ʻO Amaril ka lāʻau o ka hanauna hou

ʻO ka lāʻau lapaʻau ʻo Amaril no ka hoʻohana ʻana e hāʻawi i kahi loiloi ma ke ʻano he lāʻau lapaʻau hou o nā lāʻau lapaʻau e hakakā i ka maʻi type 2. ʻO kekahi o ka mea e hoʻohiki nui ai i kēia lā ʻo Glibenclamide-HB-419 mai ka hui sulfonylurea. ʻOi aku ma mua o ka hapalua o nā maʻi maʻi me ka ʻano lua ua ʻike iā ia.

Pharmacological hiʻohiʻona o ka lāʻau

ʻO Amaryl kahi lāʻau lapaʻau hypoglycemic i kōkua i ke kaohi ʻana o ka puna plasma. ʻO ke ʻano ikaika o ka lāʻau lapaʻau ka glimepiride. E like me kona mea i mua, ʻo Glibenclamide, ʻo Amaril nō hoʻi mai ka hui sulfonylurea, ka mea e hoʻonui ai i ka synthesis o ka insulin mai nā huina o nā papa pancreatic o Langerhans.

E hoʻokō i ka hopena i manaʻo ʻia, poloka lākou i ka kaila potasi o ka ATP me ka māhuahua o ka naʻau. Ke hoʻopaʻa 'ia ai ka sulfonylurea i nā mea ʻona e kū ana ma nā membrane cell-cell, e loli ka hana o ka mana K-AT. Ke kāohi nei i nā lānai o ka calcium me ka hoʻonui o ka pae ʻana o ka ATP / ADP i ka cytoplasm e hoʻonāukiuki i ka depolarization membrane. Hoʻopuka kēia i ka hoʻokuʻu i nā ala o ka calcium a hoʻonui i ka hoʻoili ʻana o ka calcium cytosolic.

ʻO ka hopena o ka hoʻonāukiuki o ka exocytosis o nā granule secretory, ʻo ia ke kiʻi o ka excretion o nā pūhui i loko o ka medium intercellular e nā sela, ke hoʻokuʻu i ka insulin i ke koko.

ʻO Glimepiride ka mākana o ka hanauna 3 o ka sulfonylureas. Hoʻopuka ia i ka hoʻokuʻu ʻana o ka hormone pancreatic, a hoʻonui i ka naʻau o ka insulin i ka protein a me nā lipid cell.

ʻO nā jaringan peripheral e hoʻoulu i ka glucose e hoʻohana nui ana i nā kahe o ka lawe ʻana mai nā membrane cell. Me kahi ʻano nīnūnē ʻole o ka insulin, ua hoʻolōʻihi ʻia ka hoʻololi ʻana o nā meli i loko o nā lau. Hoʻolaha ʻo Glimepiride i ka hoʻonui ʻana o ka nui o nā protein o ka halihali a hoʻonui i kā lākou hana. Kēia mea nā mana pancreatic ikaika e ho'ēmi i ka pale ʻana i ka insulin (insensitivity) i ka hormone.

Mālama ʻo Amaryl i ka hoʻohuihui ʻana o ka glucogen e ka ʻōpū ma muli o ka hoʻonui ʻana i ka nui o ka puʻu fructose-2,6-bisphosphate me ka antiaggregant (ʻāwili ʻana o ka hoʻokumu ʻana o thrombus), antiatherogenic (hoʻemi i nā kuhikuhi o ka "bad" kolesterol) a me nā antioxidant (regenerative, anti-aging). Hōʻemi nā kaʻina o ka oxidation ma muli o ka hoʻonui i ka ʻike o ka endogenous b-tocopherol a me ka hana a nā hana antioxidant.

ʻO ka Pharmacokinetics o ka lāʻau

I ka huiʻana o Amaril, ka māhele koʻikoʻi o ka glimepiride mai ka hui sulfonylurea. ʻO Povidone, lactose monohidate, magnesium stearate, cellulose microcrystalline a me nā ʻoni E172, E132 e hoʻohana ʻia ma ke ʻano he filler.

Hoʻopilikia ke ʻAmaryl i nā enzyme o 100% no laila, ʻaʻole i hoʻoweliweli ka hoʻohana ʻana i ka hōʻemi i ka hōʻiliʻili ʻana o kona nui ma nā wahi a me nā kiko. Ma muli o ke kaʻina hana, ua hoʻokumu ʻia nā hua ʻelua o ka glipemiride: hydroxymetabolite a me carboxymethabolite. Hāpai ka metabolite mua me nā waiwai o ka pharmacological i hoʻolako i kahi hopena hypoglycemic paʻa.

I loko o ke koko, e ʻike ʻia ka nui o nā kikoʻī o ka hana ikaika ma hope o nā hola ʻelua a me ka hapa. Loaʻa i ka bioavailability piha loa, ʻaʻole ka palena o ka lāʻau lapaʻau i ka maʻi maʻi i ke koho o nā huahana meaʻai me kahi e "hopu" ai ia i ka lāʻau lapaʻau. ʻO ka asimilasi ma kekahi hihia he 100%.

Hoʻomaopopo ka hoʻomaikaʻi nui ʻana i nā maʻi glycemic a me nā pilikia hana me ka ate, ʻoi aku, ma ka wā ʻelemakule (ʻoi aku ma mua o 65 mau makahiki) a me ka hoʻopiʻi ʻana o ka ate, he maʻi maʻamau ke kumu o ka hana.

Pehea e hoʻohana ai iā Amaryl

Hoʻohana ʻia kahi lāʻau lapaʻau i ke ʻano o nā papa oval me ka ʻoka hoʻokaʻawale, e hiki ai iā ʻoe ke wehe iki i ka maʻi i nā halves. Kuhi ka papa o nā papa i ka pāhau: 1 mg o glimepiride - pink ʻula, 2 mg - greenish, 3 mg - ʻono.

ʻAʻole koho ʻia kēia hoʻolālā e nā ala kūpono ʻole: inā hiki ke hoʻokaʻawale ʻia nā papa ma ke kala, ʻo ia ka hoʻēmi i ka nui o ka hōʻeha o ka overdose, keu i nā mea maʻi.

Hoʻopaʻa ʻia nā papa i nā palaka o nā 15 pcs. Hiki i kēlā me kēia pahu i nā papa like 2 a 6.

Nā hiʻohiʻona o ka hoʻohana ʻana iā Amaril:

1. Paʻa ʻia ka papa ʻaina (a ʻāpana paha) a holoi ʻia me ka wai ma ka liʻiliʻi o 150 ml. Ma hope koke o ka lawe ʻana i ka lāʻau lapaʻau, pono ʻoe eʻai.
2. Koho i ka endocrinologist i ka hoʻoponopono lāʻau lapaʻau e like me nā hopena o ka nānā ʻana o nā kuʻuna o nā mea ola.
3. E hoʻomaka i ka papa me nā hapa liʻiliʻi o Amaril. Inā ʻaʻole ma kahi o 1 mg ma hope o kekahi manawa ke hōʻike nei i ka hopena i hoʻolālā ʻia, hoʻonui ʻia ke kiʻekiʻe.
4. Hoʻoponopono iki ʻia ka lāʻau i loko, i loko o nā hebedoma 1-2, no ka manawa ke manawa ke hoʻololi nei ke ʻano o nā kūlana hou. I kēlā me kēia lā, hiki iā ʻoe ke hoʻonui i ka nui ma mua o ka 1 mg. ʻO ka palena kiʻekiʻe loa o ka lāʻau lapaʻau he 6 mg / lā. Hoʻoholo ʻia kahi kau palena pilikino e ke kauka.
5. Pono e hoʻoponopono i ka pākaukau me ka loli o ka paona o ka maʻi maʻi a i ʻole ka nui o nā ukana o ka hoowalewale, me ka hōʻeha a me ka hopena o ka hypoglycemia (i ka wā pōloli, ka pōʻino, ka hōʻemi ʻona, nā keiki a me nā pilikia o ke ake).
6. Hoʻohana ʻia ka manawa hana a me ka dosage i ke kaohi o ke ola a me nā hiʻohiʻona o ka metabolism. ʻO ka maʻamau, hoʻokaʻawale kahi hoʻokele hoʻokahi o Amaril i kēlā me kēia lā me ka hoʻopili pono ʻana me ka meaʻai. Inā piha ka ʻaina kakahiaka, hiki iā ʻoe ke inu i ka popo i ke kakahiaka, inā he hōʻailona - he maikaʻi loa ke hoʻohui ʻana i ka hoʻokipa me ka ʻaina awakea.
7. Hōʻike hoʻoweliweli ka nui o ka overdose me ka hypoglycemia, i ka wā o ka huapalapala i loko o ka lymph e hāʻule i ka 3.5 mol / L a i lalo. Hiki i ke kūlana he lōʻihi loa: mai 12 mau hola a i 3 lā.

Loaʻa nā papa ʻaʻa Amaryl (i loko o kahi pahu o nā ʻāpana 30) no ke kūʻai ʻana aku ma ke kumu kūʻai.

• 260 ʻōpala - 1 mg pākahi;
• 500 rub - 2 mg i kēlā me kēia;
• 770 rub. - 3 mg i kēlā me kēia;
• 1020 ʻōpala. - 4 mg i kēlā me kēia.

Hiki iā ʻoe ke loaʻa nā paʻi o ka 60, 90,120 ʻāpana o nā papa.

Hoʻohui hou aʻe nā lāʻau lapaʻau

ʻO ka maʻi maʻamau, ʻoi aku ka "me ka ʻike", ma ke ʻano he kānāwai, he ʻāpana piha o nā hoʻopiʻi kikowaena: hypertension, puʻuwai a me nā pilikia vascular, nā hana hoʻohālikelike o ka metabolic, a me nā puʻuwai a me nā puʻuwai. Me kēia pahu, pono ʻoe e lawe i nā lāʻau lapaʻau wale nō.

No ka pale ʻana i nā hōʻino o nā moku koko a me ka puʻuwai, ua kau ʻia nā lāʻau lapaʻau me ka aspirin. Hoʻokuʻu ʻia ʻo Amaryl iā ia mai nā ʻōnaehana protein, akā e loli ʻole ka pae o ke koko. E loli paha ka hopena holoʻokoʻa o ka hoʻohana ʻana.

Hoʻokāʻoi 'ha awina AMARE kona hou i ka insulina, Allopurinu, coumarin nā mea loaʻa, anabolic steroid, guanethidine, chloramphenicol, fluoxetine, fenfluramine, pentoxifylline, Feniramidolu, fibricʻakika nā mea loaʻa, phenylbutazone, miconazole, azapropazone, probenecid, quinolones, oxyphenbutazone, salicylates, tetracycline, sulfinpyrazone, Tritocqualin a me sulfonamides.

Ua hōʻemi ʻo Amaril i ka hiki ke hoʻohui i ka Epinephrine, glucocorticosteroids Diazoxide, laxatives, Glucagon, barbiturates, Acetazolamide, saluretics, thiazide diuretics, acid nikotinic, Phenytoin, Phenothiazine, Rifampicin, Chlorpromazine, a me ka progestin.

Amaryl hoʻohui hīmeni H2 contactor blockers, reserpine a me clonidine hāʻawi i kahi hopena i manaʻo ʻole ʻia e nā hāʻule iho o ka glucometer ma kahi āpau. Loaʻa kahi hopena like i ka hoʻokomo ʻana i ka waiʻona a me Amaril.

ʻAʻole pili ka lāʻau lapaʻau i ka hana o nā inhibitor ACE (Ramipril) a me nā mea anticoagulant (Warfarin) i kekahi ʻano.

Nā kikowaena Hypoglycemic

Inā kū pono iā ia kekahi lāʻau hypoglycemic me Amaril, hoʻokaʻawale ʻia nā mea laʻa liʻiliʻi (1 mg), i loko o nā hihia i loaʻa ai i ka mea maʻi ma mua nā lāʻau lapaʻau nui loa. ʻO ka mea mua, ke nānā ʻia nei ka hopena o ka mea maʻi me nā hebedoma ʻelua, a laila hoʻoponopono ʻia ke ʻano.

Inā hoʻohana ʻia kahi antidiabetic me ka hapalua hapalua i mua o Amaril e pale ai i ka hoʻomohala ʻana o ka hypoglycemia, pono kahi hoʻomaha no kekahi mau lā ma hope o ka hoʻopau ʻia.

Inā hiki i ka maʻi lolo ke hoʻomau i ka hiki o ka pancreas e hana i kona iho ponoʻī, a laila hiki i nā inikini insulin hiki ke 100% ke hoʻololi iā Amaryl. Hoʻomaka ka papa ʻana me ka 1 mg / lā.

Ke ʻole ka ʻae ʻana i ka hoʻonaʻauao hoʻonaʻauao ʻo Metformin ma ke kō i ka holo ʻana i ka maʻi ʻaihue, hiki ke hoʻohui ʻia i 1 mg o Amaril. Inā ʻaʻole ʻoluʻolu nā hopena i ka hopena, e hoʻololi lohi ʻia ka maʻamau i 6 mg / lā.

Inā ʻaʻole i ola i ka hoʻolālā ʻo Amaril + Metformin i nā manaʻo, ua hoʻololi ʻia e Insulin, ʻoiai e mālama ana i ka ʻōlelo maʻamau ʻo Amaril. Hoʻomaka kekahi injections Insulin me ka liʻiliʻi liʻiliʻi. Inā ʻaʻole paipai nā hōʻailona o ka glucometer, hoʻonui i ka nui o Insulin. Hoʻohana maikaʻi ka hoʻohana ʻana i nā lāʻau lapaʻau, ʻoiai e hiki iā ʻoe ke hōʻemi i ka hoʻokomo ʻana o ka hormone ma o 40% hoʻohālikelike ʻia me ka lāʻau lapaʻau kino maʻemaʻe.

Ma kahi o Amaril, loaʻa i ka endocrinologist nā koho no nā analogues: Amaperid, Glemaz, Diapyrid, Diameprid, Glimepiride, Diagliside, Reclide, Amix, Glibamide, Gllepid, Glayri, Panmicron, Glibenclamide, Gligenclad, Glliblik Dimari, Dimari, Dimari, Dimari Glimaril, Glyclazide, Manil, Maninil, Glimed, Glioral, Olior, Glynez, Glyrid, Gluktam, Glypomar, Glyrenorm, Diabeton, Diabresid.

No ka mea ua manaʻo ʻia ʻo ia, a i ʻole ʻia e kau ʻia ka lāʻau lapaʻau

Ua kūkulu ʻia ka lāʻau lapaʻau no ka mālama ʻana i nā maʻi diabetes type 2. Hoʻohana ʻia ia me ka monotherapy a ma ka mālama ʻia paʻakikī ma ka ʻaoʻao me Metformin a i ʻole Insulin.

Ua loaʻa i ka hāmeʻa ikaika ʻo Amaril ka pale i ka plasenta, a ke komo aku nei ka lāʻau i ka waiū umauma. No kēia kumu, ʻaʻole kūpono ia no nā māmā a me ka lactating. Inā makemake ka wahine e lilo i makuahine, ʻoiai ma mua o ka hāpai ʻana o kahi keiki, pono ia e hoʻoneʻe i ka inikini insulin e ʻole ʻo Amaril. No ka manawa hānai, mālama ʻia kēlā mau koho, inā naʻe he pono no ka mālama ʻana me Amaril, e hoʻopau ʻia ka umauma.

Hoʻohana ʻole ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau i ka maʻi maʻi maʻi coma a me ke ʻano i mua o ka coma. Ma nā hopena hoʻonā o ka maʻi maʻi (e like me ke ketoacidosis), ʻaʻole i hoʻohui ʻia ʻo Amaryl. ʻAʻole kūpono ia ka lāʻau lapaʻau no nā maʻi maʻi me ka maʻi like ʻole.

Me nā hana hana pono o nā aʻalā a me nā puʻuwai, ʻaʻole pono ʻo Amaril, ʻaʻole hōʻike ʻia ʻo Amaril no ka hemodialysis a me nā maʻi maʻi maʻi maʻi, a me ke ʻano ʻole o ka intolerance pilikino i ka glipemiride a i ʻole nā ​​lāʻau'ē aʻe o ka papa sulfonamide a me ka sulfonylurea.

Me ka paresis peʻe a i ʻole a me nā pale i ka ʻawa, pilikia ka hoʻopili ʻana o nā lāʻau lapaʻau, no laila ʻaʻole kuhikuhi ʻo Amaril i kēlā mau pilikia i ka wā o ka exacerbation Pono lākou i ka hoʻololi ʻana i ka insulin a me nā hōʻeha he nui, nā hōʻeha, nā maʻi kiʻekiʻe, ke koʻikoʻi koʻikoʻi.

Me Amaril i hui pū ʻia me nā hopena hypoglycemic. I kekahi manawa e hoʻopiʻi nei ka poʻe maʻi i ka maʻi ʻawaʻawa, ʻoi aku ka pōʻino o ka maikaʻi o ka hiamoe, aia nō ke kaʻe, nā kahe ʻana nui, a me nā maʻi haʻi. Ma ka maʻi diabetes, loaʻa pinepine nā hihia o ka pōloli ʻole, ka maʻi dyspeptic, ʻehaʻeha ma ka ʻaoʻao o ke ake. Hiki paha ke kalepa maikaʻi ʻole o ka ʻōpū o ka puʻuwai, kahi koʻikoʻi ma ka ʻili. Kūʻē ke kahe o ke koko i kekahi manawa.

Nā hopena o kahi overdose

ʻO ka hoʻohana lōʻihi ʻana i ka lāʻau lapaʻau, me ka overdose koʻikoʻi, hiki ke hoʻonāukiuki i ka hypoglycemia, nā hōʻailona o ka mea i hōʻike ʻia i ka pauku i hala.

Pono ka maʻi maʻi maʻi i kahi palapala aʻo i kahi hōʻike pōkole o kāna maʻi a me kekahi mea mai nā momona o ka wikiwiki (kaila, nā kuki). ʻOluʻolu pū kekahi wai a iʻa paha kekahi, ʻaʻole wale me nā mea momona maoli. Ma nā pilikia koʻikoʻi, pono e hoʻokaʻawale loa ka mea maʻi i ka gastric lavage a me ka hoʻokele ʻana i nā mea hoʻoikaika (i hoʻāla ka carbon, etc.).

Nā hopena hopena

Ma nā hihia pinepine, ʻo ka hoʻohana pū ʻana o Amaril i hele pū me ka hopena o ka hopena i ke ʻano o ka lilo ʻana o ka hihiʻo, nā pilikia me ka kaʻai o ka uila, nā maʻi o ka hoʻokalakupua, nā pilikia o ka gastrointestinal.

I waena o ka maʻamau maʻamau:

1. ʻO ke ʻano o ka maʻi glycemic, kahi hiʻohiʻona i ka nalowale o ka ikaika, kahi i hoʻokaʻawale i ka hoʻoweliweli, ka nalowale o ka ʻike, arrhythmia, ka huhū i ka pōloli, ka ʻalohilohi loa.
2. ʻO nā ʻokoʻa i loko o nā kuhikuhi gula, hoʻonāukiuki i ka ʻike maka ʻana.
3. ʻO ka maʻi Dyspeptic, ka halaʻole o ka nīneʻe o ka defecation, i nalowale i ka wā e hoʻihoʻi ana ka lāʻau.
4. Allergies of variing Severity (papaleka ke kino, ʻeha, hives, alika vasculitis, shock anaphylactic, kahaha ke koko a me ka pōkole o ka hanu).

Ke hopu nei iā Amaril e pili pono ana i ka wikiwiki o ka hopena psychomotor - ke kaʻa ʻana i kahi kaʻa, a me ka hana e koi ana i ka huli ʻana, ʻoi aku hoʻi i ka hoʻomaka ʻana o ka maʻi, ʻaʻole ia i kūpono me ko ke ʻano ʻo Amaril.

Hoʻoholo i nā kauka a me nā maʻi maʻi e pili ana iā Amaril

ʻO nā loiloi o ka endocrinologists e hālāwai me kēlā me kēia lā i nā hōʻike āpau o ka maʻi ʻehaʻeha kahi waiwai nui, no ka mea, ua loaʻa iā lākou ka manawa kūpono e hoʻopaʻa i nā maʻi ʻana o ka poʻe maʻi i ka lāʻau lapaʻau i mea e loaʻa ai nā manaʻo e pili ana i kona pono.

Wahi a nā kauka, me ka ulu lāʻau mālama kūpono i hoʻoponopono ʻia, kōkua ʻo Amaril e hoʻomaʻamaʻa i nā ʻōlaʻi glycemic wikiwiki. ʻO ka hoʻomokoke ʻana i ka lāʻau lapaʻau he mau hoʻopiʻi o ka hypoglycemia inā koho maikaʻi ʻia ka hala. A ʻoiai, e pili ana i ka lāʻau lapaʻau Amaril, he hoʻomanawanui ka loiloi o ka maʻi.

ʻO ka meaʻai o ka haʻahaʻa-low, ka hana kino dosed, ka hopena koʻikoʻi ka hopena i ka hopena o ka hoʻomaʻamaʻa Amaril. Pono ka maʻi maʻi i ka endocrinologist i ka manawa e pili ana i nā hopena hopena, nā hōʻailona o ka hypo- a me ka hyperglycemia e ulu pū me Amaril.

Hoʻomaʻamaʻa ʻia ka mālama ʻana i ka mālama pono ʻole i nā mākau me ke nānā ʻana i nā hana ate, ka hoʻokolohua ʻana o ka limahana, ka hoʻāʻo ʻana no ka hemoglobin glycated, i kēia lā ka mea i ʻike ʻia i ke ʻano nui loa o ka mālama ʻana i ke ʻano o kahi mea maʻi me ka maʻi maʻi. E kōkua kēia i ka hōʻoia ʻana i ke kūʻokoʻa o ka pale ʻana iā Amaril no ka hoʻoponopono ʻana i ka hoʻoponopono lāʻau lapaʻau.

Hiki iā ʻoe ke aʻo e pili ana i nā hiʻohiʻona hou o Amaril mai ke wikiō.