ka pae o ka plasma o rosuvastatin.
- Hoʻokomo ʻia. ʻO ka hui pūʻana o rosuvastatin me nā antacids, kahi e hoʻopili ai i ka alumini a me ka magnesium hydroxide, alakaʻi i kahi emi iki o ka plasma o ka rosuvastatin ma mua o ka hapa. E hōʻemi i kahi hopena like, mālama ʻia nā antacids i ʻelua mau hola ma hope o ka hopena o ka rosuvastatin.
- Elethromycin Antibiotic. Ke alakaʻi nei ka hoʻomohala kūpono ʻana i ka emi ʻana o ka neʻe o ka rosuvastatin. ma muli o ke ʻano o ka pehu o ka ʻōpū.
- Hoʻohui ʻia nā mea hoʻohālikelike waha a me nā ʻano ʻē aʻe o ka lāʻau hormonal. Hoʻohui pono me ka rosuvastatin e hoʻonui i ka hoʻoliʻiliʻi o nā mea hoʻoikaika o ka hormonally i loko o ke koko koko. No ka hoʻopauʻana i kēia mau ʻano, hana ʻia kahi hopena o ka hopena o ka hopena.
- ʻO nā mea kūlima Cardiac.
Ua haʻahaʻa ka haʻahaʻa me nā lāleʻa i luna. Pono e koho ʻia ʻo ia ka manawa like e like me nā ʻano pilikino o ka mea maʻi.
ʻO ka lāʻau lapaʻau i ka mākeke home
Hiki ke kūʻai ʻia kēia lāʻau lapaʻau ma kekahi lāʻauʻai i loko o Rūsia a me nā ʻāina CIS.
Loaʻa ka lāʻau lapaʻau ma ka mākeke home me ke kū ʻole o ka wai.
Kuhi ke kumukūʻai ma ke ʻano o ka lāʻau lapaʻau.
I kēia lā ke ʻano o ka uku:
- papa me kahiʻuʻuku o 5 mg no 90 mau pcs. - 1056 nā rubles;
- papa me kahi papaʻa he 10 mg no 30 pcs. a me 90 pcs. - 461 ʻōpala. a he 999 mau rubles. ia pono;
- papa me kahi maʻi o 15 mg no 30 a me 90 pcs. - 404 rub. a he 1225 mau rubles. ia pono;
- nā papa me kahi papa o 20 mg no 30 mau pcs. aneane 690 rub.
Ma ka mākeke farmacological o Lūkini he nui nā kikowaena o Roxers. ʻO ka analogue kahi lāʻau lapaʻau me kahi mea hana pilikino like. ʻO ka lāʻau lapaʻau honua ākea Rosuvastatin ka mea paʻa i nā lāʻau he nui i ka mākeke Russian. ʻOkoʻa ʻē ka inoa o ka lāʻau lapaʻau.
Hoʻopuka ʻia ka lāʻau maʻi e ka hopohopo a Slovenian "Krka". Akā he nui nō nā mea hana, e pili ana i nā poʻe ʻāina, i loko o ka helu puka ʻana o rosuvastatin. Eia kekahi, aia kekahi mau inoa inoa o ka pūʻulu statin.
ʻO ka hoʻomākaukau ʻana i nā pūʻulu e pili ana (Atorvastatin, Rosuvastatin Canon, Tevastor, etc.) he mea hoʻohui pū kekahi i nā hiʻohiʻona o ka hana o ka hana. Ke koho nei i kahi lāʻau lapaʻau kūikawā e pili ana i nā hiʻohiʻona o ka mea maʻi.
He nui nā loiloi a Roxer i nā mea maʻi e lawe ana i kēia lāʻau lapaʻau.
ʻO nā loiloi pinepine pinepine ʻia he mau kūpono ʻole, koe wale nō nā hihia kū'ē. ʻO nā loiloi Roxera maikaʻiʻole i nā hihia o ka lōʻihi o ka mālama ʻana.
Hōʻike pinepine ʻia ka hopena maikaʻi loa i ke kino ma muli o ka mea i lawe i ka mea maʻi i ka ʻeha i ka wā o ka hoʻolaʻa, kuhikuhi i ka lāʻau lapaʻau ma luna ponoʻī a i ʻole eʻoi aku i ka nui o ka ʻōlelo i hōʻike ʻia no kona kūlana. ʻAʻole kūkā kēia loiloi ʻo ka lāʻau lapaʻau a ʻaʻole hiki ke lawelawe ʻo ia ke kumu kūpono o ka hōʻole ʻana i ka lāʻau.
Me ka hoʻokolokolo kūpono, pono ka lāʻau lapaʻau e kōkua i ka mea maʻi. ʻO ia ka mau lipid-hoʻohaʻahaʻa i ka lāʻau lapaʻau e hiki ke hōʻemi i ka kolesterol a me ka hopena o ka atherosclerosis a me nā hoʻopiʻi ona. ʻO ka hopena hopena o ka lawe ʻana i ka lāʻau e hōʻemi loa ia i ka hopena therapeutic i manaʻo ʻia.
He mea nui ia e hoʻohui i ka hoʻopili ʻana o nā lāʻau lipid-hoʻohaʻahaʻa i ka lāʻau kūpono ʻole a me ka ola e neʻe ai.
ʻO kahi ala komo e hoʻopili ai i ka maʻi naʻau coronary a me nā hōʻike ʻē aʻe o ka atherosclerosis ka maikaʻi loa a ʻāpono.
Ua wehewehe ʻia nā statins i ke wikiō ma kēia ʻatikala.
