Yanumet - kahi hui hoʻohui lāʻau no nā maʻi maʻi 2 like ʻole

ʻO Yanumet kahi lāʻau mālama wai-ʻelua hoʻonaninani me ke ʻano o 2 mau mea ikaika: metformin a me sitagliptin. Ua hoʻopaʻa ʻia ka lāʻau lapaʻau ma ka Russian Federation ma 2010. ʻO ke ao holoʻokoʻa, nā papa lāʻau sitagliptin e loaʻa ma kahi o 80 miliona mau maʻi. Kahi ʻia nā mea kaulana e pili ana i ka pono kūpono a me ka palekana piha o ka DPP-4 inhibitors, ʻo ia hoʻi kahi sitagliptin. Hoʻomaopopo pinepine ʻia ʻo Metformin i ka maʻamau "gula" i ka mālama ʻana i ka maʻi mellitus, ua kuhikuhi mua ʻia i nā poʻe maʻi me ka maʻi 2. Wahi a nā poʻe maʻi maʻi, ʻaʻohe o nā mea o ka lāʻau lapaʻau e alakaʻi i ka hypoglycemia, ʻaʻole nā ​​kumu ʻelua i mea e hoʻonui ai i ka paona a hiki i ka hāʻawi ʻana i kona nalowale.

Pehea e hana ai nā papa ʻo Yanumet

Ma hope o ka hoʻomohala ʻana o ka maʻi maʻi, ka hoʻoholo ma ka ʻano kūpono e pono ai ke kau ʻana ma muli o ka hopena o ka huli ʻana no ka hemoglobin glycated. Inā aia kēia hōʻailona ma lalo o 9%, pono i kahi mea maʻi wale nō ka lāʻau, metformin, e hoʻomaʻamaʻa i ka glycemia. Hoʻohana nui ia i nā mea maʻi me ke kiʻekiʻe kiʻekiʻe a me ke kiʻekiʻe kiʻekiʻe. Inā ʻoi aku ka kiʻekiʻe o ka hemoglobin glycated, ʻoi aku ka nui o ka lāʻau i ka hapanui o nā hihia, no laila, ʻaʻole kūpono ka lāʻau hoʻohui, no ka maʻi maʻi, kahi lāʻau hoʻohaʻahaʻa i kō aʻe mai ka hui e hoʻohui ʻia me ka metformin. Hiki ke lawe i kahi hui o nā mea ʻelua i hoʻokahi papa. ʻO nā hiʻohiʻona o ia mau lāʻau ʻo Glibomet (metformin me glibenclamide), Galvus Met (me vildagliptin), Janumet (me sitagliptin) a me kā lākou mau analogue.

Ke koho ʻana i ka hui pūnaehana pono, nā mea ʻona e loaʻa i nā papa antidiabetic āpau. Hoʻonui ka huaʻai o ka sulfonylureas a me ka insulin i ka hōʻemi o ka hypoglycemia, hoʻolaha i ka loaʻa kālā, hoʻonui ka PSM i ka hoʻoemi ʻana o nā ʻāpana beta. No ka hapanui o nā mea maʻi, ʻo ka hui pū ʻana o ka metformin me nā DPP4 inhibitors (gliptins) a i ʻole ka rēkēmū o ka minima. Ua hoʻonui kēia ʻelua o kēia mau pūʻulu i ka synthesis o ka insulin me ka ʻole e hōʻeha i nā cell beta a me ka ʻole e hoʻonāukiuki i ka hypoglycemia.

ʻO ka sitagliptin i loko o ka lāʻau lapaʻau Janumet ʻo ia ka mea mua o nā kipi. ʻO ia ʻo ia ka ʻelele i aʻo ʻia o kēia papa. Hoʻonui ka waiwai i ka ola o ka incretins, nā hormone kūikawā i hana ʻia e pane ai i ka hoʻonui i ka glucose a hoʻoneʻe i ka hoʻokuʻu ʻana i ka insulin i ke kahe koko. I ka hopena o kāna hana i ka maʻi diabetes, e hoʻomaikaʻi ʻia ka synthesis o insulin a hiki i ka 2 mau manawa. ʻO ka pōmaikaʻi ʻole o Yanumet, ʻo ia wale nō ke hana me ke kō koko kiʻekiʻe. Ke kūleʻa ka glycemia, ʻaʻole i hua ʻia nā incretins, ʻaʻole e komo ka insulin i ke kahe koko, no laila, ʻaʻole i hele mai ka hypoglycemia.

ʻO ka hopena nui o ka metformin, ka māhele ʻelua o ka lāʻau Janumet, he hōʻemi i ka pale ʻana i ka insulin. Mahalo i kēia, ua komo maikaʻi ka glucose i nā loko, hoʻopuʻi i nā moku koko. ʻO nā hopena hou aʻe akā nui ka hopena o ka hoʻohaʻahaʻa ʻana i ka hoʻohuihui o ka glucose i loko o ka ate, a me ka hoʻolohi ʻana i ke kō ʻana o ka glucose i nā meaʻai. ʻAʻole pā ka Metformin i ka hana pancreatic, no laila, ʻaʻole ia e kumu i ka hypoglycemia.

ʻO ka maʻi maʻi a me nā hoʻohaʻahaʻa manaʻo e hana ia i ka wā ma mua

• Ka hana maʻamau o ke kō -95%
• Hoʻokuʻuina o ka pua thrombosis - 70%
• Hoʻopau i kahi puʻuwai ikaika -90%
• Hoʻopau i ke kiʻekiʻe o ke koko - 92%
• ʻO ka hoʻonuiʻana i ka ikehu i ka wā, hoʻomaikaʻi i ka hiamoe i ka pō -97%

Nā hōʻailona no ka koho

Hoʻohana ʻia ka lāʻau lapaʻau ʻo Yanumet no ka hoʻemi ʻana i ke kō me nā maʻi maʻi type 2. ʻAʻole ke kāpae ʻia nei ka lāʻau lapaʻau ʻana i ka meaʻai ma mua a me ke hoʻonaʻauao mua, ʻoiai ʻaʻole hoʻokahi lāʻau lapaʻau i hiki ke lanakila i ka kū i ke kiʻekiʻe o ka insulin, e wehe i kahi nui o ka glucose mai ke koko.

ʻO ke aʻo ʻana no ka hoʻohana e hiki ai iā ʻoe ke hoʻohui i nā papa o Yanumet me metformin (Glucofage a me nā analogues), inā makemake ʻoe e hoʻonui i kona dosage, a me ka sulfonylurea, glitazones, insulin.

Hoʻomaopopo iki ʻia ʻo Yanumet no nā poʻe maʻi i makemake ʻole e mālama pono i nā ʻōlelo a ke kauka. ʻO ka hui pū ʻana o ʻelua mau mea i loko o kahi papa hoʻokahi ʻaʻole ia kahi mākaukau o ka mea hana, akā he ala e hoʻomaikaʻi ai i ka mana glycemic. ʻAʻole lawa ka lawa ʻana o nā lāʻau lapaʻau kūpono, pono ʻoe i kahi maʻi hānai e lawe iā lākou i kahi ʻano aʻo ʻia, ʻo ia hoʻi, e hana i ka mālama ʻana. No nā maʻi maʻi a me ka maʻi diabetes, ʻo ia hoʻi kēia kūpaʻa he mea nui loa. Wahi a nā loiloi a nā mea maʻi, ua ʻike ʻia 30-90% o nā mea maʻi i kuhikuhi piha ʻia. ʻOi aku nā mea i kau ʻia e ke kauka, a me nā papa ʻē aʻe e pono ai ʻoe e lawe i kēlā me kēia lā, ʻoi aku ka kiʻekiʻe o ka manawa i ʻimi ʻole ʻia ka mālama ʻia. ʻO nā lāʻau i hui pū ʻia me kekahi mau mea ikaika e ala maikaʻi e hoʻonui ai i ka pili ʻana i ka mālama ʻana, a no laila e hoʻomaikaʻi i ke kūlana olakino o nā maʻi.

Ka puka ʻana a me ka helu ʻana

ʻO ka lāʻau lapaʻau ua hana ʻia e ka ʻoihana ʻo Merck, ʻo ka Netherlands. I kēia manawa ua hoʻomaka ka hana ma ke kumu o ka hui Lūkini Akrikhin. ʻO nā lāʻau kūloko kūloko a me ka hoʻokomo ʻia e like me ke kūlike. Loaʻa i nā papa papa i kahi ʻano elongated, i uhi ʻia me ka membrane film. No ka maʻalahi o ka hoʻohana, ua kālai ʻia lākou i nā ʻano ʻano like ʻole ma ka dosage.

Nā koho hiki:

ʻO Yanumet Long kahi lāʻau lapaʻau hou, ma ka Russian Federation i hoʻopaʻa ʻia i ka 2017. He like nā ʻano o ka Yanumet a me Yanumet Long, ʻokoʻa wale nō i like i ke ʻano o ka papa papa. Pono e lawe ʻia i ʻelua mau manawa i ka lā, no ka mea he kūpono ka metformin no nā manawa he 12. Aʻo Yanumet, hoʻokuʻu ʻia ʻo Long Metformin i kahi loli maʻalahi, no laila hiki iā ʻoe ke inu iā ia i hoʻokahi lā i ka lā me ka ʻole o ka hana kūpono.

Hōʻike ʻia ka Metformin e ka nui o nā hopena ʻokoʻa i loko o ka hoʻopili ʻana. Hoʻonui nui ʻo Metformin Long i ka hoʻomanawanui i ka lāʻau, hoʻopau i ka hōʻeha o nā maʻi a me nā hopena maikaʻi aʻe eʻoi aku ma mua o ka 2 o ka manawa. I ka hoʻoponopono ʻana i nā loiloi, ma nā palena nui loa, ʻo Yanumet a me Yanumet Long hāʻawi i kahi kaukani like me ka uku. Inā ʻaʻole, lanakila ʻo Yanumet Long, hāʻawi ʻo ia i ka mana glycemic maikaʻi aʻe, ʻoi aku ka maikaʻi o ka hoʻohaʻahaʻa ʻana i ka pale o ka insulin a me ka cholesterol.

ʻO 2 ka nui o ke ola o ka noho ʻana o Yanumet 50/500, nā makahiki he nui - 3 mau makahiki. Kuhi ʻia ka lāʻau lapaʻau e like me ka papa lāʻau o ka endocrinologist. ʻO ke kumu kūʻai i nā lāʻau lapaʻau:

Nā ʻōkuhi no ka hoʻohana

Ua kauoha ʻia ke kauoha a ka maʻi maʻi mellitus no ka maʻi mellitus:

1. ʻO ka dosage kiʻekiʻe loa o ka sitagliptin he 100 mg, a i ʻole nā ​​papa ʻelua.
2. Koho ʻia ka nui o ka metformin ma muli o ke kiʻekiʻe o ka naʻau o ka insulin a me ka ʻae o kēia ʻano. E hōʻemi i ka hopena o nā hopena leʻaleʻa e lawe ai, e hoʻonui mālie ka nui, mai 500 mg. ʻO ka mea mua, inu lākou i ka Yanumet 50/500 papalua i ka lā. Inā ʻaʻole hoʻemi ka nui o ke kō koko koko, ma hope o hoʻokahi pule a ʻelua paha, hiki ke hoʻonui ʻia ka nui ma ka papa ʻelua o 50/1000 mg.
3. Inā hoʻohui ʻia ka lāʻau lapaʻau Janumet i nā derivatives o sulfonylurea a i ʻole insulin, pono e hoʻonui i kona pākī me ka nui o ka makaʻala o ke ʻano ʻole i ka hypoglycemia.
4. ʻO ka nui loa o ka waihona Yanumet he 2 mau papa. 50/1000 mg.

E hoʻomaʻamaʻa i ke ahonui i ka lāʻau lapaʻau, lawe ʻia nā papa i ka manawa like me ka meaʻai. Hōʻike ka loiloi o ka maʻi maʻi i nā kīʻaha e hana no kēia kumu, ʻoi aku ka maikaʻi o ka hoʻohui ʻana i ka lāʻau lapaʻau me ka ʻai paʻa i piha nā protein, a me nā haʻahaʻa puʻupuʻu. Hoʻokahele ʻia ʻelua mau pahuhopu a ma waena o lākou i huli ai i waena o 12 mau hola.

Ke mālama ʻana i ka wā e lawe ai i ka lāʻau lapaʻau:

1. ʻO nā mea ikaika e hana ai iā Yanumet, hōʻiliʻili nui ʻia i ka urine. Me ka hana ʻole o ka renal, ke piʻi aʻe o ka hoʻāla me ka hoʻonui ʻana i ka metformin me ka hoʻolālā hou o ka acidact lactic. I mea e pale aku ai i kēia hoʻopiʻi ʻana, pono ia e nānā i nā ʻōpū ma mua o ke kuhikuhi ʻana i ka lāʻau lapaʻau. I ka wā e hiki mai ana, hōʻike ʻia nā hōʻike i kēlā me kēia makahiki. Inā kiʻekiʻe ka creatinine ma mua o ka mea maʻamau, pau ka lāʻau lapaʻau. Hōʻike ʻia nā maʻi maʻi ʻelemakule e ka pilikia o ka makahiki o ka hana ʻana, no laila, ʻōlelo ʻia lākou i ka palena iki o Yanumet.
2. Ma hope o ka hoʻopaʻa inoa ʻana o ka lāʻau lapaʻau, loaʻa nā loiloi o nā hihia o ka maʻi pancreatitis ma ka maʻi maʻi e lawe ana iā Yanumet, no laila ua ʻōlelo aku ka mea hana hou i ka mea pili i ke kuʻuna no ka hoʻohana ʻana. ʻAʻole hiki ke hoʻokū i ka maʻamau o kēia mau hopena, no ka mea ʻaʻole i hoʻopaʻa ʻia kēia hoʻopiʻi i nā pūʻulu mana, akā hiki ke manaʻo ʻia he mea maʻamau loa. Nā hōʻailona o ka pancreatitis: ʻeha hōʻeha ma ka ʻōpū o luna, e hāʻawi ana i ka hema, e luaʻi ana.
3. Inā lawe pū ʻia nā papa o Yanumet me gliclazide, glimepiride, glibenclamide a me kekahi mau PSM, hiki i ka hypoglycemia. I ka wā e loaʻa ana, ke waiho nei ka hewa o Yanumet i loli ʻole, ua hōʻemi ʻia ka nui o ko PSM.
4. ʻAe maikaʻi ʻole ka hoʻōla ʻo Yanumet. ʻO Metformin i loko o ka hoʻonāukiuki a me ka hoʻōla i ka waiʻona hiki ke hoʻomau i ka hoʻōho lactic acidosis. Eia kekahi, e hoʻolōʻihi i nā mea inu wai i ka hoʻomohala ʻana o ka hoʻopiʻi o ka maʻi diabetes a hoʻonāukiuki i kona uku.
5. ʻO ke kaumaha o ka physiological (ma muli o ka hōʻeha hōʻeha, ke kuni, overheating, hoʻomakeʻa, nā mālamalama ākea, ʻoihana) hiki ke hoʻonui nui i ke kō koko. I ka wā e hoʻolaʻa ʻia ai, ʻōlelo ke aʻo ʻana ke kaloli nei i kahi manawa i ka insulin, a hoʻi hou i ka hoʻōla ʻana ma mua.
6. Aʻo kēia ʻōlelo aʻoaʻo e hoʻokele i nā kaʻa, e hana pū ana me nā mīkini no nā maʻi maʻi e lawe ana iā Yanumet. Wahi a nā loiloi, hiki i ka lāʻau lapaʻau ke hōʻeha i ka ʻoluʻolu a me ka dizziness, no ka hoʻomaka ʻana o kāna ʻoihana e pono nui ʻoe i kou ʻano.

Nā hopena o ka lāʻau

Ma keʻano laulā, ua helu ʻia ka maikaʻi o kēia lāʻau lapaʻau. Hiki i ka metformin ke hoʻopuka i nā hopena hopena. ʻO nā hopena maikaʻi loa me ka mālama ʻana me ka sitagliptin i nānā nui ʻia e like me ka placebo.

Wahi a ka ʻike i hāʻawi ʻia i loko o nā ʻōkuhi no nā papa, ʻo ka lōʻihi o ka loaʻa ʻana o ka hopena ʻino ʻaʻole iʻoi aku o 5%:

• kūlia - 3,5%;
• pāʻālua - 1,6%;
• ʻeha, hōʻeha ma ka ʻōpū - 1.3%;
• ka hoʻonuiʻana o ke kinoea - 1,3%;
• hōʻeha - 1.3%;
• pulu - 1.1%;
• hypoglycemia - 1.1%.

I ka wā o nā noiʻi ʻana a i ke wā o ke kākau inoa ʻana, ʻike ʻia nā maʻi maʻi:

• nā maʻi maʻi, me nā ʻano paʻakikī;
• maʻi nui pancreatitis;
• hana ʻole;
• maʻi ʻeha;
• constipation
• ʻeha i nā ʻāpana, hope, hope ʻeha.

ʻO ka mea ʻē aʻe, ʻaʻole pili kēia o Yanumet i kēia mau hoʻokamakama, akā ua komo pū ka mea hana iā lākou i nā ʻōlelo kuhikuhi. Ma keʻano holoʻokoʻa, ʻo ka maʻamau o kēia mau hopena i nā maʻi maʻi i ka maʻi ma Yanumet ʻaʻole i ʻokoʻa i ka pūʻulu o ka mana i loaʻa ʻole i kēia lāʻau.

Kekahi hopena pohihihi, akā ʻoiai he mea hiki ʻole ke haki i ka wā e lawe ai i Janumet a me nā papa ʻē aʻe me metformin he lactic acidosis. He paʻakikī kēia e mālama i ka hoʻopiʻi kūlohelohe o ka maʻi maʻi - kahi papa inoa o nā hoʻopiʻi o ka maʻi maʻi. Wahi a ka mea hana, ʻo ka uku o ka mauʻu he 0,03 i kēlā me kēia kanaka 1000 mau makahiki. ʻAʻole hiki ke mālama ʻia o 50% o nā maʻi maʻi. ʻO ke kumu o ka acidosis lactic hiki i ke keu aku o ka hopena Janumet, ʻoi aku ka hoʻohui me nā mea hoʻonāukiuki: nā māpuna, ka puʻuwai, ka lolo a me ka hāʻule ʻana o ka hanu, ka inu ʻona, ka pōloli.

Hoʻohālikelike Kahumoku

Arkady Alexandrovich

Endocrinologist me kaʻike

E nīnau i ka mea loea

ʻO nā hōʻailona mua o kahi hoʻopiʻi he hōʻeha nā mākele, sternum, pōkole o ka hanu, pōkole o ka hanu, nā hiamoe. A laila hypotension, arrhythmia, kahi hāʻule o ka mahana wela kino e komo i loko. Pono kēia ʻano i ka hoʻokele maikaʻi. Pono e hoʻomaopopo ʻia nā limahana olakino no ka maʻi o ka mea maʻi a lawe ʻo ia iā Yanumet.

Nā Hoʻohui

Ma mua o ka lawe ʻana i kekahi lāʻau lapaʻau, pono ʻoe e familiarize iā ʻoe iho me ka papa inoa o nā contraindications i loaʻa i nā ʻōlelo kuhikuhi. ʻO ka hele ʻana i nā maʻi koʻikoʻi e pono e hōʻike i kāu kauka.

ʻAʻole hiki ke lawe ʻia ka lāʻau lapaʻau ʻo Janumet ma kēia mau hihia:

• me ka hypersensitivity i nā mea e hoʻomā ana i ka papa. Ma kahi o ka sitagliptin a me ka metformin, aia ʻo Yanumet i ka stearyl fumarate a me ka sodium lauryl sulfate, cellulose, povidone, dyes, titanium dioxide, talc, polyvinyl alkohol. Loaʻa paha nā analog i kahi hiʻohiʻona like ʻole i ka mea ʻaʻole e hoʻonāukiuki i nā maʻi pā;
• hōʻino ʻia i ke kino ʻole;
• ka hoʻonui ʻana o ka hana ʻana i ke koko ma mua o ke ʻano o ka makahiki;
• maʻi type type 1;
• ketoacidosis ka maʻi a kūleʻa paha, ʻoiai inā ʻaʻole ia e hele pū me ka ʻike maka ʻole. ʻO ka maʻi Diabetika me kahi precoma hyperglycemic a me kahi coma ma ka mōʻaukala o ke kuhikuhi ʻana i ka lāʻau lapaʻau hiki ke hāʻawi ʻia nā kaila koko i nānā mau ʻia;
• me ka type 2 lōʻihi o ka umauma decompensated e hoʻohālikelike ʻia, insulin. Hiki i ka lāʻau Yanumet ke hele ma hope o ka hoʻopaʻa ʻana;
• kahi mōʻaukala o ka lactic acidosis, kahi o nā mea i hoʻonāukiuki iā ia;
• inu waiwaho, i hoʻokahi manawa a me ke ʻano;
• uha kapili āpau;
• ʻO nā kūlana ʻē aʻe e hoʻonui ai i ka hoʻouka o ka lactic acidosis - maʻi maʻi, nā mea hanu. I kēia hihia, e nānā ʻia ai ka pilikia e ke kauka ma luna o ka ʻike hoʻokolokolo;
• halepule ikaika;
• hanau, hanau mai;
• i ka wā o ke kaumaha no ke kino. Hiki i ke kumu ke hōʻeha koʻikoʻi a me nā hōʻeha, hōʻeha ka naʻau a me nā kūlana koʻikoʻi.

Nā kuʻina

ʻO ka lāʻau Yanumet hoʻokahi wale nō analogue - Velmetia. Hana ʻia e ka hui ʻo Berlin-Chemie, kahi lālā o ka hui ʻo Menarini. Ua kūʻai ʻia ka lāʻau lapaʻau i loko o Sepania a me Italia, nā papa a me nā kāpili i Russia, ma ka lālā Kaluga o Berlin-Chemie. Loaʻa iā Velmetia 2 mau papa helu o 50/850 a 50/1000 mg. Nui kiʻekiʻe ke kumukūʻai o Velmetia ma mua o ka lāʻau lapaʻau mua, hiki iā ʻoe ke kūʻai wale ma ke kauoha. ʻAʻole hoʻohālikelike ʻia nā kikowaena ma Lūkia a ʻaʻole e kokoke mai.

ʻO hui kikowaena o Yanumet ka hui pū ʻana e hoʻohui pū i kekahi gliptin a me metformin. Ma Lūkia, 3 mau koho koho i hoʻopaʻa ʻia: Galvus Met (loaʻa vildagliptin), Combogliz Prolong (saxagliptin) a me Gentadueto (linagliptin). ʻO ka hoʻohālikelike hoʻohālikelike maʻalahi loaʻo Galvus Met, ʻo kona kumukūʻai he 1600 rubles. kēlā me kēia ʻaha pū. ʻO Combogliz Prolong a me Gentadueto ke kumukūʻai ma kahi o 3,700 rubles.

Hiki i ka lāʻau "Yanumet ke" hōʻiliʻili "me ke kūʻokoʻa mai Januvia (kahi lāʻau lapaʻau o ka mea hana like, ke ʻano o ka honi i lalo o sitagliptin) a me Glucofage (metformin kumu). E kūʻai ʻia nā lāʻau ʻelua ma kahi o 1650 rubles. no ia pākahi. Wahi a nā loiloi, ʻaʻole hana hewa kēia hui ʻana ma mua o Yanumet.

Nā Hōʻike Kokua