Hoʻohana ʻia nā ʻano lāʻau like ʻole me ke ʻano o ka maʻi maʻi.
No ke ʻano 1, kuhikuhi ʻia nā insulins, a no ke ʻano 2, hoʻomākaukau nui ʻia nā papa papa.
ʻO nā lāʻau lapaʻau kōkō haʻahaʻa ka poʻe Glucovans.
ʻO ka ʻike nui o ka lāʻau lapaʻau
ʻ .lelo Metformin
ʻO Glucovans (glucovance) - kahi lāʻau lapaʻau paʻakikī e loaʻa ana kahi hopena hypoglycemic. ʻO kāna mea kūʻokoʻa ka hui ʻana o nā mea hana ʻelua o nā hui lāʻau lapaʻau like nui o ka metformin a me glibenclamide. Hoʻonui kēia hōʻuluʻulu i ka hopena.
ʻO Glibenclamide kahi mākaʻi o nā makahiki 2 o nā derivatives o ka olakololina. Hoʻomaopopo ʻia e like me ka ʻoi aku ka hopena maikaʻi loa ma kēia pūʻulu.
ʻIke ʻia ʻo Metformin he lāʻau lapaʻau mua-kulana, i hoʻohana ʻia ma ka haʻalele ʻana o ka hopena o nā lāʻau lapaʻau. ʻO ke kinona, i ka hoʻohālikelike ʻana me ka glibenclamide, he haʻahaʻa ka haʻahaʻa o ka hypoglycemia. ʻO ka hui pūʻana o nā māhele ʻelua e hiki ai iā ʻoe ke hoʻokō i kahi hopena e hiki ke hoʻonui i ka pono o ka hana ʻana.
ʻO ka hana o ka lāʻau lapaʻau ma muli o 2 mau mea ikaika - glibenclamide / metformin. Hoʻohui i kahi papa inoa, ua hoʻohana ʻia nā magnesium stearate, povidone K30, MCC, sodium croscarmellose.
Loaʻa i ka papa pālapa ma ʻelua mau palapala: 2.5 mg (glibenclamide) +500 mg (metformin) a me 5 mg (glibenclamide) +500 mg (metformin).
Ka hana lāʻau lapaʻau
Pākuʻi Glibenclamide
ʻO Glibenclamide - poloka i nā wahala pālolo a hoʻoulu i nā ʻāpana pancreatic. A ke hopena, hoʻonui ʻia ka hoʻonaʻauao hāmeʻe, e komo i loko o ke kahe a me ke kaila intercellular.
ʻO ka hana pono o ka hoʻoulu ʻana i ka hiona huna e kau ʻia ana i ka hana i lawe ʻia. Hoʻemi i ke kō i loko o nā mea maʻi me ka maʻi a me ka poʻe olakino.
Metformin - pale i ka hoala o ka glucose i loko o ka ate, hoʻonui i ka hoʻowalewale o nā ʻili i ka hormone, pale i ka hoʻāʻo ʻana o ka glucose i loko o ke koko.
ʻAʻole i like glibenclamide, ʻaʻole ia e hoʻoulu i ka synthesis synt. Eia kekahi, he hopena kūpono ma ka profil lipid - kūlou kolamu, LDL, triglycerides. ʻAʻole e hōʻemi i ka pae mua o ka kō i loko o nā kānaka olakino.
Lapaʻau lāʻau
Hoʻopau ikaika ʻo Glibenclamide ma muli o ka ʻai ʻana o ka meaʻai. Ma hope o nā hola 2.5, ua hōʻea kona kiʻekiʻe i loko o ke koko, ma hope o nā hola 8 e emi iki ana ia. ʻO ka hapalua-ola he 10 mau hola, a ʻo ka hoʻopau piha ʻana he 2-3 lā. Hoʻoweliweli a komo i loko o ka ate. Hoʻopili ʻia ka waiwai i ka urine a me ka bile. ʻO ka nakinaki ʻana i nā protein plasma ʻaʻole iʻoi aku ma mua o 98%.
Ma hope o ka lawelawe waha, ua piha like ke metformin. E ʻai ana ka ʻai i ka hoʻopili ʻana o ka metformin. Ma hope o nā hola 2.5, ua loaʻa ka pae kiʻekiʻe o ka waiwai; e haʻahaʻa ia i ke koko ma mua o ke kaila koko. ʻAʻole ia i hoʻohuli ʻia a haʻalele ʻole i nā lau. ʻO ka hapalua hapalua-ola he 6.2 mau hola.ʻO ka excreted ka nui me ka urine. ʻAʻohe waiwai nui ka kamaʻilio ʻana me nā protein.
ʻO ka bioavailability o ka lāʻau e like me nā hoʻokaʻawale kaʻawale o kēlā me kēia ʻano ikaika.
Nā hōʻailona a me nā contraindications
Ma waena o nā hōʻailona no ka lawe ʻana i nā papa Glucovans:
- ʻO ka maʻi diabetes type 2 i ka loaʻa ʻole o ka hopena o ka mālamaʻana i nā meaʻai, ka hana kino;
- ʻO ka maʻi diabetes type 2 i ka haʻalele ʻana o ka hopena i ka wā o ka monotherapy me nā Metformin a me Glibenclamide;
- i ka wā e hoʻopihapiha ai i ka mālama ʻana i nā mea maʻi me kahi kaohi o ka glycemia.
ʻO nā hoʻohalike e hoʻohana ʻia nā:
- ʻO ka maʻi mellitus type 1;
- hypersensitivity a sulfonylureas, metformin;
- hypersensitivity i nā māhele ʻē aʻe o ka lāʻau;
- hana lima kino;
- hapai / lactation;
- diabetes ketoacidosis;
- hoʻoweliweli kaʻaila;
- lactic acidosis;
- mai ka waiʻona make;
- ʻaʻano pāʻālua;
- makahiki o na keiki;
- hana ʻole naʻau;
- ke aho hanu;
- maʻi ʻino loa;
- puʻuwai puʻuwai;
- porphyria;
- paʻa inoa ʻole.
Nā ʻōkuhi no ka hoʻohana
Hoʻonohonoho ʻia ka dosage e ke kauka, i ka ʻike i ke kiʻekiʻe o ka glycemia a me nā ʻano pilikino o ke kino. ʻO ka maʻamau, hiki i ka regimen mālama maʻamau ke ʻano me ka i kuhikuhi ʻia. ʻO ka hoʻomaka ʻana o ka lāʻau maʻi hoʻokahi i kēlā me kēia lā. I mea e pale ai i ka hypoglycemia, ʻaʻole pono ia e ʻoi aku ma mua o ke ʻano o ka mua o ka metformin a me glibenclamide ʻokoʻa. ʻO ka hoʻonui, inā pono, e lawe ʻia ana i kēlā me kēia 2 a i hoʻokahi pule paha.
I nā hihia o ka hoʻoneʻe ʻana mai kahi lāʻau i Glucovans, e kuhikuhi ʻia ana ka lāʻau lapaʻau i ka mālama ʻana i nā hana i hala mua o kēlā me kēia mea ikaika. ʻO ka nui o kēlā me kēia lā i hoʻokumu ʻia he mau ʻāpana o 5 + 500 mg a i ʻole 6 mau kō o ka 2.5 + 500 mg.
Hoʻohana ʻia nā papa pili i ka meaʻai. I mea e hōʻemi ai i ka liʻiliʻi o ka glucose i ke koko, e hana i kahi ʻai i kiʻekiʻe ma nā puʻukū i kēlā me kēia manawa ke lawe ʻoe i ka lāʻau.
Nā wikiō mai Dr. Malysheva:
ʻO nā maʻi kūikawā
ʻAʻole i kuhikuhi ʻia ka lāʻau lapaʻau i ka wā o ka hoʻolālā a i ka wā hāpai. I kēlā mau kūlana, e hoʻoneʻe ʻia ka mea maʻi i ka insulin. Ke hoʻolālā i kahi hāpai, pono ʻoe e hoʻomaopopo i kāu kauka. Ma muli o ka nele o nā noiʻi noiʻi, me ka lactation, ʻaʻole hoʻohana ʻia ʻo Glucovans.
ʻAʻole i kuhikuhi ʻia nā mea maʻi kahiko (> 60 mau makahiki). ʻAʻole makemake ʻia ka poʻe e hana i ka hana kaumaha koʻikoʻi e lawe i ka lāʻau lapaʻau. Ua pili kēia me nā pilikia kiʻekiʻe o ka acidact lactic. Me ka anemia megoblastic, pono e noʻonoʻo ʻia ua kani ka lāʻau i ka haʻalulu ʻana o ka B 12.
Nā ʻōlelo kikoʻī
Hoʻohana me ka mālama aka ʻana i nā maʻi o ka nui o ka hoʻopuni thyroid, nā kūlana febrile, ka nele adrenal. ʻAʻohe lapaʻau i kuhikuhi ʻia no nā keiki. ʻAʻole ʻae ʻia nā Glucovans e hoʻohui pū me ka wai ʻona.
E hele pū ʻia ka ʻāria me ke kaʻina no ka ana ʻana i ka kōʻai ma mua / ma hope o ka ʻaina. Manaʻo ʻia no ia e nānā i ka ʻike kukui. I kahi hihia o ka hana renal i loko o ka pākeke, ke mālama ʻia nei ka mālama ʻana i 3-4 mau manawa i ka makahiki. Me ka hana maʻamau o nā mea maʻi, ua lawa ka lawe ʻana i kahi loiloi i hoʻokahi makahiki i ka makahiki.
48 mau hola ma mua / ma hope o ka hana, hoʻopau ʻia ka lāʻau lapaʻau. ʻO 48 mau hola ma mua / ma hope o kahi hulina X-ray me kahi mea radiopaque, ʻaʻole i hoʻohana ʻia ʻo Glucovans.
ʻO ka poʻe me ka nele i ka naʻau ua loaʻa i ka nui o ka uluʻana o ka hoʻoulu ʻana o ka pūpū me ka hypoxia. Paipai ʻia ka ʻike ikaika ʻana i ka naʻau a me ka hana.
Loaʻa i ka ʻaoʻao a me ka overdose
Ma waena o nā hopena ʻaoʻao i ka wā o ka intake ka nānā ʻana:
- ka mea maʻamau loa he hypoglycemia;
- lactic acidosis, ketoacidosis;
- kuʻe o ka hoʻāʻo;
- thrombocytopenia, leukopenia;
- hoʻonui i nā creatinine a me urea i ke koko;
- nele i ka momona a me nā pilikia ʻē aʻe o ka gastrointestinal tract;
- urticaria a ʻeha ka ʻili o ka ʻili;
- hana ino i ka hana ate;
- hepatitis;
- hyponatremia;
- vasculitis, erythema, dermatitis;
- nā wahi hūnā ʻia o ke ʻano kūʻokoʻa.
Ma kahi o kahi overdose o Glucovans, hiki i ka hypoglycemia e ulu ma muli o ka loaʻaʻana o glibenclamide. Ke lawe ʻana i ka 20 g o ka glucose i mea e pale ai i ka māmā o ka mahele o ke kaumaha. ʻOi aku, hana ʻia ka hoʻoponopono ʻia ʻana, ʻike ʻia ka mea ʻai. Pono ka hypoglycemia koʻikoʻi e mālama i ka mālama a hiki i ka hoʻokipa. Hiki i ke overdose nui ke alakaʻi i ka ketoacidosis ma muli o ka heleʻana o ka metformin. Hoʻohana ʻia kahi ʻano like ʻole i ka haukapila. ʻO ke ala kūpono ʻo ka hemodialysis.
Hoʻopili me nā lāʻau lapaʻau ʻē aʻe
Mai hoʻohui i ka lāʻau lapaʻau me phenylbutazone a danazole. Inā pono, mālama pono ka mea maʻi i ka hana. Hoʻemi ka ACE inhibitors i ke kō. Hoʻonui - corticosteroids, chlorpromazine.
ʻAʻole i ʻōlelo ʻia ʻo Glibenclamide e hui pū me ka miconazole - ʻo ia ʻano hoʻopilikia e hoʻonui i ka hopena o ka hypoglycemia. Ke hoʻoikaika nei i ka hana o ka mea hiki ke lawe ʻoiai e lawe ana iā Fluconazole, anabolic steroid, clofibrate, antidepressants, sulfalamides, male kāne, Coumarin derivatives, cytostatics. ʻO nā hormones wahine, nā hormone thyroid, glucagon, barbiturates, diuretics, sympathomimetics, corticosteroids i ka hopena o ka glibenclamide.
Me ka hoʻomohala pinepine ʻana o ka metformin me ka diuretics, hiki i ka hiki ke hoʻomohala i ka hoʻōho lactic acidosis. ʻO nā mea momona o Radiopaque i ka wā e hui pū ai e hoʻonāukiuki i ka hana o ka palaka Hōʻalo ʻaʻole wale ka hoʻohana ʻana i ka waiʻona, akā, ʻo ka lāʻau lapaʻau pū me nā mea i loko o ia mea.
Hōʻike hou, ʻikepili
ʻO ke kumukūʻai o ka lāʻau lapaʻau ʻO Glukovans he 270 mau rubles. ʻAʻole pono i nā kūlana mālama. Hoʻokuʻu ʻia e ka papa lāʻau. ʻO 3 mau makahiki kahi ola.
Ke Hana - Merck Sante, Farani.
ʻO ka analogue kūloko (ʻo nā mea ikaika a ʻoihana hoʻohui) ʻo Glybomet, Glybofor, Duotrol, Glukored.
Aia kekahi mau hui pū kekahi o nā hana ikaika (metformin a me glycoslide) - Dianorm-M, metformin a glipizide - Dibizid-M, metformin a glimeperide - Amaryl-M, Douglimax.
Hiki i nā mea pili ke kala me nā mea ikaika. Glucofage, Bagomet, Glycomet, Insufort, Meglifort (metformin). ʻO Glibomet, Maninil (glibenclamide).
Hoʻohālikelike Opisina
Hoʻomaopopo nā loiloi hoʻomanawanui i ka hiki o nā Glucovans a ma kahi kumukūʻai kūpono. Eia hoʻi ʻōlelo ʻo ke ana o ke kōpaʻa ʻo ka wā e lawe nei i ka lāʻau lapaʻau e pono pinepine ai.
I ka wā mua ua lawe ʻo ia i Glucophage, ma hope o ka hoʻonā ʻia ʻana e ia ʻo Glucovans. Ua hoʻoholo ke kauka e lilo ia i mea maikaʻi aʻe. ʻOi aku ka maikaʻi o kēia lāʻau lapaʻau i ke kō. I kēia manawa pono mākou e hana i nā ana i nā manawa pinepine e pale i ka hypoglycemia. Ua haʻi mai ke kauka iaʻu e pili ana i kēia. ʻO ka ʻokoʻa ma waena o Glucovans a me Glucophage: ʻo ka lāʻau lapaʻau mua ka hana o ka glibenclamide a me ka metformin, a ʻo ka lua ka mea i loaʻa ka metformin.
Alohaina Svetlana, 49 makahiki, Novosibirsk
Ua hala wau i ka maʻi diabetes i nā makahiki 7. ʻO ka manawa nei ua kauoha ʻia au i ka hui ʻana i nā lāʻau Glucovans. Ma ka hoʻopiʻi koke: pono, maʻalahi ka hoʻohana ʻana, palekana. ʻAʻole kuhi ʻia ke kumukūʻai - no ka ʻaʻa aʻu e hāʻawi aku ai na 265 r wale nō, lawa no ka hapalua mahina. I waena o nā hemahema: loaʻa nā contraindications, akā ʻaʻole wau i pili i kēia ʻāpana.
Lidia Borisovna, 56 makahiki, Yekaterinburg
Ua kauoha ʻia ka lāʻau lapaʻau no koʻu makuahine, he maʻi maʻi ia. Lawe ʻo Glucovans no 2 mau makahiki, manaʻo maikaʻi loa, ʻike wau iā ia e hoʻoikaika a ʻoliʻoli. I ka wā mua, ua ʻeha koʻu makuahine i kahi ʻeha ʻeha - huhū a me ka nalowale o ka momona, ma hope o ka malama aku i hala aku nā mea a pau. Ua hopena wau he kūpono ka lāʻau lapaʻau a kōkua maikaʻi.
Sergeeva Tamara, 33 makahiki, Ulyanovsk
Lawe wau iā Maninil ma mua, ke kō ka mālama ʻana ma kahi o 7.2. Ua hāleʻa ʻo ia i Glucovans, i loko o hoʻokahi hebedoma hoʻopau i ka 5.3. Hoʻohui wau i ka mālama ʻana i ka hoʻomaʻamaʻa kino a me kahi meaʻai kūikawā i wae ʻia. Paʻi pinepine wau i ka meli a ʻaʻole i ʻae i nā kūlana koʻikoʻi. Pono e hoʻololi i ka lāʻau lapaʻau wale nō ma hope o ka nīnau ʻana i ke kauka, e nānā pono i nā ʻano kikoʻī.
Alexander Savelyev, 38 makahiki, St. Petersburg
