ʻO nā lāʻau lapaʻau maʻi hou e hoʻomaka nei e kū mai i nā makahiki 2000 he mau huaʻōlelo peninike. Kūmole, ua hoʻonohonoho ʻia lākou e hoʻohaʻahaʻa i ke kōhi koko ma hope o ka ʻai ʻana me ka maʻi maʻamau 2. Eia naʻe, eia nō kēia manaʻu iki lākou. No ka mea ke hana like nei kēia mau lāʻau lapaʻau e like me Siofor (metformin), a ināʻaʻole i kūpono ka hopena, ʻoiai ua nui ke kumukūʻai. Hiki ke kuhikuhi iā lākou e hoʻohui i Siofor, inā ʻaʻole lawa kāna hana, a ʻaʻole makemake ka mea maʻi manaʻo e hoʻomaka i ka injecting insulin.
ʻO Baeta lāua ʻo Viktoza lāʻau lapaʻau maʻi mea i ka pūʻulu o nā agonist receptor GLP-1. He mea nui lākou ʻaʻole ka hoʻohaʻahaʻa ʻana i ke kōpaʻa koko ma hope o ka ʻai ʻana, akā e hōʻemi hoʻi i ka momona. A ʻo kēia āpau me ka ʻole o nā hopena kūikawā.
ʻO ka ʻoiaʻiʻo maoli o ka lāʻau lapaʻau type 2 hou e hoʻēmi ana i ka momona a kōkua i ke kāohi ʻana i ka overeating. Mahalo i kēia, e lilo ia i mea maʻalahi no ka poʻe maʻi e hahai i kaʻai haʻahaʻa-haʻahaʻa a pale i nā hōʻoki ʻana. ʻO ke kuhikuhi ʻana i nā lāʻau lapaʻau hou e hoʻemi ai i ka leʻaleʻa ʻaʻole ke apono ʻia e kēlā me kēia. Eia nō kekahi, ʻo kā lākou hoʻokolohua lapaʻau i hui pū ʻia me ka ʻai haʻahaʻa haʻahaʻa, ʻaʻole i mālama ʻia. Eia nō naʻe, ua hōʻike ka hana i kēia mau lāʻau lapaʻau ke kōkua pono i ka hoʻopalapula ʻole ʻia i ka gluttony, a he liʻiliʻi nā hopena hoʻopiʻi.
ʻO nā penikala kūpono e kūpono no ka hoʻemi ʻana i ka makemake
Ma mua o ke hoʻololi ʻana i kahi meaʻai hoʻohaʻahaʻa haʻahaʻa, ʻo nā mea maʻi a pau me ka maʻi āpau 2 e hōʻeha ʻia i ka palapalaʻaiʻai. Hōʻike kēia hilinaʻi iā ia iho i ke ʻano o ka overeating me ka mea ʻole a / a me nā bouts maʻamau o ka monstrous gluttony. ʻO ka like like me ka mea e loaʻa ana i ka wai ʻona, hiki iā ia ke "ma lalo o ka hop" a / a i ʻole wā e hōʻalo hele i nā hakakā.
ʻO ka poʻe me ka momona a me / a i ʻole nā lā diabetes type 2 i ʻōlelo ʻia he mea ʻono ʻole kā lākou luhi. ʻO ka mea maoli, heʻai palaka ia e ka hewa i ka mea i loaʻa i kēlā mau maʻi i ke ʻano o ka pōloli. I ka manawa e hoʻololi ai i ka ʻai i nā protein a me nā momona momona maoli, hoʻihoʻi kā lākou makemake i ka maʻamau.
ʻO kahiʻai haʻahaʻa-haʻahaʻa haʻahaʻa ke kōkua i kahi kokoke o 50% o nā mea maʻi e hoʻokō i ka dependant o ka haʻaleka. ʻO nā maʻi ʻē aʻe me ka maʻi diabetes type 2 e pono ke ana hou aku. ʻO ka hua ʻōlelo nui o nā hua'ōlelo o ka "gat line" o ka pale "i hāpai ʻia e Kauka Bernstein ma hope o ka lawe ʻana i ka chromium picolinate a me ka home-hypnosis.
Aia i kēia mau lāʻau lapaʻau ʻelua mau pūʻulu o nā lāʻau lapaʻau:
- Nā papa DPP-4;
- ʻO kahi poʻe agonist ka mea hoʻokipa GLP-1.
Pehea ka maikaʻi o nā lāʻau lapaʻau hou?
Ua hōʻike ʻia nā hoʻokolohua haukapila e lawe aku ana nā DPP-4 inhibitors a me GLP-1 agelist reseptant koko koko ma hope o ka ʻai ʻana i nā mea maʻi me ka maʻi diabetes type 2. ʻO kēia no ka mea e hoʻoulu ana i ka ʻona i ka insulin e ka pancreas. I ka hopena o kā lākou hoʻohana ʻana i ka hui me kahi pākeke "pālākiō", hoʻoemi ʻia ka gogekē hemoglobin e ka 0.5-1%. Eia nō kekahi, hoʻemi iki kekahi mau mea hōʻike.
ʻAʻole kēia he akua akua ka mea e hoʻokō ai, no ka mea, ʻo ka Siofor maikaʻi (metformin) maikaʻi ma lalo o nā ʻano like me ka hoʻēmi ʻana i ka hemoglobin glycated e ka 0.8-1.2% a kōkua maoli i ka hāʻawi ʻana i ka momona ma kekahi mau kilogram. Eia nō naʻe, ua kuhikuhi ʻia e kuhikuhi aku i nā lāʻau lapaʻau type-type hou aʻe i ka metformin i mea e hoʻonui ai i kona hopena a hoʻolōʻihi i ka hoʻomaka ʻana o ka lapaʻau no ka maʻi type type 2 me ka insulin.
Ua ʻōlelo aku ʻo Kauka Bernstein e lawe ka maʻi maʻi i kēia mau lāʻau lapaʻau ʻaʻole e hoʻoikaika i ka mea huna o ka insulin, akā no ka mea ma o ko lākou hopena i ka hoʻemi ʻana o ka makemake. Kōkua lākou i ka mālama ʻana i ka ʻai o ka meaʻai, ke hoʻolale i ka hoʻomaka ʻana o ka māhu. Ma muli o kēia, hiki i nā hihia ke hoʻopiʻi nei i ka meaʻai a me ka mea laʻa haʻahaʻa i ka mea maʻi e hōʻemi nui pinepine.
Kūkulu ʻo Bernstein i nā lāʻau hōʻola ʻokoʻa no nā maʻi me ka maʻi diabetes type 2, akā no nā mea maʻi me ka maʻi type kīkē 1 ka mea i loaʻa ka pilikia ma luna o ka inu ʻana. Kūmaʻa ʻia, kēia mau lāʻau lapaʻau ʻaʻole ʻia no nā maʻi maʻi type 1. Hoʻomaopopo ʻO nā mea maʻi me ka maʻi maʻi type 1 i hoʻomohala i ka gastroparesis maʻi, i.e., i kali i ka nalo ʻana o ka ʻōpū ma muli o ka maʻi neural impaired, ʻaʻole hiki ke hoʻohana i kēia mau lāʻau. No ka mea e hōʻino ʻia lākou.
Pehea e hana ʻia ai nā lāʻau lapaʻau?
Hoʻēmi i nā mea kanu hoʻopau i ka momona no ka mea lohi i ka huki o ka ʻōpū ma hope o ka ʻai ʻana. ʻO ka hopena ʻaoʻao paha o kēia ka nausea E hōʻemi i ka makaʻuʻole, hoʻomaka e lawe i ka lāʻau lapaʻau me ka liʻiliʻi liʻiliʻi. E lohi pinepine i ka wā e hoʻopili ai ke kino. ʻO ka lōʻihi o ka wā, ua nalo ka nausea i ka hapa nui o nā maʻi. ʻAnoʻuhane, hiki i nā hopena ʻokoʻa ke hoʻoili - hoʻopili, ʻeha o ka ʻōpū, constipation a i ʻole nā hopena ʻeha. Kauka ʻo Dr. Bernstein ma ka hoʻomaʻamaʻa ʻaʻole lākou i nānā.
Loaʻa nā inhibitors DPP-4 i nā papa, a me nā agonist receptor GLP-1 i ke ʻano o kahi hopena no ka hoʻokō subutaneus i loko o nā cartridges. Minamina, ʻaʻole pono ka poʻe i loko o ka lāʻau i ka mālama ʻana i ka makemake, a hoʻemi iki ʻia ka hilahila koko. ʻO ka mea hana maoli nā mea hoʻohana i nā mea hoʻokipa GLP-1. Ua kapa ʻia lākou ʻo Baeta a ʻo Viktoza. Pono lākou e kiʻi ʻia, aneane e like me ka insulin, hoʻokahi a i ʻole kekahi manawa i ka lā. ʻO ia ka ʻoi aku ka maʻi ʻehaʻeha kūpono e like me nā inikini insulin.
ʻO kahi poʻe agonist ka mea hoʻokipa GLP-1
ʻO GLP-1 (e like me ka peptide-like pona-1) kekahi o nā hormones i hana i loko o ka papa gastrointestinal i kahi pane ʻana i ka ʻaina meaʻai. Hoʻoikaika i ka pancreas o ka manawa kēia e hana i ka insulin. Hoʻololi i kēia hāmeʻa ka hakahaka o ka ʻōpū a hoʻēmi i ka momona. Manaʻo ʻia nō hoʻi e hoʻoulu i ka hoʻihoʻi hou ʻana i nā cell beta pancreatic.
Hoʻopauʻia nā kūlohelohe o ke kūlohelohe kanaka like-peptide-1 i ke kino i 2 mau minuke ma hope o ka synthes. Hoʻohana ʻia ia e like me ka pono a hana wikiwiki. ʻO nā analogues synthetic kāna mau lāʻau Bayeta (exenatide) a me Viktoza (liraglutide). Loaʻa lākou ma ke ʻano o nā injections. Hana ʻia ʻo Baeta no kekahi mau hola, a ʻo Viktoza - ia lā.
Baeta (Exenatide)
Hoʻomaopopo nā mea hana i ka lāʻau Baeta i kahi lāʻau hoʻokahi i hoʻokahi hola ma mua o ka ʻaina kakahiaka, a i kekahi i ke ahiahi, hoʻokahi hola ma mua o ka ʻaina. Ua ʻōlelo ʻo Dr. Bernstein e hana ʻokoʻa - e kāʻili ana iā Bayete 1-2 mau hola ma mua o ka manawa o ka mea maʻi e hoʻomaʻamaʻa pinepine a iʻa paha o ka gluttony. Inā he overeat hoʻokahi i hoʻokahi lā, ʻo ia ka mea e lawa ia no Bayet e kiʻi i hoʻokahi manawa ma ka maʻa o 5 o 10 mau micrograms. Inā nui ka pilikia o ka overeating i nā manawa i ke ao, a laila e hāʻawi i kahi inikua i kēlā me kēia manawa i ka hola ma mua o ka puka ʻana o kahi ʻano maʻamau, ke ʻae ʻoe iā ʻoe iho e ʻai nui.
Pēlā, ua hoʻokumu pono ka manawa kūpono no ka maʻi a me ka hala ma ka hoʻāʻo a me ka hewa. Ma ke ʻano, ʻo ka nui loa ka nui o nā lā ʻo Baeta he 20 mcg, akā makemake paha nā poʻe me ka huʻeha i ka maʻi nui. E kū'ē i ke kua o ke ʻano o ka lapaʻau o Bayeta, hiki ke hoʻohaʻahaʻa koke ʻia ka nui o ka nui o ka insulin a i ʻole ka lāʻau diabetes i ka 20%. A laila, e pili ana i nā hopena o ke ana ʻana i ke kōpaʻa koko, ʻike inā pono ʻoe e hoʻohaʻahaʻa a e hoʻonui paha iā ia.
ʻO Victoza (liraglutide)
Hoʻohana ʻia ka lāʻau lapaʻau ʻo Viktoza ma 2010. Pono e hana ʻia kāna maʻi i ka manawa 1 i kēlā me kēia lā. Hoʻomaopopo ka maʻi maʻi i kahi mau hola 24, e like me ka mea e koi ai nā mea hana. Hiki iā ʻoe ke hana i kēlā me kēia manawa i ka lā. Akā inā he pilikia nui kāu me ka ʻai nui ma ka manawa like, no ka laʻana, ma mua o ka pāʻina awakea, a laila e kāhea iā Victoza 1-2 mau hola ma mua o ka ʻaina awakea.
Ua manaʻo ʻo Kauka Bernstein i ka lāʻau lapaʻau ikaika ʻo Victoza e kāohi ai i ka leʻaleʻa, hoʻokō i ka overeating a lanakila i ke kūpaʻa ana o ka pale. Eʻoi aku ka maikaʻi ma mua o ka Baeta, a maʻalahi hoʻi ka hoʻohana.
Nā mea DPP-4
ʻO DPP-4 kahi dipeptyl peptidase-4, kahi enzyme e hoʻopau ai i ka GLP-1 ma ke kino kanaka. Hoʻopili nā DPP-4 i kēia kaʻina hana. I kēia lā, aia nā huaʻōlelo i kēia hui:
- Januvia (sitagliptin);
- Onglisa (saxagliptin);
- Galvus (vidlagliptin).
ʻO kēia mau lāʻau lapaʻau a pau i loko o nā papa, ke manaʻo ʻia e lawe i ka manawa 1 i kēlā me kēia lā. Aia pū kekahi lāʻau lapaʻau (linagliptin), ʻaʻole kūʻai aku ma nā ʻāina e ʻōlelo nei me Rūsia.
Kauka ʻo Dr. Bernstein no ka aneane o ka inhibitors ʻo DPP-4 ʻaʻole i loaʻa kahi hopena i ka mea momona, a he haʻahaʻa hoʻi i ka holi koko ma hope o ka ʻai ʻana. Ua koho ʻo ia i kēia mau lāʻau lapaʻau no ka poʻe maʻi me ka maʻi diabetes type 2 ke keʻa nei i ke metformin a me ka pioglitazone, akā hiki ʻole ke hele i ke kō koko aʻai a hōʻole e mālama ʻia me ka insulin. ʻAʻole lawa nā hoʻololi mai ka DPP-4 i kēia kūlana, akā, ʻoi aku ka maikaʻi ma mua o ka mea ʻole. ʻAʻole ma nā hopena ʻaoʻao mai ka lawe ʻana iā lākou e hana.
Nā hopena hopena o nā lāʻau lapaʻau e hōʻemi ai i ka makemake
Ua hōʻike ʻia nā haʻawina holoholona holoholona i ka lawe ʻana i nā lāʻau lapaʻau type-type ka mea i hoʻihoʻi hou i kā lākou pancreatic beta cell. ʻAʻole paha i hoʻoholo ʻia inā e like ka hana like me ka mea i ka poʻe. Ua ʻike ʻia nā haʻawina like holoholona like me ka ulu ʻana o kekahi mau maʻi thyroid maʻa liʻiliʻi e hoʻonui iki ʻia. Ma kekahiʻaoʻao, hoʻonui ka nui o ke kō koko koko nui i ka ʻokoʻa ʻana o nā ʻano ʻehā like ʻole. No laila ʻoi aku ka maikaʻi o nā hua o ka lāʻau lapaʻau ma mua o ka hopena e hiki ai.
Me ka lawe ʻana i nā lāʻau lapaʻau type-type, he hoʻonui nui loa o ka pancreatitis - ka huhū o ka pancreas - ua hoʻopaʻa ʻia no ka poʻe i loaʻa ka pilikia me ka pancreas. E pili ana ka pilikia ma mua, i ka mea āpau. ʻO nā koena ʻokoʻa o nā maʻi maʻi kōpū i hopohopo nui.
ʻO kahi hōʻailona o ka pancreatitis ka mea a me ka hōʻeha a me ka ʻeha hōʻeha o ka ʻōpū. Inā ʻoe e manaʻo, e kiʻi koke i ke kauka. E hōʻoia ʻo ia a hōʻole paha i ka maʻi maʻi pancreatitis. I kēlā me kēia hihia, hoʻōki koke i ka lawe ʻana i nā lāʻau lapaʻau me ka hana incretin a pau ʻole nā mea āpau.
