ʻO ka Noliprel Bee kahi lāʻau lapaʻau e hoʻohui i nā mea hoʻoikaika 2 - perindopril arginine a me ka indapamide. Ma muli o ka hana i hui pū ʻia, hiki ke hoʻokō ʻia ka piʻi ʻana o ke koko i ke kūpaʻa ʻana o ka hopena diuretic o ka hopena. ʻAʻole mālama ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana i nā keiki a me nā wahine hāpai.
Inoa Kūʻai ʻole honua
Perindopril + Indapamide.
ʻO ka Noliprel Bee kahi lāʻau lapaʻau e hoʻohui i nā mea hoʻoikaika 2 - perindopril arginine a me ka indapamide.
ATX
C09BA04.
E hoʻokuʻu i nā palapala a me ka ʻano
Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa biconvex keʻokeʻo me kahi ʻiliʻoni kiʻi ʻoniʻoni. ʻO ka papa lāʻau o ka lāʻau lapaʻau ka loko o ka paʻakai arginine a i ʻole nat-butylamine, 10 mg o perindopril a me 2.5 mg o ka indapamide. ʻO ka hui o nā kumuhana hou e komo pū ana:
- domedrogenated silica colloidal;
- waiū waiū;
- sodium carboxymethyl starch;
- maltodextrin;
- paʻahau magnesium.
ʻO ka kiʻi o waho o ka papa ma ka macrogol 6000, titanium dioxide, glycerol, magnesium stearate a me hypromellose.
Ka hana lāʻau lapaʻau
Loaʻa ka lāʻau lapaʻau i ka hopena hypotensive a diuretic ma ke kino. Hāʻawi ka lāʻau hoʻohui i ka hoʻopau ʻana i ka hoʻouluulu angiotensin (ACE). Loaʻa nā lāʻau Pharmacological o ka lāʻau lapaʻau ma muli o ka hopena pilikino o kēlā me kēia mea ikaika. ʻO ka hui pūʻana o ka indapamide a me perindopril e hoʻonui i ka hopena antihypertensive.
Ma muli o ka hopena diuretic o ka lāʻau lapaʻau, hōʻemi ke koko o ka mea maʻi.
ʻO ka paʻakai Perindopril tertbutylamine e pale i ka hoʻololi o ka angiotensin I i ka angiotensin type II ma ka pale ʻana i ke kinase II (ACE). ʻO ka mea hope loa he peptidase kūwaho, kahi i komo i ka wāwahi i ka bradykinin vasodilating i kahi heptapeptide, kahi metabolite kūlike. Hoʻopili ke ACE i ka hoʻololi ʻana o nā ʻano kaitensin chemical type i kahi ʻano vasoconstrictor.
Hoʻokomo ʻo Indapamide i nā papa o ka sulfonamides. ʻO nā waiwai Pharmacological e like me ka hana o ka hana ma thiazide diuretics. Ma muli o ke kāohi ʻana i ka reabsorption o ka molika sodium i ka glomerulus o ka pūpū, hoʻonui ka excretion o ka chlorine a me ka sodium sod, a me ka hoʻōla ʻana o ka magnesium a me ka pāhana. Aia ka nui o ka diuresis. I ka hopena o ka diuretic, ua emi ke koko.
Lapaʻau lāʻau
A lawe ʻia ma ka waha, ua wāwahi ʻia ka papa e ka esterases peʻe. Hoʻokuʻu ʻia ʻo Perindopril a me indapamide i loko o ka ʻōpū liʻiliʻi pono, kahi e hoʻopiʻi ai nā mea e nā villi kūikawā. Ke komo lākou i ka moe vascular, hiki i nā punawai keu ʻelua ke piʻi i pae kiʻekiʻe loa i loko o hoʻokahi hola.
I ka komo ʻana o perindopril i ke kīʻaha koko, e wāwahi ia i ka perindoprilat e 27%, he hopena antihypertensive a pale i ka hoʻokumu ʻana o ka angiotensin II. He mea nui hoʻi e hoʻomanaʻo e hoʻoluhi ka ʻai i ka loli o ka perindopril. Ua hiki i ka huahana metabolic kahi ana o ka plasma kiʻekiʻe ma loko o nā hola 3-4. ʻO ka hapalua hapalua o nā perindopril he 60 mau minuke. Hoʻopili ʻia ka mea kanu mea i loko o ka urinary system.
Ua hiki i ka huahana metabola ka hopena o ka plasma kiʻekiʻe loa i loko o nā hola 3-4, a ʻo ka hapalua-ola kahi 60 mau minuke.
Hoʻopili ʻo Indapamide i kahi albumin e 79% a ma muli o ka hoʻokumu ʻana o ka paʻakikī i māhele ʻia i nā kiko āpau. ʻO ka hoʻopau hapa hapalua-ola ma ka awelika lōʻihi mai 14 a 24 mau hola. Me ka hoʻokele hoʻomau, ʻaʻole ʻike ʻia ka hoʻohui ʻia ʻana o nā mea ikaika. ʻO 70% o indapamide i ke ʻano o nā huahana metabolic e waiho ana i ke kino ma o nā keiki, 22% - me nā feces.
Nā hōʻailona no ka hoʻohana ʻana
Pono ka lāʻau e hoʻemi i ke kahe koko i mua o ke ʻano o ka hypertension koʻikoʻi i nā mea maʻi e koi ana i ka lāʻau lapaʻau me indapamide i kahi pākaʻi o 2.5 mg a me 10 mg perindopril.
Nā Hoʻohui
ʻAʻole i kuhikuhi ʻia ka lāʻau lapaʻau i loko o nā hihia penei:
- ka hana like ʻana o nā lāʻau lapaʻau e hoʻonui ai i ka palena QT, a me nā lāʻau lapaʻau e pili ana i ka lithium a me nā paʻakai pālolo, e kūʻē ana i ke kumu o hyperkalemia;
- hypersensitivity i nā mea e hoʻoholo ai i ka lāʻau;
- hereditary form of lactose intolerance, galactosemia, lactase deficiency, malabsorption o monosaccharides;
- clearance hana (Cl ma mua o 60 ml / min) - koʻikoʻi pilikia ʻole;
- pilikia hōʻeha ʻole i ka hana decompensation;
- malalo o 18 makahiki.
Pono e mālama ʻia i ka wā e lawe ai iā Noliprel i mua o kahi kaʻina pili i ka kiko o ke kiko (lupus erythematosus, sclerodermaem), ka hōʻino o ka hematopoiesis, ka maʻi naʻau coronary, hyperuricemia.
Pehea e lawe ai iā Noliprel Bi
Pono e hoʻopili pono i nā papa, 1 ʻāpana i hoʻokahi lā i ka lā. Hoʻomaopopo ʻia e inu i ka lāʻau i ke kakahiaka ma mua o ka ʻaina kakahiaka, no ka mea ʻai ʻana i ka lohi ʻana i ka nalo ʻana a hōʻemi i ka bioavailability o nā mea ikaika.
Pehea e mālama ai i ka maʻi diabetes type 2
ʻAʻole pono ka lāʻau lapaʻau i ka hana huna o ka hormonal o nā peka beta o ka pancreatic a ʻaʻole hoʻololi i ka kaʻe o ke kō i loko o ke koko koko, no laila, nā mea maʻi me ka diabetes-mellitus non-insulin e pono ai i ka hoʻoponopono o ka dosis.
Nā hopena hopena o ka noliprel bi
Hoʻopilikia nā hopena ʻaoʻao ma ke kāʻei o kahi regimen hewa hewa a i ʻole i ka hiki ʻana o ka hoʻonui ʻia ʻana o ka iwi i nā mea pili.
ʻŌpala Gastrointestinal
Hōʻike ka maikaʻi o nā maʻi i ka digestive tract e:
- ka malo maloʻo
- kūhā maikaʻi;
- eha epigastric;
- ua hōʻemi i ka momona;
- pūpū, huehue, dyspepsia a me nā ʻōnaehana ʻōnaehana.
I nā hihia lohi, ʻo ka mea i kū mai ai ka pancreatitis, jaundice cholestatic e pili ana i ke kua ʻana o ka hyperbilirubinemia, angioedema o ka ovi.
Hematopoietic mau hui
I loko o ke koko a me nā limu, hiki ke ʻike ʻia ka emi ʻana o ka helu a me ka pale o ka hoʻokumu ʻana o nā platelets, neutrophils a me leukocytes. Me ka nele o nā sela toto mūnū, ʻike ʻia ka anemia o nā ʻano aplastic a me ka hemolytic. Hiki ke hiʻohiʻona o ka agrenulocytosis. I nā hihia kūikawā: nā mea maʻi hemodialysis, kahi manawa hoʻoponopono ma hope o ka hoʻololi ʻana i nā keiki - ua hoʻoweliweli ʻo ACE inhibitors i ka hoʻomohala ʻana i ka anemia.
Pūnaehana pīhoihoi waena
Me ka uhai ʻole o ka pūnaehana neʻe i waena, i ka loaʻa ʻana o:
- vertigo;
- mai;
- paresthesia;
- ʻʻAla
- ʻO ka haunaele hiamoe a me ka nalowale o ka noho naʻau.
I nā hanana kūikawā, he maʻi 1 no kēlā me kēia 10,000 mau maʻi e ʻike i ka hilahila a me ka nalowale o ka ʻike.
Hoʻomaʻamaʻa ʻia nā hopena ʻaoʻao i ka hihalili me ke kahena o ka ʻike maka, aʻo ko ka lohe ʻana i ke kani ʻana ke hōʻike ʻia i ke ʻano o ka hāmeʻa ʻana i nā pepeiao.
Mai ka pūnaehana urinary
I nā hihia pinepine, ulu a pālaʻi a me ka erectile dysfunction.
Mai ka papa huhū
E pale aku i ke ʻano o ka lāʻau lapaʻau, hiki i nā mea hoʻonaʻauao ACE ke hoʻomohala i ka ʻōpala maloʻo, pōkole o ka hanu, bronchospasm, hōʻeha a me ka pneumonia eosinophilic.
Allergies
Aia ke kūpono o kahi kahe, ka erythema a me ka ʻeha i ka ʻili. I kekahi mau hihia, ulu ka angioedema o ka maka a me nā mea e ulu ai, ʻo ka edema o Quincke, urticaria, vasculitis. Ma mua o ke kūpaʻa o kahi predisposition i kahi hopena anaphylactoid. I mua o ka systemus lupus erythematosus, ke kino nei ke kiʻi o ka maʻi. Ma ka hoʻomaʻamaʻa lāʻau lapaʻau, ua hōʻike nā hihia o ka photosensitivity a me epidermal necrolysis o ka momona subcutaneous.
Hoʻopilikia i ka hiki ke mālama i nā mīkini
ʻAʻole pili ka lāʻau lapaʻau i ka hiki ke hoʻokaʻawale a ʻaʻole i hōʻemi i ka wikiwiki o ka hopena, akā ma muli o ka hopena o nā hopena hopena i loko o ke kaila maoli, pono e mālama ʻia ka mālama ʻana i nā hana paʻakikī, nā hāmeʻa koʻikoʻi, ka hoʻokele kaʻa.
Nā ʻōlelo kikoʻī
ʻO ka lawe ʻana i ka lāʻau i hoʻohui ʻia ʻaʻole i pale i ka hoʻomohala ʻana o ka hypokalemia, ʻo ia hoʻi nā mea maʻi me ka dysal function o ka renal a me ka maʻi diabetes. I kēia kūlana, koi ʻia ka mākaʻikaʻi pinepine ʻana i ka paʻū o ka pāhana ma ka plasma.
I ka wā mālama, hiki i ka hōʻemi i nā ʻoleka o ka sodium i loko o ke kino e hiki ai ma muli o ka hiki ʻana o ka hypotension. Hoʻonui ka pilikia o ka hyponatremia me ka bilateral stenosis o nā kīʻaha o nā keiki, no laila, i kēia mau hihia he mea pono e hoʻomaopopo i ke kauka e pili ana i ka hoʻomoʻikiʻi, ka luaʻi a me nā maʻi aʻa. ʻO ka emi iki o ka hoʻokahe koko ke pale ʻole i ka hoʻokele hou ʻana o Noliprel.
Hoʻohana i ka wā kahiko
ʻO nā mea maʻi ma luna o 65 mau makahiki ʻoi aku ka hana o ka maʻi maʻamau, ʻaʻole pono e hoʻoponopono hou ʻia. I ka hihia ʻē aʻe, hoʻoponopono ʻia ke ʻano kupa a me ka lōʻihi o ka lapaʻau ʻana ma muli o ka makahiki, ke kino kino a me ke ʻano o ka mea maʻi.
Ke koho ʻana i ka noliprel bi i nā keiki
Ma muli o ka nele o nā ʻike i ka hopena o nā mea ikaika i ka ulu a me ka hoʻomohala ʻana i ka wā kamaliʻi a me nā ʻōpio, ua ʻānai ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana e nā keiki ma lalo o 18 makahiki.
Hoʻohana i ka wā hāpai a me ka lactation
ʻO ka lawe ʻana i ka lāʻau lapaʻau i loko o ka hoʻolālā ʻana o II a me III i kahi ulu embryonic e hoʻonāukiuki i ka waiho kūpono ʻana o nā pūpū a me nā iwi o kahi ʻōpala, oligohydramnios, a me ka hoʻonui pū aʻe i ka hopena o ka hypotension arterial a me ka renal dysfunction i loko o ka wahine hou. No laila, pāpā ʻia ka hoʻohana ʻana o Noliprel i nā wahine hāpai.
I ka wā mālama, hoʻopau i ka lactation.
Ke noi no ka hana renal haukapole
Me ka clearance creatinine ma luna o 60 ml / min, pono ia e kiaʻi pinepine i ka pae o ka creatinine a me nā paʻakai paʻakai i ka plasma.
Hoʻohana no ka hana lawelawe lēwa
Ke pāpā ʻia nei ka lāʻau lapaʻau no ka hoʻohana ʻana i nā maʻi me ka hōʻaiʻē paʻakikī.
ʻO ke kauā o ka Noliprel Bi
Me kahi pākahi hoʻokahi o ka nui o ka lāʻau lapaʻau, ʻike ʻia kahi kiʻi haumania o kahi overdose:
- he hii nui loa o ke kahe koko, i hui pū ʻia e ka pulu a me ka pupule;
- nā wahī pilipila;
- ʻʻAla
- oliguria me ka hoʻolālā ʻana o anuria;
- ka haki ʻana o ka ʻike wai-paʻakai;
- hilahila, nāwaliwali.
Pono ka mea make e mālama i ka mālama olakino e pili ana i ka pale ʻana i ka hoʻopili hou ʻana i ka lāʻau. Ma kahi hale haukapila, holoi ʻia ka mea maʻi me ka ʻōpū o ka ʻōpū, hoʻōla ʻia nā carbon carbon. Me ke kahe nui o ka neʻe koko, neʻe ka mea maʻi i kahi kūlana a hāpai ʻia nā wāwae. Me ka hoʻomohala ʻana o ka hypovolemia, hoʻōla kūlia ʻo 0.9% sodium chloride.
Hoʻopili pū me nā lāʻau ʻē aʻe
Me ka hoʻokaʻawale ʻana o nā lāʻau anti antipsychotic a me nā antidepressants, hiki ke hoʻonui i ka hopena antihypertensive, e hoʻonui ai i ka hopena o ka hoʻokūkū orthostatic hypotension. Hoʻopilikia ka Glucocorticosteroids a me tetracosactides i ka wai a me ka mālama sodium, e hoʻonāwaliwali ai i ka hopena diuretic. I ka hopena, ulu ka piʻi ʻana o ka pume koko. Hoʻopiʻi no ka anesthesia maʻamau e hoʻonui i ka kahe o ke koko i loko o nā huawai.
Me ka mālama pono
A laila e noʻonoʻo ʻia ka mālama ʻana i ka wā i koho
- ʻO nā lāʻau anti-inflammatory nonsteroidal, acetylsalicylic acid me kēlā me kēia lā he nui o ka nui o ka 3000 mg. Aia ka emi ʻana o ka hopena antihypertensive, e kūloi i kahi paʻa o ka renal a me ka hyperkalemia serum.
- Cyclosporin. Hoʻonui ʻia ka pilikia o ka hoʻonui ʻana i nā pae creatinine me ka ʻole o ka hoʻololi ʻana i ka neʻe o ka cyclosporine me kahi ʻike wai maʻamau.
- Hiki iā Baclofen ke hoʻonui i ka hopena therapeutic o ka lāʻau, no laila i kuhikuhi ʻia, pono ia e nānā i ke koko a me ke ʻano o ke keiki. Inā pono, ua hoʻoponopono ʻia ka lāʻau pākana o nā lāʻau ʻelua.
ʻAʻole kuhikuhi ʻia nā hui
Ke lawe nei i nā huahana kī lithium me Noliprel Bi-Forte, nānā ʻia ka lāʻau lapaʻau. Me ka hoʻāʻo ʻana i ka lāʻau lapaʻau like, hiki ke hoʻonui i ka plasma o ka lithium no ka manawa pōkole a piʻi ka nui o ka maʻi o nā maʻi.
Hoʻolaha ka waipuna
ʻAʻole pāpā loa ia e hoʻohana i ka waiʻona i ka wā o ka lāʻau lapaʻau. Hoʻomaikaʻi ka Ethyl alkohol i ke ʻano o ka pūpū a hoʻonāwaliwali i ka hopena therapeutic o ka lāʻau lapaʻau, hoʻomaikaʻi i ka hopena inhibitory i nā nū a me nā papa hepatobiliary.
Nā kuʻina
ʻO nā mea hoʻohālikelike me nā mea hana e like me:
- Ko-perineva;
- Noliprel A;
- Noliprel A-Forte;
- i ka manawa like ʻo ia e lawe ai iā Perindopril a me Indapamide, kahi e kūʻai ʻia aku ai ka uku ʻia ma mua o nā generics.
Hiki iā ʻoe ke hoʻololi i kekahi lāʻau lapaʻau ma hope o ke kūkā ʻana me ke olakino.
Waihue huaʻōlelo waiho nā huaʻōlelo
I kūʻai ʻia e ka lāʻau lapaʻau.
Hiki iaʻu ke kūʻai me ke kī ʻole
Hoʻohālikelike ʻia ke kūʻai ʻana ma muli o ka loaʻa ʻana o ka maʻi overdose a me nā hopena paha i ka wā e lawe ʻole ʻia me ka lāʻau lapaʻau pololei.
Kumukuai no noliprel bi
ʻO ka awelika o ka lāʻau lapaʻau he 540 rubles., Ma Ukraine - 221 UAH.
Ke waiho nei i nā kūlana no ka lāʻau lapaʻau
Hoʻonohonoho ʻia e mālama i ka mahana + 15 ... + 25 ° C.
ʻO ka lā kau
36 mahina.
Mea hana
ʻO Labs Servier hana, Farani.
Nā Hōʻikeʻike e pili ana iā Noliprel Bi
Ma nā pūnaewele Pūnaewele aia nā loiloi kūpono o nā lāʻau lapaʻau a me nā mea maʻi e pili ana i ka lāʻau lapaʻau.
Cardiologists
Olga Dzhikhareva, cardiologist, Moscow
Ke noʻonoʻo nei au i ka hui pū lāʻau antihypertensive ʻano maikaʻi. ʻO ka lāʻau lapaʻau e hōʻemi pono i ke kahe o ke koko i ka mahalo i ka indapamide e loaʻa kahi hopena diuretic. Hoʻomaopopo ʻia ka lāʻau lapaʻau i nā mea maʻi 1 manawa i kēlā me kēia lā i ke kakahiaka. Hoʻoholo ʻia ka papa hana o ka mālama ʻana ma ke kumuhana hoʻokahi.
Svetlana Kartashova, cardiologist, Ryazan
ʻO ka lāʻau maikaʻi no ka mālama antihypertensive kumu mua me ka hoʻoponopono hou ʻana o ka hoʻoponopono dosage. E kōkua ana ka lāʻau lapaʻau e hōʻemi i ka hypertrophy left left a hoʻomaikaʻi i ka elasticity o ka pūpū o ka naʻau a me nā paia vascular. He lāʻau lapaʻau maoli kēia no ka mālamaʻana i ka maʻi hypertension.
ʻO nā maʻi maʻi
Anastasia Yashkina, 37 makahiki, Lipetsk
Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka hypertension. ʻAʻole i hoʻokiʻekiʻe ʻia ke koʻikoʻi, no laila i ka wā mua, ʻaʻole au i hele i ke kauka. I ka wā i kū mai ai kahi pilikia hypertensive, ua piʻi ke koko i ka 230/150. Hāʻawi i kahi haukapila. Papa papa ʻia Noliprel Bi-Fort i ʻōlelo ʻia. Ma hope o 14 mau lā o ka hana maʻamau, hoʻi hou ke kaohi i ke ʻano maʻamau. ʻAʻohe allergy, hele aku nā pōpoki i ke kino. Pono ke kaomiʻike no 3 mau makahiki.
Sergey Barankin, 26 makahiki, Irkutsk
I ka makahiki i hala, ua piʻi ka pēpē i ka 170/130. Ua ʻimi ʻo ia i ke kōkua olakino - ʻ prescribedlelo ke kaukaʻi he 10 mg o Noliprel a ʻōlelo ʻo ia e lawe i ka papa 1 i ke kakahiaka ma ke ʻōpū ʻole. I ka wā mua, uaʻike au i ka maʻū ʻole a me ka ʻoluʻolu nui. Hoʻoholo wau e lawe i hapalua papa. Ua hoʻi hou ʻia ke kūlana a me ke kaomi. Ua hōʻea nā huina i ka 130/80.
