Hoʻohana ʻia ʻo Metformin no ka hānai ʻana a me ka non-insulin e hilinaʻi ʻole ʻia, ka ʻokoʻa a me ka hui pū ʻana me nā meaola e hoʻemi ana i ke kō.
Hoʻomaʻamaʻa pinepine ʻia nā mea maʻi maʻamau i ka hope o ke kaumaha. ʻAʻole hiki i kēlā me kēia kanaka ke lanakila ma luna o ke kaumaha. Eia nō naʻe, kōkua ka dragees i nalowale i kekahi mau paona keu, no laila e hoʻohana nā kānaka olakino iā lākou e hōʻemi i ka paona.
ʻAʻole mākou e poina i kēlā me kēia pūlea lāʻau lapaʻau kekahi ʻano hiʻohiʻona o ka hoʻohana ʻana a me ka luhi. ʻO ka lāʻau lapaʻau i hōʻike ʻia, ʻae like ka inoa o ke ao me kāna pūnaehana koʻikoʻi, ʻaʻohe ʻokoʻa. Pono ka mea maʻi e ʻike kikoʻī pehea e lawe ai i nā papa me kēia ʻano hana ʻenehana ikaika, nā waiwai, nā ʻenehana like ʻole a me nā kumukūʻai kumukūʻai.
ʻO nā hiʻohiʻona maʻamau o ka lāʻau
ʻO ka inoa inoa honua no kēia pūlapa lāʻau lapaʻau ka metformin hydrochloride. I ʻike ʻia i nā loea he nui mai nā ʻāpana like ʻole o ka honua, no laila ke hāʻawi nei ka mākeke pharmacological i kahi ākea o nā dragees me kēia pūnao ulu ikaika.
Hiki ke kapa ʻia kekahi hiʻohiʻona o ka lāʻau i kona hōʻemi lohi ʻana i ka pae o ka glycemia i ka maʻi maʻi maʻi maʻi. Ka mea wale no ka mākaukau o ka papa biguanide, ʻaʻole pili ka lāʻau hoʻohui i ke kiʻekiʻe o ke kō i ka poʻe olakino.
Hana ka mea hana hana i ka lāʻau i loko o ka papa ʻaelike me ka nui o ka hoʻopiʻi nui ʻana o ka hoʻohui o 500, 850 a me 1000 mg. I nā lāʻau lapaʻau, loaʻa i kahi ʻano hoʻokuʻu o ka mana lōʻihi. Hoʻokahi i hoʻokahi blister he 30 a 120 mau papa. Hoʻohuiʻia i ka pūnaehana koʻikoʻi, talc, magnesium stearate a me nā hua liʻiliʻi he nui i hoʻokomo ʻia i loko o hoʻokahi waihona.
Hoʻomaopopo ka hopena o ka lāʻau lapaʻau i ka hoʻoneʻe ʻana i ke kaʻina hana o ka hana glucose i ka ʻāʻae (gluconeogenesis). ʻAʻole pili i ka hana ʻana o ka insulin e nā cell beta, no laila ʻaʻole ia e hoʻonāukiuki i ka emi ʻana o ka nui o ka kō i lalo o ka maʻamau. Hōʻike nā ʻano i kēia ala:
- ʻO ka hōʻemi ʻana i ke kiʻekiʻe o ka lawe ʻana o nā mea hoʻohuihui māmā e nā paia ʻeha.
- ʻO ka hoʻonui i ka hiki o ka hooneʻe ʻana o nā kaila i ka insulin.
- Ke hoʻoikaika nei i ke kaʻina hana o peripheral hoʻohana i ka glucose.
- Hoʻopau i nā hyperinsulinemia.
- Ka hoʻokūpaʻa a me ka hoʻohaʻahaʻa ʻana i ka momona.
- ʻO ka hōʻemi ʻana i ka nui o nā linoproteins haʻahaʻa haʻahaʻa a me nā triglycerides i ka plasma koko.
- Ma kekahi mau ala, ʻo ka hāʻawi ʻana i ka hopena fibrinolytic.
- ʻO ka hōʻemi ʻana i ka helu o ka momona oxidation.
- Hōʻikeʻike i ka hana waikawa momona.
- Hoʻonui maikaʻi i ka puʻuwai a me nā ʻōnaehana vascular.
- ʻO ka hoʻokuʻuʻana i ka hoʻomohalaʻana o ka hoʻomaʻemaʻe kiko o ke kīwī hoʻomaʻemaʻe o ka paia vascular.
Hāʻawi ka hana o ka hana i ka pale ʻana o nā hoʻopiʻi like ʻole o ka maʻi maʻi e like me ka angiopathy diabetes, e pili ana i nā ʻōnaehana vascular o ka kokoke loa o nā kino o loko o kahi kanaka.
Ma hope o ka komo ʻana i loko, e holo ka hana i loko o nā hola he 2 mau hola. Hoʻomoʻa ka mea i ka hana o ke aihue, a laila komo i nā moku. Pono ka mea maʻi e ʻike i ka wā e ʻai ai, ke hoʻemi iki ʻia ʻana o ka mea nui o ka hana ikaika. ʻO ka hapalua hapalua he 6,5 mau hola. ʻAʻole paʻa ka pūnao koʻikoʻi i ka protein plasma.
Ma kahi o 20-30% o ka loaʻaʻana o ka lāʻau lapaʻau e hoʻopā ʻia ma o nā keiki.
Nā ʻōkuhi no ka hoʻohana ʻana i nā papa
ʻO nā ʻōmua no ka hoʻohana ʻana i ka pahu hana: penei ka maʻi maʻamau o ke ʻano mua a me ka lua (ʻelua monotherapy a hui pū ʻia me nā lāʻau lapaʻau hou), polycystic ovary. Pono maikaʻi ka lāʻau lapaʻau inā hiki ʻole i nā mea maʻi ke hoʻohaʻahaʻa i nā kiʻekiʻe o ko lākou glucose i ka mākaukau me ka papa lāʻau a me ka momona nui.
I ke kūʻai ʻana i nā papa, pono e ʻike pono nā ʻōkuhi no ka hoʻohana ʻana. Inā he nīnau kāu, e akahele e nīnau aku i kāu kauka.
E hoʻopau ʻia ka papa ʻaina holoʻokoʻa, holoi ʻia me ka wai nui. ʻO ka lawe ʻana i ka lāʻau lapaʻau no ka manawa mua, ʻōlelo ke aʻo ʻana ʻaʻole eʻoi aku i kahi hapa o 500-1000 mg i kēlā me kēia lā. Ma hope oʻelua pule, hiki i ke kauka ke hoʻoponopono i ka hoʻoponopono lapaʻau ma o ka lawe ʻana i nā kaila kiʻekiʻe o ka lāʻau.
Pono e hoʻomaka ʻia ma ka hoʻomaka ʻana o ke ʻano maʻi, ʻo ka hapa nui o nā mea maʻi e loaʻa i nā hopena ʻino e pili ana me ka ʻoihana kūwali. ʻO kēlā mau hiʻohiʻona maikaʻiʻole ka hopena o ka hoʻololi ʻana o ke kino i ka hopena o ka mea ikaika. Ma hope o ka hoʻohana ʻana o ke kino kanaka iā ia, hoʻōki nā hōʻailona.
ʻO ka nui loa i hāʻawi ʻia i kēlā me kēia lā a hiki i 3000 mg, a ke manaʻo ʻia kahi mālama mālama e 1500-2000 mg. No ka mea e pili paha i nā papa papa i ka lolo ʻōpiopio i ka hana o nā keiki, ʻaʻole pono ka nui o ka nui i ʻōlelo ʻia ma mua o 2000 mg i kēlā me kēia lā. Hoʻopau kēia ʻōkuhi i nā poʻe maʻi e hōʻeha nei i nā maʻi metabolic koʻikoʻi.
Inā inu kekahi mea maʻi i kekahi mea hypoglycemic mea e pono e inu i ka lāʻau i hōʻike ʻia, a laila pono ia e haʻalele i ka lāʻau ma mua. I ka hoʻohuiʻana i nā papa me nā inikini insulin, hiki ke hoʻemi ʻia ka nui o ka nui o ka hopena ma o ka ʻōlelo mua me ke kauka.
Ke hoʻohana nei i nā papa o ka hoʻokuʻu i hoʻokuʻu ʻia, pono e hoʻopili ʻia ka nui o ka palena ma ka - 500 a i ʻole 850 mg (e like me ke ʻano o ka hoʻokuʻu ʻana). Kahi ka mea i koho ʻia e nā mea kiʻekiʻe aʻe, e lawe ʻia ana i ka pae o ka glucose i loko o ke koko koko a me ka mālama nui o ka mea maʻi.
Loaʻa i kahi lāʻau lapaʻau i nā lāʻau lapaʻau me kahi laʻana. E mālama pono ana ka pōʻai i kahi wahi pōʻeleʻele, pono ia i kahi hoʻoponopono koʻikoʻi no ka nui o 25 mau māka.
I ke kūʻai ʻana, pono ʻoe e makaʻala i ka lā i hala, ʻo ia ka mau makahiki ʻekolu.
ʻO nā maʻi a me nā hōʻeha
Pono ka maʻi maʻi e hoʻomaopopo e like me ka hiki e pili ana i ka pūhui, no ka mea aia kēia mau paila i kahi papa inoa nui o nā contraindications.
I ka heluhelu ʻana i ka wehewehe o ka lāʻau lapaʻau, pono ʻoe e heluhelu pono i ka papa inoa o nā maʻi a me nā kūlana a pau i ka pāpā ʻia ʻana o ka lāʻau.
No laila, ua pāpā ʻia ka hoʻohana ʻana i nā lāʻau antidiabetic no nā mea maʻi ma ke ʻano o kekahi mau kūlana a me nā kūlana o ke kino.
Hoʻololi ʻia ka ʻae ʻana ma nā hihia penei:
- ka heleʻana o ka puʻuwai a me ka hana ʻole o kaʻili;
- ka heleʻana o nā pono o ka maʻi maʻi ma mua a me ka precoma;
- ma nā hana palaki - i ka make, kiʻekiʻe kiʻekiʻe, nā ʻano maʻi like ʻole, kahi kūlana o ka hypoxia (maʻi bronchopulmonary, pīhoihoi, sepsis, maʻi pāpaʻi);
- i ka mua o nā ala e alakaʻi ai i ka kiko hypoxia (hoʻonāukiuki myocardial acute, respiratory / failed heart);
- ka nui o ka make ʻana o ka ʻawaʻawa, a me ka ʻalo ʻole o ka maʻi;
- ka loaʻaʻana o nā hōʻailona o ka acidosis lactic;
- i ka hihia e ʻike ai ka naʻau o kēlā kanaka i nā kumuwaiwai nui a me nā mea hou aʻe;
- inā he mau mea ʻokoʻa i loko o ka iodine e hoʻohana ʻia i ka wā X-ray a i ʻole radioisotope e hoʻohana ai;
- wā hāpai;
- inā he hoʻohana ʻana o kahi pākeke haʻahaʻa (emi iho ma lalo o 1 tausani kcal i hoʻokahi lā);
- liilii;
- i ka wā o ka hōʻeha kino a i ʻole hōʻeha (me ka hoʻomaka ʻana o nā inikini insulin).
ʻO ka hana kūponoʻole no ka maʻi maʻi ma mua o 60 mau makahiki he nui, ka ʻae ʻia e hana i ka hana paʻakikī, i hele pū ʻia e ka nui o nā mea hana kino. Inā ʻaʻole, he kiʻekiʻe ka hopena o ka hoʻomohalaʻana i ka acidact lactic.
Mawaena o nā hopena hopena i loaʻa mai i ka hoʻohana ʻia ʻana o nā lāʻau hypoglycemic, kahiʻokoʻa ka ʻike:
- Hiki paha i ka mea maʻi ke hoʻopiʻi i kahi indigestion, ʻo ia i ka vomiting, ke kaʻaʻi, kahi hoʻololi i ka ʻono, hoʻoemi a i ʻole ka makemake i ka makemake, nui ka ulu ʻana, hoʻonui ʻōpū a me nā ʻōpū.
- I kekahi mau hihia, hiki i ka hoʻomohala ʻana o ka anemia megaloblastic.
- Me ka hoʻomehana lōʻihi, kūlohelohe ka vitamin B12 i kahi maʻamau, ka mea e hōʻemi ai i ka pōʻai.
- ʻO ka hoʻomohalaʻana i ka acidosis lactic, hypoglycemia a me ka hiʻohiʻona o ke ʻano o ka ʻula.
ʻO nā hihia o ka overdose i kekahi manawa, ka mea e hoʻopili i ka hoʻomohalaʻana i ka waikena lactic. Pilikia loa kēia kūlana no ka mea hiki iā ia ke alakaʻi i kahi hopena momona. ʻO nā hōʻailona nui o ka lactic acidosis nā hōʻeuʻeu o ka maʻi iki a me ka luaʻi, ka hoʻohaʻahaʻa kino kino, ke nānā ʻana, ka maʻi hopohopo, ka ʻōpū, ka ʻeha o ka naʻau, ka hanu wikiwiki a me ka hoʻomohala ʻana i ka piko.
Ke kū ʻia nei nā hōʻailona kiʻekiʻe, pono e lawe koke i ka mea maʻi i kahi lāʻau lapaʻau. Pono hoʻoholo koke ke keʻena ʻoihana lapaʻau i ke kiʻekiʻe o ka lactate a me ka hemodialysis.
Hoʻohana pū ʻia ka maʻi Symptomatic.
Hoʻopili pū kekahi me nā lāʻau lapaʻau
ʻAʻohe ʻano lapaʻau like ʻole ia, i ka wā e hoʻopili pū ai me nā lāʻau ʻē aʻe, ʻaʻole ia e hopena i ke kino o ke kanaka.
No laila me ka māhele ʻākala i wehewehe ʻia: i ka wā e hui pū me kekahi mau mea, kū ka hypoglycemia, i hui pū ʻia me nā poʻe ʻē aʻe, e kū aʻe ana ka hyperglycemia, a me nā mea ʻē aʻe, e hoʻomohala ʻia ka lactic acidosis.
ʻAʻole hui ʻia nā pū me nā mea e hoʻoulu ai i ka piʻi nui o ka glucose i ka lolo.
ʻO kēia mau lāʻau lapaʻau:
- Danazole;
- Chlorpromazine;
- nā mea kūlohelohe;
- glucocorticosteroids;
- hormonal control mana lāʻau;
- Epinofirn;
- nā kumulāʻau o nā waikem Nikotinic a me phenothiazine;
- nā diuretics loop;
- o nā hormone thyroid
- paeʻāina
- nāonaona.
Hoʻonui nā hua ma lalo o nā lāʻau e hopena i ka hopena hypoglycemic:
- Nā hua palapala o nā sulfonylureas.
- Nā NSAID.
- MAO a me ACE inhibitors.
- Acarbose.
- Cyclophosphamide.
- ʻO nā hua o ka clofibrate.
- Inii injection
- Nā māka hua Beta.
- PolohanaHula.
ʻO ka hoʻohana like ʻana i ka wai ʻāʻī a me ka cimetidine hiki i ka ulu ʻana o ka hoʻomehana lactic acidosis. ʻO ka hoʻohana nui ʻana o ka mea hoʻohui a me nā anticoagulants e hiki ai ke hoʻonāwaliwali i ka hopena ma ke kino o ka mea hope.
He nui nā mea maʻi e makemake pehea e hana ai ka lāʻau lapaʻau a me ka antibiotika. Pono nā maʻi maʻi maʻi e hopohopo i nā maʻi bakteria, kūpono lākou. ʻO ka mea nui ka lawe iā lākou ma nā manawa like ʻole.
ʻO nā kumu uku a me nā loiloi pili
Hāʻawi ka mākeke pharmacological i nā papa he nui me ka mea hoʻākina ikaika i hōʻike ʻia.
ʻOiai ke ʻano o nā mea like like o nā mea kōkua, ʻaʻole nui ka nui o nā pills.
No ka laʻana, ke kumukūʻai ma Rūsia mai 90 a 260 mau rubles.
Heʻokoʻa ʻole ke kumukūʻai o Metformin mai nā ʻĀina ʻē aʻe o nā lāʻau ʻakaʻaka.
ʻO ke kumu kūʻai o Metformin mai nā ʻano mea hana ʻē aʻe:
- Slowakia - mai 130 a 210 mau rubles.
- Hungarian - mai 165 a 260 rubles.
- Polani - mai 75 a 320 mau rubles.
Ma Metformin, kūʻiʻo ke kumukūʻai i nā maʻi āpau. He polokalamu koʻikoʻi nui a hoʻohui ʻia. E pili ana i nā pale, hiki iā ʻoe ke loaʻa i nā loiloi maikaʻi o nā kolamu like ʻole. ʻOiaʻiʻo, he lāʻau lapaʻau e hōʻemi pono i ka hoʻokaʻina glucose. Me ka hoʻokele pono, hypoglycemia aneane ʻaʻole i ʻike pololei.
Eia kekahi o nā loiloi maikaʻi e pili ana iā Metformin mai Lyudmila (49 makahiki paha):
He lāʻau lapaʻau kūlohelohe kēia i kōkua i ka lawelawe ʻana i ka hyperglycemia ʻaʻole wale nō iaʻu, akā no kaʻu kāne hoʻi. Ua inu mākou a hoʻomau i ka inu ʻana i nā makahiki ʻelua i hala. Hoʻōla maoli nō ia, noʻu ʻaʻohe mea'ē aʻe. ʻO kaʻoiaʻiʻo, ma ka hoʻomaka mua i ʻelua nō "adaptation", ma aneane he mau lā 1,5-2 mau manawa he indigestion. Akā i kēia manawa ʻaʻole iʻoi aku ka pae o ke kōpake ma mua o 6.5-7 mmol / l, a ua hōʻemi koʻu momona ma ka 4 kg i ka makahiki i hala.
ʻO nā loiloi o nā kauka he mea maikaʻi nō hoʻi. He nui nā loea e kuhikuhi i kēia lāʻau lapaʻau ma muli o kāna waiwai e hoʻohaʻahaʻa i ke kō ʻana o ke kō, me ka ʻole e alakaʻi i ka hypoglycemia a i ʻole glycemic coma. Eia naʻe, ke ao nei nā kauka i nā poʻe e hoʻoholo e hōʻemi i ka lawe ʻana ma o ka hoʻohana ʻana i ka mea hoʻoikaika e pili ana i ka hopena kūpono. Ma ke ʻano he kānāwai, ʻaʻole i kuhikuhi nā kauka i kēia lāʻau lapaʻau no ka hoʻolilo ʻana i ke kaumaha.
I kekahi manawa hiki iā ʻoe ke hele mai i nā ʻōlelo maikaʻi ʻole mai nā mea maʻi e lawe ana i ka pūnana. Ua pili lākou me kahi maʻi gastrointestinal tract. ʻO ka ʻoiaʻiʻo o kēlā me kēia loea e ʻike i ka lāʻau lapaʻau ʻokoʻa, no laila he ʻokoʻa ka paʻakikī o nā hopena ʻino. Ma kēia mea, ke hoʻololi nei kekahi mau maʻi maʻi maʻi lapaʻau e mālama me kekahi mea pena hypoglycemic ʻē aʻe.
ʻO ka mea maʻi e inu i ka waiʻona i ka wā ʻo Metformin e pono ai ke ʻike i nā hoʻopiʻi hiki paha mai ka haʻalele ʻana i kona olakino ponoʻī.
Nā lāʻau lapaʻau e hoʻohālikelike ai
Ma muli o nā mea i hōʻike ʻia ʻaʻole kūpono ia no nā maʻi āpau āpau, i ka wā e hoʻopili ai i kahi keʻena olakino, koho lākou i nā analogues.
I waena o kēia mau kālā, ua hoʻokaʻawale ʻia nā mea i loaʻa i ka ʻāpana like, a me nā mea e loaʻa ana nā ʻano ʻokoʻa like ʻole, akā ʻike ʻia ka hopena like ʻole.
ʻO ka lāʻau lapaʻau antidiabetic kaulana loa e loaʻa ana i ka pūhui wehewehe ʻia ʻo Glyformin, Glucofage, Metfogamma Forte, Siofor.
ʻO ka Gliformin kahi lāʻau lapaʻau kūloko. Ma ka hoʻohui i nā mea ola, povidone, crospovidone, starch, silicon dioxide, glycerol a me ka stearic acid e komo.
ʻO ka Glucophage kahi paena i hana ʻia e Farani. Ma ke kumu, hana like ʻole lākou. No laila, hiki i ke kauka ke hoʻohālikelike i ko lākou uluʻana.
ʻO Metfogamma Forte kekahi hoa kūʻai ʻeke ʻē aʻe. I keʻano kūikawā, he mea kūpono i ka hikiʻole o ke mālama me nā lāʻau lapaʻau sulfonylurea. Aia nā mea kikoʻī i nā mea like like.
Siofor - nā papa, kahi e pili ai i ka povidone, magnesium stearate, macrogol a me nā silicon dioxide.
Hiki iā ʻoe ke loaʻa nā mea ʻē aʻe ma ka puke olakino Vidal. Hāʻawi ka pūnaewele Vidal i kahi hoʻolaha e pili ana i ka lāʻau lapaʻau, pehea e hana ai, ka mea i ʻae ʻia e lawe, a me ka mea e kōkua. ʻO ka lāʻau maikaʻi loa ka mea paʻakikī e ʻōlelo. E hoʻoholo ka mea maʻi iā ia iho, ma muli o ke kumu kūʻai a me ka hopena therapeutic.
Me ka naʻau pilikino o ka mea nui, ua kuhikuhi ke kauka i ka lāʻau lapaʻau ka ʻokoʻa o kona ʻano. No ka laʻana, he pā papaʻa ʻo Glibenclamide me ka hypoglycemic, antithrombotic a me nā hopena hypolipidemic. I ka pūlima pū me ia ka glibenclamide hāmeʻa ikaika, Glucobai (Kelemānia), Altar (Kelemānia), a me nā mea ʻē aʻe, hiki ke hāʻawi ʻia i ka ʻike ʻana i ka papa kuhikuhi olakena Vidal, hiki iā ʻoe ke ʻike i ka ʻike i kekahi mea hoʻohālikelike o ka hoihoi, kona ʻano a me ke ʻano o ia ʻokoʻa mai nā ʻano ʻē aʻe.
Ma aneane āpau i kēlā me kēia maʻi me ka maʻi diabetes ua loaʻa ka pōmaikaʻi i ka wā e lawe ai i ka hydrochloride. Hoʻohana wale ia a i ʻole me nā inikini insulin. A inā ʻike ʻole nā papa, hoʻohālikelike i kāu kauka i nā ʻola like ʻole. ʻOi aku ka maikaʻi e kōkua i ke koho ʻana i nā kuhikuhi kūikawā a i ʻole nā kuhikuhi koʻikoʻi lāʻau. Kaulana ka paila no kona pono maikaʻi, no laila me ka hyperglycemia pono ia e hoʻāʻo. Ke hoʻi nei ka glucose i ka maʻamau, a me ke olakino āpau.
E haʻi nā mea loea i nā waiwai haʻahaʻa i ke kō o Metformin i loko o kēia wikiō.
