ʻO ka lāʻau lapaʻau ʻO Trazhenta: ʻōlelo aʻoaʻo, nā loiloi o ka maʻi diabetes a me ke kumukūʻai

He lāʻau hou nā Trazhenta no ka hoʻemi ʻana i ke kaʻe koko i loko o ka maʻi diabetes, ma Lūkini i kākau ʻia i ka makahiki 2012. ʻO ka papa hana ikaika o Trazhenta, linagliptin, nona kekahi o nā papa palekana o nā ʻaila hypoglycemic - DPP-4 inhibitors. Ua hoʻomaopopo maikaʻi lākou iā lākou, ʻaʻohe ʻāpana o nā ʻaoʻao, a hoʻomaʻamaʻa ʻole ʻia no ka hypoglycemia.

Kahi trazenta ma kahi hui o nā lāʻau lapaʻau me ka hana kokoke e kū kaʻawale. ʻO Linagliptin ka hopena kiʻekiʻe loa, no laila aia i loko o kahi papa pānaʻi 5 mg wale nō o kēia ʻano mea. Eia kekahi, ʻaʻole i komo ka ʻili a me ka puʻuwai i kāna excretion, ʻo ia ka mea e mālama ai ka mea maʻi me ka nele o kēia mau mea i lawe ai iā Trazhentu.

Nā hōʻailona no ka hoʻohana ʻana

Aʻo kēia ʻōlelo e hiki ke kuhikuhi ʻia iā Trazent i nā maʻi maʻi hakahaka me nā maʻi type 2. Ma ke ʻano he laikini, he laina 2 nā lāʻau lapaʻau, ʻo ia ka mea i hoʻokomo ʻia i loko o ka lāʻau mālama lāʻau inā ka hoʻoponopono ʻana i ka meaʻai, hoʻomaʻamaʻa, ʻike ʻana i ka metformin i ke kūleʻa maikaʻi loa a ʻoi paha ka hopena e hoʻolako i kahi uku no ka maʻi maʻi.

Nā hōʻailona no ka hoʻokomo

1. Hiki ke ʻōlelo ʻia ʻo Trazhent e like me ka hypoglycemic wale nō inā ʻaʻole i ʻae ʻia ka metformin a i ʻole ka hoʻohana ʻia ʻana o kona hoʻohana.
2. Hiki ke hoʻohana e like me ka mahele o ka mālama kūʻokoʻa me ka derivatives o sulfonylurea, metformin, glitazones, insulin.
3. ʻO ka hopena o ka hypoglycemia i ka wā e hoʻohana ai iā Trazhenta he mea liʻiliʻi loa, no laila, ʻoi aku ka maikaʻi o ka lāʻau lapaʻau no nā mea maʻi e hoʻōki i ka huka.
4. ʻO kekahi o nā hopena koʻikoʻi a me ka hopena maʻamau o ka maʻi diabetes is the impaired renal function - nephropathy me ka hoʻomohala ʻana i ka hana renal. I kahi ākea, loaʻa kēia hauna i ka 40% o nā maʻi maʻi, e hoʻomaka pinepine i ka asymptomatic. ʻO ka hoʻohuiʻana o nā hoʻopiʻi e koi ai i ka hoʻoponopono ʻana o ka lāʻau hoʻoponopono, no ka mea, ʻo ka hapa nui o nā lāʻau lapaʻau e hoʻoiho ʻia e nā keiki. Pono ka mea maʻi e hōʻole i ka metformin a me vildagliptin, e hōʻemi i ka dosage o acarbose, sulfonylurea, saxagliptin, sitagliptin. I ka hoʻolako ʻana i ke kauka, koe wale nō glitazones, glinids a Trazhent noho mau.
5. Loaʻa ma waena o nā mea maʻi me ka maʻi aho a me ka hana aho lēwa, ʻo ia hoʻi ka hepatosis momona. Ma kēia hihia, ʻo Trazhenta wale nō ka lāʻau mai nā DPP4 inhibitors, ʻo ia ka ʻāpono e hiki ai ke hoʻohana me ka ʻole o ka palena. Kēia maoli kēia no ka poʻe maʻi maʻi me ka kiʻekiʻe o ka maʻi hypoglycemia.

Hoʻomaka me Trazhenta, hiki iā ʻoe ke manaʻo e hāʻule ka gogala hemoglobin e pili ana i ka 0.7%. I ka hui pū me ka metformin, ʻoi aku ka maikaʻi o nā hopena - e pili ana i ka 0.95%. Ua hōʻike ʻia e nā kauka a nā kauka e mālama like ka lāʻau lapaʻau i nā mea maʻi me ka maʻi mellitus no ka maʻi maʻi a me kahi ʻike maʻi ʻoi aku ma mua o 5 mau makahiki. Ua hōʻike ʻia nā haʻawina i hoʻopaʻa ʻia ma 2 mau makahiki i ka hopena o ka lāʻau lapaʻau o Trazent ʻaʻole i emi iho i ka wā lōʻihi.

ʻO ka maʻi maʻi a me nā hoʻohaʻahaʻa manaʻo e hana ia i ka wā ma mua

• Ka hana maʻamau o ke kō -95%
• Hoʻokuʻuina o ka pua thrombosis - 70%
• Hoʻopau i kahi puʻuwai ikaika -90%
• Hoʻopau i ke kiʻekiʻe o ke koko - 92%
• ʻO ka hoʻonuiʻana i ka ikehu i ka wā, hoʻomaikaʻi i ka hiamoe i ka pō -97%

Pehea e hana ai ka lāʻau lapaʻau?

Hoʻopili pololei nā hormones o ka palapoka i ka hōʻemi ʻana i ka glucose i kahi pae physiological. Hoʻonui ko lākou naʻau i ka pane i ka hoʻoili ʻana o ka glucose i nā moku. ʻO ka hopena o ka hana o ka incretins he hoʻonui i ka synthesis o ka insulin, kahi hōʻemi i ka glagonagon, kahi e hoʻokaʻawale ai i kahi glycemia.

Ua luku koke ʻia nā incretins e nā enzymes kūikawā DPP-4. ʻO ka lāʻau Trazhenta hiki ke hoʻopili i kēia mau kaena, e hoʻolohi i ka hana, a no laila, hoʻolōʻihi i ka ola o nā incretins a hoʻonui i ka hoʻokuʻu ʻana i ka insulin i ke kahe koko i ka maʻi mellitus.

ʻO ka pono kūpono ʻole o Trazhenta ka lawe ʻana i ka mea ikaika me ka nui me ka bile ma loko o nā ʻōpū. Wahi a nā ʻōlelo kuhikuhi, ʻaʻole ʻoi aku ma mua o 5% o linagliptin e komo i ka urine, ʻoi aku ka emi o ka metabolized ma ke ake.

Wahi a nā maʻi maʻi, ʻo nā pono o Trazhenty:

• ka lawe ana i ka la- hu i ka la hookahi;
• e kau ʻia nā mea maʻi a hoʻokahi dosage;
• ʻaʻole koi ka hoʻoponopono ʻana i nā maʻi no nā maʻi o nā ate a me nā pōpoki;
• ʻaʻohe no nā hoʻokolohua ʻē aʻe e koho iā Trazenti;
• ʻaʻole ʻona ka lāʻau lapaʻau i ka ate;
• ʻaʻole e loli ka dosage ke lawe ʻia ʻo Trazhenty me nā lāʻau lapaʻau ʻē aʻe;
• lāʻau lapaʻau pili o linagliptin aneane ʻaʻole i hōʻemi i kona pono. No ka poʻe maʻi maʻi, he ʻoiaʻiʻo kēia, ʻoiai pono lākou e lawe i kekahi mau lāʻau i ka manawa like.

Ka puka ʻana a me ka helu ʻana

Loaʻa ka lāʻau lapaʻau ʻo Trazhenta i ke ʻano o nā papa i loko o kahi kala ʻulaʻula hohonu. No ka pale aku i ka hoʻopunipuni, i kekahi ʻaoʻao kahi mea hōʻailona o ka mea hana, he hui ʻoihana ʻo Beringer Ingelheim, i ʻō, ma kekahi ʻaoʻao - D5 hōʻailona.

Aia ka papa papa i kahi kiʻi kiʻiʻoniʻoni, ʻaʻole i hāʻawi ʻia ka māhele i nā ʻāpana. Ma ke ʻeke i kūʻai ʻia ma Lūkia, 30 mau papa (3 blisters o 10 pcs.). ʻO kēlā me kēia papa o Trazhenta ka 5 mg linagliptin, starch, mannitol, magnesium stearate, dyes. Hāʻawi nā ʻōlelo no ka hoʻohana ʻana i kahi papa helu piha o nā mea kōkua.

Nā ʻōkuhi no ka hoʻohana

I ka hihia o ka maʻi diabetes mellitus, ʻōlelo ʻia i kēlā me kēia lā he 1 papa papa. Hiki iā ʻoe ke inu iā ia i kēlā me kēia manawa, me ka ʻole e pili me ka meaʻai. Inā ʻōlelo ʻia ka lāʻau lapaʻau a Trezhent i hoʻohui ʻia i ka metformin, ua waiho wale ʻia kona momona.

Inā nalowale ʻoe i kahi paila, hiki iā ʻoe ke lawe iā ia i ka lā like. ʻO ka inu ʻana iā Trazhent i loko o kahi pālua ʻelua i ʻae ʻia, ʻoiai ʻo ka hoʻokipa ʻia ʻana i ka lā ma mua.

Ke hoʻohana pono ʻia me ka glimepiride, glibenclamide, gliclazide a me nā analogues, hiki i ka hypoglycemia. Ke pale iā lākou, ka ʻawa ʻo Trazhenta e like me ka wā ma mua, a hoʻemi ʻia ka nui o nā lāʻau ʻē aʻe a hiki i ka hoʻokō ʻana o ka normoglycemia. I loko o kahi liʻiliʻi no ʻekolu mau lā mai ka hoʻomaka ʻana o ka paʻakai o Trazhenta, koi ʻia ka wikiwiki o ka glucose, no ka mea e ulu maikaʻi ka hopena o ka lāʻau. Wahi a nā loiloi, ma hope o ke koho ʻana i kahi maʻi hou, ua hoʻolōʻihi ʻia ka nui a me ka hōʻemi o ka hypoglycemia ma mua o ka hoʻomaka ʻana o ka mālama ʻana me Trazhenta.

Hiki i nā mea pili kino e like me nā ʻōlelo i:

Ma nā lāʻau ʻē aʻe, ʻaʻole i loaʻa ka pili pili me Trazhenta.

He aha hana ʻino

Hiki ke ʻike ʻia nā hopena ʻē aʻe o Trazenti i ka wā o nā hoʻokolohua lapaʻau a ma hope o ke kūʻai ʻana aku i ka lāʻau lapaʻau. Wahi a kā lākou hopena, ʻo Trazhenta kekahi o nā mea palekana palekana hypoglycemic. ʻO ka loaʻaʻana o nā hopena pōʻino e pili ana me ka lawe ʻana i nā paila he liʻiliʻi.

ʻO ka mea mahalo, i ka hui o nā maʻi maʻi i loaʻa i kahi placebo (nā papa ʻole me nā mea ikaika), 4.3% hōʻole i ka mālama ʻana, ua ʻike ʻia ke kumu. I ka hui ua lawe aku iā Trazhent, ua emi iki kēia mau maʻi maʻi, 3.4%.

I nā ʻōlelo kuhikuhi no ka hoʻohana ʻana, e hōʻiliʻili ʻia nā pilikia olakino āpau i loaʻa i ka poʻe maʻi ma ka papa ʻaina i kahi papa nui. Eia, a me nā momi, a me nā maʻi, a me nā maʻi maʻi parasitē. Me kahi kiʻekiʻe kiʻekiʻe ʻo Trazenta ʻaʻole ke kumu o kēia mau ʻaʻa. Ua hoʻohālikelike ʻia ka palekana a me monotherapy o Trazhenta. I nā hihia āpau, ʻaʻole i ʻike ʻia nā hopena kūpono.

Hoʻohana palekana me ka Trazhenta a ma ka ʻōlelo o ka hypoglycemia. Hōʻike nā loiloi a hiki i ka poʻe maʻi maʻi me ka predisposition i ke kaomi wai (nā kānaka makua e loaʻa ana i nā maʻi o ka lolo, ka momona,) ʻaʻole iʻoi aku ka nui o ka hypoglycemia ma mua o 1%. ʻAʻole hoʻopilikia ʻo Trazhenta i ka hana o ka puʻuwai a me nā kīʻaha koko, ʻaʻole ia e alakaʻi i ka hoʻonui hoʻonui nui i ke kaupaona ʻana, e like me ka sulfonylureas.

Ke keu

ʻO kahi dosis hoʻokahi o 600 mg o linagliptin (120 papa o Trazhenta) ke hoʻomanawanui maikaʻi a ʻaʻole pilikia i ka pilikia olakino. ʻAʻole i aʻo ʻia nā hopena o nā piʻi kiʻekiʻe i ke kino. Kālai ʻia i nā ʻano o ka ʻōkake o ka lāʻau, kahi hana kūpono e hihia ai ka hopena o ka overdose ka lawe ʻana i nā papa no undigested mai ka gastrointestinal tract (gastage lavage). Hoʻomohana ʻia ka mālama mālama ʻana a me ka nānā ʻana i nā hōʻailona koʻikoʻi. ʻO nā Dialysis i kahi hihia o ka overdose o Trazhenta hikiʻole.

Nā Hoʻohui

ʻAʻole pili nā papa ʻōpuhi:

1. Inā ʻaʻohe mea maʻi i ka maʻi diabetes e hiki ai ke hana i ka insulin. ʻO ke kumu ke ʻano type 1 diabetes or pancreatic resection.
2. Inā kūleʻa ʻoe i kekahi o nā māhele o ka paila.
3. Ma nā hopena hoʻopiʻi hyperglycemic maʻi o ka maʻi maʻi. ʻO ka ʻae ʻia i kā ketoacidosis ka mea i hoʻokomo ʻia i ka insulin e hōʻemi i ka glycemia a me ka paʻakai e hoʻoponopono i ka wai. Hoʻopau ʻia kekahi hoʻomākaukau hoʻomākaukau ʻana i ka papa a hiki i ka hoʻomau ʻana o ke ʻano.
4. Me ka ʻōpoki. Hiki i ka Linagliptin ke komo i loko o ka waiū, kahi hana kūwele a kahi keiki, e kau i ka hopena ma nā ʻano o ka huina.
5. I ka wā hāpai. ʻAʻohe mea iʻike i ka hiki ke komo a linagliptin i waena o ka plasenta.
6. Ma ka maʻi kamaliʻi ma lalo o nā makahiki 18. ʻAʻole i aʻo ʻia ka hopena ma ke kino o nā keiki.

Kuhi ʻia ka hoʻonui ʻana i ke olakino, ʻae ʻia iā Trazhent e koho i nā mea maʻi i ʻoi aku ma mua o 80 mau makahiki, me ka maʻi pancreatitis a me ka maʻi maʻamau. Hoʻohana me ka hui pū me ka insulin a me ka sulfonylurea e koi ai i ka hoʻomehana glucose, no ka mea e hiki ai i ka hypoglycemia.

ʻO nā mea kuʻuna e hiki ke hoʻololi

He lāʻau lapaʻau hou ʻo Trazhenta, kahi paʻa i ka pale aku i ka make ʻana, no laila ua pāpā ʻia ʻo ia e hana i nā analogues ma Lūkini me ka ʻano like. Ma nā hopena o ka hana pono, palekana a me ka hana o ka hana, ʻo nā hui nā kikowaena kokoke i Trazent - DPP4 inhibitors, a i ʻole gliptins. ʻO nā mea a pau mai kēia pūʻulu e kapa ʻia ʻo ka hoʻopau me -gliptin, no laila hiki ke maʻalahi ke kaawale ʻia mai nā papa antidiabetic ʻē aʻe.

ʻO nā hoʻohālikelike hoʻohālikelike o nā gliptins:

ʻO nā haʻahaʻa Sulfonylurea (PSM) nā mea kiko'ī o Trazhenta. Hoʻonui lākou i nā synthesis insulin, akā ua ʻokoʻa ka ʻano o kā lākou hopena i nā cell beta. Hana wale ʻo Trazenta ma hope o ka ʻai ʻana. Hoʻomau ka PSM i ka hoʻokuʻu ʻana o ka insulin, ʻoiai inā maʻa ke kō o ke koko, no laila mea pinepine lākou i ka hypoglycemia. Aia ma laila he hōʻike nō ka hoʻopilikia kino ʻia ʻo PSM i ka moku'āina o nā cell beta. ʻO ka lāʻau lapaʻau Trazhenta i kēia hana he palekana.

ʻO ka loli hou a me ka ʻole o ka PSM kahi glimepiride (Amaryl, Diameride) a lōʻihi ka glycazide (Diabeton, ʻO Glidiab a me nā kikoʻī hou aku). ʻO ka pōmaikaʻi o kēia mau lāʻau i ke kumukūʻai haʻahaʻa, ʻo ka mahina o ka hoʻokele e uku ana i ka 150-350 rubles.

ʻO nā kānāwai mālama a me ke kumukūʻai

ʻO ka uku Trazhenty ka uku 1600-1950 mau rubles. Oe ke kuai ia ma ka lealea ole. Hoʻopili ʻia ʻo Linagliptin i ka papa inoa o nā lāʻau lapaʻau pono (Vital a me nā pono i nā lāʻau lapaʻau), no laila inā he mau hōʻailona, ​​hiki ke loaʻa ka maʻi diabetes me ka endocrinologist no ia me ka manuahi.

ʻO 3 mau manawa i ka hala o Trazenti he 3 mau makahiki, ʻo ka mahana o ka wahi e waiho ai, ʻaʻole pono e oi aku i 25 mau kiʻekiʻe.

Hoike Mai