ʻO nā hoʻokolohua Laboratory no ka maʻi maʻi, me ka hoʻomehana ʻana, he pāʻani nui. ʻAʻole mau ka hōʻailona o ka maʻi a me ka pae o ka glycemia o ke koko e hōʻike ana i ke kaʻina pathological maoli i loko o ke kino, kahi e alakaʻi ai i nā hewa diagnostic i ka hoʻokumu ʻana i ke ʻano o ka maʻi maʻi.
ʻO Proinsulin ka hana like ʻole o ka protein protein o ka insulin i synthesized e β-cells of islets i ka pancreas i nā kānaka. Ma hope o ka hoʻohemo ʻana mai ka proinsulin, ka pūnaewele pālala (kahi i ʻike ʻia ʻo C-peptide), loaʻa i kahi molika insulin, nāna e hoʻoponopono i ka metabolism holoʻokoʻa i loko o ke kino o ke kanaka, ʻo ia hoʻi ka catabolism o glucose a me nā puna hou.
Mālama ʻia kēia mea i loko o nā pūhaka o nā mokupuni o Langerhans, kahi i hoʻohuli ʻia ai i ka insulin hāneʻe ikaika. Eia naʻe, pili ka 15% o ka waiwai i komo i ke kahawai ke loli ʻole. Ma ke ana ʻana i kēia helu, ma ka hihia o C-peptide, hiki i kekahi ke hoʻoholo i ka hana o nā cells-cell a me ko lākou hiki i kā lākou hana i ka insulin. ʻO ka Proinsulin ka liʻiliʻi o ka hana catabolic a he lōʻihi aku i ke kino o ke kanaka ma mua o ka insulin. Akā, ʻoiai, ʻo nā haʻahaʻa kiʻekiʻe o proinsulin (i ʻike ʻia i ka wā o nā kaʻina oncological i nā pancreas (insulinoma, etc.)) hiki ke hoʻonāukiuki i ka hypoglycemia i loko o nā kānaka.
Ka hoʻomākaukau ana no kahi hōʻike proinsulin
No ka hoʻoholoʻana i ke kiʻekiʻe o ka proinsulin i kanaka, hōʻiliʻili ʻia ke koko manamana. Ma mua, pono ka mea maʻi e hahai i kekahi o nā ʻōlelo paʻakikī ʻaʻole paʻakikī, kahi e kūlike ai i ka hoʻomākaukau no ka noiʻina biochemical e hoʻoholo i ka pae glucose.
- Lawe ʻia ka hāʻawi koko koko i ke kakahiaka ma mua o ka ʻaina awakea, ma luna o ka ʻōpū ʻole. Aia ia e lawe i kahi liʻiliʻi o ka wai i heluhelu ʻia, me ka ʻole o nā mea hoʻohui hoʻohui.
- ʻO ka lā ma mua o ka hoʻopaʻa ʻia, pono ia e hoʻokaʻawale i ka ʻai ʻana i nā mea inu wai ʻawa, ka ulaula, ka hoʻōho kino ʻana o ke kino, a me ka hoʻokele ʻana o nā lāʻau lapaʻau, inā hiki, inā paha he mau mea hoʻohaʻahaʻa i ka hilo (glibenclamide, maʻi maʻi, amaryl, etc.).
Nā hōʻike no ka noiʻi ʻana i nā kahu hana
Hana ʻia ka loiloi no ka proinsulin e like me ke kuhikuhi ʻana i nā lāʻau lapaʻau, i mea e wehewehe pono ai i kēia mau ʻike.
- ʻO ka hoʻomaikaʻi ʻana i nā kumu o nā kūlana hypoglycemic wikiwiki.
- Ka ʻike ʻana i nā insulin.
- Ke nānā nei i ke ʻano o ka hana hana o ka β-cells cells.
- Ka hoʻoholoʻana o ke ʻano o ke ʻano maʻi o ka maʻi mellitus (type 1 a i ʻole 2).
ʻO ka wehewehe ʻana i nā hopena he loina proinsulin
ʻO ka maʻamau, ma kahi ʻōpū ʻole, maʻamau ka pae maʻamau o ka proinsulin i kahi kanaka ʻaʻole iʻoi aku i ka 7 pmol / L (heʻe liʻiliʻi loa nā hopena o nā hopena, ma nā ʻano diagnostika like ʻole i loko o 0.5-1 pmol / L, i wehewehe ʻia e ka hewa o nā mea diagnostic).
ʻO ka emi haʻahaʻa o ka neʻe o ka ʻike i ka proinsulin koko e ʻike ʻia ma ka hihia o ka maʻi mellitus type 1 wale nō. ʻO ka hoʻonui aʻe aʻe ma mua o ka paepae maʻamau ke maʻamau no ka type 2 diabetes mellitus, pancreatic oncology, endocrine pathology o ka thyroid gland, ate a me nā pēpē.
