I kēia lā, ʻo nā huahana pharmacological e hana i nā hoʻomākaukau ʻana i nā inikini like ʻole no ka maʻi maʻi maʻi maʻi, i manaʻo ʻia no ka maʻi maʻi. Hiki i kēia mau lāʻauʻokoʻa ke loaʻa nā inoa like ʻole, ka maikaʻi a me nā kumukūʻai. ʻO kekahi o lākou iho i ka insulin Humalog.
Lapaʻau lāʻau
ʻO ka humalog insulin he mea hoʻohālikelike DNA recombinant o ka hormone i hūnā ʻia e ke kino kanaka. ʻO ka ʻokoʻa ma waena o Humalog a me ka hana kūlohelohe kūlohelohe o ka ʻōnaehana amino acid i nā kūlana 29 a me 28 o ka kaulahao B B. ʻO ka hopena koʻikoʻi ʻo ia ka hoʻoponopono ʻana o ka ʻaila glucose
Loaʻa i ka Humalog kahi hopena anabolic. I loko o nā pūpuna o nā uaua, ʻo ka nui o nā kinemona momona, hoʻonui ʻia ka glycogen a me ka glycerol, hoʻonui ʻia ka hana ʻana o ka protein, nui ka hoʻohana ʻana o nā waikawa amino, akā hoʻonui nui ka glycogenolysis, gluconeogenesis, a me ka hoʻokuʻu ʻana i nā waikawa amino.
Ma ke kino o nā mea maʻi me ka maʻi maʻi o nā ʻano ʻelua ma muli o ka hoʻohana ʻana iā Humalog, ka nui o ka hōʻeha o ka hyperglycemia e kū mai ana ma hope o ka hoʻoemi ʻana o kahi ʻaina i hiki i kahi nui me ka mahalo o ka hoʻohana ʻana i ka insulin soluble kanaka.
No nā mea maʻi e loaʻa i ke ʻano basal o ka insulin i ka manawa like me ka manawa pōkole, pono ʻoe e koho i ka ʻai ʻana o nā ʻano like ʻole o ka insulin e hoʻokō pono i nā ʻike glucose i loko o ke ao.
Pēlā e like me nā hoʻomākaukau no ka inemina, ʻo ka lōʻihi o ka hopena o ka lāʻau Humalog e like me nā mea maʻi a i ʻole nā manawa like ʻole i hoʻokahi maʻi. ʻO nā pharmacodynamics o Humalog i nā keiki pili pū me kāna pharmacodynamics i nā pākeke.
I ka poʻe maʻi me ka maʻi diabetes type 2 a lawe i nā nui o nā derivatives o ka sulfonylurea, ʻo ka hoʻohana ʻana iā Humalog e hoʻoluhi kahi nui i ka pae o ka hemoglobin glycated. Ke hoʻohana ʻia nei ʻo Humalog i kēlā me kēia maʻi o ka maʻi maʻi, aia ka make i ka helu o ka episod hypoglycemic i ka pō.
ʻAʻole i pili ʻia ka hoʻonāʻana o ka glucodynamic me Humalog i ka nele o ka hana hepatic a me ka hana. Ua hoʻokumu ʻia ka polaroma o ka lāʻau no ka insulin kanaka, akā, ʻo ka hopena o ka lāʻau e ola wikiwiki ana a ʻoi aku ka liʻiliʻi.
Hōʻike ka humalog i kāna hopena e hoʻomaka koke (i kahi o 15 mau minuke) ma muli o ka nui o ka absorption nui, hiki iā ia ke hōʻike iā ia ma mua o ka ʻai (i ka mau minuke 1-15), aʻo ka insulin maʻamau, he mau manawa pōkole loa ia, hiki ke lawelawe ʻia ma 30 -45 mau minuke ma mua o ka ʻai ʻana.
Lapaʻau lāʻau
Me ka loaʻa ʻana o ka subcutaneous, ua koke koke mai ka lilo ʻana o ka insulin lyspro, ʻike ʻia kona Cmax ma hope o 1-2 mau hola. ʻO Vd o ka insulin i ka hana o ka lāʻau lapaʻau a me nā insulin like maʻamau e like, like lākou mai ka 0.26 a 0.36 lita i pākeke.
Nā Hōʻike
ʻO kahi ʻano e hana ai i ka insulin i ka maʻi pākahi: ke kūlohelohe o kēlā me kēia ma kahi o ka hoʻomākaukau ʻana i nā insulin; postprandial hyperglycemia, ʻaʻole hiki ke hoʻoponopono ʻia e nā ʻano ʻē aʻe o ka insulin.
Non-insulin-like ole o ka maʻi diabetes: ke kū'ē i nā lāʻau anti-diabetes i lawe ʻia i ka maʻi maʻamau (malabsorption o nā hoʻomākaukau ʻana i nā insulin, postprandial hyperglycemia, ʻaʻole ʻae ʻia e hoʻoponopono); interventions opiʻi a me nā maʻi intercurrent (e hoʻopiʻi i ka papa o ka maʻi diabetes).
Ke noi
Hoʻoholo kū hoʻokahi ʻo Dosage Humalog. Hoʻokomo ʻia ka humalog i ke ʻano o nā kīʻaha ma ke kūloko a me ka intravenously a me ka intramuscularly. ʻO ka humalogue i ka ʻano o nā pahu loea wale nō ka subcutaneous. Kūpono ʻia nā ʻōkuhi 1-15 mau minuke ma mua o ka pāʻina.
I kāna hana maʻemaʻe, e mālama ʻia ka lāʻau lapaʻau i nā manawa 4-6 i ka lā, i hui pū ʻia me ka hoʻomākaukau ʻana i ka insulin me ka hopena lōʻihi, ʻekolu mau lā i kēlā me kēia lā. ʻAʻole hiki i ka nui o kahi ʻōmole hoʻokahi ma mua o nā ʻāpana 40. Hiki ke hoʻohui ʻia nā humalog i loko o kahi pahu me nā huahana insulin me ka hopena lōʻihi i kahi syringe hoʻokahi.
ʻAʻole hoʻonohonoho ʻia ka pahu kāwili i ka hoʻāla ʻana iā Humalog me nā hoʻomākaukau ʻē aʻe i loko o ka inika i loko a me ka hoʻohana mau ʻia.
Ke pono ke hoʻohaʻahaʻa i ka nui o ka insulin e hiki mai ana i ka hopena o ka hōʻemi o nā manaʻo o nā kalapika i nā huahana meaʻai, ke koʻikoʻi o ke kino nui, ke hoʻohana hou ʻana i nā lāʻau e loaʻa ai ka hopena hypoglycemic - sulfonamides, non-selective beta-blockers.
Nā hopena hopena
ʻO ka hopena nui o kēia lāʻau lapaʻau ka hopena o ka hopena i lalo: ʻoi aku ka hoʻonui ʻana, ke hiamoe ʻana, coma. I nā hanana pinepine, hiki mai nā maʻi a me nā lipodystrophy.
Kahawai
I kēia manawa, ʻaʻohe hopena ʻino o Humalog no ke kūlana o ka wahine hāpai a ua loaʻa ka embryo. ʻAʻohe mea pili i hana ʻia.
ʻO kahi wahine o ka hānau keiki ʻana i ka maʻi maʻi maʻi e hoʻomaopopo i ke kauka e pili ana i ka hapai i hoʻolālā ʻia a i ʻole ka hoʻopiʻi ʻana. No nā poʻe maʻi me ka maʻi maʻi, lactation i kekahi manawa e koi aku i ka hoʻoponopono ʻana i ka nui o ka insulin a i ʻole kaʻai.
Ke keu
Hōʻike manamana: kahi puʻukū i ka glucose koko, ka mea i hele pū me ka lethargy, hoʻoheheʻe, pulse wikiwiki, ʻeha ma ke poʻo, ka luaʻi, hoʻohilahila.
Hoʻomaʻamaʻa: ma kahi ʻano haʻalulu, hiki ke hoʻokuʻu ʻia ka hypoglycemia e ka hoʻokomo ʻana i ka glucose o loko a i ʻole kekahi mea waiwai mai ka hui o ke kō, a i ʻole nā huahana e loaʻa i ke kō.
Hiki ke hoʻoponopono ʻia ka hypoglycemia i ke kiʻekiʻe o ka maʻi e ka intramuscular a i ʻole subcutaneous injections o ka glucagon a me ka komo ʻana o ka paʻakai i ka hopena ma hope o ke ʻano o ka maʻi.
Hāʻawi ʻia nā mea maʻi ʻole i pane ʻole i nā glucagon. I ka hihia o ke koma, e lawelawe ʻia ana ka glucagon i ka subcutaneously a i ʻole intramuscularly. Ke hala ʻole o ka glucagon a i ʻole ka hopena i ka hoʻonāukiuki ʻana o kēia mau mea, pono e hoʻokō ʻia ka hana intravenous i kahi hopena glucose.
Ma hope o ka hoʻomanawanui hou ʻana o ka mea maʻi, pono ʻo ia e lawe i ka meaʻai i lawe i ka huamina. Oe e pono e lawe i ka kalaka i ka wā e hiki mai ana, a pono nō hoʻi oe e nānā i ka mea maʻi, no ka mea, aia he hopena o ka mea hoʻi i kā hypoglycemia.
Laki
Pono e mālama i ka humalog i kahi mahana o +2 a +5 (i loko o ka friji. ʻAʻole ʻae ʻia ka paʻi manuahi. ʻAʻole hiki ke lōʻihi ka lōʻihi o kahi pahu pahu a i ʻole paha i ka wai ma mua o ka mahana. Pono ʻoe e pale i ka Humalog mai ka lā maka.
ʻAʻole hiki ʻole ke hoʻohana i ka hoʻonā i ka ʻina i ka wā i loaʻa ai ke aniani, a me nā hi a i ʻole a waiho ʻia, a i ka hele ʻana o nā pā hiʻona i loko.
Hoʻohui ʻano lāʻau
ʻO ka hopena hypoglycemic o kēia lāʻau lapaʻau ke hōʻemi ʻia i ka wā e lawe ai i ka ʻāʻī waha, nā lāʻau lapaʻau e pili ana i nā hormone thyroid, beta2-adrenergic agonists, danazole, antidepresan tricyclic, diuretics thiazide-type, diazoxide, chlorprotixen, isoniazid, nicotinic acid, lithium carbonate, lithium carbonate
Hoʻonui ka hopena hypoglycemic o Humalog me nā beta-blockers, ethyl alkohol a me nā lāʻau lapaʻau e loaʻa ai iā ia, fenfluramine, anabolic steroid, tetracyclines, guanethine, salicylates, oral hypoglycemic drug, sulfonamides, ACE inhibitors and MAO and octre.
Hiki ke hoʻohana ʻia i ka humalog (e pili ana i ka mālama maka olakino) i hui pū ʻia me ka insulin kanaka, he hopena lōʻihi kēia, a i ʻole pū me nā huaʻōlelo hypoglycemic waha e loaʻa mai ka sulfonylurea.
