ʻO Vipidia 25 kahi mea maʻi hypoglycemic e hoʻohana ʻia i loko o ka hana lapaʻau e hoʻomaʻamaʻa i ke kōpaʻa koko ma ke ʻano maʻi diabetes ʻole-hilinaʻi nui. Hiki i ka lāʻau lapaʻau ke lilo i ʻāpana o ka hui ʻana e hoʻomaʻamaʻa i nā mana o ke kō. Loaʻa ka lāʻau lapaʻau i kahi ala hoʻomehana kūpono o nā papa. ʻAʻole pono ka lāʻau hypoglycemic e nā keiki a me nā wahine hāpai.
Inoa Kūʻai ʻole honua
Alogliptin.
ʻO Vipidia 25 kahi mea maʻi hypoglycemic e hoʻohana ʻia i loko o ka hana lapaʻau e hoʻomaʻamaʻa i ke kōpaʻa koko ma ke ʻano maʻi diabetes ʻole-hilinaʻi nui.
ATX
A10BH04.
E hoʻokuʻu i nā palapala a me ka ʻano
ʻO ka lāʻau lapaʻau i hana i loko o kahi papa papa he 25 mg o ka waiwai ikaika - alogliptin benzoate. ʻO ke kumu nui o nā papa i hoʻohui ʻia e nā mea hoʻohui hoʻohui:
- mikulamulamina selulose;
- magnesium stearate;
- mannitol;
- sosa ʻo ke pākeke laupili;
- haiia.
ʻO ke kumu nui o nā papa i hoʻohui ʻia e ka cellulose microcrystalline.
ʻO ka papa o ke papa nā kiʻi kiʻi ʻula e pili ana i ka hypromellose, titanium dioxide, macrogol 8000, kahi kinipōpō melemele e pili ana i ka oxide iron. ʻO 25 mau papa ʻaina he ʻulaʻula.
Ka hana lāʻau lapaʻau
Aia ka lāʻau i ka papa o ka poʻe hana hypoglycemic ma muli o ke kaohi koho ʻana o ka hana o dipeptidyl peptidase-4. ʻO DPP-4 kahi kīʻaha koʻikoʻi i pili i ka hoʻohaʻahaʻa wikiwiki ʻana o nā pūhaka o ka hormonal - enteroglucagon a me ka peptide insulinotropic, e hilinaʻi nei i ka pae o glucose (HIP).
Hoʻokumu ʻia nā ʻōpili mai ka papa o ka incretins i loko o ka ʻili o ka pūpū. Hoʻonui ʻia ke ʻano o nā mea kanu kemo me nā kōʻai o ka meaʻai. ʻO ka peptide like-Glucagon a me ka GUI e hoʻonui i ka synthesis o ka insulin i nā mokupuni pancreatic o Langerhans. Hoʻopili ʻo Enteroglucagon i ka paleʻana i ka syntagon glucagon a pale aku i ka gluconeogenesis i nā hepatocytes, e hoʻonui ai i ka plasma o ka nui o nā kūmole. Hoʻonui ʻo Alogliptin i ka huna ʻana i ka insulin, e hilinaʻi ana ma ke kō o ke koko.
Lapaʻau lāʻau
Ke lawe pono ʻia, hoʻohuihui ʻia ka alogliptin i loko o ka paia ʻōpū, mai kahi e kolo ana i ka wahi vascular. Loaʻa ka bioavailability o ka lāʻau i ka 100%. I loko o nā kīʻaha koko, ua hōʻea ka mea hana i ka neʻe ʻana o ka plasma nui loa i loko o 1-2 mau hola. ʻAʻohe hōʻiliʻili o ka alogliptin i loko o nā kiko.
Ke lawe pono ʻia, hoʻohuihui ʻia ka alogliptin i loko o ka paia ʻōpū, mai kahi e kolo ana i ka wahi vascular.
Hoʻohālikelike ka mea hana ikaika i ka albumin plasma ma 20-30%. I kēia hihia, ʻaʻole pono ka lāʻau i ka hoʻololi a me ka pala i nā hepatocytes. Mai 60% a 70% o ka lālapa ke waiho i ke kino i kāna ʻano kumu ma o ka urinary system, 13% o alogliptin e hoʻopili ʻia me nā feces. ʻO ka hapalua-ola kahi 21 hola.
Nā hōʻailona no ka hoʻohana ʻana
Ua hōʻike ʻia ka lāʻau lapaʻau i nā mea maʻi no ka mālama ʻana i ka non-insulin type dependence type 2 diabetes mellitus a me ka hana maʻamau o ka mana glycemic e pili ana i ke kua ʻana o ka haʻahaʻa haʻahaʻa o ka lāʻau lapaʻau a me ka hana kino. No nā maʻi maʻi, hiki ke kuhikuhi ʻia ka lāʻau lapaʻau e like me ka monotherapy, a ma ke ʻano he nui o ka mālama ʻana me ka Insulin a i nā lāʻau lapaʻau hypoglycemic ʻē aʻe.
Nā Hoʻohui
Hoʻokomo ʻia ka lāʻau lapaʻau i nā maʻi aʻe:
- i ka heleʻana o ka kiko hypersensitivity i alogliptin a me nā meaʻokoʻa'ē aʻe;
- inā he hopena ka mea maʻi i nā anaphylactoid kūlike i nā DPP-4 inhibitors;
- maʻi mellitus type 1;
- keiki malalo o 18 makahiki;
- nā maʻi me ka paʻa ʻole o ka naʻau;
- pilikia nui a me ka hana lohi;
- nā wahine hāpai a me nā lactating.
ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no ka ketoacidosis maʻi.
Me ka mālama pono
Hoʻomaopopo ʻia e makaʻala i nā maʻi me ka maʻi pancreatitis koʻikoʻi, ma nā mea maʻi me ka hikiʻole i ka hoʻololi hāmeʻa. Pono e nānā pono i ka mokuʻina o nā mea i ka wā o ka hui pū ʻana me nā derony e pili ana i ka sulfonylurea a i ʻole ka hoʻōla paʻakikī me ka glitazones, Metformin, Pioglitazone.
Pehea e lawe ai iā Vipidia 25?
Kuhi ʻia nā papa no ka hoʻohana waha. Hoʻomaopopo ʻia e hoʻohana i ka lāʻau me ka maʻa o 25 mg hoʻokahi i ka lā hoʻokahi, me ka loaʻa ʻole o ka meaʻai. ʻAʻole hiki ke ʻōmole nā ʻāpana o ka lāʻau lapaʻau, no ka mea ʻo ka hoʻoneʻe ʻana i ka hopena o ka hōʻemi ʻana i nā alogliptin i loko o ka pūpiki liʻiliʻi. Mai lawe i kahi pāpālua pālua. Pono kahi papa pālea no kekahi kumu e pono e lawe ʻia e ka mea maʻi i ka hiki ke hiki.
Hoʻohana ʻia i ka maʻi maʻi
Manaʻo nā mea Nutrists e lawe i nā papa Vipidia ma hope o ka papa ʻaina ke piʻi ka nui o ke kō koko koko. Ke koho ʻana i kahi lāʻau lapaʻau ma ke ʻano he mea hana maʻalahi no ka lapaʻau me ka Metmorphine a i ʻole Thiazolidinedione, ʻaʻohe pono o ka hoʻoponopono ʻana i ka regimen dosage o nā wahi.
Me ka hana like ʻana o nā derivatives o ka sulfonylurea, ua hoʻemi ʻia kā lākou dosis e pale i ka hoʻomohala ʻana o kahi kūlana hypoglycemic. I ka pilina me ka hiki ke kahakaha paha o ka hypoglycemia, pono ia e hoʻomalu i ka pae o ke kō ma ka wā e mālama ai me ka Metformin, ka maʻi pancreatic a me Thiazolidinedione pū me Vipidia.
Ma muli o ka hopena hiki i ka hypoglycemia, pono ia e hoʻomalu i ke kiʻekiʻe o ke kōpaʻa i ka wā ʻo Metformin.
Nā hopena hopena o Vipidia 25
Hōʻike ʻia nā hopena maikaʻi ʻole i nā ʻōpū a me nā ʻili no ka regimen koho kūpono ʻole.
ʻŌpala Gastrointestinal
ʻOi paha ka hoʻomohala ʻana o ka ʻeha ma ka wahi o ka epigastric a me nā ulia e hoʻopau i ka ʻōpū o ka ʻōpū, duodenum. I nā hanana pinepine, hiki mai ka maʻi pancreatitis.
Nā kuhi hewa o ka pūpū a me ka pāpili
Ma ka ʻōnaehana hepatobiliary, hiki ke ʻike ʻia ke ʻano o nā pilikia o ka pūpū a me ka hiki ʻana o ka hōʻeha ʻana o ka ate.
Pūnaehana pīhoihoi waena
I kekahi mau hihia, ulu ʻia ke poʻo.
Hoʻokomo ʻia kahi ʻōnaehana Pūnaewele
E pale aku i ke kua o nā mea nāwaliwali nāwaliwali, hiki i ka lesima infectious o ka papa ʻōpū o luna a me ka hoʻomohala ʻana o ka nasopharyngitis.
Ma ka ʻāpana o ka ʻili
Ma muli o ke kiko hypersensitivity, ʻike ʻia ka rashes ʻili a i ʻole ʻeha. ʻO ke ʻano, ka hiʻohiʻona o ka maʻi Stevens-Johnson syndrome, urticaria, exfoliative maʻi o ka ʻili.
Allergies
I nā poʻe maʻi i hoʻomaka mua i ke ʻano o nā hopena anaphylactoid, urticaria, ua ʻike ʻia ka edema o Quincke. Ma nā pilikia koʻikoʻi, ulu ka huluhulu anaphylactic.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻole pili ka lāʻau lapaʻau i ka hiki ke lawe i nā kaʻa a me nā mīkini, akā me ka hoʻohui pū ʻana me nā lāʻau ʻē aʻe, pono ʻoe e makaʻala loa.
Nā ʻōlelo kikoʻī
ʻO nā mea maʻi me ka lawa ʻole o ka renal pono e hoʻoponopono i kēlā me kēia lā o ka lāʻau lapaʻau a ma loko o ka papa o ka lāʻau lapaʻau e pono ai e kiaʻi mau i ka moku'āina o ke ʻano. I nā hihia koʻikoʻi o ka hana pathological, ʻaʻole i ʻōlelo ʻia ʻo Vipidia, e like me nā poʻe maʻi ma ka hemodialysis a i nā mea maʻi me ka maʻi maʻi o kahi aʻi pū kekahi.
Ma muli o ka hoʻonui nui o ka hana hoʻonā, pono e hōʻike i nā mea maʻi e pili ana i ka hiki ke hiki mai o ka pancreatitis.
Hiki i nā mea paʻa DPP-4 ke hoʻonāukiuki i ka huhū aʻeha o ka pancreas. I ka loiloi ʻana i nā hoʻokolohua 13 ma ka wā i lawe ai nā mea hana ma muli o 25 mg o Vipidia i kēlā me kēia lā, hōʻoia ʻia ka hopena e ulu ai ka pancreatitis ma ka 3 mai nā poʻe maʻi 1000. Ma muli o ka hoʻonui nui o kahi kaʻina hana, pono ia e hōʻike i nā mea maʻi e pili ana i ka hiki ʻana mai o ka pancreatitis, i hōʻike ʻia e nā hōʻailona aʻe:
- ʻeha ka maʻi maʻamau ma ka ʻāpana epigastric me ka radiation i ke kua;
- kahi manaʻo kaumaha i loko o ka hypochondrium hema.
Inā hōʻike ka mea maʻi i ka pancreatitis, pono e hoʻokuʻu koke i ka lāʻau lapaʻau a hana ʻia kahi hōʻike no ka maʻi ʻana i ka pancreas. I ka loaʻa ʻana o nā hopena kūpono o nā hoʻokolohua hōʻoia, ʻaʻole hana hou ka lāʻau lapaʻau.
I ka manawa hana ma hope o ka kūʻai ʻana, ua hoʻopaʻa ʻia nā hihia o ka hoʻopili ʻana o ka nui me nā pōpoki o hope. ʻAʻole pili ʻia ka pilina me ka hoʻohana ʻana o Vipidia i nā wā aʻo, akā i ka wā o ka mālama ʻana me ka lāʻau lapaʻau, pono ia e hiki i nā mea hōʻeha ke hoʻomaʻamaʻa pinepine i ka mālama ʻana i ka hana o ka naʻau. Inā ma muli o nā haʻawina, ʻike ʻia nā mea kūpaʻa i ka hana o kahi mea maʻi me kahi etiology ʻike ʻole, pono ia e hōʻea i ka lawe ʻana i ka lāʻau me ka hoʻomau hou ʻana.
I ka wā o ka mālama ʻana me ka lāʻau lapaʻau predisposed i ka kōpū hana, ua ʻōlelo ʻia nā mea maʻi e hoʻomaʻamaʻa pinepine i ka nānā ʻana i ka hana o ka ate.
Hoʻohana i ka wā hāpai a me ka lactation
ʻAʻole i hoʻokō ʻia nā haʻawina haukaʻi ma ka hopena o ka lāʻau lapaʻau ma ke kino o nā wahine i ka wā hāpai. I ka wā o nā hoʻokolohua holoholona, ʻaʻole i hoʻopilikia ka lāʻau lapaʻau i nā kino o ka ʻōnaehana o ka hānau a ka makuahine, ka embryotoxicity, a i ʻole teratogenicity o Vipidia. I ka manawa like, no nā kumu palekana, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā wahine i ka wā hāpai (ma muli o ka hiki ke ʻae ʻia o ka waiho ʻana o ka waiho ʻana o nā io a me nā ʻōnaehana i ke kaʻina o ka embryonic development).
Hiki ke hoʻohālikelike ʻia ʻo Alogliptin ma o nā kelepa momona, no laila ke noi ʻia e haʻalele i ka lactation i ka wā o ka hopena o ka lāʻau lapaʻau.
Kuhi ʻana iā Vipidia i nā keiki 25
Ma muli o ka hapa ʻole o ka ʻike i ka hopena o ka hana ikaika ma ka ulu a me ka hoʻomohala ʻana o ke kino o ke kanaka i ka wā kamaliʻi a me ka wā ʻōpio, ua contraindicated ka lāʻau no ka hoʻohana ʻana a hiki i ka 18 mau makahiki o ka makahiki.
Hoʻohana i ka wā kahiko
ʻAʻole pono nā mea maʻi ma mua o 60 mau makahiki i ka hoʻoponopono hou ʻia.
Ke noi no ka hana renal haukapole
I mua o ka hikiʻole o ka renal holomua ma waena o ka cleance creatinine (Cl) mai 50 a 70/70 ml / min, ʻaʻole i hanaʻia nā loli hou o ka regimen dosage. Me Cl mai 29 a 49 ml / min, pono ia e hōʻemi i ka helu o kēlā me kēia lā i ka 12.5 mg no hoʻokahi pākahi.
I mua o ka hikiʻole o ka renal holomua ma waena o ka cleance creatinine (Cl) mai 50 a 70/70 ml / min, ʻaʻole i hanaʻia nā loli hou o ka regimen dosage.
Me ka hana ʻino koʻikoʻi (Cl hiki ke emi mai ka 29 ml / min), ua pāpā ʻia ka lāʻau lapaʻau.
ʻOuki aku o Vipidia 25
I loko o nā hoʻokolohua lapaʻau, ua hoʻokū ʻia ka nui o ka nui i hāʻawi ʻia - 800 mg i kēlā me kēia lā i nā mea maʻi maʻi, a me 400 mg i kēlā me kēia lā no nā maʻi me ka maʻi ole e hilinaʻi nei i ka insulin i ka wā e mālama ʻia ai ka lāʻau no 14 lā. Uaʻoi aku kēia i ka dosage maʻamau ma waena o 32 a 16 mau kekona. ʻAʻole kuhi ʻia nā hiʻohiʻona o kahi kiʻi lapaʻau o kahi overdose.
Me ka hōʻino maikaʻi ʻana, hiki ke ʻano e hoʻonui i ka piʻi ʻana o ka hoʻomohala ʻana a i nā hopena paha. Me nā hopena maikaʻi ʻole, pono ke lavage gastric. I nā kūlana paʻa, hoʻokō ʻia ka maʻi hōʻailona maʻi. Ma loko o 3 mau hola o ka hemodialysis, hiki wale ke neʻe o 7% o ka inikua i hala, no laila ʻaʻole pono nā hoʻokele.
Hoʻopili pū me nā lāʻau ʻē aʻe
ʻAʻole i loaʻa i ka lāʻau pili nā lāʻau lapaʻau me ka hoʻokūkū pū ʻana o Vipidia me nā lāʻau lapaʻau ʻē aʻe. ʻAʻole ke kālai ʻia ka lāʻau i ka hana o ka isoenzymes cytochrome P450, m izaoxygenase 2C9. ʻAʻole i launa pū me nā substrate p-glycoprotein. Ma ka Alogliptin ma ke ʻano o nā haʻawina lāʻau lapaʻau ʻaʻole i hoʻopilikia i nā loli i ke kiʻekiʻe o ka caffeine, warfarin, dextromethorphan, nā mea hoʻohālikelike waha i loko o ka plasma.
ʻAʻole hopena ka lāʻau lapaʻau i nā loli i ka pae o Dextromethorphan i loko o ke kino.
Hoʻolaha ka waipuna
I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, pāpā ʻia i ka inu ʻawa. ʻO ka Ethanol i loko o nā mea inu wai hiki ke hoʻonāukiuki i ka momona o ka ate ma muli o nā hopena o nā pakanā i nā hepatocytes. Ke lawe nei i Vipidia, e hoʻonui ʻia ka hopena o ka mea ʻona e kūʻē i ka ʻōnaehana hepatobiliary. Hoʻopilikia ka waiona Ethyl i ka pale ʻana o ke kaila ma waena, e hoʻopukū ana i ke kahe o ke koko a he hopena diuretic. Ma muli o ka hopena o ka hopena o ka waiʻona ma ke kino, ua hoʻemi ʻia ka hopena therapeutic i ka lāʻau.
Nā kuʻina
ʻO nā hoʻohalike o ka lāʻau lapaʻau me nā waiwai olakino like a me ka hoʻolālā kemika o ka mea ikaika e waiho ana:
- Galvus;
- Trazenta;
- Januvius;
- Onglisa;
- Xelevia.
Koho ʻia ka lāʻau synonym e ka mea hele i ke kauka e hilinaʻi nei i nā kuhikuhi o ke kaila koko koko a me ke ʻano maʻamau o ka mea maʻi. Hoʻololi wale ʻia ka mea i ka lilo ʻole o kahi hopena therapeutic a i ʻole e kū i kahi papa o nā hopena maikaʻi ʻole.
Waihue huaʻōlelo waiho nā huaʻōlelo
ʻAʻole kūʻai ʻia ka lāʻau lapaʻau me ka loaʻa ʻole o kahi lāʻau lapaʻau.
Hiki iaʻu ke kūʻai me ka loaʻa ʻole o ka hōʻailona?
Hiki i nā hewa hōʻino ke hoʻonāukiuki i ka hypoglycemia a i ʻole hyperglycemia. Hoʻohana ʻia ka hoʻomohala ʻana o ka comog hypoglycemic, no laila, palena ʻole ka kūʻai ʻana no ka palekana o nā maʻi.
Kumukūʻai no Vipidia 25
ʻO ka awelika kumukūʻai o nā papa he 1100 rubles.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Ke manaʻo ʻia nei e mālama iā Vipidia i nā mahana a hiki i + 25 ° C ma kahi a me ka mana haʻahaʻa haʻahaʻa haʻahaʻa, aia i kahi mamao o ka lā.
ʻO ka lā kau
3 mau makahiki
Mea hana
Takeda Island Limited, ʻĀina.
ʻO kahi hoʻohālikelike o ka lāʻau lapaʻau ʻo Onglisa.
Nā Hōʻikeʻike iā Vipidia 25
Ma nā papa kūkākūkā pūnaewele loaʻa nā ʻōlelo maikaʻi mai nā lāʻau lapaʻau a me nā ʻōlelo hoʻolālā e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau.
Kauka
Anastasia Sivorova, endocrinologist, Astrakhan.
He pono hana ma ka hakakā me nā maʻi maʻi type 2. Hoʻomaʻamaʻa maikaʻi ʻia nā maʻi. Ma nā hana kulekele, ʻaʻole i hui i ka hypoglycemia. Pono e lawe ʻia nā papa i 1 manawa i kēlā me kēia lā me ka ʻike ʻole ʻana ma ka helu ʻana me ka helu ʻana. ʻO kahi kahu hypoglycemic mai kahi hanauna hou, no laila, ʻaʻole i hāʻawi i ka hoʻonui ʻana i ke kaupaona kino. Mālama ʻia ka hana hana o nā kōpena beta pancreatic.
ʻO Alexey Barredo, ka mea hoʻokau manuahi, Arkhangelsk.
ʻO wau makemake me ka hoʻohana mau ʻana o ka lāʻau lapaʻau, ʻaʻole mau ka hōʻike hoʻomohala. Loaʻa i ka hopena therapeutic ka hopena hypoglycemic maʻalahi, akā ʻaʻole hiki ke ʻike koke. He kūpono ka lawe - 1 mau lā i ka lā. Loaʻa maikaʻi kālā no ke kālā. ʻAʻole ia e hoʻokau i ka hopena alerine i nā maʻi.
ʻO kahi analogue o ka lāʻau lapaʻau ʻo Januvia.
ʻO nā maʻi maʻi
Gabriel Krasilnikov, 34 makahiki, Ryazan.
Ke lawe nei wau iā Vipidia i kahi maʻi o 25 mg no 2 mau makahiki me ka 500 mg o Metformin i ke kakahiaka ma hope o ka ʻai ʻana. I ka mua, ua hoʻohana ʻo ia i ka Insulin e like me ka papa hana 10 + 10 + 8 mau ʻāpana. ʻAʻole i kōkua maikaʻi i ka hōʻemi i ke kō. He lōʻihi ka hana a nā papa.Ma hope iho o 3 mau mahina, e hoʻomaka ka honu gula, akā ma hope o ʻeono mahina, ua hāʻule ka glucose mai ka 12 i ka 4.5-5.5. Hoʻomau ka noho mau i loko o 5.5. Makemake wau ua hoʻemi ke kaumaha: mai 114 a 98 kg me kahi ulu o 180 cm. Akā, pono ʻoe e hahai i nā ʻōlelo a pau mai nā ʻōlelo kuhikuhi.
ʻO Ekaterina Gorshkova, 25 makahiki, Krasnodar.
Aia ka papa i ka maʻi maʻi type 2. Kauoha ke kauka iā Maninil, ʻaʻole naʻe i kūpono. ʻAʻole i emi iho ka Sugar a hōʻemi ke olakino ma muli o nā pilikia naʻau. Hoʻomoʻa ʻia e nā papa Vipidia. He kūpono ka lawe - 1 mau lā i ka lā. ʻAʻole i hōʻemi ʻia ka Sugar, akā me ka lohi, akā ʻo ka mea nui ka manaʻo maikaʻi ka makuahine. ʻO ka haki wale nō, ʻo ia i ka hoʻopilikia kino i ka ate.
