ʻO ka maʻi diabetes mellitus, ma muli o kona ulu wikiwiki a me ke kiʻekiʻe nui o ka make, ua hoʻonā ʻia ka weliweli i ke kanaka. I nā makahiki he 20 i hala iho nei, ua komo ke hapanui i nā kumu nui ʻekolu o ka make. ʻAʻole ia he mea kupanaha ua komo ʻia ka maʻi ma kahi helu o nā pahuhopu mua i hoʻonohonoho ʻia no nā kauka ma ka honua.
ʻO ka ʻano dosis o ka lāʻau
ʻO ka lāʻau Metformin-richter me ka mea hana nui o ka metformin hydrochloride e hana ʻia e ka mea hana hale ma loko o nā ʻano ʻelua: 500 mg a i ʻole 850 mg kēlā me kēia. Ma waho aʻe o ka mea maʻamau, aia kekahi mau poʻe kuhi i ka mea hoʻonohonoho: Opadry II, silic dioxide, magnesium stearate, copovidone, cellulose, polyvidone.
Hiki ke hoʻomaopopo i ka lāʻau lapaʻau e nā hōʻailona ʻokoʻa: puni (500 mg) a oval (850 mg) convex papa keʻokeʻo i loko o kahi pūpū i hoʻouka ʻia i nā poli palika o nā ʻāpana he 10. Ma ka pahu e hiki ai iā ʻoe ke loaʻa mai ka 1 a 6 i kēlā mau papa. Hiki iā ʻoe ke loaʻa ka lāʻau lapaʻau ma o ka lāʻau lapaʻau wale nō.. ^ E Ha yM. Ma Metformin Richter, ʻo ke kumu kūʻai o nā papa 60 o 500 mg a i ʻole 850 mg no 200 a 250 rubles paha. ia wa. Ua kaupalena ka mea hana i ka lā hoʻomaha i loko o 3 mau makahiki.
Ke ʻano o ka hana o ka lāʻau
Aia ʻo Metformin Richter i ka papa o ka biguanides. ʻO kāna papa hana pono, metformin, hoʻohaʻahaʻa i ka glycemia me ka hoʻoulu ʻana i ka pancreas, no laila ʻaʻohe ʻano hypoglycemia ma waena o kona mau ʻaoʻao.
Loaʻa ka metformin-richter i kahiʻenehana triple i nā hopena antidiabetic.
- ʻO ka lāʻau lapaʻau e 30% e pale i ka hana o ka glucogen i loko o ke akea ma ka lawe ʻana i ka glucogenesis me glycogenolysis.
- Hoʻopuka i ka lāʻau lapaʻau ka lilo ʻana o ka glucose i nā paia o ka pūpū, no laila ke komo hou nei nā kākaʻakai i ke kahe koko. ʻAʻole pono nā kumu lawe kīpē i kumu no ka hōʻole ʻana i ka pāʻai haʻahaʻa.
- Hoʻemi ka Biguanide i ka pale ʻana o nā pūpū i ka glucose, e hoʻolalelale i kona hoʻohana ʻana (i kahi nui o nā ʻōpū, e emi ana i ka papa momona).
Hoʻonui maikaʻi loa ka lāʻau lapaʻau i ka hoʻokumu ʻana o ka lipid o ke koko: me ka wikiwiki o ka hoʻoliʻi redox, ke kāohi nei i ka hana o ka triglycerol, me ka ʻano maʻamau a "maikaʻi" (haʻahaʻa haʻahaʻa) o ka kolamu, a hoʻēmi i ka pale ʻana i ka insulin i nā ʻenehana.
No ka mea β-nā sel o ka islet appardus pili i ka hana ʻana o ka insulin endogenous ʻaʻole i hoʻopilikia e ka metformin, ʻaʻole kēia e alakaʻi i ka pōʻino mua a me ka necrosis.
ʻAʻole like me nā laila hypoglycemic koho, ʻo ka hoʻohana mau ʻana i ka lāʻau i hāʻawi i ke kūpaʻa ʻana. He mea nui kēia mea no ka hapanui o nā maʻi maʻi, no ka mea ʻo ka maʻi maʻamau ʻo ka maʻi type 2 e hele pū me ka momona, e hoʻopiʻi nui ana i ka mana o ka glycemia.
Loaʻa ia he hopena biguanide a me nā fibrinolytic, kahi i hoʻokumu ʻia ma ka hoʻomānoelike ʻana o ka mea hoʻopihapiha plasminogen.
Mai ka wahi gastrointestinal, ua hoʻopiha piha ʻia ka waha o ka waha me ka bioavailability o 60%. ʻIke ʻia ka kiʻekiʻe o kona neʻe ʻana ma hope o nā hola o 2.5. Ua kahele ʻia ka lāʻau lapaʻau ma luna o nā ʻōpū a me nā ʻōnaehana: ʻo ka hapa nui o ia mea i hōʻiliʻili i loko o ka ate, renal parenchyma, mākē, a me nā māla salivary.
Hoʻokuʻu ʻia nā koena metabolite e nā keiki (70%) a me nā ʻōpū (30%), ʻo ka hapalua hapalua-ola he ʻano like mai 1.5 a 4,5 hola.
ʻO wai ka mea i hōʻike ʻia i ka lāʻau lapaʻau
Hoʻololi ʻia ka metformin-richter no ka mālama ʻana i ka maʻi type 2, ma ke ʻano he lāʻau mua-a a i nā ala ʻē aʻe o ka maʻi, inā e loli ke ʻano o ka noho ʻana (ka haʻahaʻa-kākā, hoʻohiolo i ke ʻano o ka naʻau a me ka hana kino) ʻaʻole i hāʻawi i ka mana glycemic piha. Hoʻohana ʻia ka lāʻau lapaʻau no monotherapy, hoʻohana ʻia nō hoʻi ia i ka mālama paʻakikī.
Hoʻi ʻino ʻia mai ka lāʻau
Hoʻopili ʻia nā pā i nā poʻe me hypersensitivity i nā mea o nā loiloi. Eia kekahi, ʻaʻole i kuhikuhi ʻia ʻo Metformin Richter:
- Me nā renal a me nā leʻaleʻa o ke akeʻai;
- ʻO ka maʻi maʻi maʻi me ka naʻau kaumaha a me ka hana ʻole hanu;
- Nā makuahine hāpai a me ka lactating;
- Alkoholika a me nā mea hōʻino no ka maʻi ʻawaʻawa;
- ʻO nā mea maʻi ma kahi kūlana o ka acidosis lactic;
- I ka wā o ka hōʻeha ʻana, ka mālama ʻana i nā hōʻeha, ka wela;
- I ka manawa radioisotope a me nā haʻawina radiopaque;
- I ka wā i hoʻolaʻa ʻia ma hope o ka infarction myocardial;
- Me kaʻai hypocaloric a me ka hoʻoikaika kino kaumaha.
Nā manaʻo e hoʻohana
Hāʻawi ke kauka i kahi lāʻau lapaʻau no kēlā me kēia maʻi maʻi pākahi, me ka hōʻike ʻana i ka ʻike makana, ke ʻano o ka hoʻomohala ʻana o ka maʻi, nā hopena hoʻohui, ka makahiki, ka ʻano kū hoʻokahi i ka lāʻau lapaʻau.
No Metformin Richter, ʻo nā ʻōlelo e pili ana i ka hoʻohana ʻana e hoʻomaka ʻoe i ke papa me ka palena liʻiliʻi o 500 mg me ka titration stepwise o ka pāʻiliʻi me kona hopena ʻole i kēlā me kēia 2 pule. ʻO ka palena kiʻekiʻe o ka lāʻau lapaʻau ka 2.5 g / lā. No nā maʻi maʻi hakahaka, he nui ka pilikia o nā keiki, ʻo ka nui loa ka nui o ka 1 g / lā.
Ke hoʻololi nei i Metformin Richter mai nā papaʻaila e hoʻohiolo ana i ke kō, ua helu ʻia ʻo ka paila mua ma mua o 500 mg / lā. Ke kau nei i kahi hana hou, e alakaʻi pū ʻia nō hoʻi lākou e ka huina o nā lāʻau i hala.
Hoʻoholo ʻia ka papa no ka mālama ʻana e ke kauka, me kahi ʻano maʻamau o ke kino, ua lawe ʻia nā mea maʻi maʻi lapaʻau no ke ola.
ʻO ka loiloi o ka lāʻau lapaʻau e nā kauka a me nā maʻi maʻi
E pili ana i ke kumu ʻo Metformin Richter, ua hui ʻia nā loiloi. Hoʻomaopopo nā kauka a me nā maʻi maʻi i ka hana kiʻekiʻe o ka lāʻau lapaʻau: kōkua ia e kāohi i ka kōpili a me ka makemake, ʻaʻohe hopena addictive, hopena hopena liʻiliʻi, pale maikaʻi o nā cardiovascular a me nā pilikia'ē aʻe.
ʻO nā poʻe olakino e hoʻokolohua ana i ka lāʻau lapaʻau e nalowale i ka paona e nui paha ka hoʻopiʻi ʻana i nā hopena i makemake ʻole ʻia. Pono e hoʻolako ʻia nā ʻōkuhi no ka hoʻoponopono ʻana i ke ʻano o kēia ʻano o nā maʻi e ka mea mālama olakino, ʻaʻole hoʻi interlocutors ma ka Pūnaewele.
ʻAʻole wale nā endocrinologists e hana me ka metformin, akāʻo cardiologists, nā maʻi lapaʻau, oncologists, gynecologists, a me kēia loiloi kahi hōʻoia hou o kēia.
Irina, 27 makahiki, St. Petersburg. Ma nā papa kūkala, he nui ke kūkākūkā pinepine ʻana ʻo Metformin Richter e nā maʻi maʻi maʻi a me nā mea hoʻokūkū paha, a inu au i ka wā hāpai. Ua mālama wau i kaʻu ovary polycystic, i kapa ʻia e nā kauka i ke kumu o ka hōʻiliʻili ʻia, no ka makahiki o 5. ʻAʻole ʻo Progesterone (injections) a me nā lāʻau hoʻomohala hormonal i kōkua i ka huki i ka pilikia, hāʻawi lākou i ka laparoscopy e hoʻonāukiuki i nā ovaries. Ke hoʻomākaukau nei au i nā hoʻokolohua a me ka mālama ʻana i kaʻu nānā - kahi hana koʻikoʻi i ka hana, ua ʻōlelo mai kekahi i ke ʻano maʻi gynecologist iaʻu e hoʻāʻo iā Metformin Richter. Mālama koke aku nei ke ʻano o ka pōʻaiʻi, a i ka hana ʻana i ʻeono mau mahina ma hope o nā hōʻailona o ka hapai, ʻaʻole wau i manaʻoʻiʻo i nā hoʻokolohua a i nā kauka paha. Ke manaʻoʻiʻo nei wau ua hoʻopakele kēia mau penikala iaʻu, ma ka makemake ʻole wau e aʻo aku iā ʻoe e hoʻāʻo, ʻae wale nō i ka maʻi gynecologist no ka hoʻolālā intake.
ʻO ka hopena pākaha a me nā ʻaoʻao
ʻOiai ka hoʻonui ʻana o kahi hapa he ʻumi o ka nui o ka metformin i loaʻa i nā mea hana ma nā hoʻokolohua lapaʻau ʻaʻole i hoʻonāukiuki i ka hypoglycemia. Ma kahi o, lactic acidosis hoʻomohala ʻia. Hiki iā ʻoe ke ʻike i kahi kūlana pōpilikia ma ka hōʻeha o ka naʻau a me ka hōʻiliʻili ʻana, ka hoʻohaʻahaʻa ʻana i ke ʻano kino o ke kino, nā maʻi dyspeptic, ka nalowale o ka hui ʻana, nāwaliwali o ka ʻiʻo i kahi coma.
Pono ka mea ʻai i ka hoʻokipa koke. Ma loko o kahi halemai, ke hoʻoneʻe ʻia nā koena o ka metabolite e ka hemodialysis, a lawe ʻia ana ke ʻano hōʻailona me ka mālama aku i nā hana o nā ola ola nui.
ʻO ka hana ikaika o ka metformin hydrochloride kahi kumu hōʻike ikaika no ka palekana. Akā e pili kēia, nā mea mua, ma ke Glucophage kumu. He ʻokoʻa nā ʻōnaehana i ka hoʻonohonoho ʻana, ʻaʻole i hana ʻia nā noiʻina nui o kā lākou koʻikoʻi, a no laila e haʻi nui ʻia nā hopena.
Ma kahi o ka hapalua o nā maʻi maʻi e hoʻopiʻi nei i nā maʻi dyspeptic, ʻoiai i ka wā hoʻohālikelike. Inā hoʻoponopono ʻoe i ka wīwī, inu i ka lāʻau lapaʻau me ka ʻai, nausea, ka ʻono ʻana i ka metala a me nā mea hoʻonā. ʻO ke ʻano o nā meaʻai ka mea nui: ka hopena o ka metformin a me ke kino ke ʻano maʻamau no nā huahana protein (ka ʻi, ka iʻa, ka waiū, nā hua manu, ka ʻala, nā mea ʻai ʻai).
Pehea e hiki ai iaʻu ke hoʻololi i ka mīkini kumu waiwai ʻo Metformin
No ka lāʻau lapaʻau Metformin Richter, hiki i nā mea hoʻomau ke koho ʻia me nā papa like me ka hui like ʻole, ka metformin hydrochloride, a i ʻole nā ʻano lāʻau hypoglycemic like me ka hopena like:
- Huhu;
- ʻO Glyformin;
- Metfogamma;
- NovoFormin;
- Metformin-Teva;
- Bagometua;
- Diaformin OD;
- Metformin Zentiva;
- Puka Puka;
- Metformin-Canon;
- ʻO Glyminfor;
- Siofor;
- Methadiene.
Ma kahi o nā analogue me ka hoʻokuʻu wikiwiki ʻana, aia nā papa me ka hopena lōʻihi, a me ka hoʻohui pū ʻana o kekahi mau ʻano mea hana like i ka pulu hoʻokahi. ʻO kahi kohoʻokoʻa o nā lāʻau lapaʻau, ʻo ia no nā kauka wale nō, ʻaʻole ia e ʻae iā ʻoe i ka koho pono ʻana i kahi koho a me ka waiana, a me ka hoʻomaʻamaʻa ʻana me kou ʻano ponoi ponoʻī iā ʻoe iho kahi papahana pilikino ponoʻī.
ʻO ka hana i kahi mea maʻi hānai i ke kōkua i ka hana a ka lāʻau lapaʻau i kona hiki pono loa, no ka mea me ka ʻole o ka loli ʻana, ke lilo ʻana o ka manaʻo āpau i ko lākou ikaika.
ʻO ka ʻōlelo a Kauka E. Malysheva i ka poʻe a pau e kau ai ke kauka i ka metformin, ma luna o kahi kaʻa
