ʻO ka hui o statins (pauku-hōʻemi i ka lāʻau lapaʻau) hoʻohui pū me Lovastatin ka hopena. Hoʻohana ʻia ka lāʻau lapaʻau ʻaʻole wale nō ma ka mālama ʻana o hypercholesterolemia, hyperlipoproteinemia, akā i ka pale ʻana o nā maʻi cardiovascular.
Pono e hoʻohana ʻia ka lāʻau lapaʻau me ka hui pū me kahi meaʻai kūikawā, hoʻomaʻamaʻa a me ka hoʻoponopono pono ʻana. I kēiaʻatikala, hiki iā ʻoe ke aʻo hou e pili ana iā Lovastatin, nā ʻōlelo no ka hoʻohana ʻana, ke kumu kūʻai, nā loiloi, nā loiloi.
Ke ʻano o ka hana o ka lāʻau
Aia ʻo Lovastatin i ka hui o nā lipid-hoʻemi haʻahaʻa i ka pale ʻole i ka synthesis o kolesterol i loko o ke kao i ka manawa mua. Ua manaʻo ʻia kēia lāʻau lapaʻau ka mea nui loa ma waena o nā statins. Hoʻokuʻu ʻia ia mai ka biocultures Aspergillusterreus a me Monascusruber.
Kahi manawa i ka digestive tract, hāʻawi ka lāʻau lapaʻau iā ia iho i nā hopena o nā huina digestive a e palu maikaʻi ʻia. Eia kekahi, ʻoi aku ka nui o ka nui o ka lāʻau, ʻo ka wikiwiki e hoʻopili ʻia i ka pā o ka huina. Hoʻopuka ka mea ikaika i ka ʻōpū o ka ʻōpū, a laila komo i ke kahawai. Loaʻa ka ʻikepili plasma nui loa ma hope o 2-4 mau hola. ʻO ka penetration i loko o nā kumulepuna a pau o ke kino ke ʻano ma ke ʻano o ka beta-hydroxy free.
Kuhi ʻia ka hana o Lovastatin ma ʻelua mau kaʻina hana. ʻO ka mea mua, hoʻonāukiuki ia i ka hōʻailona o ke kolamu ma ka puʻuwai, pale i ka hoʻololi o ka hoʻoneʻe ʻana i loko o ka melovanate. ʻO ka lua, alakaʻi ia i ka hoʻouluʻana o ka catabolism wikiwiki (kaʻina decabolic decay process) o LDL. Ma ka like me kēia kaʻina hana, he nui no ka hoʻonui ʻia ʻana o HDL, a i ʻole ka “cholesterol” maikaʻi.
ʻO ka hapalua hapalua o ka hana ikaika he 3 mau hola. Hoʻālaʻi ʻia nā metabolites me nā mea ikaika e nā ʻōpū a me nā ʻāpana.
Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau
Loaʻa i ka Lovastatin 20 mg a i ka 40 mg paha ma kahi puka papa, ka mana ikaika o ia mau inoa like. ʻO nā kumuwaiwai hou o ka lāʻau lapaʻau ka lactose monohydrate, starch, cellulose, magnesium stearate, butylhydroxyanisole, citric a ascorbic acid.
Ke kūʻai lilo aku nei ka lāʻau lapaʻau inā loaʻa ke kanaka i kahi lāʻau lapaʻau me ia. Ke kūʻai aku i ka huahana, pono e mālama ka mea maʻi i ka hoʻopili pili. He nui nā hōʻike e aʻo ai no ka hoʻohana ʻana i kēia lāʻau lapaʻau.
- ka hana ʻana o ka hypercholisterinemia mua, hui pū me IIa a me IIb;
- ka maʻi hyperlipoproteinemia (paʻakikī me ka maʻi maʻi a me ka nephrotic syndrome);
- ka mālama ʻana i ka atherosclerosis coronary (me ka lāʻau o ka waiū a me nā momona momona unsaturated);
- ka pale ʻana i nā pilikia o ka maʻi cardiovascular;
- hoʻokūkū maʻi hypertriglyceridemia.
Pono ka hoʻohana ʻana i nā papa i hoʻokahi manawa i kēlā me kēia lā i ka ʻaina ʻaina. ʻO ka hopena o ka lāʻau lapaʻau e hilinaʻi ʻia i ka maʻi. No laila, me ka hyperlipidemia, kahi kikoʻī hoʻokahi o 10-80 mg i kuhikuhi ʻia. Hoʻomaka ka hoʻokaumaha o ka pathology me nā liʻiliʻi liʻiliʻi, me ka ʻae a ke kauka, hiki ke hoʻonui iki ʻia. A ʻoi ʻia e koho i kahi kao i kēlā me kēia 4 hebedoma. Hiki ke hoʻokaʻawale ʻia ke ana ka nui (80 mg) i ʻelua mau puʻupuʻu - i ke kakahiaka a me ke ahiahi.
I ka loaʻa ʻana o ka atherosclerosis coronary, ʻo ka nui loa ma ka nui o 20-40 mg. Inā nele ka lāʻau, hiki i ka hoʻonui ke 60-80 mg. Inā lawe ka mea maʻi i ka fibrates a i ka acid nicotinic i ka manawa like, pono e hoʻohana ʻia ʻo Lovastatin ma mua o 20 mg i ka lā. Eia kekahi, pono e hōʻemi ʻia ka dosage i ia mau hihia:
- Hoʻohana pinepine ʻia nā immunosuppressants.
- ʻO ka hoʻohana ʻana i nā mea hoʻohui antibiotika.
- Therapy me nā lāʻau antifungal.
- Mahele o nā maʻi ate o ka etiology a maʻa paha.
- ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau e loaʻa ana nā anticoagulants.
Pono e mālama i ka lāʻau lapaʻau i kahi mahana ʻaʻoleʻoi aʻe ma mua o 25 tikelika Celsius.
Ma hope o ka lā pau, kahi 2 mau makahiki, pāpā ʻia ʻole ia e hoʻohana i ka huahana.
Nā hiʻohiʻona a me nā hopena ʻaoʻao
Lovastatin kahi papa inoa liʻiliʻi o nā contraindications. Ua papa ʻia ka hoʻohana ʻana i ka lāʻau no ka myopathy (maʻi neuromuscular maʻi), ka hapai, ka cholestasis, ka hōʻiho ʻana o ka ate ma lalo o ka 18 makahiki a me ka hypersensitivity pilikino i nā mea.
Pono e hoʻohana ʻia ka lāʻau lapaʻau me ka mālama ʻana i nā maʻi i loaʻa i ka coronary artery bypass grafting. No ka hihia ʻaʻole hiki iā ʻoe ke inu i ka lāʻau lapaʻau me ka waiʻona.
I kekahi mau hihia, hiki i kahi lāʻau lapaʻau ke hōʻeha i nā hopena ʻaoʻao. I waena o lākou, pono e hōʻike i:
- ʻO nā hopena pili i ka hana o ka ʻeha gastrointestinal: nā hōʻeha o ka ʻōpū, ka puʻuwai, ka hoʻonui ʻana i ke kino, hoʻololi i ka ʻono, ʻeha, a hoʻololi i ka constipation.
- Nā hemahema o ka pūnaehana nīnaehana: nā hōʻeha, ka hiamoe maikaʻi, ka hopohopo, ka dizz, paresthesia, myositis, nā ʻeha o ka naʻau a me myalgia. Ke hoʻohana nei i ka cyclosporine, gemfibrozil a i hamotinic acid, hiki i ka nui o ka rhabdomyolysis.
- ʻO nā hopena o ka ʻōnaehana biliary: ka hana i hoʻonui ʻia o ka bilirubin, ka phosphatase alkaline, nā transaminases ate a me ka phosphokinase creatine. I kekahi manawa hepatitis, jaundice cholestatic a me nā cholestasis biliary.
- He maʻi kūlohelohe: itching, lapalapa ʻili, urticaria, angioedema, arthralgia.
- Hōʻailona i nā aniani: atrophy o ka optic nerve a me ka hoʻomohala ʻana i nā cataracts.
- ʻO nā hopena ʻē aʻe: ua hoʻemi i ka potency, ka malaise maʻamau, alopecia.
ʻO ka hōʻailona ʻohi o ka wā e hoʻohana ai i nā pona he nui o ka lāʻau lapaʻau ʻaʻole i ʻike ʻia. ʻO ke kumu o ka hana maʻi, ʻo ia ka hoʻopau ʻana i ka Lovastatin, gastage lavage, ka hoʻohana ʻana i nā sorbents (activated carbon, Smecta, Polysorb, Atoxil) ka mālama ʻana i nā hana koʻikoʻi, hana ate a me ka hana o ka phosphokinase hana.
Hoʻohui a me nā ʻano ʻē aʻe
ʻAʻole pono e hoʻohana Lovastatin me nā lāʻau āpau, no ka ʻo kā lākou pilina hiki ke alakaʻi i nā hopena maikaʻi ʻole o ke kino. Eia kekahi, hiki i kekahi mau lāʻau lapaʻau ke hoʻonui i ke kao o ka waiwai hana, a hiki ke emi i kekahi.
Hōʻeha ka nui o ka luku ʻana i ka musi a me ka myopathy, a me ka hoʻonui ʻia ʻana o ka ʻike o ka māhele ikaika, hoʻonāukiuki i ka hoʻohana like ʻana o Lovastatin me ka waikika nicotinic, Cyclosporine, Ritonavir, Erythromycin, Fazodon a me Clarithromycin.
ʻO ka hoʻohana pinepineʻana i kahi lāʻau lapaʻau me ka wai huaʻai, fenofibrate, gemfibrozil e hoʻonui pū i kahi manawa o ka myopathy.
Hōʻalo ka pilikia o ke koko me ka hoʻohana hoʻopukapuka ʻana o warfarin. Hoʻemi ka bioavailability o lovastatin i ka wā e hoʻohana ai i ka colestyramine. I mea e mālama ai nā bioavailability o ka lāʻau lapaʻau, pono e hoʻohana i nā lāʻau lapaʻau me kahi huakaʻi o nā hola 2-4.
Me nā maʻi hoʻopukapuka, pono e nīnau aku ka mea maʻi i ke kauka e pili ana i ka lawe ʻana i nā lāʻau lapaʻau.
ʻO kekahi o lākou ʻaʻole i kūlike me Lovastatin, no laila, pāpā paʻa ke hoʻohana kūʻokoʻa.
ʻO ke kumukūʻai, nā mea hoʻohui a me nā loiloi hoʻomanawanui
ʻO ka mea pōʻino, hiki i kēia wā ke kūʻai aku iā Lovastatin no ka ʻAʻole hana ia ma Rūsia.
ʻO nāʻoihana lapaʻau e like me Lekpharm (Belarus), Replekpharm AD (Makedonia) a me Kievmedpreparat (Ukraine) nā mea hana o ka lāʻau.
Ma kēiaʻano, hiki i ke kauka ke kuhikuhi i kahi mea hoʻohālikelike o Lovastatin, nona ka ʻano like me nā therapeutic.
ʻO nā lāʻau lapaʻau kaulana loa:
- ʻO Holetar. Loaʻa iā ia kahi papa hana - lovastatin, no laila ke kahapili ia no Lovastatin. Ke hōʻike nei ka lāʻau i nā hōʻailona like, nā contraindications a me nā hopena ʻino e like me Lovastatin.
- Cardiostatin. ʻO kekahi lāʻau lapaʻau maikaʻi loa i kapa ʻia ka Lovastatin, no ka mea aia ka māhele like pū me ia. Ke lawe nei iā Cardiostatin, he hopena therapeutic i haʻi ʻia i mālama ʻia no nā pule he ʻelua, a ʻo ka nui ma hope o ka 4 mau hebedoma o ka lawe ʻana i ka lāʻau. ʻO ka kumukūʻai kūpono he 290 mau rubles (i loko o kahi pahu o nā papa he 30 o 20 mg).
- Pravastatin. He palahalaha nui o ka hana. ʻO ka pogala hoʻoikaika e pravastatinum. Hoʻohana ʻia ka lāʻau lapaʻau no ka hypercholesterolemia haʻahaʻa a me nā dyslipidemia i hoʻohui ʻia, a no ke pale ʻana o ka maʻi ischemic puʻuwai. Hiki i ka hoʻohana ʻana o Pravastatin ma ke ʻano he pale paʻa no ka infiction myocardial, angina pectoris a me ka hyperlipidemia post-transplant.
- Zokor. ʻO ka mea ikaika o ka lāʻau ka simvastatin. ʻO ka hōʻike nui o ka lāʻau lapaʻau ka mālama ʻana i ka hypercholesterolemia. Hoʻohana ʻia ʻo Zokor ma ke ʻano he prophylactic i mea e pale ai i ka hoʻomohala ʻana o nā pathologies cardiovascular. ʻO ka kumukūʻai kūpono he 380 rubles (28 mau papa o 10 mg) a me 690 mau rubles (28 mau papa o 20 mg).
Wahi a ka Vyshkovsky Index, nā alakaʻi i loko o ka mākeke lāʻau Lūkini ʻo Cardiostatin, Mevacor, Holetar a me Rovacor.
He kūpono ke ʻoluʻolu no Lovastatin, mai nā mea maʻi a mai nā kauka paha. E palekana a hoʻomanawanui ʻia ka lāʻau lapaʻau e nā maʻi, ʻoiai me ka hoʻohana mau ʻana.
Hōʻike nā hana pili i ka maʻi dyspeptic i kekahi manawa ma ka hoʻomaka ʻana o ka hopena. Ma hope oʻelua pule, i ka manawa e hana ai ke kino i ka manaʻo o ka mea hana, hoʻopau ʻia nā hōʻailona. ʻO ka manawa, hoʻonui nā pae o ALT a me AST, no laila e pono e kāohi i kā lākou ʻike.
Ma hope o 1.5 mau mahina mai ka hoʻomaka ʻana o ka ʻoihana, hoʻomaʻamaʻa ʻia ka nānā ʻana. E like me ke kānāwai, aia kahi kūpono maikaʻi i nā kākela, i.e. hoʻemi ʻia ka ʻike lipid.
Pehea e hoʻohaʻahaʻa ai i ka cholesterol i loko o ka wikiō ma kēia atikala.
