Hypoglycemic oral drug o ka lua o ka pūʻulu Glybomet

Ma kahi o 6% o ka heluna o ka honua i kēia lā e maʻi ana i ka maʻi mellitus - he maʻi kahi nui ka hōʻailona nui o ka nui o ke kō. Hoʻokomo ʻia nā mea o waho i ke kūkulu ʻana mai o ka maʻi;

ʻO ka lāʻau maikaʻi loa no ka maʻi diabetes is a low-carb diet: inā hiki i kahi mea maʻamau ke ʻai a hiki i 400 g o nā kalama māmā i kēlā me kēia lā, a laila ma lalo o ka maʻi o ka maʻi diabetes.

Akā me ka hōʻole ʻana o ka cereal, ʻuala, pastries, ka nui o nā mea kanu a me nā hua me ka hoʻopili ʻana iā lākou me nā momona holoholona ʻaʻole e hoʻonui i ka glucometer, ʻaʻole hiki i nā mea āpau ke hoʻopiha piha i ka glycemia. Kono maoli kēia no ka maʻi maʻi me ka lua o nā maʻi, kahi no ka mōʻaukala o ka maikaʻi ʻole.

No ka mālamaʻana i ka maʻi maʻi, ua kūkulu ʻia nā ʻano lāʻau 4 i ʻokoʻa i ka hoʻolālā a me ke ʻano o ka ʻike i ka pilikia.

1. ʻO nā lāʻau hōʻemi e hoʻohaʻahaʻa i ka kiʻekiʻe o ka pale ʻana i nā inokini o nā cell are biguanides (Metformin, Glucofage) a me thiazolidinediones (Pioglitazone, Rosiglitazone).
2. Hoʻokomo i ka syntraants synthesant o ka insulin endogenous he huaʻala o ka sulfanylureas (Diabeton, Maninil) a me ka pālolo.
3. ʻO nā lāʻau lapaʻau o ka laikini incrlet, e kāohi ai i ka paona a me nā makemake - Galvus, Januvia, Onglisa, Viktoza, Bayeta.
4. ʻO nā lāʻau lapaʻau e pale i ka hoʻopuka ʻana o ka glucose i loko o nā ʻōpū o Acarbose, Glucobay.

Hōʻike ʻia ʻo Glybomet i ka hoʻomākaukau ʻana i ka waha hypoglycemic o ka lua o nā kolamu, nā ʻōlelo no ka hoʻohana ʻana e hōʻike ʻia no ka loiloi. Lawe ʻia nā ʻikepili mai nā wahi i loaʻa i ka lehulehu, no laila ʻaʻole ia he mea pono no ka hoʻomā ʻana ponoʻī a me ka mālama pono iā ʻoe iho.

Glybomet - kaʻili

ʻO ka hui pū i kēlā me kēia papa o ka pūnaehana ikaika ʻelua - metformin hydrochloride (400 mg) a me glibenclamide (2.5 mg) hiki i ka hiki ke kāohi wale i ka glycemia, akā ua hōʻemi pū i ka maʻi o kēia mau mea. Inā ua hoʻohana ʻia kēlā me kēia nona i ka monotherapy, e kiʻekiʻe loa ka nui o ka nui.

Loaʻa ia i ka pula a me nā mea loaʻa i ke ʻano o ka cellulose, starch corn, colloidal silicon dioxide, gelatin, glycerin, talc, magnesium stearate, acetylphthalyl cellulose, diethyl phthalate.

Nā hiʻohiʻona Pharmacological

ʻO kekahi o nā mea hana ikaika, ka glibenclamide, kahi lāʻau lapaʻau hou o ka papa o ka sulfonylurea, kahi i waiho ʻia ma ka papa inoa o nā lāʻau nui me ka pancreatic a me nā kaha extrapancreatic.

ʻAʻole ia e hoʻoulu wale i ka hana o ka pancreas holoʻokoʻa, akā e hoʻonui pū i ka hana o ka insulin endogenous. Kūkulu ka hana o kā lākou hana i ka pale o ka pancreatic β-cells i hoʻopau ʻia e ka glucose hoʻonāukiuki, e hoʻoholo ai i ka holo mua o ka maʻi diabetes, a me ka hoʻoulu ʻana i ka naʻau o ka insulin o nā cell target.

ʻO ka lawe ʻana i Glibomet i kahi kuʻikahi me ka mana glycemic e hoʻomaikaʻi i ka metabolid lipid a me ka hoʻohaʻahaʻa ʻana i nā hopena o ke koko. Hoʻonui ka hana o ka insulin, a me ia mea ʻo ka unuhi ʻana o ka glucose e nā io ʻo nā ʻūpū a me ka puʻuwai. Hoʻohana ka lāʻau lapaʻau i ka lua o ka hana o ka hana hana i ka insulin.

Aia ka Metformin no ka biguanides - kahi papa o nā mea hoʻonāukiuki e hōʻemi ana i ka insensitivity o nā selela makapō i kā lākou iho ponoʻī. ʻO ka hoʻihoʻi ʻana i ka naʻauao, ʻaʻole iʻoi aku ka mea nui ma mua o ka hoʻonui ʻana i ka mea huna o ka hormone, no ka mea me ka maʻi diabetes type 2, hoʻohālikelike ka pancreas i ka pau loa.

Hoʻonui ka Metformin i ka pilina o nā mea paʻi a me ka insulin, hoʻonui i ka hoʻoponopono o ka postreceptor o ka hormone. I ka make ʻole o ka insulin i ka kahe koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic.

Loaʻa kahi hiʻohiʻona o ka Metformin:

• Hoʻonui i ka hoʻopili ʻana o ka glucose e nā paia ʻeha a kōkua i kona hoʻohana ʻana i nā ʻili;
• Ke hōʻike nei i ka gluconeogenesis;
• Mālama i ka b-cell mai ka apoptosis wikiwiki;
• Hoʻemi i ka pilikia o kekahi ʻano acidosis a me nā maʻi koʻikoʻi;
• Hoʻoulu i ka microcirculation o nā kahe, ka hana endothelial a me ka momona o ka momona (e hoʻemi ana i ke kāʻei o ka "kino" kolamu a me ka triglycerol i ke koko);
• Mālama i ka hoʻolilo kaupaona - kahi kūlana koʻikoʻi no ka mālama glycemic maikaʻi i nā mea maʻi me ka type 2 DS;
• Hoʻemi i ke koko hoʻohaʻahaʻa a me ke kaumaha o ka oxidative;
• Loaʻa ia i kahi hopena fibrinolytic ma ka hoʻopili ʻana i ka hoʻonaninani plasminogen kiko;
• Mālama i nā ʻōnaehana oncological (ma ka laulā, hoʻonui ka maʻi diabetes i ka nui o ka oncology ma ke 40%);
• Hoʻemi i ka pilikia o ka make mai nā hanana cardiovascular.

Ua nānā ʻia kahi hōʻike hoʻohālikelike o ka maʻi maʻi maʻi 5800 me ke ʻano maʻi type 2 i Kina. Ua loaʻa nā mea komo i ka hoʻokalakupua me ka metformin i hui pū me nā loli ʻano. I ka hui hoʻomalu, ua hoʻoponopono maoli nā mea hana ma ko lākou ola kino. No 63 mau mahina i ka hui mua, he 7.5 nā kānaka ma kahi o 1000 mau kānaka / mau makahiki, ma ka lua - no 45 mau mahina, e 11 mau kānaka.

Hoʻomaka ka lāʻau lapaʻau e hana i ʻelua mau hola ma hope o ke komo ʻana i ka esophagus, ua hoʻolālā ʻia kona pono no nā hola 12. ʻAʻole hoʻokomo ʻo Metformin i kahi hoʻoweliweli hypoglycemic. ʻO ka lāʻau lapaʻau me kahi waihona hōʻike ʻoi nui, ua hala i kahi hōʻike paʻa mau o ka manawa a pono i ka maʻi maʻi i nā manawa a pau o ka hoʻonui ʻana i ka ʻoihana.

I kēia mau lā, hāʻawi ke kūʻai aku i ka lāʻau lapaʻau i nā papa he 10 o nā lāʻau antidiabetic, akāʻo ka metformin ka mea kaulana loa no ka mālama ʻana i ka maʻi type 2 i kēlā me kēia manawa o ka maʻi.

ʻO ka hui pūʻohu synergistic o nā mea hana ʻelua o Glibomet ka hopena paʻakikī i ke kino.

1. Hoʻopuka i ka pancreatic - ka hōʻemi ʻana i ka lāʻau i ka "makapō" o nā sela, hoʻoulu i ka ʻōheu ʻana o kāna iho insulin, e pale aku i nā b-cell.
2. Hoʻopili ka hopena o ka pancreatic - ka biagudin e hoʻopili pololei i ka uaua a me ka momona momona, hōʻemi i ka gluconeogenesis, e hoʻonui i ka pākēneka o ka uptake glucose piha.

ʻO ka palena kiʻekiʻe o nā kikoo ikaika o nā mea ikaika e hiki ke hoʻoponopono nui i ka nui o ka lāʻau. No nā b-cells, he mea nui loa ka hoʻoulu ʻana o ka hōʻoluʻolu: hoʻonui ʻia ka palekana i ka lāʻau, hōʻemi i ka hōʻemi o kā lākou hana hana, a hōʻemi i ka hopena o ka hopena o ka hopena.

Hiki i nā maʻi Pharmacokinetic

Hoʻopili ʻia ʻo Glybenclamide mai ka gastrointestinal tract a hoʻoiho ʻia a hoʻokau maikaʻi loa ʻia - ma ka 84%, hiki ke nānā ʻia ka hopena nui o ka lāʻau lapaʻau ma hope o 1-2 mau hola. Hoʻopili ka māhele i nā ʻōnaehana koko ma 97%.

Hoʻolaha ka metabolible Glibenclamide i loko o ke akea, kahi e hoʻohuli ʻia i loko o nā mea i hana ʻole ai ka metabolites. ʻO ka hapalua o nā mea i hoʻopau ʻia e hele i waho o nā ʻōpū, ʻo kekahi ʻaoʻao ma o nā kumu o ka bile. ʻO ka hapalua hapalua ke ola i nā hola 10.

Hoʻopau piha ka Metformin i ka ʻōnaehana kūwili, lawe koke ʻia i nā ʻāpana a me nā io, ʻaʻole paʻa i nā palekō i ke koko a pau. ʻO ka bioavailability o nā mea kikoʻī mai 50-60%.

Ka laulā maʻamau, ka lōʻihi o ka minamina o nā mea o ke ʻano o ke ʻano i loko o ke koko e loaʻa i hoʻokahi hola a i ʻole ʻelua ma hope o ka lawe ʻana i ka paila.

Nā hōʻailona no ka mālama ʻana me Glybomet

Ua hōʻike ʻia nā ʻōkuhi pili ʻole ka lāʻau lapaʻau i kuhikuhi ʻia no ka maʻi diabetes type 2, me ka maʻi diabetes-dependence-like, inā he meaʻai kūikawā, ka hana kino dosed a me nā hopena hypoglycemic lapaʻau ʻaʻole i hāʻawi i ka hopena i hoʻolālā ʻia.

He nui nā hopena lapaʻau he nui inā pane ʻole ke kino i ka lāʻau lapaʻau, hoʻololi lākou i ka algorithm lapaʻau e ka kuhikuhi ʻana iā Glibomet i loko o nā papa.

Ka mea, ua hoʻonoho ʻia o ka hopena

Mai ka hopena o ka lāʻau lapaʻau ka hopena paʻakikī o ka pilikia, ʻaʻole ia he mea kupanaha no ka loaʻa ʻana o nā mea paʻa i ka hoʻokomo.

Hoʻopilikia i ka lāʻau.

• Me ka maʻi maʻi gestational;
• Inā loaʻa ka mea maʻi i ka manaʻo nui o nā mea o ka ʻano;
• ʻO ka maʻi diabetes me ke ʻano mua o nā maʻi;
• Me ka maʻi maʻi coma a me nā palena palena;
• Inā he mōʻaukala o ka ate a me nā hana ʻole;
• Ke kū nei ka creatinine i ka 110 mmol / l i nā wahine a me 135 mmol / l i nā kāne;
• ʻO nā mea maʻi me ka acidact lactic a i ʻole ketoacidosis;
• Inā loaʻa i ka maʻi diabetes ka hoʻonāukiuki ʻia e ka maʻi metabolic;
• Me ka hypoxia o nā ʻano genesis ʻē aʻe;
• Ma hope o nā hōʻeha, ka gangrene, ka maʻi, ka puhi ʻeha;
• Me ka mālama koʻikoʻi koʻikoʻi;
• ʻO ka maʻi maʻi i hōʻike ʻia me ka leukopenia, porphyria;
• Me nā mea ʻai pōloli me nā heluʻai he liʻiliʻi ma mua o 1000 kcal / lā .;
• Me ka waiʻona a me ka waiʻona meaʻala;
• Kamaliʻi liʻiliʻi;
• Nā makuahine hāpai a me lactating.

Pehea e lawe ai iā Glibomet

Ke kau nei nā kau palena iā Glibomet:

1. Me nā mākaʻi o nā kelena thyroid;
2. Inā he maʻi ka mea maʻi;
3. I ka manawa o kahi mōʻaukala o ka hypofunction o ka cortex cuitex a me nā kelepa adrenal.

Hoʻoholo ʻia ka dosage e ka endocrinologist e like me nā makahiki a me ke ʻano maʻi, akā ua hōʻike ka mea hana e hoʻomaka me ʻelua papa i kēlā me kēia lā, hopu mau i ka lāʻau. ʻO ka nui loa o ka lāʻau lapaʻau ka 2 g / lā. Hoʻouna ʻia e hāʻawi i ka hoʻokipa i nā manawa maʻamau. Inā ʻaʻole i loaʻa kēia kālā i ka hopena i manaʻo ʻia, ʻōlelo ʻia ka hoʻomaʻemaʻe ʻana me ka hoʻohui ʻana i nā lāʻau ikaika ikaika.

Nā hopena ʻaoʻao a me ka overdose

Nui nā hopena he hikiʻole ke hiki ke kiʻi ma hope o ka lawe ʻana iā Glibomet, akā ʻaʻole naʻe kēia kumu ke kumu o ka hōʻole ʻana i ka lāʻau lapaʻau, no ka mea, ʻo ka hoʻopōʻino i hōʻeha ʻia i ke kino e ka maʻi kīnā ʻole e ʻoi aku ka kiʻekiʻe ma mua o ka hiki mai o ka hopena o ka hopena.

I mea e pale aku ai i kēlā mau kūlana, he mea nui e helu pololei i kāu maʻa. Inā overestimated ka maʻamau, hoʻāla ka maʻi diabetes i ka pōloli pōloli, ka nalowale o ka ikaika, ka huhū, lima nui.

Hiki ke ʻano o ka hōʻailona o ka overdose ke tachycardia, ke kīwaha ʻana o ka ʻili, hoʻonui nui ʻia, nāwaliwali.

ʻO nā hopena hopena koʻikoʻi ma hope o ka lawe ʻana iā Glibomed, hypoglycemia e hōʻeha loa i kēia kūlana no nā poʻe maʻi e nawaliwali nei i kahi maʻi maʻi, maʻi maʻi o ka wā maʻi me ka maʻi diabetes, nā waiʻona, ka poʻe i komo i ka hana hoʻoikaika kino, a me nā mea āpau a ʻoi ka hapalua-a make ʻole. ua emi loa ma 1000 kcal / lā.) nā meaʻai.

ʻO nā hōʻailona maʻamau, ka mea maʻamau.

• Nāuliʻi;
• ʻO ka hōʻeha i ka epigastrium;
• Nā maʻi Dyspeptic;
• Nā ʻano like ʻole o nā ʻano kūlohelohe.

Inā hele mai kahi luhi pōkole o ka pōpilikia ma hope o ka lawe ʻana i nā papa, hiki ke hoʻopau ʻia e ka hōʻailona hōʻailona. Inā i ʻōlelo ʻia nā hōʻailona a hōʻailona ʻia nā hōʻailona o nā alerio, a laila pono ʻoe e koho i nā analogues no Glibomet.

Nā hopena hoʻopuka lāʻau lapaʻau

ʻO ka hoʻonui ʻana i ka hopena hypoglycemic o Glybomet i nānā ʻia i ka wā e pili ana i ka hopena me nā mea kikoʻī o ka decumarol, phenylbutamazone, β-blockers, oxytetracycline, allopurinol, cimetidine, ethanol, sulfinpyrazone i nā wai nui, probenecid, chloramphenicol, ka lāʻau nui, . ^ E Ha yM.

ʻO ka hui pū ʻana me nā hormone no ka thyroid gland, oral contraceptives, barbiturates, thiazide diuretics pale i ka hiki o Glibomet.

Nā ʻōlelo kikoʻī

Hoʻomaʻamaʻa koke ka hoʻohana ʻana o Glibomet i ka wā e loaʻa ai nā hōʻailona o ka acidosis lactic: nāwaliwali koʻikoʻi, luaʻi a me ka hōʻeha, ka ʻeha o ka ʻōpū, ʻeha i loko o ka ʻeha o ka ʻōpū. Pono ka mea i hili i ka haukapila.

Kauka ke aʻo i ka mālama ʻana me Glybomet e hele pū me ka nānā ʻana o ka creatinine i nā hōʻike koko. No nā mea maʻi me nā keiki olakino, pono ia hoʻokolohua i kahi liʻiliʻi i hoʻokahi manawa i ka makahiki, nā mea maʻi e pili pono ana ka nui o ka creatinine i nā palena palena o ke ʻano maʻamau, a pono e hoʻāʻo ʻia nā maʻi maʻi ʻo 2-4 mau makahiki i ka makahiki.

ʻElua mau lā ma mua o ka hoʻolālā ʻana o ka hoʻomaʻamaʻa ʻana, kahi ka hoʻohana ʻana i ka anesthesia spinal a epidural paha, e lawe ana i Glibomet e kāpae ʻia a hoʻololi ʻia ka maʻi maʻi i ka insulin. ^ E Ha yM. Hiki iā ʻoe ke hoʻihoʻi i ka papa o ka mālama ʻana me Glybomet ma hope o ka ʻae ʻana i ka mea maʻi i nā meaʻai kūpono. ʻOiai me nā pēpē maʻamau e hana ai, ke hoʻoholo nei ke kauka i kēia hoʻoholo ma mua o ʻelua mau lā ma hope o ka hana.

Pono ka mālama ʻana i nā paila e mālama ʻia i ka wā e hoʻokau nei i nā hana i hiki i ke ola i ke ola a me ke olakino, e like me ke kaomi ʻana i nā kaʻa. Hoʻopili kēia i ka pilikia o ka hypoglycemia, kahi emi o ka hopena o ka hopena psychomotor a me ka hiki ke hoʻoikaika.

ʻO nā hopena o ka mālama ʻana me Glibomet e hilinaʻi nui i ka pololei o ka hoʻokō ʻana i nā ʻōlelo aʻoaʻo i ʻōlelo ʻia i nā ʻōlelo a me nā ʻōlelo a ka endocrinologist: nā meaʻai a me ka hiamoe a me ka hoʻomaha ʻana, ka hana kino pilikino, ka mana o ka maʻi glycemic system, me ka home.

Ke hoʻohana ʻana i ka lāʻau lapaʻau, pono e hoʻokaʻawale i ka hoʻohana ʻana i ka wai ʻalani e like me ka mea hiki (ʻo ke ʻano ke aniani o ka ʻulaʻula maloʻo ʻekahi hoʻokahi manawa i ka hebedoma), no ka mea, e hoʻonāukiuki ana ka eʻai ʻana i ka hoʻomohala ʻana i ka glycemia, a me nā maʻi like ʻole a disulfiram - ʻeha i ka ʻāpaʻā epigastric, nā maʻi dyspeptic, pākaha wela i loko o ke kino ma luna a me ke poʻo; coordination, headache, palpitations.

He kumukūʻai o nā lāʻau lapaʻau a me nā lula mālama

Loaʻa iā Glybomet ma ke kaulahao kūʻai? Wahi a ka moku'āina, hiki ke kūʻai ʻia ka lāʻau lapaʻau no 200-350 rubles. ʻO kēlā me kēia pūʻulu o Glibomet, ke kiʻi o ke kiʻi e ʻike ʻia ma kēia ʻāpana, aia iā 40 papa.
No ka nalowale ʻana o ka lāʻau lapaʻau ka hana pono, pono ia e pale ʻia mai ka lā pololei a me ka haʻahaʻa kiʻekiʻe.

Nā lāʻau like ʻole

Inā ʻo Glibomed ma loko o ka loaʻa ʻana o ka pela paʻakai, ʻaʻole ia e hāʻawi i ka hopena i makemake ʻia, he allergy a i ʻole nā ​​hopena koʻikoʻi koʻikoʻi, ua hoʻololi ʻia ka lāʻau lapaʻau me nā mea hoʻomehana me kahi mea kūpono kūpono.

No Glibomed, hiki i nā lāʻau lapaʻau ke kau i nā papa Diabeton, nā mea hoʻomohala nui e pili ana i ka glyclazide, a i Dimaril paha, aia ka ʻano hana like me nā mea like o Glibomed, glimepiride.

ʻO nā lāʻau lapaʻau antidiabetic e like me ka hopena like, ʻo Gluconorm, Bagomet Plus, Glucovans, Glibenclamide i hui pū me Metformin, ua ʻōlelo ʻia ʻo Glucofast.ʻO ka poʻe endocrinologist kahi mea e hoʻololi ai, nāna nō e helu i ka dosage. Hiki ke loli ka hoʻoponopono ʻia ʻana: ʻoi aku ke ʻano o nā analogues ma ke ʻano paʻakikī a me ke ʻano o ka monotherapy, ma ka hoʻohui i ka ʻai haʻahaʻa a me ka hana kino.

ʻAʻole hiki i 100% hiki ke wānana ka pane o ke kino i nā lāʻau hou, no laila ʻo ka manawa mua loa hoʻolohe i nā ʻōuli a pau a hoʻomaopopo i ke kauka e pili ana i ka loli wikiwiki ʻana o ka paona, ke ākea, nā hopena o ka nānā ʻana i ka glycemia me kahi glucometer a me nā mea ʻē aʻe i ka manawa o ka hoʻololi ʻana i nā ala ʻē aʻe o nā hanana.

Hōʻikeʻike i nā hiʻohiʻona o Glibomet

E pili ana i nā loiloi o Glycomet e pili ana i nā maʻi maʻi i ka algorithm o kāna noi ma mua o ka hana pono.

Inā koho pololei ʻia nā dosage, he kūpono nā pane, i kekahi manawa aia nā mau kuhikuhi e pili ana i nā hopena ʻaoʻao. Akā no ka mea hoʻokahi kanaka kēia helu helu, hoʻokumu ʻia e pili ana i nā loiloi a me nā ʻano o ke ala o ka maʻi i kahi maʻi hoʻomanawanui, ʻo ka hoʻololi o ke ʻike i kēia ʻano he mea ʻole, a hiki i kekahi manawa kūpono ʻole ka hōʻino.

Ma ka hōʻuluʻulu ʻana i nā ʻōmaka āpau, hiki iā mākou ke manaʻo i ka Glibomed ke koho maikaʻi loa i ka laʻana no ka maʻi diabetes type 2: ke kumukūʻai kūpono, uku pālahalaha palekana, ka waiwai me ka mālama ʻana i ke kaumaha o ke kino, ka hopena maikaʻi i ka hopena cardiovascular a me ka hopena oncological.

ʻOiaʻiʻo, ʻaʻole hiki ke hoʻohana ʻia e nā mea āpau (e like me nā lāʻau hypoglycemic ʻokoʻa), akā pili ka lāʻau lapaʻau me nā kūlana o kēia wā a me ka maikaʻi o ka pilina.