Lisinopril Ratiopharm i ka hopena vasodilating ma muli o ka hana o ka like o ka hoʻopalike ʻana o ka angiotensin II. Ma muli o ka hoʻokō ʻana i kahi hopena therapeutic, ua ʻike ʻia kahi hopena maikaʻi o ka lāʻau ma nā pūnaewele ischemic tissue. Hāʻawi ka lāʻau lapaʻau iā ʻoe e hoʻomake i ke kūpaʻa o ka votone endothelium a me ka me ka cardiac i hoʻonui ʻia i nā ukana i ka wā e hoʻomohala ai i ka hypertension arterial. No laila, hoʻohana ʻia ka lāʻau lapaʻau e nā cardiologists e mālama i ke koko kiʻekiʻe, hōʻehaʻeha o ka naʻau a me ka puʻuwai ʻole.
Inoa Kūʻai ʻole honua
Lisinopril.
Hāʻawi ka lāʻau lapaʻau iā ʻoe e hoʻomake i ke kūpaʻa o ka votone endothelium a me ka me ka cardiac i hoʻonui ʻia i nā ukana i ka wā e hoʻomohala ai i ka hypertension arterial.
ATX
C09AA03.
E hoʻokuʻu i nā palapala a me ka ʻano
Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa no ka hoʻohana waha.
Nā Palaki
Wahi a ka dosage o ka mea hana - lisinopril, ua ʻokoʻa nā papa i loko o ka ikaika kala:
- 5 mg ka keʻokeʻo;
- 10 mg - mālamalama kukui;
- 20 mg - kakū.
E hoʻomaʻamaʻa i nā hiʻohiʻona pharmacokinetics, loaʻa i ka kī papaʻaina nā māhele ʻē aʻe:
- magnesium stearate;
- kalekika hydrogen phosphate;
- kōpī pregelatinized;
- mannitol;
- kahi sodium a ʻaihoe.
ʻAukā
ʻAʻohe mea hana.
Ka hana lāʻau lapaʻau
Hoʻopili ʻo Lisinopril i ka hana hana o ka angiotensin e hoʻohuli ana i ka enzyme (ACE). A kahi hopena, hoʻemi ka pae o ka angiotensin II, e hōʻiliʻili i ka lumen o ka moku a hōʻemi i ke ʻano o ka aldosterone. ʻO ka hoʻohui pū ʻana o ka lāʻau lapaʻau ikaika e pale ai i ka wāwahi o bradykinin, kahi maʻi peptide me kahi hopena vasopressor.
Hoʻololi ʻo Lisinopril i ka pae o ka angiotensin II, kahi e hoʻopuka ai ka lumen o ka moku.
E kū'ē i ke kua o ke vasodilation, aia ka emi ʻana o ke kaomi koko, ke kū'ē i nā moku peripheral. Hoʻemi ʻia ka ukana ma ka myocardium. Me ka hoʻohana mau ʻana o Lisinopril, ka pale ʻana o ka viva endothelium a me ka puʻuwai cardiac i ka nui o nā ukana, e hoʻonui ai i ka holo ʻana o ka microcirculatory ma nā wahi me ischemia. Ke kōkua nei ka lāʻau lapaʻau e hōʻemi i ka hopena o ka hoʻolālāʻana i ka hemahema ventricular hema.
Lapaʻau lāʻau
Ke lawe waha ʻia, hiki i ka pae plasma lisinopril i hōʻea i kona manawa nui ma hope o nā hola 6-7. ʻO ka ʻai o ka ʻai, ʻaʻole ia e pili i ka hoʻopili ʻana a me ka bioavailability o ka mea ikaika. Lisinopril, i ka wā e komo ai i ke kahe wai, ʻaʻole hana i kahi mea paʻakikī me ka protein o ka plasma a ʻaʻole ia e hele i ka loli i loko o nā puʻuwai o ke ake. No laila, haʻalele ka mea hana i ke kino ma o nā keiki me ke kumu kumu. ʻO ka hoʻopau hapa-hapalua ke ola i ka hola 12,6.
Nā hōʻailona no ka hoʻohana ʻana
Hoʻohana ʻia ka lāʻau lapaʻau i ka hana lapaʻau e mālama ai:
- pilikia paʻa ʻole me ka hapa hema o ka eelection ventricular haʻahaʻa ma lalo o 30%;
- ke koko kiʻekiʻe;
- kaʻeha myocardial infarction i nā poʻe maʻi me ka pani ʻole ʻole.
Nā Hoʻohui
ʻAʻole pāpā ʻia ka lawe ʻana i ka lāʻau lapaʻau i loko o kēia mau hihia.
- ka holomua ʻana o kēlā me nā ʻili i nā ʻano kaila o ka lāʻau;
- stenosis o nā ʻāpana o ke keiki;
- nā mea maʻi me nā maʻi o ka pūpū me ka hana hoʻopihapiha ma lalo o 30 ml / min;
- stenosis valve mitral a aorta;
- nā kahe koko systolic o 100 mm Hg a haʻahaʻa;
- nā hemodynamics paʻa ʻole e kū'ē aʻe i kahiʻaoʻao o kahi ʻano aʻeha o ka puʻuwai puʻuwai;
- hāpai a wahine a lactating;
- huki;
- Hoʻoulu hou ʻia ma hope o kahi hoʻololi ʻana i kahi keiki.
Me ka mālama pono
Aine ʻia e hoʻomāleo i ka lāʻau lapaʻau i loko o nā kūlana i waiho ʻia ma lalo o ka mākaʻikaʻi koʻikoʻi o ke kauka i nā mea i hala iho nei:
- hypovolemia;
- sima wai haʻahaʻa ma mua o 130 mmol / l;
- nā koko haʻahaʻa (BP);
- ka hoʻokele ʻana i ka diuretics, ʻoi paha ke ʻano kiʻekiʻe;
- paʻa ʻole ka naʻau ʻole;
- maʻi pūpū
- therapy maʻi vasodilator kiʻekiʻe;
- nā mea maʻi ma mua o 70 mau makahiki.
Pehea e lawe ai i ka ratiopharm lisinopril?
ʻO 6 mau lōʻihi ka lōʻihi o ka lapaʻau. ʻO ka maʻi me ka puʻuwai naʻau e lawe iā Lisinopril ma kahi hoʻomau. Hoʻohana ʻia ka hui ʻana me Nitroglycerin.
I ke ʻano o ka uʻi aʻu e lawe ai?
Ua kuhikuhi ʻia ka lāʻau lapaʻau no nā mea maʻi me nā koina koko kiʻekiʻe ma mua o 120/80 mm RT. ʻAniā. Ma ka haʻahaʻa haʻahaʻa i ka systole - liʻiliʻi ma mua o 120 mm RT. ʻAniā. ma mua o ka hoʻomaka ʻana i ka mālama ʻana me kahi ACE inhibitor a i ʻole ma mua o nā lā 3 o ka hōʻola, pono wale no 2.5 mg o ka lāʻau. Inā ʻaʻole ka lōʻihi o ka systolic hōʻailona ma mua o 60 maumona i luna o 90 mm Hg. Art., Pono hōʻole ʻoe e lawe i ka paila.
Lawe i ka lāʻau lapaʻau no ka maʻi maʻi maʻi
ʻAʻole koi ʻo Diabetes mellitus i ka hoʻoponopono ʻana o ka nui o ka noho ʻana o kahi inhibitor ACE.
Nā Kūlana Hypertension
ʻO nā maʻi me ke koko koko kiʻekiʻe e lawe i ka 5 mg o ka lāʻau lapaʻau i ke kakahiaka no 3 mau pule. Me kahi pae maikaʻi o ka hoʻomanawanui, hiki iā ʻoe ke hoʻonui i kēlā me kēia lā i ka 10-20 mg o ka lāʻau. ʻO ka palena ma waena o ka hoʻonui ʻana i ka dosage he liʻiliʻi ma kahi o 21 mau lā. ʻO ka helu ʻokoʻa loa i kēlā me kēia lā he 40 mg o ka lāʻau. Pono e lawe ʻia i nā papa he hoʻokahi i ka lā.
ʻAʻole koi ʻo Diabetes mellitus i ka hoʻoponopono ʻana o ka nui o ka noho ʻana o kahi inhibitor ACE.
Haki puʻuwai paʻa ʻole
ʻO ka poʻe maʻi me ka puʻuwai pu ʻole e lawe i ka lāʻau i ka manawa like me ka diuretics Digitalis. No laila, ʻo ka hopena ma ka pae mua o ka mālamaʻana he 2.5 mg i ke kakahiaka. Hoʻokumu ʻia ka dosage mālama me ka hoʻonui hou ʻana o 2.5 mg i nā lā he 2-4 mau pule. ʻO ka dosage maʻamau mai 5 a 20 mg, e kau ana i ke pae o ka hoʻomaloka no hoʻokahi mau pāʻina i kēlā me kēia lā. ʻO ka palena kiʻekiʻe he 35 mg.
Acokocococococe neume huahi
Kau ʻia ka lāʻau lapaʻau i loko o ke ao mai ka manawa mai i ʻike ʻia nā hōʻailona mua o ka hōʻeha puʻuwai naʻau. ʻAe ʻia ka lawena inā paʻa nā keiki a ʻoi aku ke kiʻekiʻe o ka systolic ma mua o 100 mm Hg. ʻAniā. Hoʻohui ʻia ʻo Lisinopril me nā lāʻau thrombolytic, beta-adrenergic blockers, nitrates a me nā hoʻokaʻawale i ke koko. ʻO ka dosis mua he 5 mg ma hope o 24 mau hola me kahi kūlana paʻa o ka mea maʻi, hoʻonui ka nui i ka ʻaha loa - 10 mg.
Nā hopena hopena
Loaʻa ʻia nā hopena maikaʻi ʻole ma muli o ke ʻano kūpono ʻole a i ʻole ka hoʻoliʻahi kū ʻana o nā mea maʻi i nā mea o ka lāʻau.
ʻŌpala Gastrointestinal
Hōʻike ʻia ka hopena maikaʻi ʻole i ka lāʻau lapaʻau ma ka ʻōnaehana hana.
- constipation, huehue;
- hoʻōla kīwī;
- lilo ka momona
- loli ma ka ʻono;
- jaundice cholestatic, hoʻonāukiuki e ka hoʻomohala ʻana o ka hyperbilirubinemia.
Hematopoietic mau hui
Hōʻike ka ʻolioli hemolytic i nā maʻi me ka glucose-6-phosphate dehydrogenase. Me ka pale ʻana o ka hematopoiesis pumehana o ka iwi, ua hōʻemi ʻia ka nui o nā pili koko.
Pūnaehana pīhoihoi waena
ʻO nā ʻano hoʻohālikelike o ka peripheral a me ke kikowaena kūwili o ke ʻano neia e like me ke ʻano hiki o nā:
- nā kuʻi;
- luhi;
- ʻʻAla
- nalowale o ka ʻenemi a me ka kaulike ma ka pae;
- kani ana i na pepeiao;
- hilahila a me ka nalowale o ka ike;
- paresthesia;
- nā wahī pilipila;
- nalowale o ke kalepona ʻana i ke ʻano;
- polyneuropathy.
Hiki i ke lāʻau lapaʻau ke hōʻeha i nā ʻehaʻeha.
Mai ka papa huhū
I kekahi mau hihia, aia kahi ʻehaʻeha a me ka hiʻohiʻona o kahi pā maloʻo maloʻo.
Ma ka ʻāpana o ka ʻili a me ke kiko
I kekahi mau hihia, hiki ke hoʻomohala i ka urticaria, rashes, Stevens-Johnson syndrome, erythema, hoʻonui ʻia photosensitivity, exacerbation of psoriasis. Hiki i ka lauoho i hāʻule i ke poʻo.
Mai ka pūnaehana cardiovascular
Aia ka hopena o ka hoʻomohalaʻana i ka hypotension orthostatic a me ka bradycardia, nā manaʻo o ka wela.
Ma ka ʻāpana o ka pūpū a me ka ʻōnaehana urogenital
Hiki i kahi maʻi renal function, exacerbation o renal failed, hoʻonui urination.
Mai ka ʻaoʻao o ka metabolism
I kekahi mau hihia, ulu ka hypernatremia a i ʻole hyperkalemia.
Nā ʻōlelo kikoʻī
Me ka hoʻohana like o lisinopril a me ka dialysis me ka lipoproteins haʻahaʻa haʻahaʻa, loaʻa kahi waihona o ka anaphylactic shock.
Me ka hoʻohana like o lisinopril a me ka dialysis me ka lipoproteins haʻahaʻa haʻahaʻa, loaʻa kahi waihona o ka anaphylactic shock.
I nā mea maʻi i hoʻomaka mua i ka hoʻomohala ʻana o nā mālamalama, hiki i ka angioedema. Inā nānā ʻia ka ʻōpū o ka maka a me nā lehelehe, pono e lawe i nā antihistamines. Me ka pale ʻana i nā alaloa o ka lewa i ke kua ʻana o ka ʻāʻī o ka lehelehe a me ka glottis, hoʻokūkū hōʻeha me ka hoʻonāukiuki koke ʻana a Epinephrine subcutaneously 0.5 mg a i 0.1 mg intravenously. Me ka hoʻoulu ʻana o ka larynx, pono ia e nānā i ka electrocardiogram a me ke kahe koko.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
I ka wā o ka mālama ʻana me Lisinopril, pono pono ke kāohi i nā mea waiwai o ke koko, no ka mea pili i nā ʻano kūʻokoʻa o nā maʻi, hiki i ka hoʻomohala ʻana o ka hypotension arterial. Ma muli o ka hoʻokaʻawale ʻana i ke koko, hiki i ka hewa ke hiki ke hoʻokele i nā mīkini paʻakikī a hoʻokele i kahi kaʻa.
Hoʻohana i ka wā hāpai a me ka lactation
ʻAʻole ʻae ʻia ka lāʻau lapaʻau e kuhikuhi ʻia i nā wahine hāpai ma muli o ka loaʻa ʻole o ka ʻike i ka hopena o nā pūhui kemika o ka ACE inhibitor ma ka hoʻomohala ʻana i ka hanana. I ka wā o nā noi preclinical, ua hōʻike ʻia ka hiki o ka mea ikaika e komo i ka pleka. I ka hoʻomaʻamaʻa mua o ka hoʻoulu ʻana o ka pūpū, hiki i ka lāʻau lapaʻau ke hoʻonāukiuki i ka hoʻomohala ʻana o ka lehelehe lip.
Ke koho ʻana iā Lisinopril i ka wā o ka hoʻoulu ʻana, pono ʻoe e hōʻea i ka hānai ʻana i ka pēpē a hoʻoneʻe iā ia i ka meaʻai maʻamau me nā hui.
Kuhi ʻana iā Lisinopril Ratiopharm i nā keiki
Ua pāpā ʻia ka lāʻau lapaʻau no nā keiki a me nā ʻōpio i lalo o 18 makahiki o kona mau makahiki.
Ua pāpā ʻia ka lāʻau lapaʻau no nā keiki a me nā ʻōpio i lalo o 18 makahiki o kona mau makahiki.
Hoʻohana i ka wā kahiko
No nā poʻe maʻi maʻi, ua hoʻoponopono ʻia ka hoʻoponopono ʻia o ka dosage ma muli o ka cleince creatinine. Hoʻopili ʻia kēia hope e ka formula ʻo Cockroft:
| No nā kāne | (140 - makahiki) × kaupaona (kg) /0.814 × serum bun serin (μmol / L) |
| Wahine wahine | Ua hoʻonui ʻia ka hopena e 0.85. |
Ke keu
ʻO ka hōʻole ʻia o ka lāʻau hiki ke hoʻowalewale i ka hoʻomohala ʻana o nā hōʻailona o ka overdose.
- he hina nui i ke koko;
- kūlohelohe cardiogenic;
- nalowale o ka ike, mahuka;
- brieociaia.
Pono e hoʻoneʻe ʻia ka mea maʻi i ka ʻāpana mālama mālama kino, kahi e mālama ai ka nui o ka serum o nā electrolytes a me ka creatinine. Inā ua lawe ʻia nā papa i loko o nā hola he 3-4 i hala iho nei, a laila pono e hāʻawi ʻia ka mea maʻi i ka lāʻau hoʻoneʻe, e holoi i ka ʻōpū o ka ʻōpū. Hiki ke hoʻopau ʻia ka Lisinopril e ka hemodialysis.
Hoʻopili pū me nā lāʻau ʻē aʻe
Me ka hoʻokaʻawale laina o nā papa Lisinopril me nā lāʻau lapaʻau ʻē aʻe, ua ʻike ʻia nā hopena aʻe:
- ʻO ka maʻi ʻokiʻoki a me nā lāʻau lapaʻau non-steroidal e hoʻonui ai i ka hopena o ka hypotension.
- Hoʻonui ka Baclofen i ka hopena therapeutic o lisinopril. Ma muli o kēia, hiki i ka hoʻolālāʻana o ka hypotension arterial.
- Nā lāʻau antihypertensive, sympathomimetics, hoʻomaikaʻi ʻo Amifostin i ka hopena therapeutic o ka lāʻau lapaʻau, ke alakaʻi nei i ka hiki ke hoʻomohala ʻia o ka hypotension arterial.
- Hoʻomākaukau kālā no ka anesthesia maʻamau, nā lāʻau hiamoe a me nā antipsychotics e alakaʻi i kahi kahe nui o ke koko.
- ʻO nā immunosuppressants, cytostatic a me nā mea kanu anticancer e hoʻonui i ka hopena o ka leukopenia.
- ʻO nā lāʻau lapaʻau hypoglycemic waha i nā hebedoma mua o ka lāʻau paʻakikī e hiki ke hoʻoikaika i ka hopena antihypertensive o ka lisinopril.
- Hoʻopau nā antacids i nā bioavailability o ka mea hana ikaika.
Hoʻonui ka Amifostine i ka hopena therapeutic o ka lāʻau, ke alakaʻi i ka hiki ke hoʻomohala ʻia o ka hypotension arterial.
ʻO Sodium chloride nā lāʻau lapaʻau e hoʻonāwaliwali i ka hopena therapeutic o ka lāʻau a hoʻonāukiuki i ka ulu ʻana o nā hōʻailona o ka hana ʻole o ka naʻau.
Hoʻolaha ka waipuna
Hiki i ka inhibitor ACE ke hoʻonui i ka paʻi o ka ethyl alkohol i ka hepatocytes, nā io o ka cardiovascular a me nā ʻōnaehana. No laila, i ka wā o ka mālama antihypertensive, pono ʻoe e kāpae i ka laweʻana i ka waiʻona.
Nā kuʻina
Hoʻopili ʻia ke ʻano loiloi ma lalo o ka mākaʻi o ke kauka e hele nei i ka nalo ʻana o ka hopena antihypertensive pono me ka komo ʻana o kekahi o kēia mau lāʻau lapaʻau:
- Dapril;
- Aurolyza;
- Vitopril;
- Diroton;
- Zonixem;
- Amapin-L;
- Amlipin.
ʻO nā kūlana hoʻomaha ʻo Lisinopril Ratiopharm mai nā lāʻau lapaʻau
Hiki ke kūʻai aku i nā peni ma ke kau ʻana.
Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?
ʻO ka lawe ʻana i ka lāʻau lapaʻau me ke aʻo ʻole ʻana i nā kauka lapaʻau e hiki ke alakaʻi i kahi kahe o ke koko, hiki iā ia ke hoʻomohala i ka bradycardia, ka nalowale o ka ʻike, naʻau paʻakikī, coma, make. No ka palekana palekana, ʻaʻole i kūʻai ʻia ka lāʻau lapaʻau ma luna o ka counter-counter-counter.
Kūʻai
ʻO ka kumukūʻai maʻamau o ka lāʻau lapaʻau e pili ana i ka 250 rubles.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Mālama ʻia ka lāʻau lapaʻau i kahi mahana ma lalo o + 25 ° C ma kahi wahi i kaawale mai ka hana a ka lā.
ʻO ka lā kau
ʻO 4 mau makahiki
Mea Hana Lisinopril Ratiopharm
Merkle GmbH, Kelemānia.
No ka ʻike ʻana iā Lisinopril Ratiopharm
Me ka mālama pono ʻana i nā ʻōlelo a nā poʻe loea, hiki ke loaʻa i ka hopena lāʻau lapaʻau pono.
Kauka
Anton Rozhdestvensky, urologist, Yekaterinburg
Hoʻomaʻamaʻa maikaʻi ka lāʻau lapaʻau e nā maʻi. E alakaʻi i ka kuhikuhi pono paʻa, ʻoi aku ka maʻalahi ma mua o Diroton. I ka manawa like, ʻaʻole wau e kuhikuhi i nā diuretics ikaika e like me ia. ʻAʻole pili ʻo Lisinopril i ka hana erectile. Pono e lawe ʻia nā papa i ke kakahiaka 1 i ka lā i kēlā lā. Mālama ka hoʻoweliweli ʻana no 24 mau hola.
Vitaliy Zafiraki, cardiologist, Vladivostok
ʻAʻole kūpono ia ka lāʻau no ka monotherapy. Ke kuhikuhi nei wau i nā poʻe maʻi i hui pū me ka diuretics haʻahaʻa haʻahaʻa. Eia kekahi, i ka wā o ka mālama ʻana, pono ka nānā ʻana i ka kānana glomerular o ka maʻi. Ua hala aku nei ka lāʻau lapaʻau i nā hoʻokolohua kūpono e pono ai a ua ʻae ʻia no ka hoʻohana ʻana e nā maʻi me ke koko kiʻekiʻe.
ʻO Amlipin kahi hoʻohālike o ka lāʻau lapaʻau.
ʻO nā maʻi maʻi
ʻO Barbara Miloslavskaya, 25 makahiki, Irkutsk
Me kahi koho kūʻokoʻa o nā lāʻau lapaʻau no ke kaomi ʻana, ʻaʻohe mea nāna i kōkua. Hele wau i ka haukapila me ka maʻi maʻi, kahi lāʻau lapaʻau i kuhikuhi ʻia no ka hypertension. Ua hōʻike aku ke kauka ʻana i ka lāʻau me kēia papa no Lisinopril-Ratiopharm. Lawe wau iā 5 mau makahiki ma 10 mg i kēlā me kēia lā. Ua hoʻi mai ka hoʻihoʻi ʻana i ka 140-150 / 90 mm Hg. ʻAniā. a aole i ala hou ia. Ua kūpono kēia BP iaʻu. Inā ʻaʻole ʻoe e lawe i ka pōkole, a laila i ke ahiahi, e piʻi aʻe ke kaumaha a pilikia nui kou olakino.
Immanuel Bondarenko, 36 makahiki, St.
Kauka ke kauka 5 mg o lisinopril i kēlā me kēia lā. Lawe au i ia kakahiaka aʻe e like me nā ʻōlelo aʻo i ka manawa like.Hoʻomaopopo ka haukapila ʻaʻole i manaʻo ʻia nā papa no ka hana wikiwiki. I hōʻiliʻili ʻia ka hopena therapeutic, a ma hope o hoʻokahi mahina i ko ʻole ke koʻikoʻi ma mua o 130-140 / 90 mm Hg. ʻAniā. I ka wā ma mua, 150-160 / 110 mmHg i nānā. ʻAniā. No laila, waiho aku i kahi loiloi maikaʻi ʻana, ʻaʻole au i ʻike i nā hopena ʻaoʻao.
