I ka hoʻomaʻamaʻa cardiological, nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka pae o ka endogenous cholesterol i loaʻa i kekahi kaulana. Pili nā helu helu like me ka mea kiʻekiʻe e pili ana i ka pathology cardiovascular ma muli o ke kiniki lipid. Wahi a nā ʻōkuhi kuahiwi honua, nā lāʻau lapaʻau o ka pūʻulu statin ka mea mua i ka lāʻau lapaʻau lāʻau o ka mea maʻi.
He koho pinepine nā kauka - Simvastatin a i Atorvastatin?
Ke kūlike nei ka koho ma waena o kēia mau lāʻau ʻelua a ke kauka o ka mea maʻi, i ka nānā ʻana i nā ʻano āpau o ka mea maʻi.
ʻOiai ʻo ka kaulana kaulana i hoʻonāukiuki ʻia ma mua o ka nui o nā hoʻopiʻi ʻana, ʻo nā statins nā lāʻau maikaʻi loa e hōʻemi i ka nui o ka make ma nā kaʻina atherosclerotic.
Nā hōʻailona no nā stins
Aia nā statins i ka hui o nā lipid-hoʻemi haʻahaʻa.
ʻO ka hōʻailona nui no ka mea i koho ʻia ka hoʻoponopono ʻana o ka hana lipid metabolism.
ʻO kahi papa hopena mua o ka lāʻau lapaʻau e hiki ai iā ʻoe ke hoʻomaʻamaʻa i ka momona metabolism a hoʻopau i nā hōʻailona āpau o ka hōʻemi kino o ka atherosclerotic.
Ma ka hoʻomaʻamaʻa lāʻau, ua pono ke hoʻohana ʻia o statins no:
- ka hana pū ʻana me ka ʻaina o ka hana kino dosed o ka poʻe maʻi me nā kiʻekiʻe kiʻekiʻe o nā lipher atherogen i loko o ke koko;
- e hoʻonui i ke kiʻekiʻe o nā lipoproteins antiatherogenic;
- no ka hoʻohana ʻana i nā maʻi e ʻike ʻole i nā hoʻopiʻi kumuhana o ka pathology pathology, akā aia nō i ka pilikia (ʻo ka luhi o nā mōʻīlau hoʻoilina, nā hoka, nā maʻi maʻi hypertensive, diabetes mellitus);
- ka mālama ʻia ʻana o ka maʻi naʻau coronary, ka mea i hōʻike ʻia e ka angina pectoris;
- ka pale ʻana o nā ulia o ka maʻi cardiovascular;
- ka mālama ʻana i nā maʻi hoʻohemo i pili me nā maʻi dyslipidemic.
- ka mālamaʻana i ka metabolic syndrome.
ʻO ke kuhi o nā noi o nā lāʻau ʻelua ke mālama i ka lipid metabolism.
ʻO ke koho e makemake ana i ka Atorvastatin a i ʻole Simvastatin, ka mea i hoʻopili ʻia o ia ʻano mea like, e hilinaʻi ʻia i nā mea he nui. No ka laʻana, ʻoi aku ka maikaʻi o ka statin i mea e pale aku ai ka lua, i ka lua no ka mālama ʻana.
Eia kekahi, pili ka pono i ke koho ʻana o nā contraindications a me nā mea e kau ʻia ai ka hoʻohana ʻana.
ʻO ka hoʻolaha ʻana i kahi lāʻau lapaʻau kūikawā, ke hoʻohuli ʻole ʻia i ke kūlana kulekele, kahi hewa ʻole ʻole. Pono ke koi ʻana i nā ʻike piha o ke kūlana olakino o ka mea maʻi.
ʻO nā hiʻohiʻona maʻamau o nā statins
Wahi a ka helu honua, ua mahele ʻia nā statins i nā lāʻau semisynthetic mua synthesized a, ma hope aku, synthetic. Hoʻohana 'iaʻi nā hanauna o nā lālani.
ʻO Simvastatin kahi statin mua-mana semi-synthetic. Atorvastatin - i ke ʻano hana o ka hanauna 4. Hōʻike ka hanauna ʻehā o nā statins i ka hoʻokō kiʻekiʻe a me nā wahi liʻiliʻi o nā hopena hoʻopiʻi.
ʻO ka maʻi Hypolipidemic hiki iā ia ke hōʻemi i ka neʻe o ka lipids atherogenic ma o ka liʻiliʻi ʻekolu.
I ka hui pū ʻana me kahi meaʻai kaulike a me ka hana kino dosed, hiki i ka lāʻau ke hoʻōla i ka hana lipid metabolism.
He nui nā poʻe maʻi e noʻonoʻo nei no ka mea ʻokoʻa ma waena o ka lāʻau Simvastatin a me ka mea hou aku ʻo Rosuvastatin (ka inoa kālepa - Crestor). I kēia lā, makemake nā poʻe loea i ka lāʻau Rosuvastatin. ʻO ka mea hope loa he huahana lāʻau lapaʻau hou. Ke koho nei i ka simvastatin a i ka rosuvastatin kahi ʻoi aku ka maikaʻi, hāʻawi ʻia ka makemake i ka rosuvastatin. ʻO ka hana o kāna hana he wikiwiki ka wikiwiki o nā molekui ikaika i ka hepatocytes, kahi ia e loaʻa ai ka hopena ma ke kiʻekiʻe o ka hōʻailona synthesized. A ke hopena, hōʻemi ʻia ka ʻike ʻana o ka cholesterol endogenous a luku ʻia nā ʻano atherosclerotic i hoʻokumu ʻia.
He mea nui ia e hoʻomaopopo i ʻae ʻia nā statins me ka ʻole o ke kauka kauka. ʻO kēia pāpā paʻa loa e pili me nā ʻano o contraindications a me nā palena.
Ma mua o ka hapalua o nā mea maʻi e lawe i nā statins i waiho i nā loiloi unflattering e pili ana i ka lāʻau. Eia naʻe, ʻo ka hapa nui o nā hopena ʻaʻole ia kahi hōʻike no ka haʻalele o ka lāʻau.
Ma keʻano holoʻokoʻa, hoʻokaʻawale maikaʻi nā statins a loaʻa i kahi hopena pono e pili ana i ka lipid metabolism.
Nā ʻōkuhi no ka hoʻohana ʻana i ka simvastatin
ʻO ka lāʻau lapaʻau he māla semi-synthetic o ka hanauna mua o nā statins. Ke kōkua nei kāna kauka maʻamau i kahi hoʻemi nui ʻana i ka pae o ka cholesterol atherogenic a me ka pale ʻana i ka hoʻomohala ʻana i ka maʻi o ka maʻi āpau.
Eia naʻe, ua haʻahaʻa ka hopena o Simvastatin me nā hanauna ʻē aʻe. Eia naʻe, me ka maʻalahi o ka hōʻeha o ka atherosclerosis a me ka hoʻohui pū ʻana me ka mea ʻai a me ke kaumaha, ua lawa ka pono o kēia lāʻau lapaʻau no ka mālama ʻana i ka mea maʻi.
Wahi a nā ʻōlelo kauoha no ka komo ʻana, e manaʻo ʻia ka huahana no ka hoʻohana ʻana i loko. Loaʻa ka lāʻau lapaʻau i kahi palapala papa.
Manaʻo ʻia e lawe i kahi pākahi hoʻokahi o ka lāʻau i ke ahiahi, me ka ʻaole ʻole ʻana i ka kūʻokoʻa o ka pūpū.
Hoʻoholo ka ʻāpana o kēlā me kēia lā i hoʻokahi manawa. Ma mua o ka hoʻomaka ʻana i ka maʻi me ka simvastatin, ʻoi ʻia e hoʻokō i ka hoʻoponopono ʻana o ka lipid metabolism me ka hoʻohana ʻana i ka hana hoʻoikaika kino a me ka meaʻai kūpono. Hiki i ke lāʻau lapaʻau ke wehewehe wale i ka pau ʻole o ka hopena o ka meaʻai a me ke kaumaha.
Hoʻoholo ʻia ka lōʻihi o ke papa a me ka loaʻa o ka simvastatin e ke kauka mea maʻi, i ka ʻike ʻana i ka pae hoʻomaka o ka cholesterol a me nā ʻano o ke kino.
Hoʻololi ʻia ka ʻōhala o kēlā me kēia lā i ka 5 a 80 milligrams.
Hiki ke hoʻoponopono ʻia i ka lāʻau ʻōlelo ma mua o hoʻokahi mahina ma hope o ka hoʻomaka ʻana o ka mālama ʻana.
Hoʻole ʻia i ka hoʻololi kūʻokoʻa a hoʻoulu i ka lāʻau lapaʻau.
ʻO ka alakaʻi kūpono ʻana i ka lāʻau lapaʻau e hōʻoia i ka hoʻomaka ʻana o kahi hopena therapeutic ma ka hopena o ka mahina mua o ka hoʻomaʻamaʻa.
Ma hope o hoʻokahi mahina a me ka hapa, e pae ʻia ka pae o ka cholesterol atherogenic.
ʻAʻohe o statins i kahi hopena cumulative. Mālama wale nō ka lāʻau lapaʻau i ka wā o kona hoʻoponopono.
Inā ʻaʻole ʻoe e hahai i kahi ola olakino ma hope o ka hoʻokuʻu ʻana i ka lāʻau lapaʻau, ma hope o kekahi manawa, hiki ke piʻi hou ka ʻaila o ka lua o ka endogenous.
Nā ʻōkuhi no ka hoʻohana ʻana i atorvastatin
Hiki i kēia lāʻau lapa ke ʻano hou me ka wikiwiki. Pono e hoʻohālikelike ʻia no ke kolamu kiʻekiʻe, ka maʻi naʻau coronary, mellitus maʻi maʻi koʻikoʻi a no ka pale ʻana o nā maʻi cardiovascular catastrophes.
Loaʻa i ka Atorvastatin ka loiloi kiʻekiʻe loa mai nā kauka olakino e pili ana i kāna hana koʻikoʻi.
ʻO ka Atorvastatin kahi lāʻau lapaʻau i manaʻo ʻia no ka hoʻoponopono waha. Pēlā nō e like me ke kūlana me Simvastatin, ʻo Atorvastatin e pono ke kuhikuhi wale ma hope o ka loaʻa ʻole o ka lāʻau lapaʻau ʻole.
Koho ʻia ka ʻōkuhi o kēlā me kēia lā e noʻonoʻo i ka nui o ka maʻi a me nā ʻano pilikino o ka mea maʻi.
ʻO ka pilina mua o ka lāʻau lapaʻau he 10 mg. Hoʻopili ʻia ka hoʻoponopono ʻana ma hope o hoʻokahi mahina mai ka hoʻomaka ʻana o ka mālama ʻana.
ʻO ka hoʻohana pinepine ʻana i ka lāʻau lapaʻau e hāʻawi i ka emi ʻana o ka neʻe o ka lipher atherogenic ma mua o ka hapalua.
ʻO kahi hiʻohiʻona o ka lāʻau lapaʻau he hopena hōʻoluʻolu i nā nephrons. Ma kēia pili, ua hōʻike ʻia no ka hoʻohana ʻana e nā mea maʻi e loaʻa ana i ka hiki ʻole o ka pilikia ʻoi. ʻO ka nui loa o ka lāʻau lapaʻau ka 80 mg. Hōʻike ʻia ʻo Atorvastatin i nā keiki i kahi pane iʻoi aku ma mua o 20 mg.
Ma mua o lawe i ka mea, pono ia e hoʻokaʻawale i nā enzyme o ka naʻau.
He mea nui ia i ka wā mālama e loiloi i ka hana a ka enzymatic o ka pepelu.
Nā hopena ʻaoʻao a me nā contraindications no nā statins
ʻO kahi hiʻohiʻona o ka hoʻohana ʻana o Atorvastatin a me Simvastatin ka mālama mau ʻana i nā lālā nui a me nā ʻōnaehana. He hopena koʻikoʻi ka lāʻau lapaʻau i nā hana momona o ka momona. Ma kēia hono e pili ana i ka mālama ʻana i ka homeostasis o ke kino.
Ua haʻi aku nā statins i nā hana pharmacological no laila, ua palena kā lākou hoʻohana i kekahi mau kūlana physiological a me ka pathological.
ʻO nā ʻano e pili ana i kēia mau contraindications i ka hoʻohana ʻana o statins:
- He mōʻaukala o ka hypersensitivity i nā lāʻau i koho ʻia.
- Ka lule a lactose. ʻO ka hoʻonohonohoʻana o nā mākaukau ka lactose.
- Nā ʻano āpau o ka myopathy.
- ʻO nā maʻi o ka ate i kahi hana ikaika.
- Nā makahiki o nā keiki a hiki i 10 mau makahiki.
- Alikaihue
- ʻO nā maʻi ʻeha hope loa.
- ʻO ka hopena kiʻekiʻe loa o ka hana renal ka hoʻomaʻamaʻa.
- Therapy me nā immunosuppressants.
- Hoʻolālā no ka hana nui.
- Ua papa ʻia ʻo ka lawe ʻana i nā kaʻa a me nā ʻenemi e koi ai i ka piʻi ʻana a me ka nānā nui ʻana i ka wā e lawe ana i nā statins.
- Kahawai Loaʻa ka lāʻau lapaʻau i ka hopena teratogenic ikaika. I kēia pili, ua pāpā ʻia no ka hoʻohana ʻana i nā wahine hāpai.
- Hoʻokaumana.
Ke lawe nei i nā statins semi-synthetic, pono e haʻalele i nā kīʻaha citrus, mai ka wā i hui pū ʻia, piʻi ka nui o nā hopena ʻaoʻao.
Hoʻokomo pinepine nā ʻaoʻao i nā hopena ma muli o nā pilala pono ʻole ke koho ʻia. Eia nō naʻe, i kekahi mau hihia, ʻaʻole i hoʻopili ʻia nā hopena o ka lāʻau.
ʻO ka hopena ʻokoʻa ka hiʻohiʻona no nā statins:
- nā poʻo, a hiki i ka hoʻomohala ʻana o ka ʻeha puʻuwai a me ka migraine;
- maʻi hana ʻōnaehana;
- nā hoʻohālikelike o ka hiamoe a me ka hiamoe hiamoe;
- nāwaliwali, nāwaliwali;
- molepole hana;
- nā pepeke
- Nā maʻi CNS.
ʻO ka mea paʻakikī loa a me ka hoʻopiʻi kūikawā o ka lāʻau statin ka hoʻomohala ʻana o ka rhabdomyolysis. ʻO kēia hiʻohiʻona ma muli o ka hopena o ka hopena o ka lāʻau ma luna o nā uaua mākeke.
He kūlana pōpilikia ʻo Rhabdomyolysis kahi e hiki ai i ka hoʻopōʻino i ka tubula renal a me ka hoʻomohala ʻana o ka hana ʻole o ka aʻalolo.
Ke koho pono lāʻau
No ka hoʻoholoʻana i ka pono o kahi lāʻau hiki ke hoʻohana wale ia inā hoʻohana i kekahi mea maʻi. I ka hoʻoponopono ʻana e nā waiwai pharmacological, ʻo Atorvastatin he hana hou aku nei i kēia mau mea hou a ikaika hou, inā mākou e lawe nei i nā ʻaina semi-synthetic i ka hoʻohālikelike. ʻO ka ʻokoʻa nui ka waiho ʻana i nā hiʻohiʻona o ka synthesis a me pharmacodynamics o nā lāʻau.
ʻO ka hoʻohana ʻana o ka atorvastatin e hoʻopili i ka hōʻiliʻili o kahi huahana mea kūlohelohe - sterol, e hoʻonāukiuki i ka hopena maikaʻi ʻana i nā hana ʻōiwi. Hoʻohui pū kekahi ʻo Simvastatin i nā hopena myotoxic, akā i ka meaʻoi loa.
Hōʻike ka hoʻohālikelike hoʻohālikelike o nā lāʻau lapaʻau e kōkua ana ka atorvastatin i ka hoʻomaʻamaʻa wikiwiki i ka kolesterol. ʻO kēia kumu nui ka pane nui ma waena o nā mea hana ʻelua.
Wahi a ke aʻo ʻana, he pono ka hui hoʻohui me nā lāʻau phyto. Loaʻa i kēia hui hui kahi hopena potentiating, a hoʻohaʻahaʻa i nā hopena ʻaoʻao o nā kālā. ʻAʻole hiki ke'ōlelo e loaʻa nā lāʻau lapaʻau, no ka laʻana, ʻo Ateroklefit a ʻo Ravisol, ʻoi aku ka maikaʻi ma mua o ka lāʻau Atorvastatin maʻamau, ʻoi aku ka maikaʻi e lawe iā lākou i ka hoʻohui.
Wahi a nā helu helu, ua hōʻoia ʻia ka hoʻohana ʻia ʻana o Atorvastatin no nā ʻano kiʻekiʻe o ka maʻi, ʻoiai ua ʻōlelo ʻia ʻo Simvastatin no prophylaxis. Pono ʻoe e kūʻai i nā lāʻau lapaʻau ma nā mākeke olakino kūpono ʻole a i ʻole nā lāʻau lapaʻau pūnaewele pūnaewele. Kūlike ke kumukūʻai ma Lūkia a me CIS i ka mea hana.
Loaʻa nā pono o ka hoʻohana ʻana i nā statins i ke wikiō ma kēia ʻatikala.
