ʻO ka poʻe maʻi e hōʻeha nei i nā maʻi lipid metabolism e koho pinepine, ʻoi aku ka maikaʻi - Atorvastatin a i ʻole Rosuvastatin? ʻOiai ua hoʻohana nui ʻia ʻo Rosuvastatin i kēia manawa, ʻaʻole hiki ke hāʻawi ʻia i kahi pane kūpono i kēia nīnau, no ka mea ua loaʻa i nā lāʻau lapaʻau nā pono āpau a me nā pono.
Pono e hoʻokaʻa ʻia nā lāʻau ʻelua no nā pathologies e like me ka palu ʻana a i ʻole homozygous hypercholesterolemia (hoʻonui LDL), hypertriglyceridemia (nui triglycerol) a me ka atherosclerosis (nāʻiliʻili ʻana o ka lumen o nā kīʻaha koko ma ke ʻano he mea hoʻopiha o ka pli kolesterol). Hoʻohana ʻia lākou e pale i nā hoʻopiʻi o ka atherosclerosis - hypertension, maʻi maʻi coronary, ʻeha a me ka puʻuwai puʻuwai.
ʻOiai he ʻokoʻa ma waena o nā contraindications, nā ʻōpiopio, nā pharmacokinetics a me nā pharmacodynamics, pono e ʻike i ka lāʻau lapaʻau i ʻoi aku ka palekana.
He aha nā helu?
Aia nā statins i kahi hui liʻiliʻi nui o nā lāʻau lapaʻau i hoʻohana ʻia e hoʻohaʻahaʻa i ka ʻike o LDL a me VLDL i ke koko.
Ma ka hana lapaʻau hou, ʻaʻole hiki ke hoʻokaʻawale ʻia nā statins no ka pale ʻana a me ka mālama ʻana i ka atherosclerosis, hypercholisterinemia (hui ʻia a i ʻole homozygous), a me nā maʻi cardiovascular.
Ma keʻano holoʻokoʻa, loaʻa i nā lāʻau lapaʻau o kēia hui like nā hopena therapeutic, i.e. haʻahaʻa haʻahaʻa LDL a me VLDL. Eia nō naʻe, ma muli o ka ʻano o ka hana like a me nā mea kōkua, aia kekahi mau ʻokoʻa e pono e noʻonoʻo i ka manaʻo e pale ai i nā hopena ʻino.
ʻO nā statins i hoʻokaʻawale ʻia ma I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) a me IV hanauna (Pitavastatin, Rosuvastatin).
Hiki i nā loina ke kūlohelohe a me ke ʻano kumu. No kahi loea, kahi koho o nā lāʻau haʻahaʻa haʻahaʻa, maʻalahi-, a i ʻole no ka mea maʻi ma kahi nui.
Hoʻohana pinepine ka Rosuvastatin a me Atorvastatin e hoʻohaʻahaʻa i ka cholesterol. ʻO kēlā me kēia mau lāʻau lapaʻau he mau hiʻohiʻona:
ʻO Rosuvastatin e pili ana i nā statins o ka hanauna ʻehā. Hoʻopili piha ʻia ka lipid-hoʻohaʻahaʻa i ka nui o ke ʻano o ka mea ikaika. Hoʻohana ʻia ia ma lalo o nā mea kūʻai aku, no ka laʻana, Krestor, Mertenil, Rosucard, Rosart, etc.
ʻO Atorvastatin e pili ana i nā stins o ka hanauna ʻekolu. E like me kona kaila, he kumu synthetic, akā loaʻa kahi kiʻekiʻe o nā mea ikaika.
Aia kahi mau like like o ka lāʻau like Atoris, Liprimar, Toovacard, Vazator, etc.
ʻO ka hiʻohiʻona kemika o nā lāʻau lapaʻau
Loaʻa nā ʻelua lāʻau i ke paʻi papa. Ua hua ʻia ʻo Rosuvastatin i hoʻokahi mauʻano - 5, 10 a me 20 mg o ka hana like. Hoʻokuʻu ʻia ʻo Atorvastatin i kahi waihona papaʻi o 10,20,40 a me 80 mg o ka mea kanu ikaika. Aia ma lalo kahi papa e hoʻohālikelike ai i nā mea kōkua o nā mākaʻi kaulana o nā statins ʻelua.
| Rosuvastatin | Atorvastatin (Atorvastatin) |
| ʻO Hypromellose, ke kō, nā titanium dioxide, crospovidone, microcrystalline cellulose, triacetin, magnesium stearate, silicon dioxide, titanium dioxide, carmine dye. | Lactose monohidrat, sosa croscarmellose, titanium dioxide, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, microcrystalline cellulose, |
ʻO ka hoʻololi nui ma waena o Rosuvastatin a me Atorvastatin ko lākou mau wahi physicochemical. ʻO ka pōmaikaʻi o rosuvastatin e maʻalahi ia i wāwahi i ka plasma koko a me nā waiila'ē aʻe, i.e. is hydrophilic. Loaʻa i ka Atorvastatin kahi hiʻohiʻona: soluble i loko o nā momona, i.e. he lipophilic.
E pili ana i kēia mau hiʻohiʻona, kuhikuhi nui ka hopena o Rosuvastatin i nā pūpuna o ka parenchyma ate, a me Atorvastatin - i ke ʻano o ka lolo.
ʻO ka pharmacokinetics a me ka pharmacodynamics - nāʻokoʻa
Aia ma ke kahua o ka lawe ʻana i nā papa, ʻokoʻa nā ʻokoʻa ma ko lākou lawe ʻana. No laila, ʻaʻole i hilinaʻi ka hoʻohana ʻana o Rosuvastatin i ka manawa o ka lā a i ʻole ka pāʻina. ʻAʻole pono e hoʻopau Atorvastatin i ka manawa like me ka meaʻai, e like me hōʻeha kēia i ka hoʻopili ʻana o ka mea hana. Loaʻa ka ʻike kiʻekiʻe loa o Atorvastatin ma hope o 1-2 mau hola, a ʻo Rosuvastatin - ma hope o 5 mau hola.
ʻO kekahi ʻano ʻē aʻe ma waena o nā statins ʻo kā lākou metabolism. I ke kino o ke kanaka, ua hoʻohuli ʻia ʻo Atorvastatin i kahi ʻano hana ʻole me ka hoʻohana ʻana i nā huina o ka ate. Pēlā e pili pili ana ka hana o ka lāʻau i ka hana o ke ake.
Pilikia pū kekahi i nā lāʻau lapaʻau i hoʻohana pinepine ʻia me ka atorvastatin. ʻO kona analogue, ma kahi ʻē aʻe, ma muli o ke kumu haʻahaʻa, ʻaʻole i kū like ka lāʻau lapaʻau ʻē aʻe. ʻOiai ʻaʻole kēia e hoʻopakele iā ia mai ke alo o kahi hopena maikaʻiʻole.
Hoʻopili ʻia ʻo Atorvastatin me ka bile.
ʻAʻole i like nā ʻelele he nui o nā statins, ʻaʻole aneane i hoʻohālikelike ʻia ʻo Rosuvastatin i loko o ke akeo: ʻoi aku ma mua o 90% o nā mea i lawe ʻia ʻole e ka ʻili a pono wale nō ʻo 5-10% e nā keiki.
Nā hiʻohiʻona a me nā hopena maikaʻiʻole
ʻO ka hele mai o nā contraindications a me nā hana maikaʻi ʻole nā mea koʻikoʻi ke koho i ka lāʻau maikaʻi loa. ʻO kēia ka maʻi nui a me nā kūlana e pāpā ʻia ai ka hoʻohana ʻana i nā lāʻau lapaʻau, a me nā hopena like ʻole.
| Nā Hoʻohui | |
| Rosuvastatin | Atorvastatin |
| Keʻano pilikino. ʻŌpū a me ka lactation. Hōʻino i nā hepatocytes a i hoʻokiʻekiʻe ʻia i nā aihue. ʻO nā keiki a me nā wā'ōpiopio ma lalo o 18 makahiki. ʻO Myopathy a i kahi predisposition iā ia. ʻO ka nānā ʻana me ka cyclosporine a me nā fibrates. Hoʻolālā gen Renal. Ka maʻi waʻeha ʻO Myotoxicity aʻo ke lawe aku i nā inhibitors hou o HMG-CoA. ʻO ka hoʻohana ʻana o nā mea paʻa protease HIV. ʻO nā Lunamakaʻāinana o ka lāhui Mongoloid (he ʻae ʻia wale nō ka lawena palena ʻae ʻia). | Hypersensitivity i nā ʻāpana. Ka hoʻonui ʻana o nā hana o nā ate enina. Hānau pālua a me ka lactation manawa. ʻO nā keiki a me nā wā'ōpiopio ma lalo o 18 mau makahiki o ka makahiki, me ka ʻokoʻa o ka lāʻau lapaʻau no ka hypercholesterolemia heterozygous. ʻO ka hemahema o ka hoʻohālikelike kūpono ʻana. ʻO ka hoʻohana ʻana o nā mea paʻa protease HIV. ʻO ka maʻi maʻi pūpū. |
| ʻO nā hopena ʻino | |
| He poʻe kuʻuna, nā pilikia hoʻonohonoho, ʻōpū ākea. Ke hoʻomohala ʻana o ka proteinuria a me hematuria. ʻOhiʻā, ʻili, ʻūhā. Hōʻeha i ka ʻōnaehana musculoskeletal. Dyspepsia, ke keʻokeʻo, hoʻopukapuka o ka pancreas (pancreatitis). Mellitus non-insulin-hilinaʻi mellitus. ʻO ka ulu ʻana o nā kāne i nā kāne. ʻO ka heleʻana o ka umala maloʻo, oki pōkole. ʻO Kēlā Kukui Stevens-Johnson. | ʻO ka hoʻomohalaʻana i ka nasopharyngitis, nā maʻi o ka urinary tract. ʻO ka hopena o ka thrombocytopenia. Hypo- a me hyperglycemia, anorexia. ʻO ka ʻeha ma ke poʻo, paresthesia, ka hoʻomohala ʻana o ka neuropathy peripheral, hypesthesia, amnesia, dizziness, dysgeusia. E hoʻolohe ana i nā hemahema, ka tinnitus, ʻike ʻole i ka ʻike. Kakahiʻe ʻāhewa, nosebleeds. ʻO ka maʻi Dyspeptic, ka belching, ka eha epigastric, ka hoʻomohalaʻana o ka pancreatitis. Urticaria, rashes ʻili ʻia, edema ʻo Quincke. ʻO ka hiʻohiʻona o ka gynecomastia. ʻO nā maʻi ʻē aʻe o ka ʻōnaehana musculoskeletal. ʻO ka hepatitis, ke kuʻi hema, cholestasis. Herterthermia, asthenia, malaise. Hoʻonui ka hana o nā enzyme o ka ate, QC a me ka hoʻoponopono maikaʻi ʻana no ka leukocytes i ka urine. |
Pono a me nāʻike ʻē aʻe
ʻO ka hana nui o ka lāʻau statin e hōʻemi i ka neʻeʻana o ka LDL i ke koko a hoʻonui i ka kiʻekiʻe o ka HDL.
No laila, ke koho nei ma waena o Atorvastatin a me Rosuvastatin, pono mākou e hoʻohālikelike i ka maikaʻi e hoʻohaʻahaʻa ai i ka cholesterol.
Ua hōʻike ʻia kahi noiʻi ʻepekema hou loa he lāʻau ʻoi aku ka maikaʻi o ka rosuvastatin.
Hōʻike ʻia nā hopena hoʻokolohua hoʻokolohua ma lalo nei:
- Me nā like pū o nā lāʻau lapaʻau, hoʻemi ʻo Rosuvastatin i ka kolamu LDL e ka 10% ʻoi aku ka maikaʻi ma mua o kāna hoʻohālikelike. Loaʻa kēia pono i ka hoʻohana ʻana i ka lāʻau lapaʻau no nā poʻe maʻi me ka hypercholesterolemia koʻikoʻi.
- ʻO ke alapine o ka hoʻomohala ʻana o nā hoʻopiʻi cardiovascular a me ka hoʻomaka ʻana o kahi hopena fatal e kiʻekiʻe aʻe ma Atorvastatin.
- ʻO ka ulu ʻana o nā hopena ʻino e like nō no nā lāʻau ʻelua.
ʻO ka hoʻohālikelike o ka maikaʻi o ka hōʻemi ʻana i ka neʻe o ka "bad" cholesterol i hōʻike i ka mea ʻoi ke maʻi ʻo Rosuvastatin. Akā naʻe, mai poina ka mea e pili i nā mea e like me ka hele ʻana o nā contraindications, nā hopena a me nā uku. ʻO ka hoʻohālikelike o nā kumukūʻai o nā lāʻau ʻelua i hōʻike ʻia i ka papaʻaina.
| ʻĀnō, helu o nā papa | Rosuvastatin | Atorvastatin |
| 5mg ʻAʻole 30 | 335 ʻōpala | - |
| 10mg ʻAʻole 30 | 360 rubles | 125 ʻōpala paha |
| 20mg ʻAʻole 30 | 485 RUB | 150 ʻōpala |
| 40mg ʻAʻole 30 | - | 245 RUB |
| 80mg ʻAʻole 30 | - | 490 rub |
No laila, ʻo ka atorvastatin kahi analogue haʻahaʻa e hiki ai i ka poʻe haʻahaʻa haʻahaʻa ke kālā.
ʻO ia ka mea e noʻonoʻo ai i nā mea maʻi e pili ana i nā lāʻau lapaʻau - ke hoʻomanawanui maikaʻi nei ʻo Rosuvastatin a ʻaʻohe pilikia. Ke lawe ʻia, hoʻemi ʻia ka cholesterol maikaʻi ʻole
Hoʻohālikelike ka lāʻau lapaʻau e hoʻopau i kēia manawa i ka hoʻomohala ʻana o ka lāʻau lapaʻau, nā kūlana mua ma waena o nā papa kolamu maikaʻi loa e noho ʻia e nā statins o ka hanauna ʻehā, me ka komo pū ʻana Rosuvastatin.
E pili ana i ka lāʻau lapaʻau Rosuvastatin a me nā mea i hoʻohālikelike ʻia i ke wikiō ma kēia ʻatikala.
