ʻO ka maʻi mellitus type type 2 he maʻi multifactorial maʻamau, i hōʻike ʻia e ka pale hewa o ka metabolism kalepa. ʻO ke kumu nui o ka mālama ʻana i ka hana pilikino, kaʻai ʻana i ka meaʻai, ka lāʻau lapaʻau. ʻO kekahi o nā lāʻau lapaʻau i kuhikuhi ʻia no ke ʻano type type 2 he glibenclamide.
ʻO ka ʻike nui o ka lāʻau lapaʻau
ʻO Glibenclamide kahi lāʻau mālama gula i hoʻahaʻa ʻia i hoʻohana ʻia i nā ʻāina ʻē, i ka Rusia hoʻi, mai ka hoʻomaka ʻana o 70s. ʻO ia kahi mea hoʻohālike o nā derivatives o ka sulfonylurea (2 mau hanauna). Hoʻohana nui ʻia ka lāʻau lapaʻau e mālama i nā maʻi maʻi type 2.
Hōʻike ka hōʻike i hōʻike ʻia i nā waiwai ʻoi aʻe e pono ai no ke kino. I nā makahiki i hala 45 mau makahiki, ua hoʻomaikaʻi ʻia nā lāʻau lapaʻau antidiabetic a me nā ʻano hana like ʻole i loaʻa ke ʻano ma ka mākeke pharmacological. Akā, ʻo Glibenclamide ke kuhikuhi ʻia e nā kauka a ʻaʻole e nalowale i kona hānai.
ʻAʻole like me kona mea i mua o ka wā, ʻoi aku ka maikaʻi o ka lāʻau lapaʻau a ikaika. Ua hoʻohālikelike ʻia i ka waiho ʻole ʻana o ka hopena o ka lāʻau lapaʻau me ka pale ʻana i nā lāʻau lapaʻau ʻē aʻe.
ʻO nā hiʻohiʻona Pharmacological a me keʻano
ʻO ka hopena o ka lāʻau lapaʻau ka hypocholesterolemic, hypoglycemic. Hoʻonui ia i ka nui o ka hoʻonui ʻia o ka insulin e ka pancreas, hoʻoikaika i ka hana o nā poli beta o ka laikini islet. Hoʻopili ka mea i nā pā pākōlani e hilinaʻi nei (nā kaila ATP).
Hoʻomoe ʻia nā hana a nā mea huna a me ka like me ka insulin, a me nā hopena, e komo nā mea kūlohelohe i ke koko a me ke ʻano intercellular.
Ma waho o ka hana nui, loaʻa ka hopena i ka hopena thrombogenic a hoʻohaʻahaʻa i ka cholesterol. Hāʻawi i kahi wikiwiki a me ka hoʻowalewale ʻana i ka pānaʻi ʻana. ʻO ka nakinakiʻana i nā protein plasma e hele kokoke a kokoke i (98%). Hoʻāluā ka lāʻau i ka pepeka. Loaʻa ka pae kiʻekiʻe loa i ke koko i loko o 2 mau hola.
Kono ia ka mea no 12 mau hola. ʻO ka hapalua-ola ma hope o ka mālama waha ʻana he 7 mau hola, hoʻopau i 2-3 mau lā. Hoʻokuʻu ʻia ia ma ka bile a me ka urine Me ka hoʻohaʻahaʻa ʻana i ka hana o ke akepaʻa, e iho lohi ana ka excretion, a me ka wikiwiki o ka hoʻololi ʻana, a ma kahi o ia mea, piʻi nui ka nui.
ʻO ka inoa o ka mea ikaika ma ka ʻōlelo Latin he glibenclamide. E hoʻokuʻu i nā palapala: nā papa pāwili papahele. Loaʻa kēlā me kēia 5 mg o ka waiwai ikaika.
Nā hōʻailona a me nā contraindications
Hōʻike hōʻailona no ka hoʻohanaʻana: ke kaila non-insulin-kōkua, i hāʻawi ʻia he hopena o ka hoʻoponopono ʻana i ka glucose e ka lāʻau mālama lāʻau.
Nā ʻōmole o ka hoʻohana ʻana:
- ke kūpaʻa i ka hana ikaika;
- hana aho pili ole;
- ka hana ʻaʻina me ka makemake o ka acidification o ke kino;
- precoma a hoʻomōmaʻomaʻi coma;
- hapai
- hana koʻikoʻi kahi keiki;
- lactation wā;
- hana paʻa piha ʻana;
- diabetes h hilinaʻi i ka insulin (DM 1);
- nā kānaka ma lalo o 18 makahiki.
Nā ʻōkuhi no ka hoʻohana
Ke lawe ʻia nei ka loli i ka glibenclamide, ʻōlelo ʻia ka lāʻau me nā papa he 0.5 i kēlā me kēia lā. Hoʻomaopopo ʻia nā poʻe ʻōpio me nā maʻi o nā kino e hoʻonui i ka nui i hoʻolālā ʻia.
He mea kūpono kēia no ka poʻe ke kaupaona ʻana a 50 kg. I ka lā, ma ke ʻano he 2.5-5 mg o ka lāʻau (a hiki i ka 1 papa). Inā pono, e hoʻonui i ka wīwī. ʻO nā palena maʻamau i kēlā me kēia 3 papa.
Lawe ʻia ka lāʻau lāʻau ma mua o ka papaʻaina. Ma ka wai o ka ʻoi aku ma mua o ka 1 papa papa, ʻia e ʻimi ai i kahi kiko o 2: 1 (kakahiaka: ahiahi). Hoʻomaka ʻia ka kiʻi ʻia i ka manawa hoʻokahi me ka haki ʻole. I ka wā o ka mālamaʻana, ka nānāʻia o ka pae o ka metabolism.
Me ka makaʻala, pono e hoʻohana ʻia ka lāʻau lapaʻau e nā ʻano o nā mea maʻi i lalo nei:
- elemakule;
- nā kānaka me ka hana maʻi lēwa;
- nā mea maʻi me ka hoʻemi ʻana i ka hana thyroid;
- me nā hōʻailona o ka sclerosis cerebral.
Ma ke kīleʻa i ka wā o ka mālama ʻana i ka hana ʻōnaehana hiki ke hoʻopilikia i ka ambiguously - e hoʻomaikaʻi ai a hoʻonāwaliwali paha i ka hopena o ka lāʻau lapaʻau. Hoʻokomo ka Dye E124 i nā maʻi kūlohelohe i nā mea maʻi hiki. Inā loaʻa kekahi maʻi (a i ʻole loaʻa paha), pono ia e hōʻike i ke kauka. ʻAʻole hiki i nā mea maʻi ke ʻoki kū ʻole i ka lawe ʻana i ka lāʻau a hoʻoponopono paha i ka ʻōleʻa me ka ʻole o ka nīnau ʻana i kā lākou kauka.
Nā hopena ʻaoʻao a me ka overdose
I waena o nā hopena hopena:
- ʻo ka waiwai kaumaha;
- loi, hehena, kaumaha i ka digestive tract, huehue;
- pruritus, holo, ʻemia;
- hana aho pili ole;
- hoʻonui i nā ʻōhua biochemical;
- ʻike ʻole i ka nānā;
- hypoglycemia;
- kūlohelohe;
- thrombocytopenia, leukocytopenia, erythrocytopenia, granulocytopenia;
- nā hopena diuretic palupalu.
ʻO ka overdose (hoʻonui i ka wā liʻiliʻi a i ʻole hoʻokahi manawa manawa e hoʻonui ai i ka wai) i nā nui he nui e alakaʻi ana i ka hypoglycemia.
ʻO ia nā ʻolua:
- kaohuu
- pallor o ka ʻili;
- wahaheʻe ʻole kūpono a me ka noʻonoʻo;
- palpitations, oki;
- me kahi holomua holomua - hypoglycemic coma.
I nā kūlana koʻikoʻi, pono ia e holoi i ka ʻōpū a hoʻonā i kahi puna o ka glucose. Inā pono, e lawelawe ʻia ka glucagon. Hiki ke hōʻoki ʻia ka hypoglycemia ʻokoʻa ma kāna iho ma ka ʻai ʻana i ke kō.
Hoʻopili pū kekahi me nā lāʻau lapaʻau a me nā hōʻailona
ʻO nā lāʻau lapaʻau e hoʻonui ai i ka hopena o Glibenclamide e loaʻa: Miconazole, tetracycline antibiotics, anabolic steroids, antidepressants, insulin a me ka nui o nā mea maʻi maʻi diabetes, male kāne.
ʻO nā lāʻau lapaʻau e kōkua i ka hōʻemi ʻana i nā hopena e komo pū ana: nā thyroid hormones, corticosteroids, nicotinates, glucagon, beta-andrenoblockers, wahine sex hormones, diuretics, barbiturates.
ʻO nā lāʻau lapaʻau e hiki ke hoʻopilikia i ka glibenclamide (hoʻoikaika a, ʻole, hoʻohaʻahaʻa, hoʻohaʻahaʻa) i nā: Clonidine, Reserpine, H2 receptor blockers, pentamidine.
ʻO nā lāʻau lapaʻau o nā hana like:
- ʻO ka analogue kūʻokoʻa loa ʻo Maninil (ʻo ka hana ikaika ka mea like);
- kahi hui o nā lāʻau lapaʻau me ka glimepiride - Amapirid, Amaril, Glibetic, Glimax, Diapride;
- hoʻomākaukau me Gliclazide - Glidia, Glicada, Gliclazide, Diagnizid, Panmicron-MV;
- kālā me Glipizidom - Glynez, Minidiab.
Nā kumuhana wikiō mai Kauka Malysheva e pili ana i nā huahana e hōʻemi i ke kō i ka maʻi diabetes a hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau:
ʻO nā manaʻo hoʻomanawanui
Mai nā loiloi o nā mea maʻi e lawe ana iā Glibenclamide, hiki iā mākou ke manaʻo e uku kūpono ke kumukūʻai o ka lāʻau a hōʻemi loa ia i ke kō, akā ma hope o kona hoʻohana ʻana, e hele pinepine ʻia nā hopena o ke ʻano o ka nausea a me ka nalowale o ka makemake.
Ua maʻi wau me ka maʻi hānai no nā makahiki 12. Ua kuhikuhi ʻia nā ʻano lāʻau like ʻole, akā ua hōʻoia ʻo Glibenclamide ka mea kūpono loa. I ka manawa mua i mālama ʻia lākou me Metformin - ʻaʻohe hopena koʻikoʻi ma ka maʻamau o ke kō a hiki i ka hāpai ʻana i ka dosage. Ma hope o ka hoʻokuʻu ʻia o Glibenclamide. ʻO ka hopena ʻaoʻao ma ke ʻano o ka nalowale o ka makemake a me ka maʻi nausea i ka malama mua, a laila hoʻi hou nā mea a pau. ʻO ka haʻahaʻa puna me ka hoʻohana ʻana i ka lāʻau lapaʻau e hōʻemi a mālama i loko o ka lā 6. I ke ʻano he mea maʻamau, a ʻoluʻolu ʻia.
Irina, 42 makahiki, ʻo Samara
Ua loaʻa mua koʻu makuahine i ka maʻi diabetes type 2. Ua kuhikuhi koke aku ke kauka komo i ko Glibenclamide a kuhikuhi i kahi papa inoa. Ma kahi hebedoma ma hope o kona hoʻohana ʻana, hoʻomaka wau e hōʻeha i ka maʻi me ka ʻole o ka makemake. Akā, e like me kāna i ʻōlelo ai, ʻaʻole pili nui kēia i ka neʻe o ka glucose i mālama ma 6-7. I ka wā mālama, pono ia e kaohi i nā ʻāpana ʻokoʻa i ka pae ʻana o ka pae glucose. Akā, manaʻo maikaʻi ka makuahine, a me Glibenklemin, e ʻoluʻolu.
Sergey, 34 makahiki, Yekaterinburg
ʻO koʻu maʻi maʻi he 6 mau makahiki ka nui. ʻAʻole hiki ke hoʻoponopono ʻia ka glucose. Pono au e koho i kahi lāʻau. ʻIke wau i ka hopena mai Glibenklemin wale nō - ua hoʻemi ʻia ka meli i ka 6.5. (Ke hoʻohana mau nei au i ka mika). Ma mua o kēlā manawa, ʻaʻole hiki iaʻu ke hoʻokō i kēlā me kēia hōʻailona e like me ka manawa lōʻihi, ma lalo o ka 7 gula i emi ʻole ai. I ka hope ua ʻohi au i kaʻu lāʻau. I ka wā mua ua loaʻa iaʻu ka paona liʻiliʻi, akā laila hoʻoponopono wau i kaʻu meaʻai. I waena o nā hopena hopena: ka manawa maʻamau, ka manawa maʻamau - ka maʻi maʻamau a me ka nalowale i ka makemake.
Oksana, he 51 makahiki o Nizhny Novgorod
ʻO ke kumukūʻai o ka lāʻau kanu mua ma waena o 90 a 120 mau rubles. Hoʻokuʻu ʻia ka lāʻau lapaʻau ma o nā lāʻau wale nō.
ʻO Glibenclamide kahi lāʻau lapaʻau kūpono no ka hoʻohaʻahaʻa i nā pae haʻahaʻa. A ʻōlaʻi ʻia ia e nā kauka a ʻaʻole nalowale i kona pili, ʻoiai i ka loaʻa o nā lāʻau lapaʻau o kahi palapala hou.
